CLEC12A (C-type lectin domain family 12 member A) - Rat Genome Database

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Gene: CLEC12A (C-type lectin domain family 12 member A) Homo sapiens
Analyze
Symbol: CLEC12A
Name: C-type lectin domain family 12 member A
RGD ID: 1605851
HGNC Page HGNC:31713
Description: Enables pattern recognition receptor activity and transmembrane signaling receptor activity. Involved in negative regulation of dendritic cell differentiation; negative regulation of immune response; and negative regulation of leukocyte activation. Is active in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-type lectin domain family 12, member A; C-type lectin protein CLL-1; C-type lectin superfamily; C-type lectin-like molecule 1; C-type lectin-like molecule-1; CD371; CLL-1; CLL1; DCAL-2; dendritic cell associated lectin 2; dendritic cell-associated lectin 2; hKLRL1; killer cell C-type lectin-like receptor L1; MGC70602; MICL; myeloid inhibitory C-type lectin-like receptor
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,951,268 - 10,006,150 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,951,316 - 9,995,694 (+)EnsemblGRCh38hg38GRCh38
GRCh371210,103,867 - 10,138,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,015,281 - 10,029,461 (+)NCBINCBI36Build 36hg18NCBI36
Celera1215,285,390 - 15,299,566 (+)NCBICelera
Cytogenetic Map12p13.31-p13.2NCBI
HuRef129,846,830 - 9,881,061 (+)NCBIHuRef
CHM1_11210,072,931 - 10,107,502 (+)NCBICHM1_1
T2T-CHM13v2.0129,837,492 - 9,892,550 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLEC12AHumancerebral malaria amelioratesISORGD:161568041412201 RGD 
CLEC12AHumanCOVID-19  HEP 28912744mRNA:increased expression:peripheral blood mononuclear cell (human)RGD 
CLEC12AHumanlymphocytic choriomeningitis disease_progressionISORGD:161568041412202 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLEC12AHumanrheumatoid arthritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17568789

1 to 20 of 41 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLEC12AHuman(+)-catechin multiple interactionsEXP 6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of CLEC12A mRNACTDPMID:24763279
CLEC12AHuman(-)-alpha-phellandrene decreases expressionEXP 6480464alpha phellandrene results in decreased expression of CLEC12A mRNACTDPMID:25075043
CLEC12AHuman(1->4)-beta-D-glucan multiple interactionsISORGD:16156806480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CLEC12A mRNACTDPMID:36331819
CLEC12AHuman17beta-estradiol multiple interactionsISORGD:15929916480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CLEC12A mRNACTDPMID:32741896
CLEC12AHuman17beta-estradiol 3-benzoate multiple interactionsISORGD:15929916480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CLEC12A mRNACTDPMID:32741896
CLEC12AHuman2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISORGD:161568064804642,2',4,4',5-brominated diphenyl ether affects the expression of CLEC12A mRNACTDPMID:38648751
CLEC12AHuman2-palmitoylglycerol increases expressionEXP 64804642-palmitoylglycerol results in increased expression of CLEC12A mRNACTDPMID:37199045
CLEC12AHuman4-hydroxynon-2-enal decreases expressionISORGD:161568064804644-hydroxy-2-nonenal results in decreased expression of CLEC12A mRNACTDPMID:19191707
CLEC12AHumanacetamide increases expressionISORGD:15929916480464acetamide results in increased expression of CLEC12A mRNACTDPMID:31881176
CLEC12AHumanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of CLEC12A geneCTDPMID:27153756
CLEC12AHumanall-trans-retinoic acid increases expressionEXP 6480464Tretinoin results in increased expression of CLEC12A mRNACTDPMID:33167477
CLEC12AHumanalpha-phellandrene decreases expressionEXP 6480464alpha phellandrene results in decreased expression of CLEC12A mRNACTDPMID:25075043
CLEC12AHumanamphetamine increases expressionISORGD:15929916480464Amphetamine results in increased expression of CLEC12A mRNACTDPMID:30779732
CLEC12AHumanbenzo[a]pyrene increases methylationEXP 6480464Benzo(a)pyrene results in increased methylation of CLEC12A promoterCTDPMID:27901495
CLEC12AHumanbeta-naphthoflavone decreases expressionEXP 6480464beta-Naphthoflavone results in decreased expression of CLEC12A mRNACTDPMID:32858204
CLEC12AHumanbis(2-ethylhexyl) phthalate increases expressionISORGD:16156806480464Diethylhexyl Phthalate results in increased expression of CLEC12A mRNACTDPMID:28085963
CLEC12AHumanbisphenol A increases expressionISORGD:15929916480464bisphenol A results in increased expression of CLEC12A mRNACTDPMID:25181051
CLEC12AHumanbisphenol A increases methylationISORGD:15929916480464bisphenol A results in increased methylation of CLEC12A geneCTDPMID:28505145
CLEC12AHumancisplatin increases expressionEXP 6480464Cisplatin results in increased expression of CLEC12A mRNACTDPMID:27594783
CLEC12AHumanCuprizon increases expressionISORGD:15929916480464Cuprizone results in increased expression of CLEC12A mRNACTDPMID:27523638

