Mia (MIA SH3 domain containing) - Rat Genome Database

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Gene: Mia (MIA SH3 domain containing) Mus musculus
Analyze
Symbol: Mia
Name: MIA SH3 domain containing
RGD ID: 1553187
MGI Page MGI
Description: Predicted to enable growth factor activity. Acts upstream of or within cell-matrix adhesion and extracellular matrix organization. Predicted to be located in extracellular region. Is expressed in several structures, including articular cartilage; autopod; respiratory system; sensory organ; and skeleton. Orthologous to human MIA (MIA SH3 domain containing).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cartilage derived retinoic acid sensitive protein; cartilage-derived retinoic acid-sensitive protein; Cd; CD-RAP; Cdrap; melanoma inhibatory activity; melanoma inhibitory activity; melanoma inhibitory activity 1; melanoma inhibitory activity protein; melanoma-derived growth regulatory protein; melanoma-inhibitory-activity; Mi; Mia1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,879,166 - 26,880,574 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,879,167 - 26,880,582 (-)EnsemblGRCm39 Ensembl
GRCm38727,179,741 - 27,181,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,179,742 - 27,181,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv37727,964,760 - 27,966,168 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36726,888,504 - 26,889,912 (-)NCBIMGSCv36mm8
Celera721,756,525 - 21,757,933 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Cloning of a retinoic acid-sensitive mRNA expressed in cartilage and during chondrogenesis. Dietz UH and Sandell LJ, J Biol Chem 1996 Feb 9;271(6):3311-6.
2. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. Garcia-Frigola C, etal., Brain Res Mol Brain Res 2004 Mar 30;122(2):133-50.
3. New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model. Kerachian MA, etal., Arthritis Res Ther. 2010;12(3):R124. doi: 10.1186/ar3062. Epub 2010 Jun 25.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7923218   PMID:8889548   PMID:9097023   PMID:10349636   PMID:10886506   PMID:11042159   PMID:11068204   PMID:11076861   PMID:11161796   PMID:11217851   PMID:11839810   PMID:12072435  
PMID:12477932   PMID:14531791   PMID:14610273   PMID:15028289   PMID:16141072   PMID:16141073   PMID:16250001   PMID:16602821   PMID:17914116   PMID:18342301   PMID:18799693   PMID:20164682  
PMID:21267068   PMID:21368873   PMID:21677750   PMID:21873635   PMID:22275070   PMID:22886976   PMID:24058167   PMID:24269712   PMID:24287514   PMID:24349210   PMID:24924191   PMID:30981829  
PMID:31172672   PMID:31669249   PMID:36672165   PMID:37591247  


