PRSS50 (serine protease 50) - Rat Genome Database

Name: PRSS50
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: PRSS50 (serine protease 50) Pan paniscus

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Symbol:

PRSS50

Name:

serine protease 50

RGD ID:

11961541

Description:

ENCODES a protein that exhibits peptidase activity (inferred); serine-type endopeptidase activity (inferred); threonine-type endopeptidase activity (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

probable threonine protease PRSS50; protease, serine 50

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PRSS50 (serine protease 50)	NCBI	Ortholog
Mus musculus (house mouse):	Prss50 (serine protease 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Prss50 (serine protease 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Prss50 (serine protease 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PRSS50 (serine protease 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Prss50 (serine protease 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PRSS50 (serine protease 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103227551 (serine protease 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Prss50 (serine protease 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	46,667,914 - 46,674,227 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	46,672,684 - 46,678,997 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	46,610,119 - 46,616,435 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	47,713,568 - 47,719,706 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	47,713,699 - 47,719,315 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteolysis (IEA)

Cellular Component

cytoplasm (IEA)

endoplasmic reticulum (IEA)

Molecular Function

peptidase activity (IEA)

serine-type endopeptidase activity (IEA)

threonine-type endopeptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PRSS50
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	46,667,914 - 46,674,227 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	46,672,684 - 46,678,997 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	46,610,119 - 46,616,435 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	47,713,568 - 47,719,706 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	47,713,699 - 47,719,315 (-)	Ensembl	panpan1.1		panPan2

PRSS50
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	46,712,117 - 46,717,869 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	46,712,117 - 46,717,869 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	46,753,607 - 46,759,359 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	46,728,610 - 46,734,368 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	46,692,302 - 46,698,069 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	46,796,456 - 46,802,223 (-)	NCBI		HuRef
CHM1_1	3	46,703,722 - 46,709,489 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	46,728,202 - 46,733,954 (-)	NCBI		T2T-CHM13v2.0

Prss50
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	110,687,032 - 110,693,697 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	110,687,035 - 110,693,697 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	110,857,964 - 110,864,629 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	110,857,967 - 110,864,629 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	110,760,471 - 110,767,132 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	111,964,631 - 111,971,369 (+)	NCBI		MGSCv36	mm8
MGSCv36	9	110,702,783 - 110,709,444 (+)	NCBI		MGSCv36	mm8
Celera	9	110,589,938 - 110,590,855 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	60.79	NCBI

Prss50
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	119,719,574 - 119,727,269 (+)	NCBI		GRCr8
mRatBN7.2	8	110,842,525 - 110,848,855 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	110,842,671 - 110,848,802 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	119,134,966 - 119,141,255 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	119,135,013 - 119,141,150 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	118,473,353 - 118,479,663 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	110,125,130 - 110,131,417 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Prss50
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955420	25,424,082 - 25,427,705 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRSS50
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	42,046,177 - 42,051,517 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	41,962,573 - 41,967,707 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	42,528,974 - 42,534,105 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	42,528,989 - 42,534,105 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	41,770,289 - 41,775,396 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	42,171,301 - 42,176,453 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	42,452,345 - 42,457,480 (+)	NCBI		UU_Cfam_GSD_1.0

Prss50
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	200,992,631 - 200,998,921 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	541,918 - 546,364 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	541,918 - 544,866 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRSS50
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	29,632,886 - 29,639,045 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	29,633,575 - 29,638,994 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	33,030,971 - 33,036,221 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103227551
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	8,135,011 - 8,142,455 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	8,135,046 - 8,140,809 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	159,009,233 - 159,015,033 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prss50
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	74,494,152 - 74,497,473 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008971799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034956284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000004214 ⟹ ENSPPAP00000000910

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	47,713,699 - 47,719,315 (-)	Ensembl

RefSeq Acc Id:

XM_008971799 ⟹ XP_008970047

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	46,667,914 - 46,674,227 (-)	NCBI
NHGRI_mPanPan1	3	46,672,684 - 46,678,997 (-)	NCBI
Mhudiblu_PPA_v0	3	46,610,180 - 46,616,193 (-)	NCBI
PanPan1.1	3	47,713,568 - 47,719,706 (-)	NCBI