1 to 20 of 41 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLEC12AHumannegative regulation of dendritic cell differentiation involved_inIDA 150520179 PMID:16239426UniProtPMID:16239426
CLEC12AHumannegative regulation of immune response involved_inIDA 150520179 PMID:14739280UniProtPMID:14739280
CLEC12AHumannegative regulation of inflammatory response involved_inISSUniProtKB:Q504P2150520179 UniProtGO_REF:0000024
CLEC12AHumannegative regulation of natural killer cell activation involved_inIMP 150520179 PMID:15238421, PMID:31269448UniProtPMID:15238421|PMID:31269448
CLEC12AHumannegative regulation of neutrophil activation involved_inIDA 150520179 PMID:34234773UniProtPMID:34234773
CLEC12AHumanpositive regulation of type I interferon production involved_inISSUniProtKB:Q504P2150520179 UniProtGO_REF:0000024
CLEC12AHumansignal transduction involved_inIBAPANTHER:PTN002334776|UniProtKB:Q9P126150520179 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLEC12AHumanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
CLEC12AHumanplasma membrane is_active_inIDA 150520179 PMID:14739280, PMID:15238421, PMID:16239426, PMID:34234773, PMID:38367667UniProtPMID:14739280|PMID:15238421|PMID:16239426|PMID:34234773|PMID:38367667
CLEC12AHumanplasma membrane is_active_inIBAMGI:1913287|MGI:3040968|PANTHER:PTN002334776|UniProtKB:Q5QGZ9150520179 GO_CentralGO_REF:0000033
CLEC12AHumanplasma membrane located_inTAS 150520179 ReactomeReactome:R-HSA-6798747|Reactome:R-HSA-6799350
CLEC12AHumanplasma membrane located_inIEAUniProtKB-SubCell:SL-0039150520179 UniProtGO_REF:0000044
CLEC12AHumanplasma membrane located_inIEAUniProtKB-KW:KW-1003150520179 UniProtGO_REF:0000043
CLEC12AHumanspecific granule membrane located_inTAS 150520179 ReactomeReactome:R-HSA-6799350
CLEC12AHumantertiary granule membrane located_inTAS 150520179 ReactomeReactome:R-HSA-6798747

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CLEC12AHumancarbohydrate binding enablesIEAUniProtKB-KW:KW-0430150520179 UniProtGO_REF:0000043
CLEC12AHumanpattern recognition receptor activity enablesIMP 150520179 PMID:31269448UniProtPMID:31269448
CLEC12AHumanpattern recognition receptor activity enablesIDA 150520179 PMID:36542980UniProtPMID:36542980
CLEC12AHumanprotein binding enablesIPIUniProtKB:Q8NC01150520179 PMID:32296183IntActPMID:32296183
CLEC12AHumansignaling receptor regulator activity enablesIEAInterPro:IPR042916150520179 InterProGO_REF:0000002
CLEC12AHumantransmembrane signaling receptor activity enablesIDA 150520179 PMID:38367667, PMID:38386511, PMID:39143217UniProtPMID:38367667|PMID:38386511|PMID:39143217
CLEC12AHumantransmembrane signaling receptor activity enablesIBAMGI:3040968|PANTHER:PTN002334776|UniProtKB:Q5QGZ9|UniProtKB:Q9P126150520179 GO_CentralGO_REF:0000033
CLEC12AHumantransmembrane signaling receptor activity enablesIMP 150520179 PMID:15238421UniProtPMID:15238421


