Tbx22 (T-box transcription factor 22) - Rat Genome Database

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Gene: Tbx22 (T-box transcription factor 22) Rattus norvegicus
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Symbol: Tbx22
Name: T-box transcription factor 22
RGD ID: 1589764
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and cleft palate. Orthologous to human TBX22 (T-box transcription factor 22); INTERACTS WITH acrylamide; bisphenol A; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC302369; similar to T-box 22 isoform 1; T-box 22; T-box 22 isoform 1; T-box transcription factor TBX22; Tbx 22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X76,796,398 - 76,847,447 (+)NCBIGRCr8
mRatBN7.2X72,723,619 - 72,774,647 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX72,723,617 - 72,774,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX74,244,108 - 74,257,825 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X77,771,054 - 77,784,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X75,337,536 - 75,351,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X78,731,738 - 78,782,542 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX78,769,419 - 78,782,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X78,929,291 - 78,980,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X95,912,796 - 95,926,843 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X95,985,061 - 95,986,580 (+)NCBI
CeleraX74,042,349 - 74,055,976 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. Braybrook C, etal., Hum Mol Genet 2002 Oct 15;11(22):2793-804.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:17846996  


Genomics

Comparative Map Data
Tbx22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X76,796,398 - 76,847,447 (+)NCBIGRCr8
mRatBN7.2X72,723,619 - 72,774,647 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX72,723,617 - 72,774,647 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX74,244,108 - 74,257,825 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X77,771,054 - 77,784,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X75,337,536 - 75,351,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X78,731,738 - 78,782,542 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX78,769,419 - 78,782,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X78,929,291 - 78,980,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X95,912,796 - 95,926,843 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X95,985,061 - 95,986,580 (+)NCBI
CeleraX74,042,349 - 74,055,976 (+)NCBICelera
Cytogenetic MapXq22NCBI
TBX22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X80,014,753 - 80,031,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX80,014,753 - 80,031,774 (+)EnsemblGRCh38hg38GRCh38
GRCh37X79,270,252 - 79,287,273 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X79,156,911 - 79,173,924 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X79,083,886 - 79,093,413NCBI
CeleraX79,510,188 - 79,527,202 (+)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX72,851,434 - 72,868,446 (+)NCBIHuRef
CHM1_1X79,163,473 - 79,180,486 (+)NCBICHM1_1
T2T-CHM13v2.0X78,447,022 - 78,464,040 (+)NCBIT2T-CHM13v2.0
Tbx22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X106,711,570 - 106,732,586 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX106,711,570 - 106,732,584 (+)EnsemblGRCm39 Ensembl
GRCm38X107,667,964 - 107,688,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX107,667,964 - 107,688,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X104,863,303 - 104,884,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X103,870,683 - 103,891,696 (+)NCBIMGSCv36mm8
CeleraX94,504,313 - 94,525,357 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.59NCBI
Tbx22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955529553,738 - 573,388 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955529541,057 - 573,486 (+)NCBIChiLan1.0ChiLan1.0
TBX22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X79,469,629 - 79,486,834 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X79,473,324 - 79,490,445 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X69,070,218 - 69,087,243 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X79,177,534 - 79,194,546 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX79,177,534 - 79,198,782 (+)Ensemblpanpan1.1panPan2
Tbx22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X55,324,345 - 55,334,449 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365471,645,118 - 1,654,332 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365471,645,118 - 1,654,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX63,837,284 - 63,846,483 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X63,837,576 - 63,845,704 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X73,272,832 - 73,280,975 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBX22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X68,969,570 - 68,991,933 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX68,978,310 - 68,987,228 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606712,306,460 - 12,316,037 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbx22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248361,021,089 - 1,071,069 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tbx22
252 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:673
Count of miRNA genes:277
Interacting mature miRNAs:372
Transcripts:ENSRNOT00000003190
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 1 9 57 18 23 3 3 3 4 49 22 46 17 56 20

