Tmf1 (TATA element modulatory factor 1) - Rat Genome Database

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Gene: Tmf1 (TATA element modulatory factor 1) Mus musculus
Analyze
Symbol: Tmf1
Name: TATA element modulatory factor 1
RGD ID: 1617347
MGI Page MGI
Description: Predicted to enable nuclear androgen receptor binding activity and nuclear receptor coactivator activity. Involved in regulation of proteasomal protein catabolic process. Acts upstream of or within several processes, including Leydig cell differentiation; regulation of gene expression; and spermatid development. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in mandible and maxilla. Orthologous to human TMF1 (TATA element modulatory factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 7030402D04Rik; androgen receptor coactivator 160 kDa protein; androgen receptor-associated protein of 160 kDa; Gm153; RIKEN cDNA 7030402D04 gene; TATA element modulatory factor; TMF; Tmf1`
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,128,911 - 97,156,107 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl697,129,958 - 97,156,083 (-)EnsemblGRCm39 Ensembl
GRCm38697,151,950 - 97,179,151 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,152,997 - 97,179,122 (-)EnsemblGRCm38mm10GRCm38
MGSCv37697,101,944 - 97,129,118 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36697,120,729 - 97,144,587 (-)NCBIMGSCv36mm8
Celera699,011,031 - 99,037,969 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map644.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
endoplasmic reticulum  (IBA,IDA)
Golgi apparatus  (IBA,IDA,ISO)
membrane  (IEA)
nucleus  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466305   PMID:12466851   PMID:12477932   PMID:15467733   PMID:16141072   PMID:16141073   PMID:16792503   PMID:20691678  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:22531781   PMID:22553199   PMID:23000399   PMID:24639530   PMID:26701263   PMID:32325033   PMID:32554809   PMID:33475194  


Genomics

Comparative Map Data
Tmf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,128,911 - 97,156,107 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl697,129,958 - 97,156,083 (-)EnsemblGRCm39 Ensembl
GRCm38697,151,950 - 97,179,151 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,152,997 - 97,179,122 (-)EnsemblGRCm38mm10GRCm38
MGSCv37697,101,944 - 97,129,118 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36697,120,729 - 97,144,587 (-)NCBIMGSCv36mm8
Celera699,011,031 - 99,037,969 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map644.89NCBI
TMF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38369,019,827 - 69,052,333 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl369,019,827 - 69,052,339 (-)EnsemblGRCh38hg38GRCh38
GRCh37369,068,978 - 69,101,484 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,151,668 - 69,184,174 (-)NCBINCBI36Build 36hg18NCBI36
Build 34369,155,017 - 69,183,927NCBI
Celera368,997,084 - 69,029,590 (-)NCBICelera
Cytogenetic Map3p14.1NCBI
HuRef369,070,037 - 69,102,555 (-)NCBIHuRef
CHM1_1369,020,189 - 69,052,693 (-)NCBICHM1_1
T2T-CHM13v2.0369,056,599 - 69,089,119 (-)NCBIT2T-CHM13v2.0
Tmf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,316,630 - 131,345,666 (-)NCBIGRCr8
mRatBN7.24129,759,952 - 129,785,705 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4129,763,114 - 129,785,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4135,187,721 - 135,210,260 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04130,968,762 - 130,991,302 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04129,586,707 - 129,609,247 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04129,521,986 - 129,546,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,521,991 - 129,544,506 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04194,025,425 - 194,047,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44131,876,012 - 131,898,533 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14132,128,029 - 132,143,297 (-)NCBI
Celera4118,639,134 - 118,661,654 (-)NCBICelera
Cytogenetic Map4q34NCBI
Tmf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542118,810,199 - 18,837,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542118,810,199 - 18,837,767 (+)NCBIChiLan1.0ChiLan1.0
TMF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2268,970,671 - 69,009,943 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1368,977,647 - 69,014,709 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0368,955,866 - 68,988,353 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1370,322,814 - 70,355,433 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl370,322,814 - 70,355,460 (-)Ensemblpanpan1.1panPan2
TMF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12022,684,150 - 22,716,107 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2022,684,159 - 22,714,432 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2022,658,805 - 22,690,795 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02022,710,043 - 22,742,243 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2022,710,062 - 22,742,235 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12022,403,879 - 22,435,817 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02022,747,315 - 22,779,308 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02022,817,189 - 22,849,345 (+)NCBIUU_Cfam_GSD_1.0
Tmf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049421,577,538 - 1,602,016 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366031,577,486 - 1,602,250 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366031,577,519 - 1,602,022 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1350,444,256 - 50,477,291 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11350,442,017 - 50,477,363 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21355,527,055 - 55,558,194 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12230,048,269 - 30,078,600 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2230,045,685 - 30,078,414 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041136,713,836 - 136,746,704 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247733,587,753 - 3,618,089 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmf1
921 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:177
Interacting mature miRNAs:194
Transcripts:ENSMUST00000095664, ENSMUST00000124173
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686783787113521563Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
11532719Sluc45_msusceptibility to lung cancer 45 (mouse)69258428798235894Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92584287111981699Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000095664   ⟹   ENSMUSP00000093325
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl697,129,958 - 97,156,083 (-)Ensembl
GRCm38.p6 Ensembl697,152,997 - 97,179,122 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124173   ⟹   ENSMUSP00000120093
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl697,132,227 - 97,155,998 (-)Ensembl
GRCm38.p6 Ensembl697,155,266 - 97,179,037 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl697,137,213 - 97,145,772 (-)Ensembl
GRCm38.p6 Ensembl697,160,252 - 97,168,811 (-)Ensembl
RefSeq Acc Id: NM_001081111   ⟹   NP_001074580
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39697,128,911 - 97,156,085 (-)NCBI
GRCm38697,151,950 - 97,179,124 (-)ENTREZGENE
MGSCv37697,101,944 - 97,129,118 (-)RGD
Celera699,011,031 - 99,037,969 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030255349   ⟹   XP_030111209
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39697,128,914 - 97,156,107 (-)NCBI
GRCm38697,152,991 - 97,179,151 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001074580   ⟸   NM_001081111
- UniProtKB: Q3UMH8 (UniProtKB/Swiss-Prot),   E9QPJ3 (UniProtKB/Swiss-Prot),   Q3UMR3 (UniProtKB/Swiss-Prot),   B9EKI3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030111209   ⟸   XM_030255349
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000120093   ⟸   ENSMUST00000124173
RefSeq Acc Id: ENSMUSP00000093325   ⟸   ENSMUST00000095664

