Apc<sup>Pirc</sup> (APC, WNT signaling pathway regulator; polyposis in the rat colon) - Rat Genome Database

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Pathways
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Gene: ApcPirc (APC, WNT signaling pathway regulator; polyposis in the rat colon) Rattus norvegicus
Analyze
Symbol: ApcPirc
Name: APC, WNT signaling pathway regulator; polyposis in the rat colon
RGD ID: 1554322
Description: Pirc allele of the adenomatous polyposis coli gene; associated with Pirc-polyposis in colon. A to T transversion at nucleotide 3409 of the coding sequence. (AAG.TAG) Amino acid 1137 (K.Xam).
ASSOCIATED WITH anemia; colon polyps; extended life span; ASSOCIATED WITH anemia; colon adenocarcinoma; Colonic Neoplasms
Type: allele  of Apc  
Previously known as: adenomatous polyposis coli; APC, WNT signaling pathway regulator; apcam1137; Apc^[Pirc]; ApcPirc
Is Marker For: Strains:   F344-ApcPirc/Uwm   BN.F344-ApcPirc   ACI.F344-ApcPircUwm  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Amos-Landgraf JM, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4036-41. Epub 2007 Feb 27.

Genomics


Related Rat Strains
The following Strains have been annotated to ApcPirc
ACI.F344-ApcPircUwm     BN.F344-ApcPirc     F344-ApcPirc/Uwm    


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-03 ApcPirc  APC, WNT signaling pathway regulator; polyposis in the rat colon  ApcPirc  APC, WNT signaling pathway regulator  Name changed 629549 APPROVED
2018-04-03 ApcPirc  APC, WNT signaling pathway regulator  ApcPirc  adenomatous polyposis coli  Name changed 629549 APPROVED