#
Reference Title
Reference Citation
1. The uric acid crystal receptor Clec12A potentiates type I interferon responses. Li K, etal., Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18544-18549. doi: 10.1073/pnas.1821351116. Epub 2019 Aug 26.
2. The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development. Raulf MK, etal., Cell Rep. 2019 Jul 2;28(1):30-38.e5. doi: 10.1016/j.celrep.2019.06.015.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
PMID:10508765   PMID:12477932   PMID:12945048   PMID:14739280   PMID:15238421   PMID:15548716   PMID:16239426   PMID:16838277   PMID:17609428   PMID:18350551   PMID:19494282   PMID:21677141  
PMID:21873635   PMID:22341585   PMID:24152218   PMID:25760768   PMID:25957656   PMID:26095365   PMID:26186194   PMID:27506934   PMID:27566820   PMID:27612176   PMID:28514442   PMID:28718199  
PMID:28810819   PMID:29316944   PMID:29411522   PMID:29427319   PMID:29959143   PMID:30520015   PMID:32296183   PMID:33094319   PMID:33095915   PMID:33369070   PMID:33778076   PMID:33961781  
PMID:34053123   PMID:34234773   PMID:34638548   PMID:34830054   PMID:35156780   PMID:35481814   PMID:36542980   PMID:36928077   PMID:37102643   PMID:38367667   PMID:38386511   PMID:39143217  



CLEC12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,951,268 - 10,006,150 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,951,316 - 9,995,694 (+)EnsemblGRCh38hg38GRCh38
GRCh371210,103,867 - 10,138,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,015,281 - 10,029,461 (+)NCBINCBI36Build 36hg18NCBI36
Celera1215,285,390 - 15,299,566 (+)NCBICelera
Cytogenetic Map12p13.31-p13.2NCBI
HuRef129,846,830 - 9,881,061 (+)NCBIHuRef
CHM1_11210,072,931 - 10,107,502 (+)NCBICHM1_1
T2T-CHM13v2.0129,837,492 - 9,892,550 (+)NCBIT2T-CHM13v2.0
Clec12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,327,207 - 129,342,266 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,319,654 - 129,342,266 (+)EnsemblGRCm39 Ensembl
GRCm386129,349,783 - 129,365,303 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,342,691 - 129,365,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv376129,300,304 - 129,315,321 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366129,315,979 - 129,330,996 (+)NCBIMGSCv36mm8
Celera6131,072,396 - 131,087,407 (+)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.26NCBI
Clec12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,484,162 - 164,502,793 (+)NCBIGRCr8
mRatBN7.24162,798,125 - 162,816,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4162,798,125 - 162,816,753 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,032,955 - 169,051,584 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04164,815,903 - 164,834,532 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,449,952 - 163,468,579 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,112,100 - 163,130,979 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,112,301 - 163,126,864 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,756,068 - 211,774,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,639,429 - 166,639,958 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4151,485,182 - 151,502,187 (+)NCBICelera
Cytogenetic Map4q42NCBI
CLEC12A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,441,991 - 15,498,736 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,438,749 - 15,495,495 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0129,999,334 - 10,056,108 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,248,163 - 10,272,070 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,248,209 - 10,272,070 (+)Ensemblpanpan1.1panPan2
CLEC12A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,040,574 - 36,051,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2736,040,577 - 36,051,184 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,572,558 - 10,583,206 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02736,386,889 - 36,397,598 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2736,386,892 - 36,397,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,274,058 - 36,284,680 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,297,581 - 36,308,213 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,094,663 - 10,105,311 (+)NCBIUU_Cfam_GSD_1.0
Clec12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494597,412,004 - 97,424,619 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936902543,670 - 556,014 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936902542,981 - 556,142 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLEC12A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl561,922,895 - 61,937,096 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1561,923,057 - 61,936,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,755,594 - 64,769,466 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLEC12A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,838,867 - 9,858,869 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660891,913,397 - 1,933,461 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in CLEC12A
77 total Variants

