Advanced Search (OLGA)

Gene: Slfn14 (schlafen family member 14) Chinchilla lanigera

Analyze

Symbol:

Slfn14

Name:

schlafen family member 14

RGD ID:

8936293

Description:

ENCODES a protein that exhibits ribosome binding (ortholog); RNA endonuclease activity (ortholog); INVOLVED IN mRNA catabolic process (ortholog); platelet maturation (ortholog); rRNA catabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); hemorrhagic disease (ortholog); peroxisome biogenesis disorder 3A (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC102015406

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	10,037,941 - 10,046,549 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	10,037,941 - 10,046,549 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hemorrhagic disease (ISO)

peroxisome biogenesis disorder 3A (ISO)

platelet-type bleeding disorder 20 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mRNA catabolic process (ISO)

platelet maturation (ISO)

rRNA catabolic process (ISO)

Cellular Component

cytoplasm (ISO)

nucleus (ISO)

Molecular Function

ribosome binding (ISO)

RNA endonuclease activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Slfn14
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	10,037,941 - 10,046,549 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	10,037,941 - 10,046,549 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLFN14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	35,543,985 - 35,560,819 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	35,543,985 - 35,560,819 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	33,871,004 - 33,887,838 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	30,899,371 - 30,909,194 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	30,785,278 - 30,795,239 (-)	NCBI		Celera
Cytogenetic Map	17	q12	NCBI
HuRef	17	30,060,100 - 30,070,064 (-)	NCBI		HuRef
CHM1_1	17	33,939,811 - 33,949,776 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	36,491,903 - 36,508,738 (-)	NCBI		T2T-CHM13v2.0

Slfn14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	83,165,936 - 83,177,552 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	83,165,936 - 83,177,552 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	83,275,110 - 83,286,726 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	83,275,110 - 83,286,726 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	83,088,614 - 83,100,228 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	83,092,183 - 83,102,915 (-)	NCBI		MGSCv36	mm8
Celera	11	92,866,891 - 92,878,903 (-)	NCBI		Celera
Cytogenetic Map	11	C	NCBI
cM Map	11	50.3	NCBI

Slfn14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	68,573,858 - 68,585,331 (-)	NCBI		GRCr8
mRatBN7.2	10	68,076,326 - 68,087,794 (-)	NCBI	mRatBN7.2	mRatBN7.2
Rnor_6.0	10	70,493,340 - 70,504,810 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	71,008,541 - 71,020,003 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	71,350,161 - 71,372,990 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	67,019,374 - 67,030,404 (-)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

SLFN14
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	28,911,359 - 28,932,633 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	30,791,141 - 30,811,290 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	21,232,934 - 21,250,368 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	21,530,009 - 21,539,589 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	21,530,009 - 21,539,589 (+)	Ensembl	panpan1.1		panPan2

SLFN14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	38,091,939 - 38,112,042 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	38,100,691 - 38,110,695 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	37,315,978 - 37,335,991 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	38,903,598 - 38,923,685 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	38,912,943 - 38,923,413 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	37,687,601 - 37,707,677 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	37,971,911 - 37,991,991 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	38,059,358 - 38,079,438 (+)	NCBI		UU_Cfam_GSD_1.0

SLFN14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	39,950,458 - 39,962,820 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	39,947,791 - 39,962,823 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLFN14
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	29,024,624 - 29,036,566 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	29,025,268 - 29,033,380 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	938,980 - 954,275 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slfn14
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624875	3,058,591 - 3,070,651 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624875	3,058,460 - 3,071,325 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005402875	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01057135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01083245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000007175 ⟹ ENSCLAP00000007063

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955481	10,037,941 - 10,046,549 (-)	Ensembl

RefSeq Acc Id:

XM_005402875 ⟹ XP_005402932

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955481	10,037,941 - 10,046,549 (-)	NCBI

