Adamts18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) - Rat Genome Database

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Gene: Adamts18 (ADAM metallopeptidase with thrombospondin type 1 motif, 18) Rattus norvegicus
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Symbol: Adamts18
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 18
RGD ID: 1560118
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and eye development. Predicted to act upstream of or within negative regulation of platelet aggregation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif 18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 18; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18; LOC361412; RGD1560118; similar to a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 isoform 1 preproprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21941,686,951 - 41,840,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1941,688,617 - 41,839,781 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1948,512,820 - 48,664,024 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01949,166,160 - 49,317,307 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01951,415,642 - 51,560,795 (-)NCBIRnor_WKY
Rnor_6.01946,005,055 - 46,167,912 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1946,005,277 - 46,101,250 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01956,829,742 - 56,992,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41943,722,117 - 43,895,889 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1941,002,954 - 41,153,002 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19218546   PMID:23818446  


Genomics

Comparative Map Data
Adamts18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21941,686,951 - 41,840,035 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1941,688,617 - 41,839,781 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1948,512,820 - 48,664,024 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01949,166,160 - 49,317,307 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01951,415,642 - 51,560,795 (-)NCBIRnor_WKY
Rnor_6.01946,005,055 - 46,167,912 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1946,005,277 - 46,101,250 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01956,829,742 - 56,992,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41943,722,117 - 43,895,889 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1941,002,954 - 41,153,002 (-)NCBICelera
Cytogenetic Map19q12NCBI
ADAMTS18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381677,282,128 - 77,435,034 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1677,247,813 - 77,435,034 (-)EnsemblGRCh38hg38GRCh38
GRCh371677,316,025 - 77,468,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361675,873,526 - 76,026,512 (-)NCBINCBI36Build 36hg18NCBI36
Build 341675,873,928 - 76,026,512NCBI
Celera1661,613,574 - 61,766,657 (-)NCBICelera
Cytogenetic Map16q23.1NCBI
HuRef1663,072,797 - 63,225,281 (-)NCBIHuRef
CHM1_11678,727,567 - 78,880,505 (-)NCBICHM1_1
T2T-CHM13v2.01683,338,334 - 83,491,167 (-)NCBIT2T-CHM13v2.0
Adamts18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398114,423,755 - 114,575,975 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8114,423,758 - 114,575,370 (-)EnsemblGRCm39 Ensembl
GRCm388113,697,123 - 113,849,343 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8113,697,126 - 113,848,738 (-)EnsemblGRCm38mm10GRCm38
MGSCv378116,222,037 - 116,372,739 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368116,584,749 - 116,734,820 (-)NCBIMGSCv36mm8
Celera8117,907,065 - 118,057,233 (-)NCBICelera
Cytogenetic Map8E1NCBI
Adamts18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955522532,534 - 666,523 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955522530,752 - 666,752 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11677,292,410 - 77,378,575 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1677,291,148 - 77,445,664 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01657,857,112 - 58,011,181 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADAMTS18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1573,769,462 - 73,907,024 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl573,772,114 - 73,905,264 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha573,719,683 - 73,854,779 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0574,077,460 - 74,214,474 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl574,079,598 - 74,213,369 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1574,018,089 - 74,155,401 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0573,857,334 - 73,988,950 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0574,338,384 - 74,479,803 (+)NCBIUU_Cfam_GSD_1.0
Adamts18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934933,757,816 - 33,890,335 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647525,699,840 - 25,831,284 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647525,698,117 - 25,831,291 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl610,328,944 - 10,652,504 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1610,488,504 - 10,652,508 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2610,445,893 - 10,488,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1562,764,081 - 62,921,394 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl562,765,939 - 62,918,697 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604713,131,507 - 13,289,294 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247469,530,093 - 9,669,129 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247469,336,284 - 9,667,389 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts18
1176 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:474
Count of miRNA genes:244
Interacting mature miRNAs:293
Transcripts:ENSRNOT00000015874
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
D19Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21941,801,730 - 41,801,917 (+)MAPPERmRatBN7.2
Rnor_6.01946,131,526 - 46,131,712NCBIRnor6.0
Celera1941,115,572 - 41,115,758UniSTS
Cytogenetic Map19q12UniSTS
BF410319  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21941,687,205 - 41,687,307 (+)MAPPERmRatBN7.2
Rnor_6.01946,003,658 - 46,003,759NCBIRnor6.0
Rnor_5.01956,828,345 - 56,828,446UniSTSRnor5.0
RGSC_v3.41943,720,722 - 43,720,823UniSTSRGSC3.4
Celera1941,001,559 - 41,001,660UniSTS
RH 3.4 Map19544.6UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 24 18 10
Low 1 12 12 6 6 6 1 1 48 6 14 1 1
Below cutoff 2 28 10 3 6 3 1 1 2 8 10 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015874   ⟹   ENSRNOP00000015874
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1941,688,617 - 41,839,781 (-)Ensembl
Rnor_6.0 Ensembl1946,005,277 - 46,101,250 (-)Ensembl
RefSeq Acc Id: NM_001191944   ⟹   NP_001178873
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21941,688,601 - 41,839,781 (-)NCBI
Rnor_6.01946,005,055 - 46,167,912 (-)NCBI
Rnor_5.01956,829,742 - 56,992,444 (-)NCBI
Celera1941,002,954 - 41,153,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097861   ⟹   XP_038953789
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21941,686,951 - 41,840,035 (-)NCBI
RefSeq Acc Id: XM_039097862   ⟹   XP_038953790
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21941,686,951 - 41,836,176 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178873 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953789 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953790 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92612 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001178873   ⟸   NM_001191944
- Peptide Label: precursor
- UniProtKB: D3Z8G4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015874   ⟸   ENSRNOT00000015874
RefSeq Acc Id: XP_038953789   ⟸   XM_039097861
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038953790   ⟸   XM_039097862
- Peptide Label: isoform X2
Protein Domains
Peptidase M12B   PLAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8G4-F1-model_v2 AlphaFold D3Z8G4 1-1054 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560118 AgrOrtholog
BioCyc Gene G2FUF-5602 BioCyc
Ensembl Genes ENSRNOG00000011575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000015874 ENTREZGENE
  ENSRNOP00000015874.8 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015874 ENTREZGENE
  ENSRNOT00000015874.8 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene 361412 ENTREZGENE
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamts18 PhenoGen
PRINTS ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART TSP1 UniProtKB/TrEMBL
Superfamily-SCOP TSP1 UniProtKB/TrEMBL
UniProt D3Z8G4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts18  ADAM metallopeptidase with thrombospondin type 1 motif, 18  Adamts18  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Adamts18  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18  RGD1560118_predicted  similar to a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 isoform 1 preproprotein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560118_predicted  similar to a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 isoform 1 preproprotein (predicted)  LOC361412  similar to a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 isoform 1 preproprotein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361412  similar to a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 isoform 1 preproprotein      Symbol and Name status set to provisional 70820 PROVISIONAL