Eef2kmt (eukaryotic elongation factor 2 lysine methyltransferase) - Rat Genome Database

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Gene: Eef2kmt (eukaryotic elongation factor 2 lysine methyltransferase) Mus musculus
Analyze
Symbol: Eef2kmt
Name: eukaryotic elongation factor 2 lysine methyltransferase
RGD ID: 1621515
MGI Page MGI
Description: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation and regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to several human genes including EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5730409G15Rik; eEF2-KMT; eEF2-lysine methyltransferase; Fam8; Fam86; Fam86a; family with sequence similarity 86; hypothetical protein LOC70511; protein-lysine N-methyltransferase EEF2KMT; putative protein N-methyltransferase FAM86A
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,062,019 - 5,073,820 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,062,016 - 5,073,847 (-)EnsemblGRCm39 Ensembl
GRCm38165,244,155 - 5,255,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,244,152 - 5,255,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,244,248 - 5,256,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,159,476 - 5,171,277 (-)NCBIMGSCv36mm8
Celera165,877,168 - 5,888,966 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12438443   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:18799693   PMID:21267068   PMID:21677750   PMID:21873635   PMID:27626380   PMID:38355793   PMID:38508183  


Genomics

Comparative Map Data
Eef2kmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39165,062,019 - 5,073,820 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl165,062,016 - 5,073,847 (-)EnsemblGRCm39 Ensembl
GRCm38165,244,155 - 5,255,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl165,244,152 - 5,255,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv37165,244,248 - 5,256,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36165,159,476 - 5,171,277 (-)NCBIMGSCv36mm8
Celera165,877,168 - 5,888,966 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map162.51NCBI
EEF2KMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,084,284 - 5,097,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,084,284 - 5,097,795 (-)EnsemblGRCh38hg38GRCh38
GRCh37165,134,285 - 5,147,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,075,236 - 5,087,782 (-)NCBINCBI36Build 36hg18NCBI36
Celera165,343,693 - 5,357,187 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef165,100,367 - 5,113,916 (-)NCBIHuRef
CHM1_1165,135,491 - 5,148,985 (-)NCBICHM1_1
T2T-CHM13v2.0165,113,786 - 5,127,302 (-)NCBIT2T-CHM13v2.0
Eef2kmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81010,843,429 - 10,853,800 (+)NCBIGRCr8
mRatBN7.21010,336,933 - 10,349,463 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1010,336,974 - 10,347,039 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1015,043,627 - 15,053,683 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01014,532,428 - 14,542,490 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01010,201,418 - 10,211,484 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01010,530,302 - 10,540,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1010,530,365 - 10,540,428 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0109,300,149 - 9,310,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41010,450,534 - 10,460,596 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11010,450,554 - 10,460,124 (+)NCBI
Celera109,303,038 - 9,313,101 (+)NCBICelera
Cytogenetic Map10q12NCBI
Eef2kmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544212,467,077 - 12,475,902 (+)NCBIChiLan1.0ChiLan1.0
EEF2KMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2185,613,290 - 5,625,864 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1169,403,868 - 9,416,646 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0164,009,227 - 4,014,944 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1165,172,663 - 5,277,224 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl165,173,979 - 5,191,174 (-)Ensemblpanpan1.1panPan2
EEF2KMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1636,353,626 - 36,370,466 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha637,744,735 - 37,763,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0636,554,792 - 36,573,955 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1636,353,667 - 36,372,607 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0636,244,755 - 36,263,844 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0636,644,889 - 36,664,041 (+)NCBIUU_Cfam_GSD_1.0
Eef2kmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344107,111,725 - 107,120,621 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365304,957,445 - 4,984,816 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EEF2KMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1337,310,915 - 37,324,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2338,315,814 - 38,330,027 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EEF2KMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.154,752,247 - 4,768,240 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606825,889,562 - 25,902,921 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eef2kmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248242,875,590 - 2,884,687 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eef2kmt
247 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1120
Count of miRNA genes:520
Interacting mature miRNAs:622
Transcripts:ENSMUST00000064635, ENSMUST00000129729, ENSMUST00000132225, ENSMUST00000139584, ENSMUST00000140718
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse

Markers in Region
UniSTS:237421  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38165,244,660 - 5,244,862UniSTSGRCm38
MGSCv37165,244,753 - 5,244,955UniSTSGRCm37
Celera165,877,673 - 5,877,875UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map16A2UniSTS
cM Map164.5UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000064635   ⟹   ENSMUSP00000068003
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,062,016 - 5,073,847 (-)Ensembl
GRCm38.p6 Ensembl165,244,152 - 5,255,983 (-)Ensembl
Ensembl Acc Id: ENSMUST00000129729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,065,251 - 5,066,734 (-)Ensembl
GRCm38.p6 Ensembl165,247,387 - 5,248,870 (-)Ensembl
Ensembl Acc Id: ENSMUST00000132225
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,062,743 - 5,073,805 (-)Ensembl
GRCm38.p6 Ensembl165,244,879 - 5,255,941 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139584   ⟹   ENSMUSP00000123572
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,065,239 - 5,073,820 (-)Ensembl
GRCm38.p6 Ensembl165,247,375 - 5,255,956 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140718
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,066,851 - 5,073,793 (-)Ensembl
GRCm38.p6 Ensembl165,248,987 - 5,255,929 (-)Ensembl
Ensembl Acc Id: ENSMUST00000230238
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl165,066,429 - 5,073,796 (-)Ensembl
GRCm38.p6 Ensembl165,248,565 - 5,255,932 (-)Ensembl
RefSeq Acc Id: NM_027446   ⟹   NP_081722
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39165,062,019 - 5,073,820 (-)NCBI
GRCm38165,244,155 - 5,255,956 (-)ENTREZGENE
MGSCv37165,244,248 - 5,256,049 (-)RGD
Celera165,877,168 - 5,888,966 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_081722   ⟸   NM_027446
- UniProtKB: Q80XE2 (UniProtKB/Swiss-Prot),   Q3TQL2 (UniProtKB/Swiss-Prot),   Q9CS89 (UniProtKB/Swiss-Prot),   Q3UZW7 (UniProtKB/Swiss-Prot),   D3YYE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000123572   ⟸   ENSMUST00000139584
Ensembl Acc Id: ENSMUSP00000068003   ⟸   ENSMUST00000064635
Protein Domains
FAM86 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UZW7-F1-model_v2 AlphaFold Q3UZW7 1-335 view protein structure

Promoters
RGD ID:8685380
Promoter ID:EPDNEW_M20721
Type:multiple initiation site
Name:Eef2kmt_1
Description:Mus musculus eukaryotic elongation factor 2 lysine methyltransferase, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38165,255,950 - 5,256,010EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917761 AgrOrtholog
Ensembl Genes ENSMUSG00000022544 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064635 ENTREZGENE
  ENSMUST00000064635.12 UniProtKB/Swiss-Prot
  ENSMUST00000139584.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAM86 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyltransf_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70511 UniProtKB/Swiss-Prot
MGD MGI:1917761 ENTREZGENE
NCBI Gene 70511 ENTREZGENE
PANTHER PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14614 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAM86 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyltransf_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eef2kmt PhenoGen
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YYE2 ENTREZGENE, UniProtKB/TrEMBL
  EF2KT_MOUSE UniProtKB/Swiss-Prot
  Q3TQL2 ENTREZGENE
  Q3UZW7 ENTREZGENE
  Q80XE2 ENTREZGENE
  Q9CS89 ENTREZGENE
UniProt Secondary Q3TQL2 UniProtKB/Swiss-Prot
  Q80XE2 UniProtKB/Swiss-Prot
  Q9CS89 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-12-16 Eef2kmt  eukaryotic elongation factor 2 lysine methyltransferase  Fam86  family with sequence similarity 86  Symbol and/or name change 5135510 APPROVED