Krt31 (keratin 31) - Rat Genome Database

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Gene: Krt31 (keratin 31) Mus musculus
Analyze
Symbol: Krt31
Name: keratin 31
RGD ID: 1615966
MGI Page MGI
Description: Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in hair cortex; hair cuticle; hair outer root sheath; and skin. Orthologous to human KRT31 (keratin 31) and KRT33A (keratin 33A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ha; Ha1; hair keratin, type I Ha1; HKA-1; K31; keratin complex 1, acidic, gene 1; keratin complex 1, gene 1; keratin, type I cuticular Ha1; keratin-31; Kha; Kha1; Krt1-; Krt1-1; MKHA-; MKHA-1
RGD Orthologs
Human
Rat
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Krt31-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,937,472 - 99,941,377 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,937,472 - 99,941,377 (-)EnsemblGRCm39 Ensembl
GRCm3811100,046,646 - 100,050,551 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,046,646 - 100,050,551 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,907,960 - 99,911,865 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,862,736 - 99,866,641 (-)NCBIMGSCv36mm8
Celera11110,662,987 - 110,666,881 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.39NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 31 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt31Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOKRT31 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of KRT31 mRNACTDPMID:23152189
Krt31Mouse2-bromohexadecanoic acid multiple interactionsISOKRT31 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of KRT31 protein]CTDPMID:38195004
Krt31Mouse2-hydroxypropanoic acid decreases expressionISOKRT31 (Homo sapiens)6480464Lactic Acid results in decreased expression of KRT31 mRNACTDPMID:30851411
Krt31Mouse3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOKRT31 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KRT31 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KRT31 mRNACTDPMID:28628672
Krt31Mouse4-hydroxyphenyl retinamide decreases expressionEXP 6480464Fenretinide results in decreased expression of KRT31 mRNACTDPMID:28973697
Krt31Mousealpha-Zearalanol decreases expressionISOKrt31 (Rattus norvegicus)6480464Zeranol results in decreased expression of KRT31 mRNACTDPMID:35163327
Krt31Mousealpha-Zearalanol multiple interactionsISOKrt31 (Rattus norvegicus)6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of KRT31 mRNACTDPMID:35163327
Krt31Mouseatrazine increases expressionISOKRT31 (Homo sapiens)6480464Atrazine results in increased expression of KRT31 mRNACTDPMID:22378314
Krt31Mousebenzo[a]pyrene increases methylationISOKRT31 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of KRT31 exon and Benzo(a)pyrene results in increased methylation of KRT31 promoterCTDPMID:27901495
Krt31Mousebeta-naphthoflavone increases expressionISOKRT31 (Homo sapiens)6480464beta-Naphthoflavone results in increased expression of KRT31 mRNACTDPMID:32151702
Krt31Mousebis(2-ethylhexyl) phthalate decreases expressionISOKRT31 (Homo sapiens)6480464Diethylhexyl Phthalate results in decreased expression of KRT31 mRNACTDPMID:31163220
Krt31Mousebisphenol A decreases expressionISOKrt31 (Rattus norvegicus)6480464bisphenol A results in decreased expression of KRT31 mRNACTDPMID:25181051
Krt31Mousebisphenol A multiple interactionsISOKRT31 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of KRT31 mRNA and [Phenolsulfonphthalein deficiency co-treated with bisphenol A] results in increased expression of KRT31 proteinCTDPMID:28628672 and PMID:31629898
Krt31Mousebisphenol A increases methylationISOKrt31 (Rattus norvegicus)6480464bisphenol A results in increased methylation of KRT31 geneCTDPMID:28505145
Krt31Mousebisphenol A multiple interactionsISOKrt31 (Rattus norvegicus)6480464[bisphenol A co-treated with Genistein] results in increased methylation of KRT31 geneCTDPMID:28505145
Krt31Mousebisphenol F multiple interactionsISOKRT31 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KRT31 mRNACTDPMID:28628672
Krt31Mousecadmium atom multiple interactionsISOKRT31 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of KRT31 protein] and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of KRT31 proteinCTDPMID:38195004
Krt31Mousecadmium dichloride multiple interactionsISOKRT31 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of KRT31 protein] and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of KRT31 proteinCTDPMID:38195004
Krt31Mousecarbon nanotube decreases expressionEXP 6480464Nanotubes and Carbon analog results in decreased expression of KRT31 mRNACTDPMID:25620056
Krt31Mousecarmustine decreases expressionISOKRT31 (Homo sapiens)6480464Carmustine results in decreased expression of KRT31 mRNACTDPMID:15980968