Genomics

Comparative Map Data
Mia
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,879,166 - 26,880,574 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,879,167 - 26,880,582 (-)EnsemblGRCm39 Ensembl
GRCm38727,179,741 - 27,181,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,179,742 - 27,181,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv37727,964,760 - 27,966,168 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36726,888,504 - 26,889,912 (-)NCBIMGSCv36mm8
Celera721,756,525 - 21,757,933 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.84NCBI
MIA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,775,160 - 40,777,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,771,648 - 40,777,490 (+)EnsemblGRCh38hg38GRCh38
GRCh371941,281,065 - 41,283,395 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,973,140 - 45,975,235 (+)NCBINCBI36Build 36hg18NCBI36
Build 341945,973,217 - 45,975,236NCBI
Celera1938,081,704 - 38,083,799 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,714,333 - 37,716,652 (+)NCBIHuRef
CHM1_11941,280,768 - 41,283,084 (+)NCBICHM1_1
T2T-CHM13v2.01943,595,839 - 43,598,169 (+)NCBIT2T-CHM13v2.0
Mia
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,601,326 - 91,603,019 (-)NCBIGRCr8
mRatBN7.2182,473,677 - 82,476,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,473,678 - 82,475,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,877,083 - 87,878,775 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,363,644 - 96,365,325 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,632,949 - 89,634,641 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,991,577 - 83,993,270 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,991,578 - 83,993,270 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,202,515 - 85,205,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,255,458 - 82,257,125 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,333,568 - 82,335,236 (-)NCBI
Celera176,886,949 - 76,919,026 (-)NCBICelera
Cytogenetic Map1q21NCBI
Mia
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578570,142 - 572,938 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955578570,142 - 572,959 (-)NCBIChiLan1.0ChiLan1.0
MIA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,024,047 - 47,035,572 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,894,756 - 48,906,513 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,818,126 - 37,820,832 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,325,755 - 46,328,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,325,755 - 46,328,065 (+)Ensemblpanpan1.1panPan2
MIA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,012,765 - 113,016,742 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,415,186 - 112,419,930 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,611,202 - 113,615,977 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,611,284 - 113,613,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,170,604 - 113,175,225 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,802,594 - 112,807,333 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,796,710 - 113,801,485 (-)NCBIUU_Cfam_GSD_1.0
Mia
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,619,332 - 14,621,009 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366613,047,747 - 3,049,064 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366613,047,735 - 3,049,050 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,986,733 - 48,988,432 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,986,232 - 49,010,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,670,903 - 44,673,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,227,681 - 35,230,718 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl635,228,411 - 35,230,704 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607313,364,862 - 13,367,904 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mia
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925694,173 - 696,696 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624925691,195 - 696,696 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mia
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:232
Interacting mature miRNAs:245
Transcripts:ENSMUST00000071986, ENSMUST00000121848, ENSMUST00000127491
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000071986   ⟹   ENSMUSP00000071876
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl726,879,167 - 26,880,574 (-)Ensembl
GRCm38.p6 Ensembl727,179,742 - 27,181,149 (-)Ensembl
RefSeq Acc Id: ENSMUST00000121848   ⟹   ENSMUSP00000114063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl726,879,169 - 26,880,582 (-)Ensembl
GRCm38.p6 Ensembl727,179,744 - 27,181,157 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127491
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl726,879,169 - 26,880,552 (-)Ensembl
GRCm38.p6 Ensembl727,179,744 - 27,181,127 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl726,879,914 - 26,880,421 (-)Ensembl
GRCm38.p6 Ensembl727,180,489 - 27,180,996 (-)Ensembl
RefSeq Acc Id: NM_019394   ⟹   NP_062267
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39726,879,166 - 26,880,574 (-)NCBI
GRCm38727,179,741 - 27,181,149 (-)NCBI
MGSCv37727,964,760 - 27,966,168 (-)RGD
Celera721,756,525 - 21,757,933 (-)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062267   ⟸   NM_019394
- Peptide Label: precursor
- UniProtKB: O09086 (UniProtKB/Swiss-Prot),   P97495 (UniProtKB/Swiss-Prot),   Q61865 (UniProtKB/Swiss-Prot),   G5E8V2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000071876   ⟸   ENSMUST00000071986
RefSeq Acc Id: ENSMUSP00000114063   ⟸   ENSMUST00000121848
Protein Domains
SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61865-F1-model_v2 AlphaFold Q61865 1-130 view protein structure

Promoters
RGD ID:6892342
Promoter ID:EPDNEW_M9621
Type:initiation region
Name:Mia_1
Description:Mus musculus melanoma inhibitory activity , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38727,181,074 - 27,181,134EPDNEW
RGD ID:6841899
Promoter ID:MM_KWN:49518
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   MEF_B6
Transcripts:ENSMUST00000121848,   OTTMUST00000067274,   OTTMUST00000067286
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36727,966,026 - 27,966,902 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109615 AgrOrtholog
Ensembl Genes ENSMUSG00000058217
  ENSMUSG00000089661 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000071986 ENTREZGENE
  ENSMUST00000071986.13 UniProtKB/Swiss-Prot
  ENSMUST00000121848.2 UniProtKB/TrEMBL
Gene3D-CATH SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MIA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12587 UniProtKB/Swiss-Prot
MGD MGI:109615 ENTREZGENE
NCBI Gene 12587 ENTREZGENE
PANTHER MELANOMA-DERIVED GROWTH REGULATORY PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47312 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mia PhenoGen
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G5E8V2 ENTREZGENE, UniProtKB/TrEMBL
  MIA_MOUSE UniProtKB/Swiss-Prot
  O09086 ENTREZGENE
  P97495 ENTREZGENE
  Q3UXX0_MOUSE UniProtKB/TrEMBL
  Q61865 ENTREZGENE
UniProt Secondary O09086 UniProtKB/Swiss-Prot
  P97495 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-08-31 Mia  MIA SH3 domain containing  Mia  melanoma inhibitory activity  Symbol and/or name change 5135510 APPROVED
2013-02-20 Mia  melanoma inhibitory activity  Mia1  melanoma inhibitory activity 1  Symbol and/or name change 5135510 APPROVED