Sequence:

show sequence

TTGTTAATACATATTTGTGATACATAATGATTACATTAATAATATGGACTGAGTACATGTACAT
AACACATCGTACTTCTTTTTACATATTCTTCTTGCCCCTCTTATAACTTTTACTTTTATTAGTA
CATGTTTATTCTACGTAATGCTTACATTTTGTTGCAAAATTGTATGCTTTAATATCAAGATCTG
CAGGGCTGGGGATTTAGCTCAGTGGCAAAGCACCTGCCTGGCAAGCGCAAGGTCATGAGTTCGG
TTCCCGGTACCGGAGAAAAACCAAAAAAAAAAAAAAAATCAAGATCTGCAATACATATATTCCT
AGTCCTCTACTGCTTTTTCATTTTCCTTTGAATTATAAGTAGGACTTCCTTGATTTCAACTTCA
TTTCTGAATATTCTGTAATAAGTTACTTGGTCTCCTTGCCAACCCATACCCTTTACAGCTGGGC
TCAATGTTGTTGTTTCGTGATTTTATGTGAAAATAGCTGACAATTTCAGGAATATAATTTTTCA
CTATGGCAAAATGTTAATAGCCCACTTTTATCTACACTTGTGCTTGTGAGAAAGGCTATGGATA
TTTGGAAATATTGTTAGAAAACAGTAATATCAAATACTATTTCTAATGTTAAAATATATTTCTA
ATAGCTTATAGTTTTAAAGGAAATATTGTCTTCTCTGTAATTCCCACTAATGTGGAAACACCAT
TCTTCTCTTGATTATTTGTAGGAGCATCTTTCTGCTACTCACTGGGGCACACAGGGGCTACTGA
GATGGAGAGTCATAAGACTACCACAGAAATGGTCTATGCTGAGATTATCGTAAATGTGGGCAGA
ATGACTTTTGGAGAAGAAAACAGGAAGAAGATGAGCAATGGCTCTTTGAAGAGAACTGAGAATT
CCAAAATCATCCAGGCTATCTGTGCACTGTTAAATTCTGGAGGGGGTATGATCAAAGCAGAGAT
TGATGATAAAACCTACAGTTACAAATGCCATGGGCTAGGGCAGGATTTGGAAACTTCATTTCAA
ACACTTCTTCCTTCAGGTTCGCAGAAATACCTCGACTATGTGCAGCAGGGACGTGATTTCCTGA
TTTTCGTGAAGTCCTGGGGTCCAGATGTTTTCAGCCCCCCACTGAGGATTTGCAGCTTGCGTTC
CAACTTGTATCAGAGAGATGTGACCTCTGCTATGAACTTGAGTGCCAGCAGTGCCCTGGAGCTT
CTGAGAGCGAAGGCATATAGAGCCCAAAGAGGTAGACCAAAGTTGCATCCTCAGAAAGTTCTCA
AAAAATATGTTCAGGAAGAGGAAGATATGAAGATGTCTGCCCTGGAATTTTTAAAAAAGGATAA
ACTCACATATAAGGAGAAGGTCAACTTCACAGAATCAACACATGTTGAGTTTAAAAGGTTCACT
ACCAAAAAGGTTGTACCTCGGATTAAAGAGATGCTGCCTCATTATGTCTCTGCTTTTGCCAACA
CTCAAGGGGGATACCTGATTATTGGGGTTGATGATAAGAGCAAAGAAGTGTTTGGATGTAAGAG
AGAAAAAGTGAACCCTGACTTATTAAAAAAAGAGATAGAAAACTGCATAGAAAAATTGCCTACA
TTCCACTTCTGTTGCAAGAAGCCCAAGGTGAATTTCACTACCCAAATCTTGAACGTGTACAAAA
AAGATGACCTGTATGGTTATGTCTGTGTGGTTCAAGTAGAGCCCTTCTGTTGTGCAGTGTTTGC
AGAGGCCCCGGATTCCTGGATCATGAGGGACAAATCTGTCACCAGGCTGACAGCTGAGCAGTGG
