Cdk5r2 (cyclin-dependent kinase 5, regulatory subunit 2 (p39)) - Rat Genome Database

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Gene: Cdk5r2 (cyclin-dependent kinase 5, regulatory subunit 2 (p39)) Mus musculus
Analyze
Symbol: Cdk5r2
Name: cyclin-dependent kinase 5, regulatory subunit 2 (p39)
RGD ID: 1558190
MGI Page MGI
Description: Enables actin binding activity and cyclin-dependent protein serine/threonine kinase activator activity. Acts upstream of or within nervous system development; positive regulation of calcium ion-dependent exocytosis; and positive regulation of protein kinase activity. Located in cytoplasm. Is expressed in several structures, including nervous system and retina. Orthologous to human CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2); INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B230310J22Rik; CDK5 activator 2; cyclin-dependent kinase 5 activator 2; cyclin-dependent kinase 5 regulatory subunit 2; p3; p39; p39I; RIKEN cDNA B230310J22 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,894,188 - 74,896,891 (+)NCBIGRCm39mm39
GRCm39 Ensembl174,894,093 - 74,896,891 (+)Ensembl
GRCm38174,855,029 - 74,857,732 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,854,934 - 74,857,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,901,603 - 74,904,306 (+)NCBIGRCm37mm9NCBIm37
MGSCv36174,788,305 - 74,789,414 (+)NCBImm8
Celera175,410,113 - 75,412,816 (+)NCBICelera
Cytogenetic Map1C4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
1. MGD data from the GO Consortium
2. MGD IEA
3. RGD automated import pipeline
4. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9581970   PMID:9655938   PMID:10349636   PMID:10683146   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11226314   PMID:11239428   PMID:11517264   PMID:11859196  
PMID:12223541   PMID:12466851   PMID:12477932   PMID:12496365   PMID:12516540   PMID:12699769   PMID:14985430   PMID:15123626   PMID:15226823   PMID:15908038   PMID:16141072   PMID:16141073  
PMID:16600913   PMID:16602821   PMID:18507738   PMID:19017796   PMID:21267068   PMID:23029270   PMID:23645679   PMID:24085300   PMID:24872417   PMID:24877974   PMID:25404468   PMID:26961956  
PMID:27480591   PMID:27807169   PMID:28969475   PMID:33127972  


Genomics

Comparative Map Data
Cdk5r2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,894,188 - 74,896,891 (+)NCBIGRCm39mm39
GRCm39 Ensembl174,894,093 - 74,896,891 (+)Ensembl
GRCm38174,855,029 - 74,857,732 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,854,934 - 74,857,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,901,603 - 74,904,306 (+)NCBIGRCm37mm9NCBIm37
MGSCv36174,788,305 - 74,789,414 (+)NCBImm8
Celera175,410,113 - 75,412,816 (+)NCBICelera
Cytogenetic Map1C4NCBI
CDK5R2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2218,959,666 - 218,962,155 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,959,666 - 218,962,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,824,388 - 219,826,877 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,532,642 - 219,535,121 (+)NCBINCBI36hg18NCBI36
Build 342219,649,902 - 219,652,381NCBI
Celera2213,594,140 - 213,596,619 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2211,678,607 - 211,680,905 (+)NCBIHuRef
CHM1_12219,831,707 - 219,834,234 (+)NCBICHM1_1
Cdk5r2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2976,416,251 - 76,417,719 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl976,416,062 - 76,418,344 (+)Ensembl
Rnor_6.0982,120,059 - 82,121,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,120,059 - 82,121,527 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0981,888,640 - 81,890,108 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,191,842 - 74,193,310 (+)NCBIRGSC3.4rn4RGSC3.4
Celera973,987,770 - 73,989,238 (+)NCBICelera
Cytogenetic Map9q33NCBI
Cdk5r2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,472,757 - 14,473,896 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545314,471,625 - 14,474,082 (-)NCBIChiLan1.0ChiLan1.0
CDK5R2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B224,810,584 - 224,813,739 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02B106,217,926 - 106,220,444 (+)NCBIMhudiblu_PPA_v0panPan3
CDK5R2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,528,934 - 25,535,795 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,529,151 - 25,530,263 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3726,349,294 - 26,350,503 (+)NCBI
ROS_Cfam_1.03725,544,512 - 25,545,721 (+)NCBI
UMICH_Zoey_3.13725,449,138 - 25,450,347 (+)NCBI
UNSW_CanFamBas_1.03725,384,173 - 25,385,381 (+)NCBI
UU_Cfam_GSD_1.03725,404,961 - 25,406,170 (+)NCBI
Cdk5r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,038,311 - 175,040,812 (+)NCBI
SpeTri2.0NW_0049365691,381,101 - 1,383,593 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK5R2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,985,245 - 120,991,318 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115120,985,069 - 120,990,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,924,680 - 133,927,298 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK5R2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,858,260 - 104,860,795 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,858,461 - 104,859,564 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604094,532,588 - 94,535,131 (-)NCBIVero_WHO_p1.0
Cdk5r2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248236,053,469 - 6,054,748 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
UniSTS:484839  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38174,855,098 - 74,856,207UniSTSGRCm38
MGSCv37174,901,672 - 74,902,781UniSTSGRCm37
Celera175,410,182 - 75,411,291UniSTS
Cytogenetic Map1C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1357721Sle17_msystematic lupus erythematosus susceptibility 17 (mouse)Not determined139093727126517573Mouse
1301166Thypr2_mthymocyte proliferative response 2 (mouse)Not determined14123396575234112Mouse
18182931Metl1_mmetabolite locus 1, pyridoxate (mouse)14123624075236240Mouse
4141032Wbcc1_mwhite blood cell count 1 (mouse)Not determined4222050876220508Mouse
1301714Vertcling_mvertical clinging (mouse)Not determined14289887276899008Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
1301670Ssta1_msusceptibility to Salmonella typhimurium antigens 1 (mouse)Not determined14590759679907723Mouse
1301225Sle7_msystematic lupus erythematosus susceptibility 7 (mouse)Not determined14681553180815680Mouse
1301616Yaa2_mY-linked autoimmune acceleration 2 (mouse)Not determined14681553180815680Mouse
1558905Gct7_mgranulosa cell tumorigenesis 7 (mouse)Not determined14731073581310854Mouse
1558822Vas1_mautoimmune vasitis resistance 1 (mouse)Not determined14884984782850051Mouse
1301211Bbaa11_mB.burgdorferi-associated arthritis 11 (mouse)Not determined14884984782850051Mouse
1301430Cdcs2_mcytokine deficiency colitis susceptibility 2 (mouse)Not determined14885318682853326Mouse
10043965Obq24_mobesity QTL 24 (mouse)Not determined15085105784851057Mouse
4141305Tgq9_mtriglyceride QTL 9 (mouse)Not determined5138244685382446Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
1357741Nidd5k_mNidd5 on KK-A<y> (mouse)Not determined15593578989935898Mouse
1357505Vtbt1_mvertebral trabecular bone trait 1 (mouse)Not determined15622705590227201Mouse
4142467Wbcq1_mwhite blood cell quantitative locus 1 (mouse)Not determined15622705590227201Mouse
1301933Insq6_minsulin QTL 6 (mouse)Not determined15668776390687918Mouse
1558717Ses1a_msalmonella enteritidis susceptibility 1a (mouse)Not determined15668776390687918Mouse
14746998Mancz1_mmandible centroid size 1 (mouse)15790219291902192Mouse
14747009Manh49_mmandible shape 49 (mouse)15790219291902192Mouse
1300746Skl1_mskeletal size (tail length) 1 (mouse)Not determined15795281891952921Mouse
1357679Egrm1_mearly growth rate, maternal effect 1 (mouse)Not determined15795281891952921Mouse
1301162Skull1_mskull morphology 1 (mouse)Not determined15795281891952921Mouse
1301444Alcw5_malcohol withdrawal 5 (mouse)Not determined15857254792572799Mouse
1301667Lxw5_mlupus BXSB x NZW 5 (mouse)Not determined15857254792572799Mouse
1301748Abbp1_mA/J and C57BL/6 blood pressure 1 (mouse)Not determined162907596120601949Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
1302119Cia15_mcollagen induced arthritis 15 (mouse)Not determined16584984788568379Mouse
27095918Ulnl1_mulna length 1, 5 week (mouse)167300000129800000Mouse
4141625Emo4_memotionality 4 (mouse)Not determined6803218686307305Mouse
1302146Cocrb1_mcocaine related behavior 1 (mouse)Not determined170205811104211835Mouse
4141393Mol2_mmodifier of LPS-response 2 (mouse)Not determined7158552078206507Mouse
1300976Bmd19_mbone mineral density 19 (mouse)Not determined173227055108910684Mouse
4142394Mssq1_mmandible size and shape QTL 1 (mouse)Not determined73687970107688108Mouse
1301304Hrq3_mheart rate quantitative locus 3 (mouse)Not determined173687970107688108Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
14697705Stsl3b_mSalmonella typhimurium susceptibility locus 3b (mouse)17410000081800000Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:694
Count of miRNA genes:396
Interacting mature miRNAs:461
Transcripts:ENSMUST00000160379
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000160379   ⟹   ENSMUSP00000125322
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl174,894,093 - 74,896,891 (+)Ensembl
GRCm38.p6 Ensembl174,854,934 - 74,857,732 (+)Ensembl
RefSeq Acc Id: NM_009872   ⟹   NP_034002
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39174,894,188 - 74,896,891 (+)NCBI
GRCm38174,855,029 - 74,857,732 (+)ENTREZGENE
MGSCv37174,901,603 - 74,904,306 (+)RGD
Celera175,410,113 - 75,412,816 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034002   ⟸   NM_009872
- UniProtKB: O35926 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000125322   ⟸   ENSMUST00000160379

Promoters
RGD ID:6874104
Promoter ID:EPDNEW_M503
Type:initiation region
Name:Cdk5r2_1
Description:Mus musculus cyclin-dependent kinase 5, regulatory subunit 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38174,854,938 - 74,854,998EPDNEW
RGD ID:6817500
Promoter ID:MM_KWN:1202
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:ENSMUST00000041620,   NM_009872
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36174,901,416 - 74,903,217 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1330828 AgrOrtholog
Ensembl Genes ENSMUSG00000033204
  ENSMUSG00000090071 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000125322 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000160379 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro CDK5_activator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12570 UniProtKB/Swiss-Prot
MGD MGI:1330828 ENTREZGENE
NCBI Gene 12570 ENTREZGENE
PANTHER PTHR23401 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CDK5_activator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk5r2 PhenoGen
PIRSF Cdk5_activator UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CD5R2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q496T6_MOUSE UniProtKB/TrEMBL
  Q496T7_MOUSE UniProtKB/TrEMBL
UniProt Secondary O35277 UniProtKB/Swiss-Prot
  Q9QYD1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Cdk5r2  cyclin-dependent kinase 5, regulatory subunit 2 (p39)  B230310J22Rik  RIKEN cDNA B230310J22 gene  Data Merged 737654 PROVISIONAL