Rsc1a1 (regulatory solute carrier protein, family 1, member 1) - Rat Genome Database

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Gene: Rsc1a1 (regulatory solute carrier protein, family 1, member 1) Mus musculus
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Symbol: Rsc1a1
Name: regulatory solute carrier protein, family 1, member 1
RGD ID: 1615861
MGI Page MGI
Description: Predicted to enable sodium channel inhibitor activity. Acts upstream of or within intestinal absorption and negative regulation of protein localization to plasma membrane. Located in brush border and membrane. Used to study obesity. Orthologous to human RSC1A1 (regulator of solute carriers 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700027M01Rik; mR; mRS1; R; regulatory solute carrier protein family 1 member 1; regulatory subunit of SGLT1; RP23-83I22.2; RS1; transporter regulator RS1
RGD Orthologs
Human
Chinchilla
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,410,874 - 141,413,027 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,411,162 - 141,412,910 (-)EnsemblGRCm39 Ensembl
GRCm384141,683,563 - 141,685,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,683,851 - 141,685,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,239,478 - 141,241,631 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364140,955,641 - 140,957,837 (-)NCBIMGSCv36mm8
Celera4143,507,133 - 143,509,286 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2675563   PMID:8889548   PMID:10349636   PMID:10725249   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15601832   PMID:16024787   PMID:16141072  
PMID:16141073   PMID:16788147   PMID:21873635   PMID:22492015   PMID:28190767   PMID:30022488  


Genomics

Comparative Map Data
Rsc1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,410,874 - 141,413,027 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,411,162 - 141,412,910 (-)EnsemblGRCm39 Ensembl
GRCm384141,683,563 - 141,685,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,683,851 - 141,685,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv374141,239,478 - 141,241,631 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364140,955,641 - 140,957,837 (-)NCBIMGSCv36mm8
Celera4143,507,133 - 143,509,286 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.7NCBI
RSC1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38115,659,713 - 15,662,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl115,659,713 - 15,662,033 (+)EnsemblGRCh38hg38GRCh38
GRCh37115,986,208 - 15,988,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,858,951 - 15,860,804 (+)NCBINCBI36Build 36hg18NCBI36
Build 34115,731,669 - 15,733,523NCBI
Celera114,469,243 - 14,471,096 (+)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef114,505,777 - 14,507,630 (+)NCBIHuRef
CHM1_1115,785,102 - 15,786,955 (+)NCBICHM1_1
T2T-CHM13v2.0115,104,444 - 15,106,764 (+)NCBIT2T-CHM13v2.0
Rsc1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555272,492,904 - 2,495,318 (-)NCBIChiLan1.0ChiLan1.0
RSC1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11210,496,015 - 210,505,178 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl115,793,469 - 15,795,325 (+)Ensemblpanpan1.1panPan2
RSC1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl674,809,350 - 74,855,423 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,428,423 - 268,429,766 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1674,846,976 - 74,865,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,100,164 - 69,136,986 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21302,350,179 - 302,351,522 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RSC1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,634,821 - 116,640,166 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605420,167,595 - 20,176,777 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:139
Interacting mature miRNAs:155
Transcripts:ENSMUST00000105782, ENSMUST00000177592
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1357534Cinda3_mcytokine induced activation 3 (mouse)Not determined4137617848142289472Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse

Markers in Region
AU040698  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384141,683,804 - 141,683,899UniSTSGRCm38
MGSCv374141,239,719 - 141,239,814UniSTSGRCm37
Celera4143,507,374 - 143,507,469UniSTS
Cytogenetic Map4E1UniSTS
Whitehead/MRC_RH41867.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000105782   ⟹   ENSMUSP00000101408
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4141,411,162 - 141,412,910 (-)Ensembl
GRCm38.p6 Ensembl4141,683,851 - 141,685,599 (-)Ensembl
RefSeq Acc Id: NM_023544   ⟹   NP_076033
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394141,410,874 - 141,413,027 (-)NCBI
GRCm384141,683,563 - 141,685,716 (-)ENTREZGENE
MGSCv374141,239,478 - 141,241,631 (-)RGD
Celera4143,507,133 - 143,509,286 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_076033   ⟸   NM_023544
- UniProtKB: Q9ER99 (UniProtKB/Swiss-Prot),   Q9CVU8 (UniProtKB/Swiss-Prot),   Q78HA0 (UniProtKB/Swiss-Prot),   B2RWX9 (UniProtKB/Swiss-Prot),   B1AUM1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000101408   ⟸   ENSMUST00000105782
Protein Domains
UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ER99-F1-model_v2 AlphaFold Q9ER99 1-582 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3526447 AgrOrtholog
Ensembl Genes ENSMUSG00000040715 Ensembl, UniProtKB/Swiss-Prot
  ENSMUSG00000078515 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000105782.2 UniProtKB/Swiss-Prot
  ENSMUST00000177592.2 UniProtKB/Swiss-Prot
InterPro UBA UniProtKB/Swiss-Prot
KEGG Report mmu:69994 UniProtKB/Swiss-Prot
MGD MGI:3526447 ENTREZGENE
NCBI Gene Rsc1a1 ENTREZGENE
PANTHER DNA DAMAGE-INDUCIBLE 1 HOMOLOG 2 UniProtKB/Swiss-Prot
  PTHR15397 UniProtKB/Swiss-Prot
PhenoGen Rsc1a1 PhenoGen
PROSITE UBA UniProtKB/Swiss-Prot
SMART UBA UniProtKB/Swiss-Prot
UniProt B1AUM1 ENTREZGENE
  B2RWX9 ENTREZGENE
  Q78HA0 ENTREZGENE
  Q9CVU8 ENTREZGENE
  Q9ER99 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B1AUM1 UniProtKB/Swiss-Prot
  B2RWX9 UniProtKB/Swiss-Prot
  Q78HA0 UniProtKB/Swiss-Prot
  Q9CVU8 UniProtKB/Swiss-Prot