Gpr52 (G protein-coupled receptor 52) - Rat Genome Database

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Gene: Gpr52 (G protein-coupled receptor 52) Rattus norvegicus
Analyze
Symbol: Gpr52
Name: G protein-coupled receptor 52
RGD ID: 1587949
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in response to xenobiotic stimulus. Predicted to act upstream of or within locomotory behavior. Predicted to be located in membrane. Orthologous to human GPR52 (G protein-coupled receptor 52); INTERACTS WITH benzo[a]pyrene (ortholog); folic acid (ortholog); hydrogen peroxide (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor 52; LOC684623; probable G-protein coupled receptor 52; similar to Probable G-protein coupled receptor 52
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81375,333,683 - 75,338,407 (-)NCBIGRCr8
mRatBN7.21372,800,265 - 72,804,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1372,800,127 - 72,806,180 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1375,391,748 - 75,396,473 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01376,677,348 - 76,682,072 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01373,936,899 - 73,941,623 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01378,326,545 - 78,331,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,326,545 - 78,329,680 (-)EnsemblRnor6.0rn6Rnor6.0
Celera1372,603,008 - 72,607,732 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:24587241   PMID:28583861  


Genomics

Comparative Map Data
Gpr52
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81375,333,683 - 75,338,407 (-)NCBIGRCr8
mRatBN7.21372,800,265 - 72,804,989 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1372,800,127 - 72,806,180 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1375,391,748 - 75,396,473 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01376,677,348 - 76,682,072 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01373,936,899 - 73,941,623 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01378,326,545 - 78,331,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1378,326,545 - 78,329,680 (-)EnsemblRnor6.0rn6Rnor6.0
Celera1372,603,008 - 72,607,732 (-)NCBICelera
Cytogenetic Map13q22NCBI
GPR52
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381174,447,964 - 174,449,545 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,447,964 - 174,449,545 (+)EnsemblGRCh38hg38GRCh38
GRCh371174,417,102 - 174,418,683 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,683,835 - 172,685,306 (+)NCBINCBI36Build 36hg18NCBI36
Build 341171,148,906 - 171,149,992NCBI
Celera1147,526,602 - 147,528,073 (+)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1145,642,851 - 145,644,322 (+)NCBIHuRef
CHM1_11175,839,796 - 175,841,267 (+)NCBICHM1_1
T2T-CHM13v2.01173,805,945 - 173,807,526 (+)NCBIT2T-CHM13v2.0
Gpr52
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,402,287 - 160,407,274 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,403,908 - 160,405,544 (-)EnsemblGRCm39 Ensembl
GRCm381160,574,717 - 160,579,704 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,576,338 - 160,577,974 (-)EnsemblGRCm38mm10GRCm38
MGSCv371162,506,799 - 162,507,884 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,413,345 - 162,414,430 (-)NCBIMGSCv36mm8
Celera1162,983,200 - 162,984,285 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
Gpr52
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540614,415,252 - 14,420,251 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540614,415,252 - 14,420,251 (+)NCBIChiLan1.0ChiLan1.0
GPR52
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2175,269,104 - 75,288,182 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1174,957,497 - 74,961,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01149,954,556 - 149,959,653 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11153,658,348 - 153,659,970 (+)NCBIpanpan1.1PanPan1.1panPan2
GPR52
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1724,858,588 - 24,862,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl724,860,473 - 24,862,117 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha724,383,660 - 24,388,208 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0724,599,380 - 24,603,928 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl724,596,655 - 24,810,192 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1724,512,474 - 24,517,022 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0724,602,982 - 24,607,530 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0724,747,842 - 24,752,390 (-)NCBIUU_Cfam_GSD_1.0
Gpr52
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934495,740,744 - 95,747,363 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648113,588,705 - 13,593,018 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR52
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9116,643,037 - 116,647,996 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19116,639,223 - 116,648,001 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29128,322,434 - 128,326,761 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR52
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12554,757,376 - 54,758,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605556,311,993 - 56,315,653 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr52
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247717,463,809 - 7,467,044 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247717,460,199 - 7,467,519 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr52
12 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 217 97 93 44 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001289935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000088425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1372,800,127 - 72,806,180 (-)Ensembl
Rnor_6.0 Ensembl1378,326,545 - 78,329,680 (-)Ensembl
RefSeq Acc Id: NM_001289935   ⟹   NP_001276864
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81375,333,683 - 75,338,407 (-)NCBI
mRatBN7.21372,800,265 - 72,804,989 (-)NCBI
Rnor_6.01378,326,545 - 78,331,349 (-)NCBI
Celera1372,603,008 - 72,607,732 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001276864 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080795.1
RefSeq Acc Id: NP_001276864   ⟸   NM_001289935
- UniProtKB: A0A8I5ZQK1 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
G-protein coupled receptors family 1 profile

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587949 AgrOrtholog
BioCyc Gene G2FUF-17759 BioCyc
Ensembl Genes ENSRNOG00000055673 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088425.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_opsins UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report rno:684623 UniProtKB/TrEMBL
NCBI Gene 684623 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 52 UniProtKB/TrEMBL
  OPSIN UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr52 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055673 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I5ZQK1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-13 Gpr52  G protein-coupled receptor 52  LOC684623  similar to Probable G-protein coupled receptor 52  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC684623  similar to Probable G-protein coupled receptor 52      Symbol and Name status set to provisional 70820 PROVISIONAL