Fbrs (fibrosin) - Rat Genome Database

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Gene: Fbrs (fibrosin) Mus musculus
Analyze
Symbol: Fbrs
Name: fibrosin
RGD ID: 1615196
MGI Page MGI
Description: Enables growth factor activity. Acts upstream of or within positive regulation of fibroblast proliferation. Located in extracellular space. Orthologous to human FBRS (fibrosin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fbs; Fbs1; fibrosin 1; fibrosin-1; probable fibrosin-1; probable fibrosin-1 long transcript protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,075,925 - 127,090,685 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,078,371 - 127,090,883 (+)EnsemblGRCm39 Ensembl
GRCm387127,478,415 - 127,491,513 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,479,199 - 127,491,711 (+)EnsemblGRCm38mm10GRCm38
MGSCv377134,628,735 - 134,635,027 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,268,941 - 127,282,853 (+)NCBIMGSCv36mm8
Celera7127,330,490 - 127,336,782 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7892239   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16107646   PMID:16141072   PMID:16141073  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:38355793  


Genomics

Comparative Map Data
Fbrs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,075,925 - 127,090,685 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,078,371 - 127,090,883 (+)EnsemblGRCm39 Ensembl
GRCm387127,478,415 - 127,491,513 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,479,199 - 127,491,711 (+)EnsemblGRCm38mm10GRCm38
MGSCv377134,628,735 - 134,635,027 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,268,941 - 127,282,853 (+)NCBIMGSCv36mm8
Celera7127,330,490 - 127,336,782 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.55NCBI
FBRS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381630,658,431 - 30,670,810 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1630,658,431 - 30,670,810 (+)EnsemblGRCh38hg38GRCh38
GRCh371630,669,752 - 30,682,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,583,279 - 30,589,632 (+)NCBINCBI36Build 36hg18NCBI36
Build 341630,584,127 - 30,589,629NCBI
Celera1629,616,682 - 29,623,035 (-)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,238,944 - 28,245,297 (+)NCBIHuRef
CHM1_11631,992,976 - 31,999,329 (+)NCBICHM1_1
T2T-CHM13v2.01631,045,402 - 31,057,781 (+)NCBIT2T-CHM13v2.0
Fbrs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,520,148 - 191,534,510 (+)NCBIGRCr8
mRatBN7.21182,090,741 - 182,104,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,089,844 - 182,103,828 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01198,925,265 - 198,938,939 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1198,932,870 - 198,937,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,926,133 - 205,939,330 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,765,024 - 186,777,299 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1179,743,471 - 179,755,760 (+)NCBICelera
Cytogenetic Map1q37NCBI
Fbrs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554937,520,982 - 7,530,862 (+)NCBIChiLan1.0ChiLan1.0
FBRS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21833,863,538 - 33,875,912 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11638,664,998 - 38,677,374 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01624,298,989 - 24,311,392 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,026,069 - 31,038,868 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,027,839 - 31,037,706 (+)Ensemblpanpan1.1panPan2
FBRS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,497,612 - 17,509,323 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,497,831 - 17,508,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,072,503 - 19,085,092 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0617,629,327 - 17,641,916 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,629,359 - 17,640,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,429,567 - 17,442,155 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0617,347,500 - 17,358,979 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,660,089 - 17,671,573 (-)NCBIUU_Cfam_GSD_1.0
Fbrs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344124,955,246 - 124,967,892 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,054,196 - 13,066,115 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,053,131 - 13,065,751 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBRS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,731,764 - 17,742,921 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,731,276 - 17,743,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,187,493 - 18,200,064 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBRS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,352,769 - 27,359,172 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660682,138,964 - 2,151,648 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbrs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478213,789,255 - 13,799,948 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:569
Count of miRNA genes:348
Interacting mature miRNAs:408
Transcripts:ENSMUST00000048896
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357460Vtbt4_mvertebral trabecular bone trait 4 (mouse)Not determined7101693381135693530Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
11059561Lmr21a_mleishmaniasis resistance 21a (mouse)7117750722127967336Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
4141945Il4ppq_mIL-4 producing potential QTL (mouse)Not determined7124513662128819324Mouse
11039524Tbbr3_mTrypanosoma brucei brucei response 3 (mouse)7100750722134750843Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301447Fembm3_mfemoral bone morphometry 3 (mouse)Not determined7100993261134993342Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
4142312Nilac4_mnicotine induced locomotor activity 4 (mouse)Not determined7102485219136485380Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
38501072Stsl7_mSalmonella typhimurium susceptibility locus 7 (mouse)7115699235128501724Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
1301903Tlsm1_mthymic lymphoma susceptible 1 (mouse)Not determined7122250663135170901Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
1301105Cfld4_mcystic fibrosis lung disease 4 (mouse)Not determined7101693381135693530Mouse
1300721Cfbw3_mcystic fibrosis body weight 3 (mouse)Not determined7101693381135693530Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
5491192Mobq1_mmultigenic obesity QTL 1 (mouse)Not determined7105250663139250811Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
1357613Bsbob2_mBSB obesity 2 (mouse)Not determined7122250663128819324Mouse
13524852Asrq7a_macoustic startle response 7a (mouse)7105350008139350008Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
15092059Wogrme1_mweek one growth rate, maternal effect 1 (mouse)7117199227134101729Mouse

