Advanced Search (OLGA)

Gene: CLEC12A (C-type lectin domain family 12 member A) Canis lupus familiaris

Analyze

Symbol:

CLEC12A

Name:

C-type lectin domain family 12 member A

RGD ID:

12079811

Description:

ENCODES a protein that exhibits carbohydrate binding (inferred); pattern recognition receptor activity (inferred); signaling receptor regulator activity (inferred); INVOLVED IN negative regulation of inflammatory response (ortholog); positive regulation of type I interferon production (ortholog); ASSOCIATED WITH cerebral malaria (ortholog); COVID-19 (ortholog); lymphocytic choriomeningitis (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	36,040,574 - 36,051,249 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	36,040,577 - 36,051,184 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	10,572,558 - 10,583,206 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	36,386,889 - 36,397,598 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	36,386,892 - 36,397,560 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	36,274,058 - 36,284,680 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	36,297,581 - 36,308,213 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	10,094,663 - 10,105,311 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebral malaria (ISO)

COVID-19 (ISO)

lymphocytic choriomeningitis (ISO)

rheumatoid arthritis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of dendritic cell differentiation (IEA)

negative regulation of immune response (IEA)

negative regulation of inflammatory response (ISO)

negative regulation of natural killer cell activation (IEA)

negative regulation of neutrophil activation (IEA)

positive regulation of type I interferon production (ISO)

Cellular Component

membrane (IEA)

plasma membrane (IEA,ISO)

Molecular Function

carbohydrate binding (IEA)

pattern recognition receptor activity (IEA)

protein binding (ISO)

signaling receptor regulator activity (IEA)

transmembrane signaling receptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CLEC12A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	36,040,574 - 36,051,249 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	36,040,577 - 36,051,184 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	10,572,558 - 10,583,206 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	36,386,889 - 36,397,598 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	36,386,892 - 36,397,560 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	36,274,058 - 36,284,680 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	36,297,581 - 36,308,213 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	10,094,663 - 10,105,311 (+)	NCBI		UU_Cfam_GSD_1.0

CLEC12A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	9,951,268 - 10,006,150 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	9,951,316 - 9,995,694 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	10,103,867 - 10,138,194 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	10,015,281 - 10,029,461 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	15,285,390 - 15,299,566 (+)	NCBI		Celera
Cytogenetic Map	12	p13.31-p13.2	NCBI
HuRef	12	9,846,830 - 9,881,061 (+)	NCBI		HuRef
CHM1_1	12	10,072,931 - 10,107,502 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	9,837,492 - 9,892,550 (+)	NCBI		T2T-CHM13v2.0

Clec12a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	129,327,207 - 129,342,266 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	129,319,654 - 129,342,266 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	129,349,783 - 129,365,303 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	129,342,691 - 129,365,303 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	129,300,304 - 129,315,321 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	129,315,979 - 129,330,996 (+)	NCBI		MGSCv36	mm8
Celera	6	131,072,396 - 131,087,407 (+)	NCBI		Celera
Cytogenetic Map	6	F3	NCBI
cM Map	6	63.26	NCBI

Clec12a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	164,484,162 - 164,502,793 (+)	NCBI		GRCr8
mRatBN7.2	4	162,798,125 - 162,816,757 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	162,798,125 - 162,816,753 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	169,032,955 - 169,051,584 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	164,815,903 - 164,834,532 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	163,449,952 - 163,468,579 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	163,112,100 - 163,130,979 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	163,112,301 - 163,126,864 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	211,756,068 - 211,774,947 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	166,639,429 - 166,639,958 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	151,485,182 - 151,502,187 (+)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

CLEC12A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	15,441,991 - 15,498,736 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	15,438,749 - 15,495,495 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	9,999,334 - 10,056,108 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	10,248,163 - 10,272,070 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	10,248,209 - 10,272,070 (+)	Ensembl	panpan1.1		panPan2

Clec12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	97,412,004 - 97,424,619 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936902	543,670 - 556,014 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936902	542,981 - 556,142 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLEC12A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	61,922,895 - 61,937,096 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	61,923,057 - 61,936,843 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	64,755,594 - 64,769,466 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLEC12A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	9,838,867 - 9,858,869 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666089	1,913,397 - 1,933,461 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in CLEC12A
151 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038439035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038513689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038576764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038641518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_534891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000069	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000021484 ⟹ ENSCAFP00000019951

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	27	36,040,577 - 36,051,184 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845048575 ⟹ ENSCAFP00845038104

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	27	36,386,892 - 36,397,560 (-)	Ensembl

RefSeq Acc Id:

XM_038439035 ⟹ XP_038294963

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	27	36,386,889 - 36,397,598 (-)	NCBI

RefSeq Acc Id:

XM_038513689 ⟹ XP_038369617

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	27	36,274,058 - 36,284,680 (-)	NCBI

RefSeq Acc Id:

XM_038576764 ⟹ XP_038432692

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	27	10,094,663 - 10,105,311 (+)	NCBI

RefSeq Acc Id:

XM_038641518 ⟹ XP_038497446

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	27	36,297,581 - 36,308,213 (-)	NCBI

RefSeq Acc Id:

XM_534891 ⟹ XP_534891

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	27	36,040,574 - 36,051,249 (-)	NCBI
Dog10K_Boxer_Tasha	27	10,572,558 - 10,583,206 (+)	NCBI