Sequence


Ensembl Acc Id: ENSRNOT00000003190   ⟹   ENSRNOP00000003190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX72,761,019 - 72,774,647 (+)Ensembl
Rnor_6.0 EnsemblX78,769,419 - 78,782,542 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083907   ⟹   ENSRNOP00000069154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX72,723,617 - 72,774,647 (+)Ensembl
Rnor_6.0 EnsemblX78,769,810 - 78,781,319 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115053   ⟹   ENSRNOP00000095375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX72,764,860 - 72,774,647 (+)Ensembl
RefSeq Acc Id: NM_001106937   ⟹   NP_001100407
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X76,833,814 - 76,847,441 (+)NCBI
mRatBN7.2X72,761,019 - 72,774,647 (+)NCBI
Rnor_6.0X78,769,419 - 78,782,542 (+)NCBI
Rnor_5.0X78,929,291 - 78,980,062 (+)NCBI
RGSC_v3.4X95,912,796 - 95,926,843 (+)RGD
CeleraX74,042,349 - 74,055,976 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257159   ⟹   XP_006257221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X76,796,398 - 76,847,447 (+)NCBI
mRatBN7.2X72,723,621 - 72,774,594 (+)NCBI
Rnor_6.0X78,731,738 - 78,782,476 (+)NCBI
Rnor_5.0X78,929,291 - 78,980,062 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257161   ⟹   XP_006257223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X76,796,418 - 76,847,447 (+)NCBI
mRatBN7.2X72,723,619 - 72,774,596 (+)NCBI
Rnor_6.0X78,731,738 - 78,782,476 (+)NCBI
Rnor_5.0X78,929,291 - 78,980,062 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001100407   ⟸   NM_001106937
- UniProtKB: D3ZMK6 (UniProtKB/TrEMBL),   A6IV69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257221   ⟸   XM_006257159
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006257223   ⟸   XM_006257161
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JUM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069154   ⟸   ENSRNOT00000083907
Ensembl Acc Id: ENSRNOP00000003190   ⟸   ENSRNOT00000003190
Ensembl Acc Id: ENSRNOP00000095375   ⟸   ENSRNOT00000115053
Protein Domains
T-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMK6-F1-model_v2 AlphaFold D3ZMK6 1-518 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589764 AgrOrtholog
BioCyc Gene G2FUF-1889 BioCyc
Ensembl Genes ENSRNOG00000002346 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003190.6 UniProtKB/TrEMBL
  ENSRNOT00000083907.2 UniProtKB/TrEMBL
  ENSRNOT00000115053.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/TrEMBL
  T-box_sf UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/TrEMBL
KEGG Report rno:302369 UniProtKB/TrEMBL
NCBI Gene 302369 ENTREZGENE
PANTHER T-BOX TRANSCRIPTION FACTOR TBX22 UniProtKB/TrEMBL
  TF_T-box UniProtKB/TrEMBL
Pfam T-box UniProtKB/TrEMBL
PhenoGen Tbx22 PhenoGen
PRINTS TBOX UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/TrEMBL
  TBOX_2 UniProtKB/TrEMBL
  TBOX_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002346 RatGTEx
SMART TBOX UniProtKB/TrEMBL
Superfamily-SCOP P53_like_DNA_bnd UniProtKB/TrEMBL
UniProt A0A0G2JUM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMI1_RAT UniProtKB/TrEMBL
  A6IV69 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Tbx22  T-box transcription factor 22  Tbx22  T-box 22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-12-17 Tbx22    Tbx 22  T-box 22  Symbol updated 1299863 APPROVED
2007-02-08 Tbx 22  T-box 22  Tbx 22  T-box 22 isoform 1  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2007-02-08 Tbx 22  T-box 22 isoform 1  LOC302369  T-box 22 isoform 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2007-02-08 Tbx22  T-box 22 isoform 1  LOC302369  similar to T-box 22 isoform 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2007-02-08 LOC302369  similar to T-box 22 isoform 1  Tbx22  T-box 22  Data merged from RGD:631364 737654 APPROVED
2006-11-19 LOC302369  similar to T-box 22 isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-11 Tbx22  T-box 22      Symbol and Name status set to approved 625702 APPROVED