Mir487b (microRNA 487b) - Rat Genome Database

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Gene: Mir487b (microRNA 487b) Mus musculus
Analyze
Symbol: Mir487b
Name: microRNA 487b
RGD ID: 1607582
MGI Page MGI
Description: Involved in energy homeostasis. Acts upstream of or within cellular response to phenylalanine; long-term synaptic potentiation; and sensory perception of sound. Orthologous to human MIR487B (microRNA 487b).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-487b; Mirn4; Mirn487b
RGD Orthologs
Human
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,693,767 - 109,693,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,693,767 - 109,693,848 (+)EnsemblGRCm39 Ensembl
GRCm3812109,727,333 - 109,727,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,727,333 - 109,727,414 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,965,543 - 110,965,624 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,924,563 - 110,924,644 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir487bMouseKagami-Ogata syndrome  ISOMIR487B (Homo sapiens)8554872ClinVar Annotator: match by term: Paternal uniparental disomy 14ClinVarPMID:18176563
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir487bMouseCarcinoid Tumor  ISOMIR487B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25105010
Mir487bMouseExperimental Neoplasms  ISOMIR487B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28030816
Mir487bMouseLung Neoplasms  ISOMIR487B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25105010
Mir487bMousepapillary thyroid carcinoma  ISOMIR487B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28030816
Mir487bMousetype 2 diabetes mellitus  ISOMIR487B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28545106

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir487bMouse2,5-hexanedione increases expressionISOMir487b (Rattus norvegicus)64804642 and 5-hexanedione results in increased expression of MIR487B mRNACTDPMID:31760062
Mir487bMouse6-propyl-2-thiouracil decreases expressionISOMir487b (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of MIR487B mRNACTDPMID:39441382
Mir487bMousearsane decreases expressionISOMIR487B (Homo sapiens)6480464Arsenic results in decreased expression of MIR487BCTDPMID:30114287
Mir487bMousearsenic atom decreases expressionISOMIR487B (Homo sapiens)6480464Arsenic results in decreased expression of MIR487BCTDPMID:30114287
Mir487bMousearsenite(3-) increases expressionISOMIR487B (Homo sapiens)6480464arsenite results in increased expression of MIR487B mRNACTDPMID:22728250
Mir487bMousebenzo[a]pyrene increases methylationISOMIR487B (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of MIR487B promoterCTDPMID:27901495
Mir487bMousedexamethasone decreases expressionISOMir487b (Rattus norvegicus)6480464Dexamethasone results in decreased expression of MIR487B mRNACTDPMID:33619658
Mir487bMousemethylisothiazolinone increases expressionISOMIR487B (Homo sapiens)64804642-methyl-4-isothiazolin-3-one results in increased expression of MIR487B mRNACTDPMID:31629900
Mir487bMousenitrofen increases expressionISOMir487b (Rattus norvegicus)6480464nitrofen results in increased expression of MIR487B mRNACTDPMID:27041227
Mir487bMouseparacetamol decreases expressionEXP 6480464Acetaminophen results in decreased expression of MIR487B mRNACTDPMID:19246379
Mir487bMouseresveratrol multiple interactionsISOMir487b (Rattus norvegicus)6480464plastochromanol 8 promotes the reaction [Resveratrol results in decreased expression of MIR487B mRNA] and Resveratrol promotes the reaction [plastochromanol 8 results in decreased expression of MIR487B mRNA]CTDPMID:22050707
Mir487bMouseresveratrol decreases expressionISOMir487b (Rattus norvegicus)6480464Resveratrol results in decreased expression of MIR487B mRNACTDPMID:22050707
Mir487bMouserotenone decreases expressionISOMir487b (Rattus norvegicus)6480464Rotenone results in decreased expression of MIR487BCTDPMID:32392329
Mir487bMousesporidesmin A increases expressionISOMIR487B (Homo sapiens)6480464sporidesmin results in increased expression of MIR487B mRNACTDPMID:28193462
Mir487bMousevalproic acid increases expressionISOMIR487B (Homo sapiens)6480464Valproic Acid results in increased expression of MIR487B mRNACTDPMID:39423997