Sequence:

show sequence

TCTCACTGCGGGAGGTGTGACACCATGAGCCAGTCCAGGGCAATGGGCTGCAAGGGTGAGGAGG
TCTGAGAATCGGCCGAGGTTAAGTTGAGGGACTCCAGGAGACTGCTTGGACCAGCGGAGTGAGG
AGAGGGAGGGGCCAAGGAGGGAAGTCAGCCGGGGCGTACCCAGCCCGGGAGGTATAAGGGAGGG
CTGTCACTAGGGGCGCCCTTGCGGGTCAGACACCACGAGCGCCGTGGCGGGTGGCCCCTGGGGG
GCGCCACGCAGGCGGGGCACTAGGAGCCTCCCCACCCAGCTCACCAGAGGCCGCGGCATGCGGC
CAACAGGGGCGCCGTCGTGGGGCGGCACTGGGAGCGCCTTCCGGAGAGACGCAGTCGGCTGCCA
CCCAGGGATGGGTCGCTGGTGCCAGACCGTCGCGCGCGGGCAGNCGCCCCGGACGTCTGCCCCC
TCCCGCGCCGGTGCCCTGCTGCTGCTGCTTCTGTTGCTGAGCTCTGCAGGTTGCTGGGGCGCAG
GGGAAGCCCCGGGGGCGCTGTCCACTGCTGATCCCGCCGACCAGAGCGTCCAGTGTGTCCCCAA
GGCCACCTGTCCTTCCAGCCGGCCTCGCCTTCTCTGGCAGACCCCGACCACCCAGACACTGCCC
TCGACCACCATGGAGACCCAATTCCCAGTTTCTGAAGGCAAAGTCGACCCATACCGCTCCTGTG
GCTTTTCCTATGAGCAGGACCCCACCCTCAGGGACCCAGAAGGCGTGGCTCGGCGGTGGCCCTG
GATGGTCAGCGTGCGGGCCAATGGCACACACATCTGTGCCGGCACCATCATTGCCTCCCAGTGG
GTGCTGACTGTGGCCCACTGCCTGATCCGGTGTGATGTTATCTACTCAGTGAGGGTGGGGAGTC
CGTGGATTGACCAGATGACGCAGACCGCCTCCGATGTCCCGGTGCTCCAGGTCATCATGCATAG
CAGGTACCGGGCCCAGCGGTTCTGGTCCTGGGTGGGCCAGGCCAACGACATCGGCCTCCTCAAG
CTCAAGCAGGAACTCAAGTACAGCAATTATGTGCGGCCCATCTGCCTGCCTGGCACGGACTATG
TGTTGAAGGACCATTCCCGCTGCACTGTGACGGGCTGGGGACTTTCCAAGGCTGACGGCATGTG
GCCTCAGTTCCGGACCATTCAGGAGAAGGAAGTCATCATCCTGAACAACAAAGAGTGTGACAAT
TTCTACCACAACTTCACCAAAATCCCCACTCTGGTTCGGATCATCAAGTCCCAGATGATGTGTG
CGGAGGACACCCACAGGGAGAAGTTCTGCTATGAGCTAACTGGAGAGCCCTTGGTCTGCTCCAT
GGAGGGCACGTGGTACCTGGTGGGATTGGTGAGCTGGGGTGCAGGCTGCCAGAAGAGCGAGGCC
CCACCCATCTACCTACAGGTCTCCTCCTACCAACACTGGATCTGGGACTGCCTCAACGGGCAGG
CCCTGGCCCTGCCAGCCCCATCCAGGACCCTGCTCCTGGCACTCCCACTGCCCCTCAGCCTCCT
TGCTGCCCTCTGACTCCGTGTGCCCTCCCTCACTTGTGGGCCCCCCTTGCCTCCGTGCCCAGGT
TGCTGTGGGTGCAGCTCTCACAGCCCTGAGAGTCAGGGTGGAGACGAGGTGCTCAATTAAACAT
TACTGTTTTCCATGCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_008970047	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000000910.1

RefSeq Acc Id:

XP_008970047 ⟸ XM_008971799

- UniProtKB:

A0A2R8ZBM2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRPTGAPSWGGTGSAFRRDAVGCHPGMGRWCQTVARGQXPRTSAPSRAGALLLLLLLLSSAGCW
GAGEAPGALSTADPADQSVQCVPKATCPSSRPRLLWQTPTTQTLPSTTMETQFPVSEGKVDPYR
SCGFSYEQDPTLRDPEGVARRWPWMVSVRANGTHICAGTIIASQWVLTVAHCLIRCDVIYSVRV
GSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGT
DYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVRIIKSQM
MCAEDTHREKFCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLN
GQALALPAPSRTLLLALPLPLSLLAAL

hide sequence

Ensembl Acc Id:

ENSPPAP00000000910 ⟸ ENSPPAT00000004214

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000003698	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000004214.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
NCBI Gene	PRSS50	ENTREZGENE
PANTHER	THREONINE PROTEASE PRSS50-RELATED	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEASE SERINE	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	A0A2R8ZBM2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-23	PRSS50	serine protease 50		protease, serine 50	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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