Msrb1 (methionine sulfoxide reductase B1) - Rat Genome Database

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Gene: Msrb1 (methionine sulfoxide reductase B1) Rattus norvegicus
Analyze
Symbol: Msrb1
Name: methionine sulfoxide reductase B1
RGD ID: 1583243
Description: Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization; innate immune response; and protein repair. Predicted to be located in actin cytoskeleton; cytoplasm; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human MSRB1 (methionine sulfoxide reductase B1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: methionine-R-sulfoxide reductase B1; MGC105753; selenoprotein R; selenoprotein X, 1; selX; Sepx1; similar to Methionine-R-sulfoxide reductase (Selenoprotein X 1) (Selenoprotein R)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,269,414 - 14,275,140 (+)NCBIGRCr8
GRCr8 Ensembl1014,269,414 - 14,274,184 (+)EnsemblGRCr8 Ensembl
mRatBN7.21013,764,883 - 13,770,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,764,883 - 13,770,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,511,465 - 18,517,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,000,325 - 18,006,054 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,499,525 - 13,505,254 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,105,750 - 14,111,463 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,105,750 - 14,111,463 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,921,478 - 13,927,191 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,992,929 - 13,998,642 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,444,614 - 13,450,324 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
hypochlorous acid  (ISO)
isotretinoin  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pyrogallol  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12775843   PMID:14699060   PMID:20634897   PMID:22479358   PMID:23911929   PMID:27752786  


Genomics

Comparative Map Data
Msrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,269,414 - 14,275,140 (+)NCBIGRCr8
GRCr8 Ensembl1014,269,414 - 14,274,184 (+)EnsemblGRCr8 Ensembl
mRatBN7.21013,764,883 - 13,770,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,764,883 - 13,770,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,511,465 - 18,517,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,000,325 - 18,006,054 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,499,525 - 13,505,254 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,105,750 - 14,111,463 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,105,750 - 14,111,463 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,921,478 - 13,927,191 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,992,929 - 13,998,642 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,444,614 - 13,450,324 (+)NCBICelera
Cytogenetic Map10q12NCBI
MSRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,938,229 - 1,943,199 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,938,229 - 1,943,199 (-)EnsemblGRCh38hg38GRCh38
GRCh37161,988,230 - 1,993,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,928,235 - 1,933,295 (-)NCBINCBI36Build 36hg18NCBI36
Build 34161,928,234 - 1,933,295NCBI
Celera162,200,442 - 2,205,502 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,912,836 - 1,917,896 (-)NCBIHuRef
CHM1_1161,988,182 - 1,993,242 (-)NCBICHM1_1
T2T-CHM13v2.0161,958,200 - 1,963,171 (-)NCBIT2T-CHM13v2.0
Msrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,955,567 - 24,961,752 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,955,616 - 24,961,752 (+)EnsemblGRCm39 Ensembl
GRCm381724,736,593 - 24,742,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,736,642 - 24,742,778 (+)EnsemblGRCm38mm10GRCm38
MGSCv371724,873,587 - 24,879,723 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,464,267 - 24,470,378 (+)NCBIMGSCv36mm8
Celera1725,259,999 - 25,266,140 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Msrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,323,039 - 15,327,406 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,322,961 - 15,328,311 (+)NCBIChiLan1.0ChiLan1.0
MSRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,404,074 - 2,409,169 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,185,920 - 6,193,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016761,003 - 766,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,027,606 - 2,032,800 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,028,487 - 2,032,636 (-)Ensemblpanpan1.1panPan2
MSRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,981,721 - 38,986,459 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,981,721 - 38,986,459 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,221,193 - 40,225,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,298,520 - 39,303,043 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,298,520 - 39,303,043 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,975,293 - 38,979,816 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,947,617 - 38,952,140 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,426,473 - 39,430,998 (+)NCBIUU_Cfam_GSD_1.0
Msrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,618,706 - 104,622,744 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,086,822 - 2,089,932 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,086,573 - 2,090,752 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,017,194 - 40,028,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,017,161 - 40,021,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MSRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,836,059 - 1,841,132 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606829,236,044 - 29,241,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624913310,708 - 315,383 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Msrb1
37 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH133426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,770,368 - 13,770,568 (+)MAPPERmRatBN7.2
Rnor_6.01014,111,223 - 14,111,422NCBIRnor6.0
Rnor_5.01013,926,951 - 13,927,150UniSTSRnor5.0
RGSC_v3.41013,998,402 - 13,998,601UniSTSRGSC3.4
Celera1013,450,084 - 13,450,283UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000090552   ⟹   ENSRNOP00000074809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1014,269,414 - 14,274,184 (+)Ensembl
mRatBN7.2 Ensembl1013,764,883 - 13,770,609 (+)Ensembl
Rnor_6.0 Ensembl1014,105,750 - 14,111,463 (+)Ensembl
RefSeq Acc Id: NM_001044285   ⟹   NP_001037750
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,269,414 - 14,275,140 (+)NCBI
mRatBN7.21013,764,883 - 13,770,609 (+)NCBI
Rnor_6.01014,105,750 - 14,111,463 (+)NCBI
Rnor_5.01013,921,478 - 13,927,191 (+)NCBI
RGSC_v3.41013,992,929 - 13,998,642 (+)RGD
Celera1013,444,614 - 13,450,324 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001037750 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH94309 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074809
  ENSRNOP00000074809.2
GenBank Protein Q52KJ8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001037750   ⟸   NM_001044285
- UniProtKB: Q52KJ8 (UniProtKB/Swiss-Prot),   A0A0G2K906 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074809   ⟸   ENSRNOT00000090552
Protein Domains
MsrB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697027
Promoter ID:EPDNEW_R7552
Type:initiation region
Name:Msrb1_1
Description:methionine sulfoxide reductase B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,105,794 - 14,105,854EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583243 AgrOrtholog
BioCyc Gene G2FUF-25824 BioCyc
Ensembl Genes ENSRNOG00000055314 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090552 ENTREZGENE
  ENSRNOT00000090552.2 UniProtKB/Swiss-Prot
Gene3D-CATH Peptide methionine sulfoxide reductase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7316479 IMAGE-MGC_LOAD
InterPro Met_Sox_Rdtase_MsrB UniProtKB/Swiss-Prot
  MsrB_Met_sulfoxide_reductase UniProtKB/Swiss-Prot
  Mss4-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:685059 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105753 IMAGE-MGC_LOAD
NCBI Gene 685059 ENTREZGENE
PANTHER METHIONINE-R-SULFOXIDE REDUCTASE B1 UniProtKB/Swiss-Prot
  METHIONINE-R-SULFOXIDE REDUCTASE B1 UniProtKB/Swiss-Prot
Pfam SelR UniProtKB/Swiss-Prot
PhenoGen Msrb1 PhenoGen
PROSITE MSRB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055314 RatGTEx
Superfamily-SCOP SSF51316 UniProtKB/Swiss-Prot
UniProt A0A0G2K906 ENTREZGENE, UniProtKB/TrEMBL
  MSRB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-16 Msrb1  methionine sulfoxide reductase B1  Sepx1  selenoprotein X, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Sepx1  selenoprotein X, 1  MGC105753  similar to Methionine-R-sulfoxide reductase (Selenoprotein X 1) (Selenoprotein R)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 MGC105753  similar to Methionine-R-sulfoxide reductase (Selenoprotein X 1) (Selenoprotein R)      Symbol and Name status set to provisional 70820 PROVISIONAL