Gpd1l (glycerol-3-phosphate dehydrogenase 1 like) - Rat Genome Database

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Gene: Gpd1l (glycerol-3-phosphate dehydrogenase 1 like) Rattus norvegicus
Analyze
Symbol: Gpd1l
Name: glycerol-3-phosphate dehydrogenase 1 like (Ensembl:glycerol-3-phosphate dehydrogenase 1-like)
RGD ID: 1560123
Description: Predicted to enable sodium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in several processes, including positive regulation of protein localization to cell surface; regulation of ventricular cardiac muscle cell membrane depolarization; and ventricular cardiac muscle cell action potential. Predicted to act upstream of or within NADH metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Brugada syndrome 2. Orthologous to human GPD1L (glycerol-3-phosphate dehydrogenase 1 like); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH 17beta-estradiol; 3,3',5,5'-tetrabromobisphenol A; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycerol-3-phosphate dehydrogenase 1 like 1; glycerol-3-phosphate dehydrogenase 1-like; glycerol-3-phosphate dehydrogenase 1-like protein; Gpd1l1; LOC363159; RGD1560123; similar to mKIAA0089 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88123,469,282 - 123,498,948 (-)NCBIGRCr8
mRatBN7.28114,591,103 - 114,620,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,588,487 - 114,620,723 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8120,207,646 - 120,237,017 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08118,406,890 - 118,436,261 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08116,249,743 - 116,279,122 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08122,957,570 - 122,987,236 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,954,948 - 122,987,191 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08122,270,749 - 122,300,415 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48119,317,528 - 119,347,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,837,868 - 113,867,534 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA)
membrane  (ISO)
plasma membrane  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:17967977   PMID:19666841   PMID:19745168   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Gpd1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88123,469,282 - 123,498,948 (-)NCBIGRCr8
mRatBN7.28114,591,103 - 114,620,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8114,588,487 - 114,620,723 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8120,207,646 - 120,237,017 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08118,406,890 - 118,436,261 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08116,249,743 - 116,279,122 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08122,957,570 - 122,987,236 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8122,954,948 - 122,987,191 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08122,270,749 - 122,300,415 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48119,317,528 - 119,347,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8113,837,868 - 113,867,534 (-)NCBICelera
Cytogenetic Map8q32NCBI
GPD1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38332,106,620 - 32,168,709 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl332,105,689 - 32,168,709 (+)EnsemblGRCh38hg38GRCh38
GRCh37332,148,112 - 32,210,201 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36332,123,148 - 32,185,205 (+)NCBINCBI36Build 36hg18NCBI36
Build 34332,123,147 - 32,185,205NCBI
Celera332,085,677 - 32,147,612 (+)NCBICelera
Cytogenetic Map3p22.3NCBI
HuRef332,082,648 - 32,145,486 (+)NCBIHuRef
CHM1_1332,097,981 - 32,160,183 (+)NCBICHM1_1
T2T-CHM13v2.0332,103,733 - 32,165,789 (+)NCBIT2T-CHM13v2.0
Gpd1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399114,728,407 - 114,763,055 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9114,728,409 - 114,763,055 (-)EnsemblGRCm39 Ensembl
GRCm389114,899,339 - 114,933,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9114,899,341 - 114,933,987 (-)EnsemblGRCm38mm10GRCm38
MGSCv379114,808,457 - 114,843,105 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369114,750,998 - 114,782,525 (-)NCBIMGSCv36mm8
Celera9115,374,567 - 115,412,670 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map965.47NCBI
Gpd1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543023,481,957 - 23,539,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543023,481,957 - 23,536,407 (+)NCBIChiLan1.0ChiLan1.0
GPD1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2232,086,093 - 32,148,039 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1332,090,860 - 32,152,806 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0332,026,586 - 32,088,512 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1332,342,776 - 32,404,172 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl332,342,776 - 32,404,172 (+)Ensemblpanpan1.1panPan2
GPD1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12312,568,914 - 12,631,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2312,522,398 - 12,632,447 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2312,497,251 - 12,606,905 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02312,813,538 - 12,923,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2312,813,607 - 12,923,377 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12312,614,598 - 12,724,182 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02312,757,296 - 12,867,104 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02312,769,710 - 12,879,345 (-)NCBIUU_Cfam_GSD_1.0
Gpd1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118189,510,519 - 189,636,146 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647322,649,133 - 22,696,959 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647322,649,107 - 22,774,719 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPD1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1318,127,088 - 18,176,666 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11318,126,471 - 18,176,669 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21320,616,343 - 20,666,755 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPD1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11576,617,122 - 76,680,508 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1576,617,441 - 76,677,713 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604149,969,861 - 50,034,102 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpd1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478810,173,551 - 10,240,704 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478810,173,629 - 10,240,200 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpd1l
215 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:986
Count of miRNA genes:328
Interacting mature miRNAs:422
Transcripts:ENSRNOT00000033976
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1599689Iddm24Insulin dependent diabetes mellitus QTL 244.720.001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)8112834440118649220Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000033976   ⟹   ENSRNOP00000036106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8114,588,487 - 114,620,723 (-)Ensembl
Rnor_6.0 Ensembl8122,954,948 - 122,987,191 (-)Ensembl
RefSeq Acc Id: NM_001191885   ⟹   NP_001178814
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88123,469,282 - 123,498,948 (-)NCBI
mRatBN7.28114,591,103 - 114,620,771 (-)NCBI
Rnor_6.08122,957,570 - 122,987,236 (-)NCBI
Rnor_5.08122,270,749 - 122,300,415 (-)NCBI
Celera8113,837,868 - 113,867,534 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001178814   ⟸   NM_001191885
- UniProtKB: D3ZAP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036106   ⟸   ENSRNOT00000033976
Protein Domains
Glycerol-3-phosphate dehydrogenase NAD-dependent C-   Glycerol-3-phosphate dehydrogenase NAD-dependent N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAP9-F1-model_v2 AlphaFold D3ZAP9 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696357
Promoter ID:EPDNEW_R6882
Type:multiple initiation site
Name:Gpd1l_1
Description:glycerol-3-phosphate dehydrogenase 1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08122,987,136 - 122,987,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560123 AgrOrtholog
BioCyc Gene G2FUF-28907 BioCyc
Ensembl Genes ENSRNOG00000026455 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033976.7 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro 6-PGluconate_DH_C_like UniProtKB/TrEMBL
  DH_multihelical UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  NAD-dep_Gly3P_DH UniProtKB/TrEMBL
  NAD-dep_Gly3P_DH_euk UniProtKB/TrEMBL
  NAD-dep_Gly3P_DH_N UniProtKB/TrEMBL
  NAD_Gly3P_DH_C UniProtKB/TrEMBL
KEGG Report rno:363159 UniProtKB/TrEMBL
NCBI Gene 363159 ENTREZGENE
PANTHER GLYCEROL-3-PHOSPHATE DEHYDROGENASE UniProtKB/TrEMBL
  GLYCEROL-3-PHOSPHATE DEHYDROGENASE 1-LIKE PROTEIN UniProtKB/TrEMBL
Pfam NAD_Gly3P_dh_C UniProtKB/TrEMBL
  NAD_Gly3P_dh_N UniProtKB/TrEMBL
PhenoGen Gpd1l PhenoGen
PIRSF Glycerol-3-P_dh UniProtKB/TrEMBL
PRINTS GPDHDRGNASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026455 RatGTEx
Superfamily-SCOP 6DGDH_C_like UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt D3ZAP9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-04-04 Gpd1l  glycerol-3-phosphate dehydrogenase 1 like  Gpd1l1  glycerol-3-phosphate dehydrogenase 1 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-03-03 Gpd1l1  glycerol-3-phosphate dehydrogenase 1 like 1  Gpd1l  glycerol-3-phosphate dehydrogenase 1-like  Name and Symbol changed 629549 APPROVED
2008-02-28 Gpd1l  glycerol-3-phosphate dehydrogenase 1-like  RGD1560123_predicted  similar to mKIAA0089 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560123_predicted  similar to mKIAA0089 protein (predicted)  LOC363159  similar to mKIAA0089 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363159  similar to mKIAA0089 protein      Symbol and Name status set to provisional 70820 PROVISIONAL