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B9EKI3-F1-model_v2 AlphaFold B9EKI3 1-1091 view protein structure

Promoters
RGD ID:6838781
Promoter ID:MM_KWN:46999
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:AK132441_7030402D04RIK,   OTTMUST00000056842,   OTTMUST00000056843
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36697,098,286 - 97,101,272 (+)MPROMDB
RGD ID:6840093
Promoter ID:MM_KWN:47003
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000095665,   NM_001081111,   OTTMUST00000073727
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36697,129,084 - 97,129,584 (-)MPROMDB
RGD ID:6890514
Promoter ID:EPDNEW_M8708
Type:initiation region
Name:Tmf1_1
Description:Mus musculus TATA element modulatory factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38697,179,128 - 97,179,188EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684999 AgrOrtholog
Ensembl Genes ENSMUSG00000030059 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000095664 ENTREZGENE
  ENSMUST00000095664.6 UniProtKB/Swiss-Prot
  ENSMUST00000124173.8 UniProtKB/TrEMBL
InterPro TMF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TMF_TATA-bd UniProtKB/Swiss-Prot
KEGG Report mmu:232286 UniProtKB/Swiss-Prot
MGD MGI:2684999 ENTREZGENE
NCBI Gene 232286 ENTREZGENE
PANTHER TATA ELEMENT MODULATORY FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TATA ELEMENT MODULATORY FACTOR TMF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TMF_DNA_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TMF_TATA_bd UniProtKB/Swiss-Prot
PhenoGen Tmf1 PhenoGen
UniProt B9EKI3 ENTREZGENE
  D6RJK7_MOUSE UniProtKB/TrEMBL
  E9QPJ3 ENTREZGENE
  Q3UMH8 ENTREZGENE
  Q3UMR3 ENTREZGENE
  TMF1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary E9QPJ3 UniProtKB/Swiss-Prot
  Q3UMH8 UniProtKB/Swiss-Prot
  Q3UMR3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Tmf1  TATA element modulatory factor 1  7030402D04Rik  RIKEN cDNA 7030402D04 gene  Data merged from RGD:1609885 737654 PROVISIONAL