1 to 10 of 112 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 12p13.33-11.22(chr12:121055-28415184)x1 copy number loss See cases [RCV000052776] Chr12:121055..28415184 [GRCh38]
Chr12:282465..28568117 [GRCh37]
Chr12:100482..28459384 [NCBI36]
Chr12:12p13.33-11.22
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:77187-34380176)x3 copy number gain See cases [RCV000053660] Chr12:77187..34380176 [GRCh38]
Chr12:282465..34533111 [GRCh37]
Chr12:56614..34424378 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.1(chr12:80412-25470329)x3 copy number gain See cases [RCV000053662] Chr12:80412..25470329 [GRCh38]
Chr12:282465..25623263 [GRCh37]
Chr12:59839..25514530 [NCBI36]
Chr12:12p13.33-12.1
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:212976-33926913)x4 copy number gain See cases [RCV000053666] Chr12:212976..33926913 [GRCh38]
Chr12:322142..34079848 [GRCh37]
Chr12:192403..33971115 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
NM_001207010.1(CLEC12A):c.508G>A (p.Ala170Thr) single nucleotide variant Malignant melanoma [RCV000062372] Chr12:9980680 [GRCh38]
Chr12:10133279 [GRCh37]
Chr12:10024546 [NCBI36]
Chr12:12p13.31
not provided
GRCh38/hg38 12p13.33-11.1(chr12:121255-34603274)x3 copy number gain See cases [RCV000136611] Chr12:121255..34603274 [GRCh38]
Chr12:282465..34756209 [GRCh37]
Chr12:100682..34647476 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-12.3(chr12:2871741-14987348)x3 copy number gain See cases [RCV000137694] Chr12:2871741..14987348 [GRCh38]
Chr12:2980907..15140282 [GRCh37]
Chr12:2851168..15031549 [NCBI36]
Chr12:12p13.33-12.3
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:121271-34603261)x3 copy number gain See cases [RCV000139052] Chr12:121271..34603261 [GRCh38]
Chr12:282465..34756196 [GRCh37]
Chr12:100698..34647463 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12p13.33-11.1(chr12:54427-34608071)x4 copy number gain See cases [RCV000139787] Chr12:54427..34608071 [GRCh38]
Chr12:282465..34761006 [GRCh37]
Chr12:33854..34652273 [NCBI36]
Chr12:12p13.33-11.1
pathogenic
1 to 10 of 112 rows

Predicted Target Of
Summary Value
Count of predictions:1240
Count of miRNA genes:568
Interacting mature miRNAs:623
Transcripts:ENST00000304361, ENST00000350667, ENST00000355690, ENST00000396507, ENST00000434319, ENST00000449959, ENST00000543839
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 14 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597437049GWAS1533123_HC-type lectin domain family 12 member A measurement QTL GWAS1533123 (human)9e-1973C-type lectin domain family 12 member A measurement1299840739984074Human
597123423GWAS1219497_Hblood protein measurement QTL GWAS1219497 (human)2e-149blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)1299736509973651Human
597477042GWAS1573116_Hblood protein measurement QTL GWAS1573116 (human)1e-28blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)1299902989990299Human
597046788GWAS1142862_Hfish consumption measurement QTL GWAS1142862 (human)0.0000001fish consumption measurement1299572429957243Human
597301704GWAS1397778_HC-type lectin domain family 12 member A measurement QTL GWAS1397778 (human)3e-41C-type lectin domain family 12 member A measurement1299579429957943Human
597123428GWAS1219502_Hblood protein measurement QTL GWAS1219502 (human)2e-114blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)1299941089994109Human
597164559GWAS1260633_Hgut microbiome measurement QTL GWAS1260633 (human)2e-08gut microbiome measurement1299559009955901Human
597174529GWAS1270603_HC-type lectin domain family 12 member A measurement QTL GWAS1270603 (human)3e-228C-type lectin domain family 12 member A measurement1299551039955104Human
597174530GWAS1270604_HC-type lectin domain family 12 member A measurement QTL GWAS1270604 (human)9e-5734C-type lectin domain family 12 member A measurement1299850469985047Human
597035628GWAS1131702_Hblood protein measurement QTL GWAS1131702 (human)5e-70blood protein amount (VT:0005416)blood protein measurement (CMO:0000028)1299941089994109Human

