Mirlet7a-2 (microRNA let7a-2) - Rat Genome Database

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Gene: Mirlet7a-2 (microRNA let7a-2) Mus musculus
Analyze
Symbol: Mirlet7a-2
Name: microRNA let7a-2
RGD ID: 1607559
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to lipid; embryo implantation; and regulation of gene expression. Located in cytoplasm. Part of RISC complex. Is expressed in several structures, including brain; inner cell mass; and lung. Orthologous to human MIRLET7A2 (microRNA let-7a-2).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: let-7a-2; Mirnle; Mirnlet7a-2
RGD Orthologs
Human
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39941,448,012 - 41,448,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl941,448,012 - 41,448,107 (+)EnsemblGRCm39 Ensembl
GRCm38941,536,716 - 41,536,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,536,716 - 41,536,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv37941,344,799 - 41,344,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera938,775,498 - 38,775,593 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map923.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:15361871   PMID:15538371   PMID:15845075   PMID:16040801   PMID:16369549   PMID:16381832   PMID:16462742   PMID:16766679   PMID:17369397   PMID:17604727   PMID:17613256  
PMID:18452032   PMID:18556655   PMID:18604195   PMID:18762567   PMID:19014979   PMID:19084527   PMID:19324969   PMID:19559694   PMID:19812317   PMID:19898466   PMID:19949436   PMID:20053268  
PMID:20215419   PMID:20413612   PMID:20547853   PMID:20548288   PMID:20668074   PMID:21037258   PMID:21267068   PMID:21430230   PMID:21718763   PMID:21822254   PMID:21841313   PMID:21991391  
PMID:21993888   PMID:22022355   PMID:22144232   PMID:22206758   PMID:22895573   PMID:23152446   PMID:23185045   PMID:23200853   PMID:23622242   PMID:23895693   PMID:24205035   PMID:25124681  
PMID:25722370   PMID:25739861   PMID:26139524   PMID:27554624   PMID:28049690   PMID:28807083   PMID:30042178   PMID:30556910   PMID:30635573   PMID:31080058   PMID:31354981   PMID:31653921  
PMID:34289374   PMID:36224178   PMID:37696797   PMID:38193570  


Genomics

Comparative Map Data
Mirlet7a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39941,448,012 - 41,448,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl941,448,012 - 41,448,107 (+)EnsemblGRCm39 Ensembl
GRCm38941,536,716 - 41,536,811 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,536,716 - 41,536,811 (+)EnsemblGRCm38mm10GRCm38
MGSCv37941,344,799 - 41,344,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera938,775,498 - 38,775,593 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map923.41NCBI
MIRLET7A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811122,146,522 - 122,146,593 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11122,146,522 - 122,146,593 (-)EnsemblGRCh38hg38GRCh38
GRCh3711122,017,230 - 122,017,301 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611121,522,439 - 121,522,510 (-)NCBINCBI36Build 36hg18NCBI36
Celera11119,177,905 - 119,177,976 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11117,963,762 - 117,963,833 (-)NCBIHuRef
CHM1_111121,904,525 - 121,904,596 (-)NCBICHM1_1
T2T-CHM13v2.011122,175,523 - 122,175,594 (-)NCBIT2T-CHM13v2.0
MIRLET7A-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1512,052,786 - 12,052,881 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl512,052,786 - 12,052,881 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha512,107,840 - 12,107,935 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0512,002,281 - 12,002,376 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl512,002,281 - 12,002,376 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1512,106,284 - 12,106,379 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0512,045,495 - 12,045,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0512,084,377 - 12,084,472 (+)NCBIUU_Cfam_GSD_1.0
MIRLET7A-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,152,586 - 49,152,665 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,152,586 - 49,152,665 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2954,378,059 - 54,378,138 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mirlet7a-2
4 total Variants
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:26260
Count of gene targets:10198
Count of transcripts:17130
Interacting mature miRNAs:mmu-let-7a-2-3p, mmu-let-7a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92850333341799326Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93410461942764866Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93715336244251323Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
12738415Lfibq8_mliver fibrosis QTL 8 (mouse)94140216245343743Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000175029
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl941,448,012 - 41,448,107 (+)Ensembl
GRCm38.p6 Ensembl941,536,716 - 41,536,811 (+)Ensembl
RefSeq Acc Id: NR_029726
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39941,448,012 - 41,448,107 (+)NCBI
GRCm38941,536,716 - 41,536,811 (+)ENTREZGENE
MGSCv37941,344,799 - 41,344,894 (+)RGD
Celera938,775,498 - 38,775,593 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Promoters
RGD ID:8669312
Promoter ID:EPDNEW_M12687
Type:single initiation site
Name:Mirlet7a-2_1
Description:Mus musculus microRNA let7a-2 (Mirlet7a-2), microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38941,536,734 - 41,536,794EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3619049 AgrOrtholog
Ensembl Genes ENSMUSG00000092770 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000175029 ENTREZGENE
MGD MGI:3619049 ENTREZGENE
miRBase MI0000557 ENTREZGENE
NCBI Gene 723965 ENTREZGENE
PhenoGen Mirlet7a-2 PhenoGen
RNAcentral URS000017B907 RNACentral
  URS0000416056 RNACentral
  URS000075C982 RNACentral