Tmed7 (transmembrane p24 trafficking protein 7) - Rat Genome Database

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Gene: Tmed7 (transmembrane p24 trafficking protein 7) Mus musculus
Analyze
Symbol: Tmed7
Name: transmembrane p24 trafficking protein 7
RGD ID: 1621542
MGI Page MGI
Description: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in embryo. Orthologous to several human genes including TMED7 (transmembrane p24 trafficking protein 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3930401E15Rik; 5830493P14Rik; AU044611; AW545765; TRAM; transmembrane emp24 domain-containing protein 7; transmembrane emp24 protein transport domain containing 7
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391846,718,995 - 46,730,602 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1846,693,302 - 46,730,602 (-)EnsemblGRCm39 Ensembl
GRCm381846,585,928 - 46,597,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1846,560,235 - 46,597,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv371846,745,582 - 46,757,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361846,710,988 - 46,722,852 (-)NCBIMGSCv36mm8
Celera1847,945,556 - 47,957,160 (-)NCBICelera
Cytogenetic Map18CNCBI
cM Map1824.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:12904583  
PMID:14610273   PMID:14691545   PMID:15782199   PMID:16141072   PMID:16141073   PMID:20178780   PMID:21267068   PMID:21873635   PMID:28378742   PMID:30550785  


Genomics

Comparative Map Data
Tmed7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391846,718,995 - 46,730,602 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1846,693,302 - 46,730,602 (-)EnsemblGRCm39 Ensembl
GRCm381846,585,928 - 46,597,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1846,560,235 - 46,597,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv371846,745,582 - 46,757,189 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361846,710,988 - 46,722,852 (-)NCBIMGSCv36mm8
Celera1847,945,556 - 47,957,160 (-)NCBICelera
Cytogenetic Map18CNCBI
cM Map1824.65NCBI
TMED7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385115,613,210 - 115,626,036 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5115,613,210 - 115,632,992 (-)EnsemblGRCh38hg38GRCh38
GRCh375114,948,907 - 114,961,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365114,977,102 - 114,989,595 (-)NCBINCBI36Build 36hg18NCBI36
Build 345114,977,101 - 114,989,595NCBI
Celera5110,898,179 - 110,911,150 (-)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5110,130,510 - 110,143,485 (-)NCBIHuRef
CHM1_15114,381,532 - 114,394,506 (-)NCBICHM1_1
T2T-CHM13v2.05116,125,992 - 116,138,818 (-)NCBIT2T-CHM13v2.0
Tmed7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,505,167 - 41,512,243 (-)NCBIGRCr8
mRatBN7.21839,318,564 - 39,325,640 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,297,351 - 39,325,640 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1841,351,781 - 41,358,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01842,054,024 - 42,061,100 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,847,145 - 39,854,221 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,579,182 - 40,586,260 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,579,182 - 40,586,260 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01840,233,821 - 40,240,942 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41840,800,887 - 40,808,002 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11840,838,427 - 40,838,519 (+)NCBI
Celera1837,570,612 - 37,577,688 (-)NCBICelera
Cytogenetic Map18q11NCBI
TMED7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24110,860,757 - 110,874,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15109,014,418 - 109,028,202 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05110,970,162 - 110,983,414 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15116,766,470 - 116,779,513 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5116,766,470 - 116,779,513 (-)Ensemblpanpan1.1panPan2
TMED7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1115,342,265 - 5,356,828 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl115,342,265 - 5,356,828 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha115,492,917 - 5,507,480 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0115,334,331 - 5,348,924 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl115,334,331 - 5,349,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1115,289,646 - 5,304,207 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,358,822 - 5,373,386 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0115,612,704 - 5,627,313 (-)NCBIUU_Cfam_GSD_1.0