1 to 20 of 31 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt31Mouseepithelial cell differentiation involved_inIBAPANTHER:PTN008383948 more ...2290270 GO_CentralGO_REF:0000033
Krt31Mouseintermediate filament organization involved_inIBAPANTHER:PTN008383948 more ...2290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt31Mousecytoskeleton is_active_inIBAPANTHER:PTN001905729 more ...2290270 GO_CentralGO_REF:0000033
Krt31Mouseintermediate filament located_inIEAUniProtKB-KW:KW-0403 and UniProtKB-KW:KW-04162290270 UniProtGO_REF:0000043

Molecular Function
1 to 12 of 12 rows

  
1 to 12 of 12 rows

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt31Mouseabnormal coat appearance  IEA 5509061 MGI 

#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:1717610   PMID:2461417   PMID:9882493   PMID:9932492   PMID:10087197   PMID:10227293   PMID:10559501   PMID:10571739   PMID:11125038   PMID:16462742   PMID:16831889   PMID:17991461  
PMID:18692037   PMID:19470461   PMID:20106865   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22144916   PMID:22241839   PMID:23271346   PMID:24706781   PMID:28378742   PMID:30973865  
PMID:32325033   PMID:38355793  



Krt31
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,937,472 - 99,941,377 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,937,472 - 99,941,377 (-)EnsemblGRCm39 Ensembl
GRCm3811100,046,646 - 100,050,551 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,046,646 - 100,050,551 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,907,960 - 99,911,865 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,862,736 - 99,866,641 (-)NCBIMGSCv36mm8
Celera11110,662,987 - 110,666,881 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.39NCBI
KRT31
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,393,721 - 41,397,608 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,393,721 - 41,397,608 (-)EnsemblGRCh38hg38GRCh38
GRCh371739,549,973 - 39,553,860 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,803,502 - 36,807,370 (-)NCBINCBI36Build 36hg18NCBI36
Build 341736,803,501 - 36,807,370NCBI
Celera1736,203,187 - 36,207,055 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,313,475 - 35,317,343 (-)NCBIHuRef
CHM1_11739,785,320 - 39,789,188 (-)NCBICHM1_1
T2T-CHM13v2.01742,249,250 - 42,253,137 (-)NCBIT2T-CHM13v2.0
Krt31
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,479,533 - 85,483,300 (-)NCBIGRCr8
mRatBN7.21084,979,393 - 84,982,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1084,979,352 - 84,982,832 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1089,997,662 - 90,001,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,495,805 - 89,499,280 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01084,887,773 - 84,891,252 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01087,959,123 - 87,962,891 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1087,959,408 - 87,962,846 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01087,745,462 - 87,749,175 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41088,982,495 - 88,985,932 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11088,996,864 - 89,000,302 (-)NCBI
Celera1083,699,202 - 83,702,624 (-)NCBICelera
Cytogenetic Map10q31NCBI
LOC100971782
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,585,941 - 23,591,143 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11725,475,917 - 25,481,118 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,918,837 - 15,923,098 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11716,136,757 - 16,140,608 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1716,136,757 - 16,140,608 (+)Ensemblpanpan1.1panPan2
KRT34
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,377,218 - 21,381,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,377,264 - 21,380,088 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,838,959 - 20,842,756 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0922,098,159 - 22,101,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl922,098,153 - 22,101,234 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,884,135 - 20,887,932 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,150,133 - 21,153,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,253,934 - 21,257,731 (+)NCBIUU_Cfam_GSD_1.0
KRT31
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,835,642 - 64,840,346 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607735,680,666 - 35,685,133 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

