Ccdc177 (coiled-coil domain containing 177) - Rat Genome Database

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Gene: Ccdc177 (coiled-coil domain containing 177) Rattus norvegicus
Analyze
Symbol: Ccdc177
Name: coiled-coil domain containing 177
RGD ID: 1561115
Description: Orthologous to human CCDC177 (coiled-coil domain containing 177); INTERACTS WITH paracetamol; vinclozolin; 3-isobutyl-1-methyl-7H-xanthine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coiled-coil domain-containing protein 177; LOC500686; RGD1561115; similar to Gene model 1568
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,135,827 - 106,142,413 (-)NCBIGRCr8
mRatBN7.26100,404,526 - 100,411,112 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,404,413 - 100,412,850 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6100,570,714 - 100,577,296 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06100,870,423 - 100,877,005 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,245,499 - 100,252,085 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,403,617 - 104,410,991 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,406,897 - 104,409,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06112,575,382 - 112,582,083 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,523,834 - 104,525,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera698,262,232 - 98,269,606 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 45 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccdc177Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOCCDC177 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC177 mRNA more ...CTDPMID:28628672
Ccdc177Rat4,4'-sulfonyldiphenol multiple interactionsISOCCDC177 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of CCDC177 mRNACTDPMID:28628672
Ccdc177Rat4,4'-sulfonyldiphenol affects methylationISOCcdc177 (Mus musculus)6480464bisphenol S affects the methylation of CCDC177 geneCTDPMID:31683443
Ccdc177Ratacrylamide decreases expressionISOCcdc177 (Mus musculus)6480464Acrylamide results in decreased expression of CCDC177 mRNACTDPMID:30807115
Ccdc177Ratacrylamide decreases expressionISOCCDC177 (Homo sapiens)6480464Acrylamide results in decreased expression of CCDC177 mRNACTDPMID:32763439
Ccdc177Rataflatoxin B1 decreases methylationISOCCDC177 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of CCDC177 geneCTDPMID:27153756
Ccdc177Ratall-trans-retinoic acid decreases expressionISOCCDC177 (Homo sapiens)6480464Tretinoin results in decreased expression of CCDC177 mRNACTDPMID:21934132
Ccdc177Rataristolochic acid A decreases expressionISOCCDC177 (Homo sapiens)6480464aristolochic acid I results in decreased expression of CCDC177 mRNACTDPMID:33212167
Ccdc177Ratarsane affects methylationISOCCDC177 (Homo sapiens)6480464Arsenic affects the methylation of CCDC177 geneCTDPMID:25304211
Ccdc177Ratarsenic atom affects methylationISOCCDC177 (Homo sapiens)6480464Arsenic affects the methylation of CCDC177 geneCTDPMID:25304211
Ccdc177Ratbenzo[a]pyrene increases methylationISOCCDC177 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of CCDC177 promoterCTDPMID:27901495
Ccdc177Ratbisphenol A decreases expressionISOCCDC177 (Homo sapiens)6480464bisphenol A results in decreased expression of CCDC177 mRNACTDPMID:31715268
Ccdc177Ratbisphenol A multiple interactionsISOCCDC177 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC177 mRNACTDPMID:28628672
Ccdc177Ratbisphenol F multiple interactionsISOCCDC177 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CCDC177 mRNACTDPMID:28628672
Ccdc177Ratchlorpyrifos decreases expressionISOCcdc177 (Mus musculus)6480464Chlorpyrifos results in decreased expression of CCDC177 mRNACTDPMID:32715474
Ccdc177Ratdexamethasone multiple interactionsISOCCDC177 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC177 mRNA more ...CTDPMID:28628672
Ccdc177Ratdorsomorphin multiple interactionsISOCCDC177 (Homo sapiens)6480464[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...CTDPMID:27188386
Ccdc177Ratentinostat decreases expressionISOCCDC177 (Homo sapiens)6480464entinostat results in decreased expression of CCDC177 mRNACTDPMID:26272509
Ccdc177Ratentinostat multiple interactionsISOCCDC177 (Homo sapiens)6480464[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CCDC177 mRNACTDPMID:27188386
Ccdc177Ratindometacin multiple interactionsISOCCDC177 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CCDC177 mRNA more ...CTDPMID:28628672