Tmed7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213128,079,197 - 128,090,975 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936742745,336 - 791,883 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936742779,964 - 791,738 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMED7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2119,788,483 - 119,804,463 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12119,794,608 - 119,804,406 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22124,682,078 - 124,691,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMED7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12318,864,021 - 18,875,089 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2318,866,758 - 18,874,975 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603459,522,754 - 59,534,106 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tmed7
330 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:478
Count of miRNA genes:344
Interacting mature miRNAs:397
Transcripts:ENSMUST00000036030, ENSMUST00000143178, ENSMUST00000151189
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558743Kcal1_mkilocalorie 1 (mouse)Not determined181901887453018992Mouse
1302163Bmd16_mbone mineral density 16 (mouse)Not determined182966791463668060Mouse
11532716Sluc41c_msusceptibility to lung cancer 41c (mouse)182261991456620127Mouse
11532715Sluc41b_msusceptibility to lung cancer 41b (mouse)182261991456620127Mouse
10412184Sstapa1_mSuseptibility to Staphylococus aureus infection 1 (mouse)Not determined184654154657590708Mouse
11532710Sluc41a_msusceptibility to lung cancer 41a (mouse)182261991456620127Mouse
25823171Hrsq10_mhost response to SARS QTL 10, D4% weight (mouse)182724111558827077Mouse
11532709Sluc41_msusceptibility to lung cancer 41 (mouse)182095369457590708Mouse
1301400Lmr13_mleishmaniasis resistance 13 (mouse)Not determined182810938062109518Mouse
25823174Hrsq11_mhost response to SARS QTL 11, log titer (mouse)182724111558827077Mouse
1301215Thcr_mT helper cell response (mouse)Not determined184513060468778777Mouse
1300638Im7_mimmunoregulatory 7 (mouse)Not determined181901887453018992Mouse
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1300994Pvcan3_mprotection against vaginal candidiasis 3 (mouse)Not determined181619964050199776Mouse
1301570Sluc14_msusceptibility to lung cancer 14 (mouse)Not determined182261991456620127Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
12880412V125Dq12_mvitamin D active form serum level QTL 12 (mouse)183023306764233067Mouse
1301771Pcyts6_mplasmacytoma susceptibility 6 (mouse)Not determined183565863269658851Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
1300877Adip8_madiposity 8 (mouse)Not determined182261991456620127Mouse
4141857Mhysq5_mmale hybrid sterility QTL 5 (mouse)Not determined2813060462130739Mouse
1300685Scc5_mcolon tumor susceptibility 5 (mouse)Not determined183198848065988629Mouse
4142366Chlq10_mcirculating hormone level QTL 10 (mouse)Not determined183629102270291180Mouse
12050070Nabq2_mnasal bone morphology QTL 2 (mouse)183910367773103793Mouse
1301307Phospq1_mphospholipid QTL 1 (mouse)Not determined181813970452139859Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
1357690Vtbt19_mvertebral trabecular bone trait 19 (mouse)Not determined183309104367091221Mouse
4142031Moen1_mmodifier of engrailed QTL 1 (mouse)Not determined182411556058115730Mouse
15039381Ltgq8_mliver triglyceride QTL 8 (mouse)183820656972206569Mouse
12904950Smmq3_msoleus muscle mass QTL 3 (mouse)182605687560056875Mouse
15039383Mvlq5_mmicrovesicular liver lesion QTL 5 (mouse)183820656972206569Mouse
25823167Hrsq5_mhost response to SARS QTL 5, D3% weight (mouse)182724111558827077Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
13463476Hctq8_mhematocrit QTL 8 (mouse)182121758055217727Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse
15039384Liviq1_mliver inflammation QTL 1 (mouse)183820656972206569Mouse
15039386Mvlq4_mmacrovesicular liver lesion QTL 4 (mouse)183820656972206569Mouse

Markers in Region
AW545765  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381846,586,171 - 46,586,251UniSTSGRCm38
MGSCv371846,745,825 - 46,745,905UniSTSGRCm37
Celera1847,945,799 - 47,945,879UniSTS
Cytogenetic Map18CUniSTS
Whitehead/MRC_RH18696.46UniSTS
AU044611  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381846,587,622 - 46,587,725UniSTSGRCm38
MGSCv371846,747,276 - 46,747,379UniSTSGRCm37
Celera1847,947,250 - 47,947,353UniSTS
Cytogenetic Map18CUniSTS
Whitehead/MRC_RH18693.14UniSTS
UniSTS:237797  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381846,585,973 - 46,586,235UniSTSGRCm38
MGSCv371846,745,627 - 46,745,889UniSTSGRCm37
Celera1847,945,601 - 47,945,863UniSTS
Cytogenetic Map18CUniSTS
px-50g7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map7B5UniSTS
Cytogenetic Map13A3.2UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map3B-DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map4C1UniSTS
Cytogenetic Map18CUniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map6G1UniSTS
Cytogenetic Map8A1.1UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic MapXDUniSTS
Cytogenetic Map2F2UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map9A1UniSTS
Cytogenetic Map4A5UniSTS
Cytogenetic Map4D2.2UniSTS
cM Map74.0UniSTS
cM Map1718.88UniSTS
cM Map241.25UniSTS
cM Map727.0UniSTS
cM Map342.1UniSTS
cM Map275.0UniSTS
cM Map153.6UniSTS
cM Map91.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_025698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV225029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV231886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW544395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB620206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC018585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD565393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN696073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX219174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000036030   ⟹   ENSMUSP00000043660
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1846,693,302 - 46,730,381 (-)Ensembl
GRCm38.p6 Ensembl1846,560,235 - 46,597,314 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1846,719,006 - 46,730,583 (-)Ensembl
GRCm38.p6 Ensembl1846,585,939 - 46,597,516 (-)Ensembl
Ensembl Acc Id: ENSMUST00000151189   ⟹   ENSMUSP00000120904
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1846,721,099 - 46,730,602 (-)Ensembl
GRCm38.p6 Ensembl1846,588,032 - 46,597,535 (-)Ensembl
RefSeq Acc Id: NM_025698   ⟹   NP_079974
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391846,718,995 - 46,730,602 (-)NCBI
GRCm381846,585,928 - 46,597,535 (-)ENTREZGENE
MGSCv371846,745,582 - 46,757,189 (-)RGD
Celera1847,945,556 - 47,957,160 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_079974 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000043660.8
  ENSMUSP00000120904
  ENSMUSP00000120904.2
RefSeq Acc Id: NP_079974   ⟸   NM_025698
- Peptide Label: precursor
- UniProtKB: E9Q7G1 (UniProtKB/TrEMBL),   D3YZZ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000120904   ⟸   ENSMUST00000151189
Ensembl Acc Id: ENSMUSP00000043660   ⟸   ENSMUST00000036030
Protein Domains
GOLD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3YZZ5-F1-model_v2 AlphaFold D3YZZ5 1-224 view protein structure

Promoters
RGD ID:13677748
Promoter ID:EPDNEW_M23023
Type:initiation region
Name:Tmed7_1
Description:Mus musculus transmembrane p24 trafficking protein 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381846,597,516 - 46,597,576EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913926 AgrOrtholog
Ensembl Genes ENSMUSG00000033184 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000036030.14 UniProtKB/TrEMBL
  ENSMUST00000151189 ENTREZGENE
  ENSMUST00000151189.2 UniProtKB/TrEMBL
Gene3D-CATH GOLD domain UniProtKB/TrEMBL
InterPro GOLD UniProtKB/TrEMBL
  GOLD_dom_sf UniProtKB/TrEMBL
  TMP21-related UniProtKB/TrEMBL
KEGG Report mmu:66676 UniProtKB/TrEMBL
MGD MGI:1913926 ENTREZGENE
NCBI Gene 66676 ENTREZGENE
PANTHER PTHR22811 UniProtKB/TrEMBL
Pfam EMP24_GP25L UniProtKB/TrEMBL
PhenoGen Tmed7 PhenoGen
PROSITE GOLD UniProtKB/TrEMBL
SMART EMP24_GP25L UniProtKB/TrEMBL
Superfamily-SCOP GOLD UniProtKB/TrEMBL
UniProt D3YZZ5 ENTREZGENE, UniProtKB/TrEMBL
  E9Q7G1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-04 Tmed7  transmembrane p24 trafficking protein 7    transmembrane emp24 protein transport domain containing 7  Symbol and/or name change 5135510 APPROVED