Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of DENND1A mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of DENND1A mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Dennd1a (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of DENND1A mRNA | CTD | PMID:32109520 | 2,5-hexanedione | increases expression | ISO | Dennd1a (Rattus norvegicus) | 6480464 | 2 and 5-hexanedione results in increased expression of DENND1A mRNA | CTD | PMID:22952946 | 4-hydroxyphenyl retinamide | decreases expression | EXP | | 6480464 | Fenretinide results in decreased expression of DENND1A mRNA | CTD | PMID:28973697 | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of DENND1A mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | DENND1A (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of DENND1A 3' UTR and Aflatoxin B1 results in increased methylation of DENND1A intron | CTD | PMID:30157460 | aflatoxin B1 | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of DENND1A mRNA | CTD | PMID:21641981 and PMID:22100608 | all-trans-retinoic acid | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of DENND1A mRNA | CTD | PMID:21934132 and PMID:23724009 | aristolochic acid A | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of DENND1A mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | DENND1A (Homo sapiens) | 6480464 | Arsenic affects the methylation of DENND1A gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | DENND1A (Homo sapiens) | 6480464 | Arsenic affects the methylation of DENND1A gene | CTD | PMID:25304211 | belinostat | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | belinostat results in decreased expression of DENND1A mRNA | CTD | PMID:26272509 | belinostat | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND1A mRNA | CTD | PMID:27188386 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of DENND1A mRNA | CTD | PMID:21715664 | benzo[a]pyrene | affects methylation | ISO | DENND1A (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of DENND1A intron and Benzo(a)pyrene affects the methylation of DENND1A promoter | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of DENND1A mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of DENND1A mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of DENND1A mRNA] | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | benzo[e]pyrene | increases methylation | ISO | DENND1A (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of DENND1A 3' UTR | CTD | PMID:30157460 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of DENND1A mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | ISO | Dennd1a (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of DENND1A mRNA | CTD | PMID:25181051 | bisphenol A | affects methylation | ISO | DENND1A (Homo sapiens) | 6480464 | bisphenol A affects the methylation of DENND1A gene | CTD | PMID:31601247 | bisphenol A | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of DENND1A gene | CTD | PMID:31601247 | bisphenol A | increases methylation | ISO | Dennd1a (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of DENND1A gene | CTD | PMID:28505145 | cadmium dichloride | increases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of DENND1A mRNA | CTD | PMID:26472689 | caffeine | decreases phosphorylation | ISO | DENND1A (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of DENND1A protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to DENND1A gene] | CTD | PMID:28238834 | cisplatin | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of DENND1A mRNA | CTD | PMID:19561079 | coumestrol | increases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Coumestrol results in increased expression of DENND1A mRNA | CTD | PMID:19167446 | cytarabine | increases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Cytarabine results in increased expression of DENND1A mRNA | CTD | PMID:19194470 | dicrotophos | increases expression | ISO | DENND1A (Homo sapiens) | 6480464 | dicrotophos results in increased expression of DENND1A mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of DENND1A mRNA | CTD | PMID:29803840 | entinostat | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | entinostat results in decreased expression of DENND1A mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND1A mRNA | CTD | PMID:27188386 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of DENND1A mRNA | CTD | PMID:35436446 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of DENND1A mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of DENND1A mRNA | CTD | PMID:23649840 | FR900359 | increases phosphorylation | ISO | DENND1A (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of DENND1A protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of DENND1A gene | CTD | PMID:31601247 | gentamycin | decreases expression | ISO | Dennd1a (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of DENND1A mRNA | CTD | PMID:22061828 | hypochlorous acid | decreases expression | EXP | | 6480464 | Hypochlorous Acid results in decreased expression of DENND1A mRNA | CTD | PMID:19376150 | isobutanol | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of DENND1A mRNA | CTD | PMID:29432896 | leflunomide | increases expression | ISO | DENND1A (Homo sapiens) | 6480464 | leflunomide results in increased expression of DENND1A mRNA | CTD | PMID:28988120 | methapyrilene | increases methylation | ISO | DENND1A (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of DENND1A 3' UTR | CTD | PMID:30157460 | methylmercury chloride | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of DENND1A mRNA | CTD | PMID:28001369 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Dennd1a (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of DENND1A gene | CTD | PMID:33148267 | N-methyl-4-phenylpyridinium | increases expression | ISO | Dennd1a (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of DENND1A mRNA | CTD | PMID:28801915 | nickel atom | increases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Nickel results in increased expression of DENND1A mRNA | CTD | PMID:24768652 and PMID:25583101 | O-methyleugenol | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of DENND1A mRNA | CTD | PMID:32234424 | panobinostat | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND1A mRNA | CTD | PMID:27188386 | panobinostat | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | panobinostat results in decreased expression of DENND1A mRNA | CTD | PMID:26272509 | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of DENND1A mRNA | CTD | PMID:37995155 | permethrin | multiple interactions | ISO | Dennd1a (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of DENND1A gene | CTD | PMID:33148267 | phenylmercury acetate | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of DENND1A mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND1A mRNA | CTD | PMID:27188386 | quercetin | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Quercetin results in decreased expression of DENND1A mRNA | CTD | PMID:21632981 | SB 431542 | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium dichromate | affects expression | ISO | Dennd1a (Rattus norvegicus) | 6480464 | sodium bichromate affects the expression of DENND1A mRNA | CTD | PMID:22110744 | sunitinib | increases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Sunitinib results in increased expression of DENND1A mRNA | CTD | PMID:31533062 | thioacetamide | decreases expression | ISO | Dennd1a (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of DENND1A mRNA | CTD | PMID:34492290 | trichostatin A | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of DENND1A mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND1A mRNA | CTD | PMID:27188386 | Triptolide | increases expression | ISO | Dennd1a (Rattus norvegicus) | 6480464 | triptolide results in increased expression of DENND1A protein | CTD | PMID:32519852 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of DENND1A mRNA | CTD | PMID:30912803 | valproic acid | affects expression | ISO | DENND1A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of DENND1A mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of DENND1A mRNA | CTD | PMID:23179753 and PMID:26272509 | valproic acid | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND1A mRNA | CTD | PMID:27188386 | vorinostat | multiple interactions | ISO | DENND1A (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DENND1A mRNA | CTD | PMID:27188386 | vorinostat | decreases expression | ISO | DENND1A (Homo sapiens) | 6480464 | vorinostat results in decreased expression of DENND1A mRNA | CTD | PMID:26272509 and PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 2. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12466851 | PMID:12477932 | PMID:12520002 | PMID:15489334 | PMID:15782199 | PMID:16141072 | PMID:16141073 |
| PMID:17182770 | PMID:18799693 | PMID:20159556 | PMID:21677750 | PMID:21873635 | PMID:30884041 | PMID:35449600 |
Genomics
Comparative Map Data
| Dennd1a (Mus musculus - house mouse) |
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| DENND1A (Homo sapiens - human) |
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| Dennd1a (Rattus norvegicus - Norway rat) |
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| Dennd1a (Chinchilla lanigera - long-tailed chinchilla) |
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| DENND1A (Pan paniscus - bonobo/pygmy chimpanzee) |
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| DENND1A (Canis lupus familiaris - dog) |
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| Dennd1a (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| DENND1A (Sus scrofa - pig) |
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| DENND1A (Chlorocebus sabaeus - green monkey) |
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| Dennd1a (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Dennd1a
9462 total Variants 
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