1 to 20 of 45 rows

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Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Ccdc177
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,135,827 - 106,142,413 (-)NCBIGRCr8
mRatBN7.26100,404,526 - 100,411,112 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,404,413 - 100,412,850 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6100,570,714 - 100,577,296 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06100,870,423 - 100,877,005 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,245,499 - 100,252,085 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,403,617 - 104,410,991 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,406,897 - 104,409,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06112,575,382 - 112,582,083 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,523,834 - 104,525,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera698,262,232 - 98,269,606 (-)NCBICelera
Cytogenetic Map6q24NCBI
CCDC177
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381469,569,799 - 69,574,871 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1469,569,799 - 69,574,871 (-)EnsemblGRCh38hg38GRCh38
GRCh371470,036,516 - 70,041,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361469,107,236 - 69,107,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 341469,106,337 - 69,107,671NCBI
Celera1450,100,643 - 50,102,030 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1450,204,992 - 50,210,055 (-)NCBIHuRef
CHM1_11469,974,657 - 69,979,720 (-)NCBICHM1_1
T2T-CHM13v2.01463,777,470 - 63,782,536 (-)NCBIT2T-CHM13v2.0
Ccdc177
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,802,221 - 80,807,489 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,800,817 - 80,807,461 (-)EnsemblGRCm39 Ensembl
GRCm381280,755,447 - 80,760,715 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,754,043 - 80,760,687 (-)EnsemblGRCm38mm10GRCm38
MGSCv371281,856,434 - 81,861,702 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,674,647 - 81,679,535 (-)NCBIMGSCv36mm8
Celera1282,220,882 - 82,226,150 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1237.02NCBI
CCDC177
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21570,694,004 - 70,699,372 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,909,772 - 69,915,885 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01450,162,816 - 50,169,232 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,036,711 - 69,041,196 (-)NCBIpanpan1.1PanPan1.1panPan2
CCDC177
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1843,334,046 - 43,339,789 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl843,336,238 - 43,338,355 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha843,019,494 - 43,030,878 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0843,559,941 - 43,571,352 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl843,566,070 - 43,568,196 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1843,174,758 - 43,185,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0843,248,730 - 43,259,878 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0843,608,359 - 43,619,537 (-)NCBIUU_Cfam_GSD_1.0
Ccdc177
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864061,419,348 - 61,424,653 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,768,996 - 12,771,113 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,767,046 - 12,772,363 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC177
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl793,224,130 - 93,226,226 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1793,222,415 - 93,227,874 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2799,499,151 - 99,504,181 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC177
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,809,813 - 46,815,668 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2446,811,853 - 46,813,964 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605335,035,865 - 35,042,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccdc177
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473431,516,465 - 31,519,627 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473431,516,439 - 31,526,254 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ccdc177
13 total Variants

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:119
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000040965
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat

1 to 10 of 34 rows
AI713025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26100,406,067 - 100,406,267 (+)MAPPERmRatBN7.2
Rnor_6.06104,405,159 - 104,405,358NCBIRnor6.0
Rnor_5.06112,576,924 - 112,577,123UniSTSRnor5.0
RGSC_v3.46104,522,096 - 104,522,295UniSTSRGSC3.4
Celera698,263,774 - 98,263,973UniSTS
RH 3.4 Map6717.6UniSTS
Cytogenetic Map6q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 7 29 112 41 41 10 25 10 6 127 70 93 31 58 31


RefSeq Transcripts NM_001399190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000040965   ⟹   ENSRNOP00000045958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6100,404,413 - 100,412,850 (-)Ensembl
Rnor_6.0 Ensembl6104,406,897 - 104,409,005 (-)Ensembl
RefSeq Acc Id: NM_001399190   ⟹   NP_001386119
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,135,827 - 106,142,413 (-)NCBI
mRatBN7.26100,404,526 - 100,411,112 (-)NCBI
Protein RefSeqs NP_001386119 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045958
  ENSRNOP00000045958.1
Ensembl Acc Id: ENSRNOP00000045958   ⟸   ENSRNOT00000040965
RefSeq Acc Id: NP_001386119   ⟸   NM_001399190
- UniProtKB: D4A8V2 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-D4A8V2-F1-model_v2 AlphaFold D4A8V2 1-702 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 12 of 12 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36905 BioCyc
Ensembl Genes ENSRNOG00000033973 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040965 ENTREZGENE
  ENSRNOT00000040965.2 UniProtKB/TrEMBL
InterPro DUF4659 UniProtKB/TrEMBL
NCBI Gene 500686 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 177 UniProtKB/TrEMBL
  PTHR33663 UniProtKB/TrEMBL
Pfam DUF4659 UniProtKB/TrEMBL
PhenoGen Ccdc177 PhenoGen
RatGTEx ENSRNOG00000033973 RatGTEx
UniProt D4A8V2 ENTREZGENE, UniProtKB/TrEMBL
1 to 12 of 12 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-11 Ccdc177  coiled-coil domain containing 177  RGD1561115  similar to Gene model 1568  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561115  similar to Gene model 1568   RGD1561115_predicted  similar to Gene model 1568 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561115_predicted  similar to Gene model 1568 (predicted)  LOC500686  similar to Gene model 1568  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500686  similar to Gene model 1568      Symbol and Name status set to provisional 70820 PROVISIONAL