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Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir487bMousemRNA base-pairing translational repressor activity enablesISOMIR487B (Homo sapiens)9068941 PMID:25660232BHF-UCLPMID:25660232


#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:16274478   PMID:16381832   PMID:17604727   PMID:20215419   PMID:20413612   PMID:21037258   PMID:21267068   PMID:23646144   PMID:25124681   PMID:25858512   PMID:25925429   PMID:26107383  
PMID:26822703   PMID:26936882   PMID:27545879   PMID:29284691   PMID:30556842   PMID:30978699  



Mir487b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,693,767 - 109,693,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,693,767 - 109,693,848 (+)EnsemblGRCm39 Ensembl
GRCm3812109,727,333 - 109,727,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,727,333 - 109,727,414 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,965,543 - 110,965,624 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,924,563 - 110,924,644 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
MIR487B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,046,455 - 101,046,538 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,046,455 - 101,046,538 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,512,792 - 101,512,875 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,582,544 - 100,582,627 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,568,849 - 81,568,932 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,696,158 - 81,696,241 (+)NCBIHuRef
CHM1_114101,451,814 - 101,451,897 (+)NCBICHM1_1
T2T-CHM13v2.01495,281,832 - 95,281,915 (+)NCBIT2T-CHM13v2.0
Mir487b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,562,890 - 134,562,971 (+)NCBIGRCr8
mRatBN7.26128,741,485 - 128,741,566 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,741,485 - 128,741,566 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,920,724 - 128,920,805 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,216,556 - 129,216,637 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,578,179 - 128,578,260 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,877,124 - 133,877,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,877,124 - 133,877,205 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,039,481 - 143,039,562 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,325,864 - 126,325,945 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR487B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,275,496 - 69,275,553 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl869,275,473 - 69,275,576 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,793,643 - 68,793,700 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,557,144 - 69,557,201 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,220,689 - 69,220,746 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,286,784 - 69,286,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,684,783 - 69,684,840 (+)NCBIUU_Cfam_GSD_1.0

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Variants in Mir487b
3 total Variants

Predicted Targets
Summary Value
Count of predictions:5602
Count of gene targets:3537
Count of transcripts:5059
Interacting mature miRNAs:mmu-miR-487b-3p, mmu-miR-487b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
1300883Ath21_matherosclerosis 21 (mouse)Not determined1285961579119961683Mouse
12910532Nrq10a_mnoise-induced hearing loss resistant QTL 10a (mouse)1292750025120092757Mouse
12910533Nrq10_mnoise-induced hearing loss resistant QTL 10 (mouse)1292750025120092757Mouse
1357463Vtbt14_mvertebral trabecular bone trait 14 (mouse)Not determined1292936097120092757Mouse
1301269Sluc12_msusceptibility to lung cancer 12 (mouse)Not determined1296860337120092757Mouse
4142007Chlq17_mcirculating hormone level QTL 17 (mouse)Not determined1288052874120092757Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
11039526Ccc1_mcolitis susceptibility in the Collaborative Cross 1 (mouse)1293528334111028223Mouse
4141297Plyid_mPolymeric IgA dominance (mouse)Not determined109183385115885122Mouse

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RefSeq Transcripts NR_030271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LM609541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000102265
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl12109,693,767 - 109,693,848 (+)Ensembl
GRCm38.p6 Ensembl12109,727,333 - 109,727,414 (+)Ensembl
RefSeq Acc Id: NR_030271
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3912109,693,767 - 109,693,848 (+)NCBI
GRCm3812109,727,333 - 109,727,414 (+)ENTREZGENE
MGSCv3712110,965,543 - 110,965,624 (+)RGD
Celera12110,924,563 - 110,924,644 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RGD ID:8679266
Promoter ID:EPDNEW_M17664
Type:single initiation site
Name:Mir487b_1
Description:Mus musculus microRNA 487b , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3812109,727,357 - 109,727,417EPDNEW


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Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000076219 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000102265 ENTREZGENE
MGD MGI:3619424 ENTREZGENE
miRBase MI0003534 ENTREZGENE
NCBI Gene 723940 ENTREZGENE
PhenoGen Mir487b PhenoGen
RNAcentral URS00000F0AF5 RNACentral
  URS000015B295 RNACentral
  URS000075EB6F RNACentral
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