Izumo1r (IZUMO1 receptor, JUNO) - Rat Genome Database

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Gene: Izumo1r (IZUMO1 receptor, JUNO) Rattus norvegicus
Analyze
Symbol: Izumo1r
Name: IZUMO1 receptor, JUNO
RGD ID: 1585174
Description: Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion; signaling receptor activity; and signaling receptor binding activity. Predicted to be involved in cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; and sperm-egg recognition. Predicted to be active in external side of plasma membrane. Orthologous to human IZUMO1R (IZUMO1 receptor, JUNO); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: folate receptor 4 (delta); folate receptor 4, delta; Folr4; JUNO; LOC690037; probable folate receptor delta; similar to folate receptor 4 (delta) isoform 1; sperm-egg fusion protein Juno
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8820,025,830 - 20,030,829 (-)NCBIGRCr8
mRatBN7.2811,744,384 - 11,748,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,725,863 - 11,748,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,729,242 - 15,733,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0814,026,986 - 14,030,756 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0812,002,693 - 12,006,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,416,418 - 13,418,907 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,416,393 - 13,420,439 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,358,388 - 13,362,662 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,697,856 - 11,703,408 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera813,213,994 - 13,216,483 (-)NCBICelera
Cytogenetic Map8q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO. Lai X, etal., Theriogenology. 2024 Jan 15;214:286-297. doi: 10.1016/j.theriogenology.2023.10.031. Epub 2023 Nov 7.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24739963   PMID:27416963  


Genomics

Comparative Map Data
Izumo1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8820,025,830 - 20,030,829 (-)NCBIGRCr8
mRatBN7.2811,744,384 - 11,748,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,725,863 - 11,748,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,729,242 - 15,733,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0814,026,986 - 14,030,756 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0812,002,693 - 12,006,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,416,418 - 13,418,907 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,416,393 - 13,420,439 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,358,388 - 13,362,662 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,697,856 - 11,703,408 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera813,213,994 - 13,216,483 (-)NCBICelera
Cytogenetic Map8q12NCBI
IZUMO1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,304,580 - 94,308,146 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,304,580 - 94,308,146 (+)EnsemblGRCh38hg38GRCh38
GRCh371194,037,746 - 94,041,312 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,678,451 - 93,680,506 (+)NCBINCBI36Build 36hg18NCBI36
Celera1191,326,626 - 91,328,681 (+)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,108,391 - 90,110,446 (+)NCBIHuRef
CHM1_11193,921,817 - 93,923,872 (+)NCBICHM1_1
T2T-CHM13v2.01194,311,597 - 94,315,165 (+)NCBIT2T-CHM13v2.0
Izumo1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,797,110 - 14,815,247 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,797,110 - 14,815,245 (-)EnsemblGRCm39 Ensembl
GRCm38914,885,814 - 14,903,951 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,885,814 - 14,903,949 (-)EnsemblGRCm38mm10GRCm38
MGSCv37914,690,258 - 14,708,395 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36914,636,207 - 14,654,325 (-)NCBIMGSCv36mm8
Celera912,166,552 - 12,184,689 (-)NCBICelera
Cytogenetic Map9A2NCBI
cM Map94.42NCBI
Izumo1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955414283,630 - 287,433 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955414283,646 - 287,422 (-)NCBIChiLan1.0ChiLan1.0
IZUMO1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2995,158,740 - 95,162,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11196,250,459 - 96,254,027 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,318,370 - 89,322,004 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,805,614 - 92,807,669 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,805,614 - 92,807,669 (+)Ensemblpanpan1.1panPan2
IZUMO1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,597,039 - 6,599,484 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,596,141 - 6,599,840 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,607,027 - 6,609,932 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0216,777,138 - 6,780,041 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,777,062 - 6,784,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,557,952 - 6,560,822 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,626,822 - 6,629,712 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,676,910 - 6,679,760 (-)NCBIUU_Cfam_GSD_1.0
Izumo1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,274,912 - 79,277,682 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936674595,106 - 616,513 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936674614,455 - 616,513 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IZUMO1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,517,292 - 26,520,860 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,516,091 - 26,520,949 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,211,999 - 30,215,363 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IZUMO1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,527,589 - 85,532,968 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,527,999 - 85,530,703 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604340,253,230 - 40,259,153 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Izumo1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473538,968,803 - 38,971,518 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473538,967,522 - 38,971,049 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Izumo1r
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:91
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000051471, ENSRNOT00000071852
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat

Markers in Region
BF390797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2811,744,387 - 11,744,538 (+)MAPPERmRatBN7.2
Rnor_6.0813,416,423 - 13,416,573NCBIRnor6.0
Rnor_5.0813,358,393 - 13,358,543UniSTSRnor5.0
Celera813,213,999 - 13,214,149UniSTS
RH 3.4 Map8105.6UniSTS
Cytogenetic Map8q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 22 106 41 32 12 22 12 4 109 63 88 24 53 20

Sequence


Ensembl Acc Id: ENSRNOT00000051471   ⟹   ENSRNOP00000048978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl811,744,390 - 11,748,465 (-)Ensembl
Rnor_6.0 Ensembl813,416,393 - 13,420,439 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118901   ⟹   ENSRNOP00000079600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl811,725,863 - 11,748,465 (-)Ensembl
RefSeq Acc Id: NM_001398801   ⟹   NP_001385730
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,025,831 - 20,029,578 (-)NCBI
mRatBN7.2811,744,384 - 11,748,131 (-)NCBI
RefSeq Acc Id: XM_063266161   ⟹   XP_063122231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8820,025,830 - 20,030,829 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385730 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122231 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ANW48057 (Get FASTA)   NCBI Sequence Viewer  
  EDL78457 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048978.4
  ENSRNOP00000079600.1
Ensembl Acc Id: ENSRNOP00000048978   ⟸   ENSRNOT00000051471
Ensembl Acc Id: ENSRNOP00000079600   ⟸   ENSRNOT00000118901
RefSeq Acc Id: NP_001385730   ⟸   NM_001398801
- Peptide Label: precursor
- UniProtKB: F1M928 (UniProtKB/TrEMBL),   A6JNA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122231   ⟸   XM_063266161
- Peptide Label: isoform X1
- UniProtKB: A6JNA9 (UniProtKB/TrEMBL),   F1M928 (UniProtKB/TrEMBL)
Protein Domains
Folate receptor-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M928-F1-model_v2 AlphaFold F1M928 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585174 AgrOrtholog
BioCyc Gene G2FUF-31677 BioCyc
Ensembl Genes ENSRNOG00000019894 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051471.7 UniProtKB/TrEMBL
  ENSRNOT00000118901.1 UniProtKB/TrEMBL
InterPro Folate_rcpt UniProtKB/TrEMBL
  Folate_rcpt-like UniProtKB/TrEMBL
NCBI Gene 690037 ENTREZGENE
PANTHER PTHR10517 UniProtKB/TrEMBL
  SPERM-EGG FUSION PROTEIN JUNO UniProtKB/TrEMBL
Pfam Folate_rec UniProtKB/TrEMBL
PhenoGen Izumo1r PhenoGen
RatGTEx ENSRNOG00000019894 RatGTEx
UniProt A0A1B1W5N3_RAT UniProtKB/TrEMBL
  A0A8I5ZNV2_RAT UniProtKB/TrEMBL
  A6JNA9 ENTREZGENE, UniProtKB/TrEMBL
  F1M928 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-02-26 Izumo1r  IZUMO1 receptor, JUNO  Folr4  folate receptor 4, delta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-02-24 Folr4  folate receptor 4, delta  Folr4  folate receptor 4 (delta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Folr4  folate receptor 4 (delta)  LOC690037  similar to folate receptor 4 (delta) isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC690037  similar to folate receptor 4 (delta) isoform 1  LOC686478  similar to folate receptor 4 (delta) isoform 1  Data merged from RGD:1597606 1643240 APPROVED
2006-11-20 LOC686478  similar to folate receptor 4 (delta) isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690037  similar to folate receptor 4 (delta) isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL