Pirt (phosphoinositide-interacting regulator of transient receptor potential channels) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pirt (phosphoinositide-interacting regulator of transient receptor potential channels) Mus musculus
Analyze
Symbol: Pirt
Name: phosphoinositide-interacting regulator of transient receptor potential channels
RGD ID: 1619036
MGI Page MGI
Description: Exhibits ion channel binding activity; phosphatidylinositol bisphosphate binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in several processes, including behavioral response to pain; phosphatidylinositol-mediated signaling; and positive regulation of cation channel activity. Localizes to plasma membrane. Is expressed in gut; nervous system; and olfactory epithelium. Orthologous to human PIRT (phosphoinositide interacting regulator of transient receptor potential channels); INTERACTS WITH 1,1,1-trichloroethane; potassium dichromate; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A530088H08Rik; P; phosphoinositide interacting protein; phosphoinositide-interacting protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391166,802,731 - 66,820,703 (+)NCBIGRCm39mm39
GRCm381166,911,905 - 66,929,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1166,911,981 - 66,929,876 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,725,493 - 66,742,202 (+)NCBIGRCm37mm9NCBIm37
MGSCv361166,728,186 - 66,744,895 (+)NCBImm8
Celera1173,851,239 - 73,867,838 (+)NCBICelera
Cytogenetic Map11B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18455988   PMID:18799693   PMID:21267068  
PMID:21655234   PMID:21734270   PMID:21873635   PMID:23863968   PMID:24462040   PMID:26151598   PMID:26216096   PMID:26373451   PMID:26376721   PMID:26521042   PMID:26657057   PMID:27270085  
PMID:27436359   PMID:27568517   PMID:27847865   PMID:28190640   PMID:28426967   PMID:28970527   PMID:29346752   PMID:29563338   PMID:29724821   PMID:29808083   PMID:29921657   PMID:29988128  
PMID:30033153   PMID:30755524   PMID:30902502   PMID:31171579   PMID:31390574   PMID:31481522   PMID:31831729   PMID:31883963   PMID:32060036  


Genomics

Comparative Map Data
Pirt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391166,802,731 - 66,820,703 (+)NCBIGRCm39mm39
GRCm381166,911,905 - 66,929,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1166,911,981 - 66,929,876 (+)EnsemblGRCm38mm10GRCm38
MGSCv371166,725,493 - 66,742,202 (+)NCBIGRCm37mm9NCBIm37
MGSCv361166,728,186 - 66,744,895 (+)NCBImm8
Celera1173,851,239 - 73,867,838 (+)NCBICelera
Cytogenetic Map11B3NCBI
PIRT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1710,822,470 - 10,838,087 (-)EnsemblGRCh38hg38GRCh38
GRCh381710,822,470 - 10,838,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371710,725,792 - 10,741,418 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371710,725,787 - 10,741,404 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361710,666,517 - 10,682,143 (-)NCBINCBI36hg18NCBI36
Celera1710,756,635 - 10,772,261 (-)NCBI
Cytogenetic Map17p12NCBI
HuRef1710,626,293 - 10,641,913 (-)NCBIHuRef
CHM1_11710,735,671 - 10,751,286 (-)NCBICHM1_1
Pirt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21051,613,202 - 51,628,108 (+)NCBI
Rnor_6.0 Ensembl1053,466,870 - 53,481,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01053,466,870 - 53,485,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01053,218,153 - 53,236,283 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41053,617,910 - 53,633,542 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1050,795,900 - 50,810,922 (+)NCBICelera
Cytogenetic Map10q24NCBI
Pirt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554676,375,992 - 6,391,764 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554676,375,992 - 6,391,770 (+)NCBIChiLan1.0ChiLan1.0
PIRT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11745,563,171 - 45,578,827 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01740,815,724 - 40,831,539 (+)NCBIMhudiblu_PPA_v0panPan3
PIRT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl535,086,173 - 35,086,589 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1535,085,480 - 35,095,752 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pirt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365953,659,356 - 3,677,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIRT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1255,513,315 - 55,519,578 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11255,513,291 - 55,526,290 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PIRT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11610,164,563 - 10,175,835 (-)NCBI
ChlSab1.1 Ensembl1610,167,342 - 10,167,755 (-)Ensembl
Pirt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478613,189,723 - 13,204,891 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111160000068600000Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1231863768609504Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111231863768609504Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111231863768609504Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1231863768609504Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1231863768609504Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111231863768609504Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1231863768609504Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1231863768609504Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1231863768609504Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111231863768609504Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111231863768609504Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111710617567187585Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111783196668609504Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115417484467187585Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
4141642Ltxs2_mlethal factor toxin susceptibility 2 (mouse)Not determined116315128768609504Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1434
Count of miRNA genes:651
Interacting mature miRNAs:810
Transcripts:ENSMUST00000123434
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000123434   ⟹   ENSMUSP00000128117
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1166,911,981 - 66,929,876 (+)Ensembl
RefSeq Acc Id: NM_178656   ⟹   NP_848771
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391166,802,817 - 66,819,526 (+)NCBI
GRCm381166,911,991 - 66,928,700 (+)NCBI
MGSCv371166,725,493 - 66,742,202 (+)RGD
Celera1173,851,239 - 73,867,838 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532579   ⟹   XP_006532642
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391166,814,106 - 66,820,703 (+)NCBI
GRCm381166,923,280 - 66,928,122 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011248822   ⟹   XP_011247124
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391166,802,731 - 66,820,703 (+)NCBI
GRCm381166,911,905 - 66,929,877 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_848771   ⟸   NM_178656
- UniProtKB: Q8BFY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532642   ⟸   XM_006532579
- Peptide Label: isoform X2
- UniProtKB: Q8BFY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011247124   ⟸   XM_011248822
- Peptide Label: isoform X1
- UniProtKB: Q3UFA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000128117   ⟸   ENSMUST00000123434

Promoters
RGD ID:8675052
Promoter ID:EPDNEW_M15557
Type:initiation region
Name:Pirt_1
Description:Mus musculus phosphoinositide-interacting regulator of transientreceptor potential channels , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15558  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381166,911,991 - 66,912,051EPDNEW
RGD ID:8675054
Promoter ID:EPDNEW_M15558
Type:single initiation site
Name:Pirt_2
Description:Mus musculus phosphoinositide-interacting regulator of transientreceptor potential channels , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15557  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381166,916,838 - 66,916,898EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2443635 AgrOrtholog
Ensembl Genes ENSMUSG00000048070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000128117 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000123434 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro PIRT UniProtKB/Swiss-Prot
KEGG Report mmu:193003 UniProtKB/Swiss-Prot
MGD MGI:2443635 ENTREZGENE
NCBI Gene 193003 ENTREZGENE
Pfam PIRT UniProtKB/Swiss-Prot
PhenoGen Pirt PhenoGen
UniProt PIRT_MOUSE UniProtKB/Swiss-Prot
  Q3UEZ1_MOUSE UniProtKB/TrEMBL
  Q3UFA4 ENTREZGENE, UniProtKB/TrEMBL
  Q8BFY0 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Pirt  phosphoinositide-interacting regulator of transient receptor potential channels  A530088H08Rik  RIKEN cDNA A530088H08 gene  Symbol and/or name change 5135510 APPROVED