Gpr52 (G protein-coupled receptor 52) - Rat Genome Database

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Gene: Gpr52 (G protein-coupled receptor 52) Rattus norvegicus
Analyze
Symbol: Gpr52
Name: G protein-coupled receptor 52
RGD ID: 1587949
Description: Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to act upstream of or within locomotory behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human GPR52 (G protein-coupled receptor 52); INTERACTS WITH benzo[a]pyrene (ortholog); folic acid (ortholog); hydrogen peroxide (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor 52; LOC684623; probable G-protein coupled receptor 52; similar to Probable G-protein coupled receptor 52
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81375,333,683 - 75,338,407 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1375,332,901 - 75,339,351 (-)EnsemblGRCr8
mRatBN7.21372,800,265 - 72,804,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1372,800,127 - 72,806,180 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1375,391,748 - 75,396,473 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01376,677,348 - 76,682,072 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01373,936,899 - 73,941,623 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1374,688,498 - 74,693,223 (-)NCBI
Lyon_Normotensive1374,896,390 - 74,901,115 (-)NCBI
Lyon_Hypertensive1374,850,495 - 74,855,219 (-)NCBI
F344_StmMcwi1374,880,103 - 74,884,827 (-)NCBI
Rnor_6.01378,326,545 - 78,331,349 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,326,545 - 78,329,680 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Celera1372,603,008 - 72,607,732 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:24587241   PMID:28583861  


Genomics

Comparative Map Data
Gpr52
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81375,333,683 - 75,338,407 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1375,332,901 - 75,339,351 (-)EnsemblGRCr8
mRatBN7.21372,800,265 - 72,804,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1372,800,127 - 72,806,180 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1375,391,748 - 75,396,473 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01376,677,348 - 76,682,072 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01373,936,899 - 73,941,623 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1374,688,498 - 74,693,223 (-)NCBI
Lyon_Normotensive1374,896,390 - 74,901,115 (-)NCBI
Lyon_Hypertensive1374,850,495 - 74,855,219 (-)NCBI
F344_StmMcwi1374,880,103 - 74,884,827 (-)NCBI
Rnor_6.01378,326,545 - 78,331,349 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,326,545 - 78,329,680 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Celera1372,603,008 - 72,607,732 (-)NCBICelera
Cytogenetic Map13q22NCBI
GPR52
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381174,447,964 - 174,449,545 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,447,964 - 174,449,545 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371174,417,102 - 174,418,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,683,835 - 172,685,306 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341171,148,906 - 171,149,992NCBI
Celera1147,526,602 - 147,528,073 (+)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1145,642,851 - 145,644,322 (+)NCBIHuRef
CHM1_11175,839,796 - 175,841,267 (+)NCBICHM1_1
T2T-CHM13v2.01173,805,945 - 173,807,526 (+)NCBIT2T-CHM13v2.0
Gpr52
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,402,287 - 160,407,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,402,289 - 160,407,590 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381160,574,717 - 160,579,704 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,576,338 - 160,577,974 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371162,506,799 - 162,507,884 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361162,413,345 - 162,414,430 (-)NCBIMGSCv36mm8
Celera1162,983,200 - 162,984,285 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
Gpr52
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540614,415,252 - 14,420,251 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495540614,415,252 - 14,420,251 (+)NCBIChiLan1.0ChiLan1.0
GPR52
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2175,269,104 - 75,288,182 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1174,957,497 - 74,961,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01149,954,556 - 149,959,653 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11153,658,348 - 153,659,970 (+)NCBIPanPan1.1PanPan1.1panPan2
GPR52
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1724,858,588 - 24,862,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl724,860,473 - 24,862,117 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha724,383,660 - 24,388,208 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0724,599,380 - 24,603,928 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl724,596,655 - 24,810,192 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1724,512,474 - 24,517,022 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0724,602,982 - 24,607,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0724,747,842 - 24,752,390 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpr52
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1108,035,796 - 8,042,287 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440934495,740,744 - 95,747,363 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648113,588,705 - 13,593,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR52
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9116,643,037 - 116,647,996 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.19116,639,223 - 116,648,001 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29128,322,434 - 128,326,761 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR52
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12555,258,473 - 55,285,241 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366605556,311,993 - 56,315,653 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12554,757,376 - 54,758,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Gpr52
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247717,460,199 - 7,467,519 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247717,463,809 - 7,467,044 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl2418,701,804 - 18,722,489 (+)Ensembl
Gpr52
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11039,853,404 - 39,857,030 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Gpr52
148 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
249 147 680 1504 3973 761 1453 89 624 474 606 137 4783 2420 419 3905 38 1232 662 885 160 158

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001289935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000088425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1375,332,901 - 75,339,351 (-)Ensembl
mRatBN7.2 Ensembl1372,800,127 - 72,806,180 (-)Ensembl
Rnor_6.0 Ensembl1378,326,545 - 78,329,680 (-)Ensembl
RefSeq Acc Id: NM_001289935   ⟹   NP_001276864
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81375,333,683 - 75,338,407 (-)NCBI
mRatBN7.21372,800,265 - 72,804,989 (-)NCBI
Dahl_SR_JrHsd1374,688,498 - 74,693,223 (-)NCBI
Lyon_Normotensive1374,896,390 - 74,901,115 (-)NCBI
Lyon_Hypertensive1374,850,495 - 74,855,219 (-)NCBI
F344_StmMcwi1374,880,103 - 74,884,827 (-)NCBI
Rnor_6.01378,326,545 - 78,331,349 (-)NCBI
Celera1372,603,008 - 72,607,732 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001276864 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080795
  ENSRNOP00000080795.1
RefSeq Acc Id: NP_001276864   ⟸   NM_001289935
- UniProtKB: A0A8I5ZQK1 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
G-protein coupled receptors family 1 profile

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587949 AgrOrtholog
BioCyc Gene G2FUF-17759 BioCyc
Ensembl Genes ENSRNOG00000055673 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088425 ENTREZGENE
  ENSRNOT00000088425.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  TAAR UniProtKB/TrEMBL
KEGG Report rno:684623 UniProtKB/TrEMBL
NCBI Gene 684623 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 52-RELATED UniProtKB/TrEMBL
  HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr52 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055673 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I5ZQK1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-13 Gpr52  G protein-coupled receptor 52  LOC684623  similar to Probable G-protein coupled receptor 52  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC684623  similar to Probable G-protein coupled receptor 52      Symbol and Name status set to provisional 70820 PROVISIONAL