Prss50 (serine protease 50) - Rat Genome Database

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Gene: Prss50 (serine protease 50) Mus musculus
Analyze
Symbol: Prss50
Name: serine protease 50
RGD ID: 1558297
MGI Page MGI
Description: Predicted to enable threonine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum. Is expressed in heart and pericardium and liver. Orthologous to human PRSS50 (serine protease 50).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 79H19C; probable threonine protease PRSS50; protease, serine 50; protease, serine, 50; testes-specific protease 50; testis-specific protease-like protein 50; Tsp; Tsp50
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,687,032 - 110,693,697 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,687,035 - 110,693,697 (+)EnsemblGRCm39 Ensembl
GRCm389110,857,964 - 110,864,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,857,967 - 110,864,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,760,471 - 110,767,132 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369111,964,631 - 111,971,369 (+)NCBIMGSCv36mm8
MGSCv369110,702,783 - 110,709,444 (+)NCBIMGSCv36mm8
Celera9110,589,938 - 110,590,855 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA,ISO)

Cellular Component
cytoplasm  (ISO)
endoplasmic reticulum  (IBA,IEA,ISO)
membrane  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12140191   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15491742   PMID:16141072   PMID:16141073   PMID:17219777  
PMID:18662669   PMID:21086474   PMID:21267068   PMID:21385156   PMID:21659515   PMID:21677750   PMID:21873635   PMID:25857663   PMID:29842883   PMID:32325033   PMID:33913480   PMID:38189580  
PMID:38355793  


Genomics

Comparative Map Data
Prss50
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,687,032 - 110,693,697 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,687,035 - 110,693,697 (+)EnsemblGRCm39 Ensembl
GRCm389110,857,964 - 110,864,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,857,967 - 110,864,629 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,760,471 - 110,767,132 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369111,964,631 - 111,971,369 (+)NCBIMGSCv36mm8
MGSCv369110,702,783 - 110,709,444 (+)NCBIMGSCv36mm8
Celera9110,589,938 - 110,590,855 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
PRSS50
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,712,117 - 46,717,869 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,712,117 - 46,717,869 (-)EnsemblGRCh38hg38GRCh38
GRCh37346,753,607 - 46,759,359 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,728,610 - 46,734,368 (-)NCBINCBI36Build 36hg18NCBI36
Celera346,692,302 - 46,698,069 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,796,456 - 46,802,223 (-)NCBIHuRef
CHM1_1346,703,722 - 46,709,489 (-)NCBICHM1_1
T2T-CHM13v2.0346,728,202 - 46,733,954 (-)NCBIT2T-CHM13v2.0
Prss50
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,719,574 - 119,727,269 (+)NCBIGRCr8
mRatBN7.28110,842,525 - 110,848,855 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,842,671 - 110,848,802 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08119,134,966 - 119,141,255 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,135,013 - 119,141,150 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,473,353 - 118,479,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8110,125,130 - 110,131,417 (+)NCBICelera
Cytogenetic Map8q32NCBI
Prss50
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542025,424,082 - 25,427,705 (+)NCBIChiLan1.0ChiLan1.0
PRSS50
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,667,914 - 46,674,227 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,672,684 - 46,678,997 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,610,119 - 46,616,435 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,713,568 - 47,719,706 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,713,699 - 47,719,315 (-)Ensemblpanpan1.1panPan2
PRSS50
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,046,177 - 42,051,517 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2041,962,573 - 41,967,707 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,528,974 - 42,534,105 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,528,989 - 42,534,105 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,770,289 - 41,775,396 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,171,301 - 42,176,453 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,452,345 - 42,457,480 (+)NCBIUU_Cfam_GSD_1.0
Prss50
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,992,631 - 200,998,921 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596541,918 - 546,364 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936596541,918 - 544,866 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS50
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,632,886 - 29,639,045 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,633,575 - 29,638,994 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21333,030,971 - 33,036,221 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103227551
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,135,011 - 8,142,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,135,046 - 8,140,809 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,009,233 - 159,015,033 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss50
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,494,152 - 74,497,473 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prss50
192 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:251
Count of miRNA genes:227
Interacting mature miRNAs:246
Transcripts:ENSMUST00000051097
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979279863113279941Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982792386116792481Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975682646114303447Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982792386116792481Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989859058118767089Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982792386116792481Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978522698112522808Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975682646114303447Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994863354112701997Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981680321115680445Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984406017118406120Mouse
13515058Adip20d_madiposity 20d (mouse)9108744078118744078Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000051097   ⟹   ENSMUSP00000059668
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,687,035 - 110,693,697 (+)Ensembl
GRCm38.p6 Ensembl9110,857,967 - 110,864,629 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196027   ⟹   ENSMUSP00000143092
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9110,690,434 - 110,693,696 (+)Ensembl
GRCm38.p6 Ensembl9110,861,366 - 110,864,628 (+)Ensembl
RefSeq Acc Id: NM_001379367   ⟹   NP_001366296
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,687,032 - 110,693,697 (+)NCBI
GRCm389110,857,964 - 110,864,629 (+)NCBI
Sequence:
RefSeq Acc Id: NM_146227   ⟹   NP_666339
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,687,035 - 110,693,696 (+)NCBI
GRCm389110,857,967 - 110,864,628 (+)NCBI
MGSCv379110,760,471 - 110,767,132 (+)RGD
Celera9110,562,680 - 110,590,855 (+)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_666339   ⟸   NM_146227
- Peptide Label: isoform 1 precursor
- UniProtKB: B2RWS9 (UniProtKB/Swiss-Prot),   Q8K466 (UniProtKB/Swiss-Prot),   Q8BLH5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001366296   ⟸   NM_001379367
- Peptide Label: isoform 2 precursor
Ensembl Acc Id: ENSMUSP00000059668   ⟸   ENSMUST00000051097
Ensembl Acc Id: ENSMUSP00000143092   ⟸   ENSMUST00000196027
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BLH5-F1-model_v2 AlphaFold Q8BLH5 1-439 view protein structure

Promoters
RGD ID:8671032
Promoter ID:EPDNEW_M13547
Type:multiple initiation site
Name:Prss50_1
Description:Mus musculus protease, serine 50 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,857,970 - 110,858,030EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2447303 AgrOrtholog
Ensembl Genes ENSMUSG00000048752 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000051097 ENTREZGENE
  ENSMUST00000051097.6 UniProtKB/Swiss-Prot
  ENSMUST00000196027.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:235631 UniProtKB/Swiss-Prot
MGD MGI:2447303 ENTREZGENE
NCBI Gene 235631 ENTREZGENE
PANTHER CHYMOTRYPSIN-LIKE PROTEASE CTRL-1 UniProtKB/Swiss-Prot
  CHYMOTRYPSIN-RELATED UniProtKB/Swiss-Prot
  THREONINE PROTEASE PRSS50-RELATED UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prss50 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JFA6_MOUSE UniProtKB/TrEMBL
  B2RWS9 ENTREZGENE
  Q8BLH5 ENTREZGENE
  Q8K466 ENTREZGENE
  TSP50_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary B2RWS9 UniProtKB/Swiss-Prot
  Q8K466 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-29 Prss50  serine protease 50  Prss50  protease, serine 50  Symbol and/or name change 5135510 APPROVED
2013-11-26 Prss50  protease, serine 50    protease, serine, 50  Symbol and/or name change 5135510 APPROVED
2011-07-27 Prss50  protease, serine, 50  Tsp50  testes-specific protease 50  Symbol and/or name change 5135510 APPROVED