Sequence:

show sequence

GGCCTCTGATAGGCTGTAGCTCCTTTGTATACACACAGGATTGGGACAATGAAAAGAGAAGTTA
AAGCTTATAAATTTAAGCTTTGGTTTATAAACAGAAGTTTAAAACCATAATTATTGTTTAACAT
TCAACTTTGTTGGTTCACCTTCATCTTTTTTTTTAATAGTTTTTTGGGCTATCTTTTCATAGCC
ATCAATGTCTGAAGAAGTTACTTATGCAGATCTAAAATTTCAGGACTCCAGAAAAGGGGAAAAT
ATCCATGAGTTTGACACAGTTGGGATAAAAGCACCACCTGCTCCTTCCCATGGATGGTGTCAGA
GAGTCTTGGCTCTTCTATGCCTTCTGCTGCTGATTGGACTAGGAGTCTTAGGAAGCATATTTTA
CACAACTTTGAAGATAGAAATGAGAAAATTGAATAAACTACAAAATTTCAAAGAAGAACTTCAG
AGGAATATTTCTCTACAACTAATGAGTAACATGAATAGTTCCAAGATGATCAGGAACTTATCTG
TCACACTGCAAGTAACAGCCACCAAATTATGTCATGAACTCTACAAAAGAGAACCAGAGCACAA
ATGTAAACCTTGTCCAAAGACATGGATGTGGCATGAGGACAGCTGCTATATACTAAAGAACAGT
TATGAAACATGGCAAGAGAGTGTCATGTTCTGTTCTGCTCAAAATGCCAGCCTGTTGACAATTA
AGAATAAAAGCGTATTGGAATTTATAAAATCCAACAGGTTATATAATTACTGGCTGGGATTATC
TCCCAAGTATGACAGAGATTACCAGAAACTGGATGAAACGATTTTCTCCTCCAACTGGTTTATG
AGAAACACAAATGATGTAAATGGTTTGATGTATTGTGGATATGTGGACATACCATTTGTTTACT
ATATAAAATGCACTGCCAGGCAGCGTGTCATATGTAAGAAGCTGGCTGATCCAGTTAAGATTGA
GAGCATGCTAATGAATGAAATACCAAATGAAAAATATAGTTAGCATTTCACTATTATCCTGTCA
TTAAAGCAACTTTTGGGAGCATACACCTTGTGGACCATGCAAAGGGAATAAAGATGCTATGAGA
TTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038294963	(Get FASTA)	NCBI Sequence Viewer
	XP_038369617	(Get FASTA)	NCBI Sequence Viewer
	XP_038432692	(Get FASTA)	NCBI Sequence Viewer
	XP_038497446	(Get FASTA)	NCBI Sequence Viewer
	XP_534891	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000019951.3
	ENSCAFP00030032964.1
	ENSCAFP00040022071.1
	ENSCAFP00845038104
	ENSCAFP00845038104.1

RefSeq Acc Id:

XP_534891 ⟸ XM_534891

- UniProtKB:

A0A8P0NFF1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEEVTYADLKFQDSRKGENIHEFDTVGIKAPPAPSHGWCQRVLALLCLLLLIGLGVLGSIFYT
TLKIEMRKLNKLQNFKEELQRNISLQLMSNMNSSKMIRNLSVTLQVTATKLCHELYKREPEHKC
KPCPKTWMWHEDSCYILKNSYETWQESVMFCSAQNASLLTIKNKSVLEFIKSNRLYNYWLGLSP
KYDRDYQKLDETIFSSNWFMRNTNDVNGLMYCGYVDIPFVYYIKCTARQRVICKKLADPVKIES
MLMNEIPNEKYS

hide sequence

Ensembl Acc Id:

ENSCAFP00000019951 ⟸ ENSCAFT00000021484

RefSeq Acc Id:

XP_038369617 ⟸ XM_038513689

RefSeq Acc Id:

XP_038497446 ⟸ XM_038641518

RefSeq Acc Id:	XP_038294963 ⟸ XM_038439035
- UniProtKB:	A0A8C0K0B0 (UniProtKB/TrEMBL), A0A8C0NWN3 (UniProtKB/TrEMBL), A0A8I3S6C8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038432692 ⟸ XM_038576764
- UniProtKB:	A0A8C0K0B0 (UniProtKB/TrEMBL), A0A8C0NWN3 (UniProtKB/TrEMBL), A0A8I3S6C8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845038104 ⟸ ENSCAFT00845048575

Protein Domains

C-type lectin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000025113	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030020539	UniProtKB/TrEMBL
	ENSCAFG00040013732	UniProtKB/TrEMBL
	ENSCAFG00845027536	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000021484.5	UniProtKB/TrEMBL
	ENSCAFT00030037779.1	UniProtKB/TrEMBL
	ENSCAFT00040025389.1	UniProtKB/TrEMBL
	ENSCAFT00845048575	ENTREZGENE
	ENSCAFT00845048575.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.100.10	UniProtKB/TrEMBL
InterPro	C-type_lectin-like	UniProtKB/TrEMBL
	C-type_lectin-like/link_sf	UniProtKB/TrEMBL
	CLEC12A/B	UniProtKB/TrEMBL
	CTDL_fold	UniProtKB/TrEMBL
	NKR-like_CTLD	UniProtKB/TrEMBL
KEGG Report	cfa:477697	UniProtKB/TrEMBL
NCBI Gene	CLEC12A	ENTREZGENE
PANTHER	C-TYPE LECTIN DOMAIN FAMILY 12, MEMBER A	UniProtKB/TrEMBL
	PTHR47647	UniProtKB/TrEMBL
Pfam	Lectin_C	UniProtKB/TrEMBL
PROSITE	C_TYPE_LECTIN_2	UniProtKB/TrEMBL
SMART	CLECT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56436	UniProtKB/TrEMBL
UniProt	A0A8C0K0B0	ENTREZGENE
	A0A8C0NWN3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3S6C8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NFF1	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:39325	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - CTD