GTAGTCATGATGCTGGACATTCAGTCAGTTTCTTCCAGTTTGGCCACAGACTCCAGTGCTCACC
TGCTTCCATCAGCTTCATCTTCACCAAGAAGCCCAGCATACCCCATAAAAGCCCTGGAATTGAA
GGGGGCTCTGCAGCAACGTCTGTTTCCAGTGACACAGGAAGAAATACATTTTAAGCCAGAATCC
CTCTGTAAGAAGTTATTCGCAGATCATAAGGAACTGGAGGAATTAATAAGGACACAGATACATC
CTTGTTCTCAGGGGATTGTGATATTTTCTAGAAGCTGGGCTGGTGATATTGGCTTCAAGAAGGA
GCAGAAGGTTCTGTGTGATGCTCTCCTGATAGCAATTAACAGCCCCCTGGTACTCTGCACAATC
CTAATAGACCCTAGTTGGACTGGAGGACTTGGATATGCCCGAGAGACTGCTTTTCAACTAAAGC
AGAAACTGCAAACTGTTGGTGGCTACACAGGGAAGGTGTGTGTCATTCCAAGGCTGATGTACCT
GACCAGCACACAGTGTAGATCTGAAGAAAATCTCGTGCACTACCCTCAATCCTACAGCCTTGCC
AGTGAGGATGAGATGGAGGACTTGTTACAGGCCCTTGTGGTCGTCTCGCTGTGCTCTCAGTCTC
TTCTGAGTGACCAGCTGGGTTGTGAGTTTTTCAACCTGCTTGTAGCGGAGCAGTGCGAACTGCT
GTCCAAGAGCCTTCAGGAGACCCGGGAACTGTTCATCCACTGCTTGCCAGGAACCAGGAGGACA
GCGCTAGCCATAAAGATCATGGAGAAAATTAAGGACTCGTTCCATTGCAAACCAAAAGAGATCC
TTTATGTCTGTGAAAGTGACTCCTTACGGGATTTTGTGATCCAGCAGACCACCTGCCAAGCTGT
GACCCGGAAAACTTTCATGCAAGGGGAATTCCCCAAAATTCAGCACATAGTGATGGATGAGGCT
GAGAATTTCTGCGGTAAATACGGGGATTGGTACATGAAAGCTAGGAGTATCACCTACCCAAAGG
TGAAAGGGGCTGGAAGTGAAAACCCTCACCACGGGATCCTCTGGCTTTTCCTGGACCTTTTCCA
AGTCCGTCATGCAGATGTCAGCGGCCTCCCTCCTCCTTCTGCTCAGTTTCCTCGGAAAGCAATC
ACTGAGGGGGTCCACTGTGCTCTGGAAATAGCAAAGGTCATGAAAGAAGAAATGAAGAGGATCA
AAGAAAACCCTCCTTCCAACATGTCTCCAGACACATTAGCGCTGTTCCAGGAAGCTGCCTATGA
GGAAGCAATGTGTGCCCAAGCTCTGCCTGGGGTGTATGAGACAAAGACTAACCTGACAATAGAA
CAAATAGCAAACTACGTGGCAGAAAGATGTCATAGTCTGTTCCAGTGTGGCTATATGCCCAAAG
ATGTGGCAATTTTGTGCAGGAGAGGGGAGGACCAAGGACGTTATAAACTTGCACTGCTAAGAGC
AGTGAAATTAATGAAGACCCAAGGAGCAACAGAGGTTGTGTTCAGCCAGGCTGCTGGTGTTCAG
GGTGATCACATTGTTTTAGACAGTGTTCAACAGTTTTCGGGCCTGGGGAGGAATATTGTGTTTG
GGCTCAGTCCAGAATGTACCCAGTCAGAGGAGTTTCATAAGCTCTGGTTTGCCTCAAGAGCCAT
TAAACACCTCTACCTTCTTTATGAAAAGAGGGCAGCCTTCTGAAAATCATTATGAACAACACAG
AGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005402932	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000007063
	ENSCLAP00000007063.1

