4930474N05Rikl2 (RIKEN cDNA 4930474N05 gene like 2) - Rat Genome Database

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Gene: 4930474N05Rikl2 (RIKEN cDNA 4930474N05 gene like 2) Rattus norvegicus
Analyze
Symbol: 4930474N05Rikl2 (Ensembl: RGD1562641)
Name: RIKEN cDNA 4930474N05 gene like 2 (Ensembl:similar to hypothetical protein 4930474N05)
RGD ID: 1562641
Description: Predicted to enable guanyl-nucleotide exchange factor activity.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 4930474N05Rikl; LOC290589; ral guanine nucleotide dissociation stimulator-like; RGD1562641; RIKEN cDNA 4930474N05 gene like; similar to hypothetical protein 4930474N05
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81611,686,164 - 11,688,992 (+)NCBIGRCr8
mRatBN7.21611,664,310 - 11,672,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1611,665,896 - 11,668,685 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01612,975,533 - 12,978,717 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1612,976,906 - 12,978,784 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01612,868,911 - 12,871,767 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41612,085,766 - 12,087,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1611,932,970 - 11,936,154 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in 4930474N05Rikl2
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:89
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000029573
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
mesenchyme
mesoderm
nervous system
reproductive system
1 5 3 4 3 2 22

Sequence


Ensembl Acc Id: ENSRNOT00000029573   ⟹   ENSRNOP00000029548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1611,435,429 - 11,437,334 (-)Ensembl
Rnor_6.0 Ensembl1612,976,906 - 12,978,784 (+)Ensembl
RefSeq Acc Id: XM_039095005   ⟹   XP_038950933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,686,164 - 11,688,992 (+)NCBI
mRatBN7.21611,664,310 - 11,672,032 (+)NCBI
RefSeq Acc Id: XM_063275806   ⟹   XP_063131876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,686,164 - 11,688,992 (+)NCBI
RefSeq Acc Id: XM_063275807   ⟹   XP_063131877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,686,164 - 11,688,992 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038950933 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131876 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131877 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074828.2
Ensembl Acc Id: ENSRNOP00000029548   ⟸   ENSRNOT00000029573
RefSeq Acc Id: XP_038950933   ⟸   XM_039095005
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K922 (UniProtKB/TrEMBL),   A6K9I2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131877   ⟸   XM_063275807
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063131876   ⟸   XM_063275806
- Peptide Label: isoform X2
Protein Domains
N-terminal Ras-GEF

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-12013 BioCyc
Ensembl Genes ENSRNOG00000022798 Ensembl
  ENSRNOG00000051457 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077513.2 UniProtKB/TrEMBL
Gene3D-CATH Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
NCBI Gene 290589 ENTREZGENE
PANTHER 1700018F24RIK PROTEIN-RELATED-RELATED UniProtKB/TrEMBL
  RIKEN CDNA 4930474N05 GENE UniProtKB/TrEMBL
Pfam RasGEF_N UniProtKB/TrEMBL
PhenoGen 4930474N05Rikl2 PhenoGen
PROSITE RASGEF_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022798 RatGTEx
  ENSRNOG00000051457 RatGTEx
SMART RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP Ras GEF UniProtKB/TrEMBL
UniProt A0A0G2K922 ENTREZGENE, UniProtKB/TrEMBL
  A6K9I2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-17 4930474N05Rikl2  RIKEN cDNA 4930474N05 gene like 2  4930474N05Rikl  RIKEN cDNA 4930474N05 gene like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 4930474N05Rikl  RIKEN cDNA 4930474N05 gene like  RGD1562641  similar to hypothetical protein 4930474N05  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1562641  similar to hypothetical protein 4930474N05   RGD1562641_predicted  similar to hypothetical protein 4930474N05 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562641_predicted  similar to hypothetical protein 4930474N05 (predicted)  LOC290589  similar to hypothetical protein 4930474N05  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290589  similar to hypothetical protein 4930474N05      Symbol and Name status set to provisional 70820 PROVISIONAL