Slfn14 (schlafen 14) - Rat Genome Database

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Gene: Slfn14 (schlafen 14) Mus musculus
Analyze
Symbol: Slfn14
Name: schlafen 14
RGD ID: 1614149
MGI Page MGI
Description: Enables RNA endonuclease activity and ribosome binding activity. Involved in mRNA catabolic process and rRNA catabolic process. Located in nucleus. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 20. Orthologous to human SLFN14 (schlafen family member 14).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm20; OTTMUSCASG00059418; OTTMUSPWKG00059403; OTTMUSWSBG00059310; schlafen family member 14; Schlafen family member 14, CAST_EiJ strain specific; schlafen family member 14, pseudogene; Schlafen family member 14, WSB_EiJ strain specific; Slfn; Slfn14-ps
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,165,936 - 83,177,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,165,936 - 83,177,552 (-)EnsemblGRCm39 Ensembl
GRCm381183,275,110 - 83,286,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,275,110 - 83,286,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,088,614 - 83,100,228 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,092,183 - 83,102,915 (-)NCBIMGSCv36mm8
Celera1192,866,891 - 92,878,903 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO,ISS)
nucleus  (IDA,ISO,ISS)

Molecular Function
ribosome binding  (IBA,IDA,ISO)
RNA endonuclease activity  (IBA,IDA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14610273   PMID:19619625   PMID:21873635   PMID:25996083   PMID:27899360   PMID:28734654   PMID:33496736   PMID:38355793  


Genomics

Comparative Map Data
Slfn14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,165,936 - 83,177,552 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,165,936 - 83,177,552 (-)EnsemblGRCm39 Ensembl
GRCm381183,275,110 - 83,286,726 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,275,110 - 83,286,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,088,614 - 83,100,228 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,092,183 - 83,102,915 (-)NCBIMGSCv36mm8
Celera1192,866,891 - 92,878,903 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.3NCBI
SLFN14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,543,985 - 35,560,819 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,543,985 - 35,560,819 (-)EnsemblGRCh38hg38GRCh38
GRCh371733,871,004 - 33,887,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,899,371 - 30,909,194 (-)NCBINCBI36Build 36hg18NCBI36
Celera1730,785,278 - 30,795,239 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,060,100 - 30,070,064 (-)NCBIHuRef
CHM1_11733,939,811 - 33,949,776 (-)NCBICHM1_1
T2T-CHM13v2.01736,491,903 - 36,508,738 (-)NCBIT2T-CHM13v2.0
Slfn14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,573,858 - 68,585,331 (-)NCBIGRCr8
mRatBN7.21068,076,326 - 68,087,794 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.01070,493,340 - 70,504,810 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01071,008,541 - 71,020,003 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,350,161 - 71,372,990 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1067,019,374 - 67,030,404 (-)NCBICelera
Cytogenetic Map10q26NCBI
Slfn14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495548110,037,941 - 10,046,549 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495548110,037,941 - 10,046,549 (-)NCBIChiLan1.0ChiLan1.0
SLFN14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,911,359 - 28,932,633 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,791,141 - 30,811,290 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,232,934 - 21,250,368 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,530,009 - 21,539,589 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,530,009 - 21,539,589 (+)Ensemblpanpan1.1panPan2
SLFN14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,091,939 - 38,112,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,100,691 - 38,110,695 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,315,978 - 37,335,991 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,903,598 - 38,923,685 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,912,943 - 38,923,413 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,687,601 - 37,707,677 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,971,911 - 37,991,991 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,059,358 - 38,079,438 (+)NCBIUU_Cfam_GSD_1.0
SLFN14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,950,505 - 39,961,513 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,947,791 - 39,962,823 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLFN14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11629,024,624 - 29,036,566 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1629,025,268 - 29,033,380 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666075938,980 - 954,275 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slfn14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248753,058,591 - 3,070,651 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248753,058,460 - 3,071,325 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slfn14
90 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:173
Interacting mature miRNAs:188
Transcripts:ENSMUST00000163961
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000163961   ⟹   ENSMUSP00000139132
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1183,165,936 - 83,177,552 (-)Ensembl
GRCm38.p6 Ensembl1183,275,110 - 83,286,726 (-)Ensembl
RefSeq Acc Id: NM_001166028   ⟹   NP_001159500
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,165,938 - 83,177,552 (-)NCBI
GRCm381183,275,112 - 83,286,726 (-)NCBI
MGSCv371183,088,614 - 83,100,228 (-)RGD
Celera1192,866,891 - 92,878,903 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006533236   ⟹   XP_006533299
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391183,165,936 - 83,174,248 (-)NCBI
GRCm381183,275,110 - 83,283,422 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001159500 (Get FASTA)   NCBI Sequence Viewer  
  XP_006533299 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000139132
  ENSMUSP00000139132.2
GenBank Protein SDA08568 (Get FASTA)   NCBI Sequence Viewer  
  SDA08588 (Get FASTA)   NCBI Sequence Viewer  
  SDA08609 (Get FASTA)   NCBI Sequence Viewer  
  V9GXG1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001159500   ⟸   NM_001166028
- UniProtKB: V9GXG1 (UniProtKB/TrEMBL),   A0A1G5SK34 (UniProtKB/TrEMBL),   A0A1G5SK54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006533299   ⟸   XM_006533236
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSMUSP00000139132   ⟸   ENSMUST00000163961
Protein Domains
Poxin-Schlafen/Schlafen-like N-terminal   Schlafen AlbA-2   Schlafen GTPase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-V9GXG1-F1-model_v2 AlphaFold V9GXG1 1-899 view protein structure

Promoters
RGD ID:8675886
Promoter ID:EPDNEW_M15973
Type:multiple initiation site
Name:Slfn14_1
Description:Mus musculus schlafen 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381183,286,671 - 83,286,731EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684866 AgrOrtholog
Ensembl Genes ENSMUSG00000082101 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000163961 ENTREZGENE
  ENSMUST00000163961.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.950.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Poxin-SLFN/SLFN_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Schlafen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Schlafen_AAA_dom UniProtKB/Swiss-Prot
  Schlafen_AAA_dom_sf UniProtKB/Swiss-Prot
  Schlafen_AlbA_2_dom UniProtKB/TrEMBL
  Schlafen_AlbA_2_dom_sf UniProtKB/TrEMBL
  SLFN_GTPase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:237890 UniProtKB/Swiss-Prot
MGD MGI:2684866 ENTREZGENE
NCBI Gene 237890 ENTREZGENE
PANTHER PROTEIN SLFN14 UniProtKB/TrEMBL
  PTHR12155 UniProtKB/Swiss-Prot
  PTHR12155:SF30 UniProtKB/Swiss-Prot
  SCHLAFEN UniProtKB/TrEMBL
Pfam AlbA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLFN_GTPase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slfn14 PhenoGen
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A1G5SK34 ENTREZGENE, UniProtKB/TrEMBL
  A0A1G5SK54 ENTREZGENE, UniProtKB/TrEMBL
  SLN14_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Slfn14  schlafen 14    schlafen family member 14  Symbol and/or name change 5135510 APPROVED
2013-04-30 Slfn14  schlafen family member 14  Slfn14-ps  schlafen family member 14, pseudogene  Symbol and/or name change 5135510 APPROVED
2011-07-27 Slfn14-ps  schlafen family member 14, pseudogene  Slfn14  schlafen family member 14  Symbol and/or name change 5135510 APPROVED