1 to 10 of 14 rows
SHGC-85259  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371210,125,305 - 10,125,601UniSTSGRCh37
Build 361210,016,572 - 10,016,868RGDNCBI36
Celera1215,286,681 - 15,286,977RGD
Cytogenetic Map12p13.2UniSTS
HuRef129,868,177 - 9,868,473UniSTS
TNG Radiation Hybrid Map124575.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2315 2721 2192 4150 1680 2106 3 601 1713 442 2020 6814 6174 9 3151 786 1616 1404 166


1 to 30 of 48 rows
RefSeq Transcripts NG_029426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001207010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001300730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_201623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005253324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006719036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011520573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047428402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054371231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 48 rows

Ensembl Acc Id: ENST00000304361   ⟹   ENSP00000302804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,971,409 - 9,985,595 (+)Ensembl
Ensembl Acc Id: ENST00000350667   ⟹   ENSP00000345448
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,971,597 - 9,985,026 (+)Ensembl
Ensembl Acc Id: ENST00000355690   ⟹   ENSP00000347916
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,951,316 - 9,985,595 (+)Ensembl
Ensembl Acc Id: ENST00000396507   ⟹   ENSP00000379764
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,971,415 - 9,980,697 (+)Ensembl
Ensembl Acc Id: ENST00000434319   ⟹   ENSP00000405244
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,971,435 - 9,984,241 (+)Ensembl
Ensembl Acc Id: ENST00000449959
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,971,505 - 9,995,694 (+)Ensembl
Ensembl Acc Id: ENST00000543839
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl129,971,597 - 9,985,026 (+)Ensembl
RefSeq Acc Id: NM_001207010   ⟹   NP_001193939
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,951,268 - 9,985,595 (+)NCBI
GRCh371210,103,915 - 10,147,704 (+)NCBI
HuRef129,846,830 - 9,881,061 (+)ENTREZGENE
CHM1_11210,072,931 - 10,107,502 (+)NCBI
T2T-CHM13v2.0129,837,492 - 9,871,760 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001300730   ⟹   NP_001287659
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,971,409 - 9,984,253 (+)NCBI
CHM1_11210,093,327 - 10,106,149 (+)NCBI
T2T-CHM13v2.0129,857,585 - 9,870,419 (+)NCBI
Sequence:
RefSeq Acc Id: NM_138337   ⟹   NP_612210
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,971,409 - 9,985,595 (+)NCBI
GRCh371210,103,915 - 10,147,704 (+)NCBI
Build 361210,015,281 - 10,029,461 (+)NCBI Archive
HuRef129,846,830 - 9,881,061 (+)ENTREZGENE
CHM1_11210,093,327 - 10,107,502 (+)NCBI
T2T-CHM13v2.0129,857,585 - 9,871,760 (+)NCBI
Sequence:
RefSeq Acc Id: NM_201623   ⟹   NP_963917
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,971,409 - 9,985,595 (+)NCBI
GRCh371210,103,915 - 10,147,704 (+)NCBI
Build 361210,015,281 - 10,029,461 (+)NCBI Archive
HuRef129,846,830 - 9,881,061 (+)ENTREZGENE
CHM1_11210,093,327 - 10,107,502 (+)NCBI
T2T-CHM13v2.0129,857,585 - 9,871,760 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005253324   ⟹   XP_005253381
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,971,409 - 9,985,595 (+)NCBI
GRCh371210,103,915 - 10,147,704 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006719033   ⟹   XP_006719096
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,965,345 - 9,985,595 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006719035   ⟹   XP_006719098
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,965,353 - 9,995,290 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006719036   ⟹   XP_006719099
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,965,354 - 9,984,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011520570   ⟹   XP_011518872
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,965,338 - 9,985,595 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011520571   ⟹   XP_011518873
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,965,350 - 9,985,595 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011520573   ⟹   XP_011518875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,965,354 - 9,995,290 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047428397   ⟹   XP_047284353
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,951,268 - 9,985,595 (+)NCBI
RefSeq Acc Id: XM_047428399   ⟹   XP_047284355
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,951,268 - 9,995,290 (+)NCBI
RefSeq Acc Id: XM_047428400   ⟹   XP_047284356
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,951,268 - 9,995,290 (+)NCBI
RefSeq Acc Id: XM_047428401   ⟹   XP_047284357
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,951,268 - 9,984,253 (+)NCBI
RefSeq Acc Id: XM_047428402   ⟹   XP_047284358
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,971,409 - 10,006,150 (+)NCBI
RefSeq Acc Id: XM_054371220   ⟹   XP_054227195
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,851,518 - 9,871,760 (+)NCBI
RefSeq Acc Id: XM_054371221   ⟹   XP_054227196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,851,511 - 9,871,760 (+)NCBI
RefSeq Acc Id: XM_054371222   ⟹   XP_054227197
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,857,542 - 9,871,760 (+)NCBI
RefSeq Acc Id: XM_054371223   ⟹   XP_054227198
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,851,523 - 9,871,760 (+)NCBI
RefSeq Acc Id: XM_054371224   ⟹   XP_054227199
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,837,492 - 9,871,760 (+)NCBI
RefSeq Acc Id: XM_054371225   ⟹   XP_054227200
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,851,526 - 9,881,772 (+)NCBI
RefSeq Acc Id: XM_054371226   ⟹   XP_054227201
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,851,526 - 9,881,772 (+)NCBI
RefSeq Acc Id: XM_054371227   ⟹   XP_054227202
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,851,527 - 9,870,419 (+)NCBI
RefSeq Acc Id: XM_054371228   ⟹   XP_054227203
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,837,492 - 9,881,772 (+)NCBI
RefSeq Acc Id: XM_054371229   ⟹   XP_054227204
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,837,492 - 9,881,772 (+)NCBI
RefSeq Acc Id: XM_054371230   ⟹   XP_054227205
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,837,492 - 9,870,419 (+)NCBI
RefSeq Acc Id: XM_054371231   ⟹   XP_054227206
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0129,857,585 - 9,892,550 (+)NCBI
1 to 30 of 51 rows
Protein RefSeqs NP_001193939 (Get FASTA)   NCBI Sequence Viewer  
  NP_001287659 (Get FASTA)   NCBI Sequence Viewer  
  NP_612210 (Get FASTA)   NCBI Sequence Viewer  
  NP_963917 (Get FASTA)   NCBI Sequence Viewer  
  XP_005253381 (Get FASTA)   NCBI Sequence Viewer  
  XP_006719096 (Get FASTA)   NCBI Sequence Viewer  
  XP_006719098 (Get FASTA)   NCBI Sequence Viewer  
  XP_006719099 (Get FASTA)   NCBI Sequence Viewer  
  XP_011518872 (Get FASTA)   NCBI Sequence Viewer  
  XP_011518873 (Get FASTA)   NCBI Sequence Viewer  
  XP_011518875 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284353 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284355 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284356 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284357 (Get FASTA)   NCBI Sequence Viewer  
  XP_047284358 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227195 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227196 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227197 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227198 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227199 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227200 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227201 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227202 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227203 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227204 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227205 (Get FASTA)   NCBI Sequence Viewer  
  XP_054227206 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH63424 (Get FASTA)   NCBI Sequence Viewer  
  AAI26290 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 51 rows
1 to 5 of 33 rows
1 to 5 of 33 rows
RefSeq Acc Id: NP_001193939   ⟸   NM_001207010
- Peptide Label: isoform 3
- UniProtKB: Q5QGZ9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_612210   ⟸   NM_138337
- Peptide Label: isoform 1
- UniProtKB: Q6RH78 (UniProtKB/Swiss-Prot),   Q6RH77 (UniProtKB/Swiss-Prot),   Q6P4H1 (UniProtKB/Swiss-Prot),   B2RA16 (UniProtKB/Swiss-Prot),   Q8TDQ6 (UniProtKB/Swiss-Prot),   Q5QGZ9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_963917   ⟸   NM_201623
- Peptide Label: isoform 2
- UniProtKB: Q5QGZ9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005253381   ⟸   XM_005253324
- Peptide Label: isoform X2
- UniProtKB: Q6RH78 (UniProtKB/Swiss-Prot),   Q6RH77 (UniProtKB/Swiss-Prot),   Q6P4H1 (UniProtKB/Swiss-Prot),   B2RA16 (UniProtKB/Swiss-Prot),   Q8TDQ6 (UniProtKB/Swiss-Prot),   Q5QGZ9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006719098   ⟸   XM_006719035
- Peptide Label: isoform X5
- Sequence:
C-type lectin