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Variants in Krt31
182 total Variants

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:156
Interacting mature miRNAs:162
Transcripts:ENSMUST00000007318
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 56 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse

1 to 10 of 56 rows
D11Mit123.3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,050,659 - 100,050,887UniSTSGRCm38
MGSCv371199,911,973 - 99,912,201UniSTSGRCm37
Celera11110,666,989 - 110,667,217UniSTS
Cytogenetic Map11DUniSTS
cM Map1158.0UniSTS
cM Map11 UniSTS
Whitehead_YAC11 UniSTS
D11Mit123  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,050,723 - 100,051,036UniSTSGRCm38
MGSCv371199,912,037 - 99,912,350UniSTSGRCm37
Celera11110,667,053 - 110,667,366UniSTS
Cytogenetic Map11DUniSTS
cM Map1158.0UniSTS
Whitehead Genetic1162.3UniSTS
M27734  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,046,788 - 100,046,869UniSTSGRCm38
MGSCv371199,908,102 - 99,908,183UniSTSGRCm37
Celera11110,663,129 - 110,663,210UniSTS
Cytogenetic Map11DUniSTS
cM Map1158.3UniSTS
Whitehead/MRC_RH111330.13UniSTS
D11Dcr21  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811100,050,877 - 100,051,021UniSTSGRCm38
MGSCv371199,912,191 - 99,912,335UniSTSGRCm37
Celera11110,667,207 - 110,667,351UniSTS
Cytogenetic Map11DUniSTS
cM Map11 UniSTS







Ensembl Acc Id: ENSMUST00000007318   ⟹   ENSMUSP00000007318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,937,472 - 99,941,377 (-)Ensembl
GRCm38.p6 Ensembl11100,046,646 - 100,050,551 (-)Ensembl
RefSeq Acc Id: NM_010659   ⟹   NP_034789
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391199,937,472 - 99,941,377 (-)NCBI
GRCm3811100,046,646 - 100,050,551 (-)ENTREZGENE
MGSCv371199,907,960 - 99,911,865 (-)RGD
Celera11110,662,987 - 110,666,881 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein RefSeqs NP_034789 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA39372 (Get FASTA)   NCBI Sequence Viewer  
  EDL02587 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000007318
  ENSMUSP00000007318.2
GenBank Protein Q61765 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_034789   ⟸   NM_010659
- UniProtKB: A2A5Y0 (UniProtKB/Swiss-Prot),   Q61765 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000007318   ⟸   ENSMUST00000007318
IF rod

Name Modeler Protein Id AA Range Protein Structure
AF-Q61765-F1-model_v2 AlphaFold Q61765 1-416 view protein structure

RGD ID:8676650
Promoter ID:EPDNEW_M16356
Type:single initiation site
Name:Krt31_1
Description:Mus musculus keratin 31 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811100,050,551 - 100,050,611EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000048981 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000007318 ENTREZGENE
  ENSMUST00000007318.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_I UniProtKB/Swiss-Prot
KEGG Report mmu:16660 UniProtKB/Swiss-Prot
MGD MGI:1309993 ENTREZGENE
NCBI Gene 16660 ENTREZGENE
PANTHER KERATIN, TYPE I CUTICULAR HA1-RELATED UniProtKB/Swiss-Prot
  PTHR23239 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
PhenoGen Krt31 PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
  Prefoldin UniProtKB/Swiss-Prot
UniProt A2A5Y0 ENTREZGENE
  K1H1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2A5Y0 UniProtKB/Swiss-Prot
1 to 25 of 25 rows