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Strain Registration

Strain: F344-ApcPirc/Uwm

Symbol: F344-ApcPirc/Uwm
Strain: F344-ApcPirc
Substrain: Uwm
RGD ID: 1641862
Citation ID: RRID:RRRC_00782
Ontology ID: RS:0001236
Alleles: ApcPirc
Also Known As: F344-Apcm1Uwm; Pirc; polyposis in the rat colon (Pirc) kindred; F344-ApcPircUwm; F344-ApcPircUwm; F344-Apc^[Pirc]/Uwm
Type: mutant
Available Source: Rat Resource and Research Center
Origination: University of Wisconsin-Madison, Madison, Wisconsin
Description: Male F344/NTac rats were injected with ENU (N-ethyl-N-nitrosourea) and then bred. Phenotypically variant pups were screened. A to T transversion at nucleotide 3409 of the coding sequence. (AAG.TAG) Amino acid 1137 (K.Xam)
Genetic Status: Heterozygous
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2018-07-16)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21825,828,558 - 25,925,511RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01827,011,710 - 27,106,323RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01826,725,560 - 26,820,837RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41826,732,147 - 26,790,383RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Amos-Landgraf JM, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4036-41. Epub 2007 Feb 27.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other more tumors were developed in the intestinal tract of males than females 1601201

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-14 F344-ApcPirc/Uwm    F344-ApcPircUwm    Symbol and/or name change 68913 APPROVED
2014-03-21 F344-ApcPircUwm    F344-ApcPircUwm    Symbol updated 68687 APPROVED
2014-03-21 F344-ApcPircUwm    F344-ApcPircUwm    Name updated 68913 APPROVED
2014-03-21 F344-ApcPircUwm    F344-ApcPircUwm    Symbol updated 68687 APPROVED
2014-03-21 F344-ApcPircUwm    F344-ApcPircUwm    Name updated 68913 APPROVED
2010-06-08 F344-ApcPircUwm    F344-ApcPirc/Uwm    Symbol updated 68687 APPROVED
2010-06-08 F344-ApcPircUwm    F344-ApcPirc/Uwm    Name updated 68913 APPROVED
2010-06-08 F344-ApcPircUwm    F344-ApcPirc/Uwm    Symbol updated 68687 APPROVED
2010-06-08 F344-ApcPircUwm    F344-ApcPirc/Uwm    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00782 RGD