Name Modeler Protein Id AA Range Protein Structure
AF-Q5QGZ9-F1-model_v2 AlphaFold Q5QGZ9 1-265 view protein structure

RGD ID:7223141
Promoter ID:EPDNEW_H17315
Type:initiation region
Name:CLEC12A_2
Description:C-type lectin domain family 12 member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17316  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,951,299 - 9,951,359EPDNEW
RGD ID:7223139
Promoter ID:EPDNEW_H17316
Type:multiple initiation site
Name:CLEC12A_1
Description:C-type lectin domain family 12 member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17315  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38129,971,414 - 9,971,474EPDNEW


1 to 40 of 43 rows
Database
Acc Id
Source(s)
COSMIC CLEC12A COSMIC
Ensembl Genes ENSG00000172322 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000304361 ENTREZGENE
  ENST00000304361.9 UniProtKB/Swiss-Prot
  ENST00000350667 ENTREZGENE
  ENST00000350667.4 UniProtKB/Swiss-Prot
  ENST00000355690 ENTREZGENE
  ENST00000355690.8 UniProtKB/Swiss-Prot
  ENST00000434319 ENTREZGENE
  ENST00000434319.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
GTEx ENSG00000172322 GTEx
HGNC ID HGNC:31713 ENTREZGENE
Human Proteome Map CLEC12A Human Proteome Map
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  CLEC12A/B UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
  NKR-like_CTLD UniProtKB/Swiss-Prot
KEGG Report hsa:160364 UniProtKB/Swiss-Prot
NCBI Gene 160364 ENTREZGENE
OMIM 612088 OMIM
PANTHER C-TYPE LECTIN DOMAIN FAMILY 12, MEMBER A UniProtKB/Swiss-Prot
  PTHR47647 UniProtKB/Swiss-Prot
Pfam Lectin_C UniProtKB/Swiss-Prot
PharmGKB PA142672094 PharmGKB
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt A8MVL9_HUMAN UniProtKB/TrEMBL
  B2RA16 ENTREZGENE
  CL12A_HUMAN UniProtKB/Swiss-Prot
  L8EAV5_HUMAN UniProtKB/TrEMBL
  Q5QGZ9 ENTREZGENE
  Q6P4H1 ENTREZGENE
  Q6RH77 ENTREZGENE
  Q6RH78 ENTREZGENE
  Q8TDQ6 ENTREZGENE
UniProt Secondary B2RA16 UniProtKB/Swiss-Prot
  Q6P4H1 UniProtKB/Swiss-Prot
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 CLEC12A  C-type lectin domain family 12 member A    C-type lectin domain family 12, member A  Symbol and/or name change 5135510 APPROVED