RefSeq Acc Id:

XP_005402932 ⟸ XM_005402875

- UniProtKB:

A0A8C2V275 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESHKTTTEMVYAEIIVNVGRMTFGEENRKKMSNGSLKRTENSKIIQAICALLNSGGGMIKAEI
DDKTYSYKCHGLGQDLETSFQTLLPSGSQKYLDYVQQGRDFLIFVKSWGPDVFSPPLRICSLRS
NLYQRDVTSAMNLSASSALELLRAKAYRAQRGRPKLHPQKVLKKYVQEEEDMKMSALEFLKKDK
LTYKEKVNFTESTHVEFKRFTTKKVVPRIKEMLPHYVSAFANTQGGYLIIGVDDKSKEVFGCKR
EKVNPDLLKKEIENCIEKLPTFHFCCKKPKVNFTTQILNVYKKDDLYGYVCVVQVEPFCCAVFA
EAPDSWIMRDKSVTRLTAEQWVVMMLDIQSVSSSLATDSSAHLLPSASSSPRSPAYPIKALELK
GALQQRLFPVTQEEIHFKPESLCKKLFADHKELEELIRTQIHPCSQGIVIFSRSWAGDIGFKKE
QKVLCDALLIAINSPLVLCTILIDPSWTGGLGYARETAFQLKQKLQTVGGYTGKVCVIPRLMYL
TSTQCRSEENLVHYPQSYSLASEDEMEDLLQALVVVSLCSQSLLSDQLGCEFFNLLVAEQCELL
SKSLQETRELFIHCLPGTRRTALAIKIMEKIKDSFHCKPKEILYVCESDSLRDFVIQQTTCQAV
TRKTFMQGEFPKIQHIVMDEAENFCGKYGDWYMKARSITYPKVKGAGSENPHHGILWLFLDLFQ
VRHADVSGLPPPSAQFPRKAITEGVHCALEIAKVMKEEMKRIKENPPSNMSPDTLALFQEAAYE
EAMCAQALPGVYETKTNLTIEQIANYVAERCHSLFQCGYMPKDVAILCRRGEDQGRYKLALLRA
VKLMKTQGATEVVFSQAAGVQGDHIVLDSVQQFSGLGRNIVFGLSPECTQSEEFHKLWFASRAI
KHLYLLYEKRAAF

hide sequence

Ensembl Acc Id:

ENSCLAP00000007063 ⟸ ENSCLAT00000007175

Protein Domains

Poxin-Schlafen/Schlafen-like N-terminal Schlafen AlbA-2 Schlafen GTPase-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004969	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000007175	ENTREZGENE
	ENSCLAT00000007175.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.950.30	UniProtKB/TrEMBL
InterPro	Poxin-SLFN/SLFN_N	UniProtKB/TrEMBL
	Schlafen	UniProtKB/TrEMBL
	Schlafen_AlbA_2_dom	UniProtKB/TrEMBL
	Schlafen_AlbA_2_dom_sf	UniProtKB/TrEMBL
	SLFN_GTPase-like	UniProtKB/TrEMBL
NCBI Gene	Slfn14	ENTREZGENE
PANTHER	PTHR12155	UniProtKB/TrEMBL
	PTHR12155:SF30	UniProtKB/TrEMBL
Pfam	AlbA_2	UniProtKB/TrEMBL
	B3R	UniProtKB/TrEMBL
	SLFN_GTPase-like	UniProtKB/TrEMBL
UniProt	A0A8C2V275	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-02-27	Slfn14	schlafen family member 14	LOC102015406		Symbol and/or name change	5135510	APPROVED
2015-08-25	LOC102015406	schlafen family member 14	Slfn14		Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM