Strain Report - Rat Genome Database

Name: F344- Apc Pirc /Uwm
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Strain Registration

General

Strain: F344-Apc^Pirc/Uwm

Symbol:

F344-Apc^Pirc/Uwm

Strain:

F344-Apc^Pirc

Substrain:

Uwm

RGD ID:

1641862

Citation ID:

RRID:RRRC_00782

Ontology ID:

RS:0001236

Alleles:

Apc^Pirc

Previously known as:

F344-Apcm1Uwm; Pirc; polyposis in the rat colon (Pirc) kindred; F344-ApcPircUwm; F344-Apc^PircUwm

Type:

mutant

Source:

University of Wisconsin-Madison, Madison, Wisconsin, Rat Resource and Research Center

Origin:

Male F344/NTac rats were injected with ENU (N-ethyl-N-nitrosourea) and then bred. Phenotypically variant pups were screened. A to T transversion at nucleotide 3409 of the coding sequence. (AAG.TAG) Amino acid 1137 (K.Xam)

Genetic Status:

Heterozygous

Last Known Status:

Live Animals; Cryopreserved Sperm (as of 2018-07-16)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	25,828,558 - 25,925,511	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	18	27,011,710 - 27,106,323	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	18	26,725,560 - 26,820,837	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	18	26,732,147 - 26,790,383	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anemia (IMP)

Colonic Neoplasms (IMP)

Colonic Polyps (IMP)

familial adenomatous polyposis (IMP)

Intestinal Neoplasms (IMP)

Jaw Neoplasms (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

anemia (IMP)

colon polyps (IMP)

extended life span (IMP)

increased colon adenoma incidence (IMP)

increased intestinal adenocarcinoma incidence (IMP)

rectal hemorrhage (IMP)

weight loss (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer.	Amos-Landgraf JM, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4036-41. Epub 2007 Feb 27.
2.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_other	more tumors were developed in the intestinal tract of males than females	1601201

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2021-05-14	F344-Apc^Pirc/Uwm	F344-Apc^PircUwm	Symbol and/or name change	68913	APPROVED
2014-03-21	F344-Apc^PircUwm	F344-Apc^PircUwm	Symbol updated	68687	APPROVED
2014-03-21	F344-Apc^PircUwm	F344-Apc^PircUwm	Name updated	68913	APPROVED
2014-03-21	F344-Apc^PircUwm	F344-Apc^PircUwm	Symbol updated	68687	APPROVED
2014-03-21	F344-Apc^PircUwm	F344-Apc^PircUwm	Name updated	68913	APPROVED
2010-06-08	F344-Apc^PircUwm	F344-Apc^Pirc/Uwm	Symbol updated	68687	APPROVED
2010-06-08	F344-Apc^PircUwm	F344-Apc^Pirc/Uwm	Name updated	68913	APPROVED
2010-06-08	F344-Apc^PircUwm	F344-Apc^Pirc/Uwm	Symbol updated	68687	APPROVED
2010-06-08	F344-Apc^PircUwm	F344-Apc^Pirc/Uwm	Name updated	68913	APPROVED

External Database Links

Database	Acc Id	Source(s)
RRRC	RRRC:00782	RGD

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description:

Send us a Message

Strain: F344-ApcPirc/Uwm

Mammalian Phenotype

Strain: F344-Apc^Pirc/Uwm