Markers in Region
G24195  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387127,491,348 - 127,491,471UniSTSGRCm38
MGSCv377134,634,862 - 134,634,985UniSTSGRCm37
Celera7127,336,617 - 127,336,740UniSTS
Cytogenetic Map7F4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000048896   ⟹   ENSMUSP00000043682
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,084,393 - 127,090,685 (+)Ensembl
GRCm38.p6 Ensembl7127,485,221 - 127,491,513 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205432   ⟹   ENSMUSP00000145783
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,078,371 - 127,090,678 (+)Ensembl
GRCm38.p6 Ensembl7127,479,199 - 127,491,506 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205651
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,086,021 - 127,090,883 (+)Ensembl
GRCm38.p6 Ensembl7127,486,849 - 127,491,711 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205696
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,084,580 - 127,088,719 (+)Ensembl
GRCm38.p6 Ensembl7127,485,408 - 127,489,547 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205803   ⟹   ENSMUSP00000145666
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,084,813 - 127,088,901 (+)Ensembl
GRCm38.p6 Ensembl7127,485,641 - 127,489,729 (+)Ensembl
Ensembl Acc Id: ENSMUST00000205967
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,086,235 - 127,087,125 (+)Ensembl
GRCm38.p6 Ensembl7127,487,063 - 127,487,953 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206394   ⟹   ENSMUSP00000146139
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,078,764 - 127,090,674 (+)Ensembl
GRCm38.p6 Ensembl7127,479,592 - 127,491,502 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206484   ⟹   ENSMUSP00000145748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,084,819 - 127,089,311 (+)Ensembl
GRCm38.p6 Ensembl7127,485,647 - 127,490,139 (+)Ensembl
Ensembl Acc Id: ENSMUST00000206980
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7127,079,187 - 127,082,393 (+)Ensembl
GRCm38.p6 Ensembl7127,480,015 - 127,483,221 (+)Ensembl
RefSeq Acc Id: NM_010183   ⟹   NP_034313
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,078,130 - 127,090,672 (+)NCBI
GRCm387127,478,958 - 127,491,500 (+)NCBI
MGSCv377134,628,735 - 134,635,027 (+)RGD
Celera7127,330,490 - 127,336,782 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006507348   ⟹   XP_006507411
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397127,075,925 - 127,090,685 (+)NCBI
GRCm387127,478,415 - 127,491,513 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034313   ⟸   NM_010183
- UniProtKB: A0A1N9PTV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006507411   ⟸   XM_006507348
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000146139   ⟸   ENSMUST00000206394
Ensembl Acc Id: ENSMUSP00000145748   ⟸   ENSMUST00000206484
Ensembl Acc Id: ENSMUSP00000145666   ⟸   ENSMUST00000205803
Ensembl Acc Id: ENSMUSP00000043682   ⟸   ENSMUST00000048896
Ensembl Acc Id: ENSMUSP00000145783   ⟸   ENSMUST00000205432

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R089-F1-model_v2 AlphaFold Q8R089 1-466 view protein structure

Promoters
RGD ID:8665683
Promoter ID:EPDNEW_M10872
Type:initiation region
Name:Fbrs_1
Description:Mus musculus fibrosin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387127,485,155 - 127,485,215EPDNEW
RGD ID:6841111
Promoter ID:MM_KWN:52784
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver
Transcripts:NM_010183,   UC009JVR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367134,627,831 - 134,629,047 (+)MPROMDB
RGD ID:6841102
Promoter ID:MM_KWN:52785
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung
Transcripts:UC009JVS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367134,630,239 - 134,630,739 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104648 AgrOrtholog
Ensembl Genes ENSMUSG00000042423 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048896.8 UniProtKB/Swiss-Prot
  ENSMUST00000205432 ENTREZGENE
  ENSMUST00000205432.3 UniProtKB/TrEMBL
  ENSMUST00000205803.2 UniProtKB/TrEMBL
  ENSMUST00000206394.2 UniProtKB/TrEMBL
  ENSMUST00000206484.2 UniProtKB/TrEMBL
InterPro AUTS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14123 UniProtKB/Swiss-Prot
MGD MGI:104648 ENTREZGENE
NCBI Gene 14123 ENTREZGENE
PANTHER FIBROSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14429 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Auts2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbrs PhenoGen
PRINTS FIBROSIN1LPF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNQ7_MOUSE UniProtKB/TrEMBL
  A0A0U1RNY3_MOUSE UniProtKB/TrEMBL
  A0A0U1RPV5_MOUSE UniProtKB/TrEMBL
  A0A1N9PTV1 ENTREZGENE, UniProtKB/TrEMBL
  FBRS_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE