MROH5 (maestro heat like repeat family member 5 (gene/pseudogene)) - Rat Genome Database

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Gene: MROH5 (maestro heat like repeat family member 5 (gene/pseudogene)) Homo sapiens
Analyze
Symbol: MROH5
Name: maestro heat like repeat family member 5 (gene/pseudogene)
RGD ID: 1602032
HGNC Page HGNC
Description: INTERACTS WITH aflatoxin B1; aflatoxin B2; benzo[a]pyrene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: hypothetical protein LOC389690; maestro heat like repeat family member 5; maestro heat-like repeat family member 5; uncharacterized protein LOC389690
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8141,433,829 - 141,507,230 (-)EnsemblGRCh38hg38GRCh38
GRCh388141,433,825 - 141,507,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378142,443,925 - 142,517,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368142,513,111 - 142,586,512 (-)NCBINCBI36hg18NCBI36
Celera8138,610,353 - 138,681,759 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8137,798,003 - 137,836,354 (-)NCBIHuRef
HuRef8137,761,305 - 137,795,358 (-)NCBIHuRef
CHM1_18142,484,157 - 142,557,292 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16344560   PMID:18976975   PMID:21988832   PMID:23870195  


Genomics

Comparative Map Data
MROH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8141,433,829 - 141,507,230 (-)EnsemblGRCh38hg38GRCh38
GRCh388141,433,825 - 141,507,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378142,443,925 - 142,517,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368142,513,111 - 142,586,512 (-)NCBINCBI36hg18NCBI36
Celera8138,610,353 - 138,681,759 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8137,798,003 - 137,836,354 (-)NCBIHuRef
HuRef8137,761,305 - 137,795,358 (-)NCBIHuRef
CHM1_18142,484,157 - 142,557,292 (-)NCBICHM1_1
Mroh5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391573,658,785 - 73,711,520 (-)NCBIGRCm39mm39
GRCm39 Ensembl1573,631,916 - 73,711,548 (-)Ensembl
GRCm381573,786,936 - 73,839,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,760,067 - 73,839,699 (-)EnsemblGRCm38mm10GRCm38
MGSCv371573,617,366 - 73,670,101 (-)NCBIGRCm37mm9NCBIm37
MGSCv361573,614,191 - 73,666,926 (-)NCBImm8
Celera1575,292,062 - 75,350,235 (-)NCBICelera
Cytogenetic Map15D3NCBI
Mroh5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27105,662,737 - 105,737,820 (-)NCBI
Rnor_6.07115,003,594 - 115,079,728 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07114,924,955 - 115,000,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47111,469,995 - 111,544,323 (-)NCBIRGSC3.4rn4RGSC3.4
Celera7102,068,757 - 102,144,721 (-)NCBICelera
Cytogenetic Map7q34NCBI
Mroh5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955454442,757 - 504,231 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955454442,857 - 503,429 (-)NCBIChiLan1.0ChiLan1.0
LOC100987797
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18141,189,759 - 141,262,348 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8141,189,814 - 141,262,269 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08138,109,975 - 138,183,612 (-)NCBIMhudiblu_PPA_v0panPan3
MROH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11335,887,434 - 35,957,954 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1335,889,010 - 35,957,861 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1335,746,540 - 35,817,459 (-)NCBI
ROS_Cfam_1.01336,273,053 - 36,344,038 (-)NCBI
UMICH_Zoey_3.11335,993,153 - 36,064,062 (-)NCBI
UNSW_CanFamBas_1.01336,084,735 - 36,153,919 (-)NCBI
UU_Cfam_GSD_1.01336,503,493 - 36,574,457 (-)NCBI
LOC101965287
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053032,552,867 - 2,614,461 (+)NCBI
SpeTri2.0NW_0049364709,991,758 - 10,040,617 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MROH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl42,282,120 - 2,342,886 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.142,282,120 - 2,344,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.241,538,079 - 1,569,070 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103237517
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18135,673,927 - 135,746,166 (-)NCBI
ChlSab1.1 Ensembl8135,674,055 - 135,744,562 (-)Ensembl
Mroh5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473514,914,479 - 14,961,747 (+)NCBI

Position Markers
RH79822  
Human AssemblyChrPosition (strand)SourceJBrowse
Celera8138,608,685 - 138,608,978RGD
Cytogenetic Map8q24.3UniSTS
HuRef8137,759,637 - 137,759,930UniSTS
SHGC-148446  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378142,452,680 - 142,452,971UniSTSGRCh37
Build 368142,521,862 - 142,522,153RGDNCBI36
Cytogenetic Map8q24.3UniSTS
HuRef8137,769,961 - 137,770,252UniSTS
TNG Radiation Hybrid Map870611.0UniSTS
SHGC-149588  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378142,443,604 - 142,443,931UniSTSGRCh37
Build 368142,512,786 - 142,513,113RGDNCBI36
Celera8138,610,028 - 138,610,355RGD
Cytogenetic Map8q24.3UniSTS
HuRef8137,760,980 - 137,761,307UniSTS
TNG Radiation Hybrid Map870604.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4452
Count of miRNA genes:980
Interacting mature miRNAs:1201
Transcripts:ENST00000430863, ENST00000521053, ENST00000521161, ENST00000523857
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 286
Low 25 115 56 1 7 206 151 65 3 150 21 1 20 190
Below cutoff 2038 2275 1169 295 730 176 3637 1916 2844 161 767 1165 122 1104 2374

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_207414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_102363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_102364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_160399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC100803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC138647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB063153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB070296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB072034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN831584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC006996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC044709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000430863   ⟹   ENSP00000431031
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,433,832 - 141,507,230 (-)Ensembl
RefSeq Acc Id: ENST00000521053   ⟹   ENSP00000429433
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,433,829 - 141,507,230 (-)Ensembl
RefSeq Acc Id: ENST00000521161   ⟹   ENSP00000429440
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,494,911 - 141,496,759 (-)Ensembl
RefSeq Acc Id: ENST00000523857   ⟹   ENSP00000427945
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,433,829 - 141,507,230 (-)Ensembl
RefSeq Acc Id: ENST00000621837   ⟹   ENSP00000481783
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8141,433,829 - 141,507,230 (-)Ensembl
RefSeq Acc Id: NR_102363
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,433,829 - 141,507,230 (-)NCBI
GRCh388141,433,825 - 141,507,229 (-)NCBI
GRCh378142,443,929 - 142,517,330 (-)NCBI
HuRef8137,798,003 - 137,836,354 (-)NCBI
HuRef8137,761,305 - 137,795,358 (-)NCBI
CHM1_18142,484,157 - 142,557,292 (-)NCBI
Sequence:
RefSeq Acc Id: NR_102364
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,433,829 - 141,507,230 (-)NCBI
GRCh388141,433,825 - 141,507,229 (-)NCBI
HuRef8137,761,305 - 137,795,358 (-)NCBI
HuRef8137,798,003 - 137,836,354 (-)NCBI
CHM1_18142,484,157 - 142,557,292 (-)NCBI
Sequence:
RefSeq Acc Id: NR_160399
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388141,433,825 - 141,507,229 (-)NCBI
Reference Sequences
RefSeq Acc Id: ENSP00000481783   ⟸   ENST00000621837
RefSeq Acc Id: ENSP00000429440   ⟸   ENST00000521161
RefSeq Acc Id: ENSP00000429433   ⟸   ENST00000521053
RefSeq Acc Id: ENSP00000427945   ⟸   ENST00000523857
RefSeq Acc Id: ENSP00000431031   ⟸   ENST00000430863


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:141131265-142117372)x3 copy number gain See cases [RCV000052186] Chr8:141131265..142117372 [GRCh38]
Chr8:142141364..143198733 [GRCh37]
Chr8:142210546..143196640 [NCBI36]
Chr8:8q24.3
uncertain significance
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142438569-142482615) copy number gain Abnormality of esophagus morphology [RCV000416898] Chr8:142438569..142482615 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.22-24.3(chr8:134825277-146280828)x3 copy number gain See cases [RCV000448348] Chr8:134825277..146280828 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136378789-146295771)x3 copy number gain See cases [RCV000512003] Chr8:136378789..146295771 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:141850516-143511413)x3 copy number gain See cases [RCV000512275] Chr8:141850516..143511413 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142446260-143549805)x3 copy number gain not provided [RCV000683005] Chr8:142446260..143549805 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142502403-142503214)x1 copy number loss not provided [RCV000747896] Chr8:142502403..142503214 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:142502507-142503214)x1 copy number loss not provided [RCV000747897] Chr8:142502507..142503214 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:142502519-142503214)x1 copy number loss not provided [RCV000747898] Chr8:142502519..142503214 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:126892814-143750028)x1 copy number loss not provided [RCV001006144] Chr8:126892814..143750028 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142132678-145569441)x1 copy number loss not provided [RCV001006150] Chr8:142132678..145569441 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.23-24.3(chr8:139188797-146295771)x3 copy number gain not provided [RCV000846814] Chr8:139188797..146295771 [GRCh37]
Chr8:8q24.23-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136059859-146295771)x3 copy number gain not provided [RCV000847171] Chr8:136059859..146295771 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:42976 AgrOrtholog
COSMIC MROH5 COSMIC
Ensembl Genes ENSG00000226807 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSP00000427945 UniProtKB/TrEMBL
  ENSP00000429433 UniProtKB/TrEMBL
  ENSP00000429440 UniProtKB/TrEMBL
  ENSP00000481783 UniProtKB/TrEMBL
Ensembl Transcript ENST00000430863 ENTREZGENE
  ENST00000521053 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000521161 UniProtKB/TrEMBL
  ENST00000523857 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000621837 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000226807 GTEx
HGNC ID HGNC:42976 ENTREZGENE
Human Proteome Map MROH5 Human Proteome Map
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:389690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 389690 ENTREZGENE
PharmGKB PA166049097 PharmGKB
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WYG4_HUMAN UniProtKB/TrEMBL
  E5RFU7_HUMAN UniProtKB/TrEMBL
  E5RII6_HUMAN UniProtKB/TrEMBL
  MROH5_HUMAN UniProtKB/Swiss-Prot
  Q6ZMW9 ENTREZGENE, UniProtKB/TrEMBL
  Q6ZUA9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-15 MROH5  maestro heat like repeat family member 5 (gene/pseudogene)    maestro heat like repeat family member 5  Symbol and/or name change 5135510 APPROVED
2016-01-26 MROH5  maestro heat like repeat family member 5    maestro heat-like repeat family member 5  Symbol and/or name change 5135510 APPROVED
2013-01-02 MROH5  maestro heat-like repeat family member 5  FLJ43860  FLJ43860 protein  Symbol and/or name change 5135510 APPROVED