Bhlhb9 (basic helix-loop-helix domain containing, class B9) - Rat Genome Database

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Gene: Bhlhb9 (basic helix-loop-helix domain containing, class B9) Mus musculus
Analyze
Symbol: Bhlhb9
Name: basic helix-loop-helix domain containing, class B9
RGD ID: 1552602
MGI Page MGI
Description: Enables protein homodimerization activity. Involved in learning or memory; negative regulation of neuron apoptotic process; and positive regulation of nervous system development. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; sensory organ; skeleton; submandibular gland primordium; and trigeminal nerve. Orthologous to several human genes including GPRASP3 (G protein-coupled receptor associated sorting protein family member 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2700087I09Rik; G protein-coupled receptor associated sorting protein 3; Gprasp3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X134,742,388 - 134,791,828 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX134,698,343 - 134,791,830 (+)EnsemblGRCm39 Ensembl
GRCm38X135,841,639 - 135,891,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX135,797,594 - 135,891,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X132,420,390 - 132,425,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X131,235,266 - 131,237,439 (+)NCBIMGSCv36mm8
CeleraX119,202,603 - 119,207,835 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15368895   PMID:15747579   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:18799693   PMID:20436479   PMID:21199326   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22172954   PMID:23341629   PMID:23391701   PMID:23677977   PMID:37196079  


Genomics

Comparative Map Data
Bhlhb9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X134,742,388 - 134,791,828 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX134,698,343 - 134,791,830 (+)EnsemblGRCm39 Ensembl
GRCm38X135,841,639 - 135,891,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX135,797,594 - 135,891,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X132,420,390 - 132,425,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X131,235,266 - 131,237,439 (+)NCBIMGSCv36mm8
CeleraX119,202,603 - 119,207,835 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.31NCBI
GPRASP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X102,720,743 - 102,753,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX102,720,688 - 102,753,540 (+)EnsemblGRCh38hg38GRCh38
GRCh37X101,975,671 - 102,008,468 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X101,862,310 - 101,894,024 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X101,781,798 - 101,813,513NCBI
CeleraX102,414,680 - 102,446,406 (+)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX91,641,229 - 91,672,865 (+)NCBIHuRef
CHM1_1X101,868,307 - 101,900,034 (+)NCBICHM1_1
T2T-CHM13v2.0X101,165,692 - 101,198,489 (+)NCBIT2T-CHM13v2.0
Gprasp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,639,366 - 103,644,561 (+)NCBIGRCr8
mRatBN7.2X98,847,591 - 98,854,949 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,817,593 - 98,854,545 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX100,985,493 - 100,988,191 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,496,103 - 104,498,801 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,047,888 - 102,050,587 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,359,981 - 106,393,457 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,390,759 - 106,393,459 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X106,726,766 - 106,739,896 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X123,149,086 - 123,151,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X123,222,518 - 123,225,279 (+)NCBI
CeleraX100,291,299 - 100,293,998 (-)NCBICelera
Cytogenetic MapXq32NCBI
Gprasp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955548230,525 - 236,043 (+)NCBIChiLan1.0ChiLan1.0
GPRASP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X102,327,152 - 102,360,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X102,330,757 - 102,363,242 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,944,691 - 91,978,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X102,324,471 - 102,358,183 (+)NCBIpanpan1.1PanPan1.1panPan2
GPRASP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X76,635,887 - 76,651,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX76,636,667 - 76,638,319 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X77,830,292 - 77,845,859 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX77,695,389 - 77,846,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X75,380,346 - 75,395,910 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X77,043,280 - 77,058,840 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X76,753,328 - 76,768,896 (+)NCBIUU_Cfam_GSD_1.0
Gprasp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,370,715 - 62,375,944 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049368131,099,164 - 1,137,974 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPRASP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X83,895,554 - 83,911,573 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,835,521 - 97,851,537 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPRASP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X90,695,125 - 90,735,910 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606515,532,543 - 15,573,372 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Bhlhb9
1235 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:415
Count of miRNA genes:262
Interacting mature miRNAs:297
Transcripts:ENSMUST00000068755, ENSMUST00000148374, ENSMUST00000151989, ENSMUST00000180025
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001098222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_198161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006528608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011247760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK012577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL683822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB863588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP760224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY272101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF729268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK625652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LXEJ02009303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000068755   ⟹   ENSMUSP00000068067
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX134,786,602 - 134,791,830 (+)Ensembl
GRCm38.p6 EnsemblX135,885,853 - 135,891,081 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148374   ⟹   ENSMUSP00000121154
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX134,786,602 - 134,790,075 (+)Ensembl
GRCm38.p6 EnsemblX135,885,853 - 135,889,326 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151989
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX134,786,732 - 134,788,219 (+)Ensembl
GRCm38.p6 EnsemblX135,885,983 - 135,887,470 (+)Ensembl
Ensembl Acc Id: ENSMUST00000180025   ⟹   ENSMUSP00000137213
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX134,786,600 - 134,791,827 (+)Ensembl
GRCm38.p6 EnsemblX135,885,851 - 135,891,078 (+)Ensembl
Ensembl Acc Id: ENSMUST00000207433
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX134,698,343 - 134,791,613 (+)Ensembl
GRCm38.p6 EnsemblX135,797,594 - 135,890,864 (+)Ensembl
RefSeq Acc Id: NM_001098222   ⟹   NP_001091692
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X134,786,676 - 134,791,828 (+)NCBI
GRCm38X135,885,851 - 135,891,081 (+)NCBI
MGSCv37X132,420,390 - 132,425,620 (+)RGD
CeleraX119,202,603 - 119,207,835 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_198161   ⟹   NP_937804
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X134,786,676 - 134,791,828 (+)NCBI
GRCm38X135,885,851 - 135,891,081 (+)NCBI
MGSCv37X132,420,390 - 132,425,620 (+)RGD
CeleraX119,202,603 - 119,207,835 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528608   ⟹   XP_006528671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X134,746,680 - 134,791,828 (+)NCBI
GRCm38X135,841,639 - 135,891,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011247760   ⟹   XP_011246062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X134,742,388 - 134,791,828 (+)NCBI
GRCm38X135,841,639 - 135,891,079 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162091   ⟹   XP_036017984
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X134,746,680 - 134,791,828 (+)NCBI
Sequence:
RefSeq Acc Id: NP_937804   ⟸   NM_198161
- UniProtKB: Q3U0C1 (UniProtKB/Swiss-Prot),   Q69ZD0 (UniProtKB/Swiss-Prot),   Q6PB60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001091692   ⟸   NM_001098222
- UniProtKB: Q3U0C1 (UniProtKB/Swiss-Prot),   Q69ZD0 (UniProtKB/Swiss-Prot),   Q6PB60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006528671   ⟸   XM_006528608
- Peptide Label: isoform X1
- UniProtKB: Q3U0C1 (UniProtKB/Swiss-Prot),   Q69ZD0 (UniProtKB/Swiss-Prot),   Q6PB60 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011246062   ⟸   XM_011247760
- Peptide Label: isoform X1
- UniProtKB: Q3U0C1 (UniProtKB/Swiss-Prot),   Q69ZD0 (UniProtKB/Swiss-Prot),   Q6PB60 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000068067   ⟸   ENSMUST00000068755
Ensembl Acc Id: ENSMUSP00000121154   ⟸   ENSMUST00000148374
Ensembl Acc Id: ENSMUSP00000137213   ⟸   ENSMUST00000180025
RefSeq Acc Id: XP_036017984   ⟸   XM_036162091
- Peptide Label: isoform X1
- UniProtKB: Q6PB60 (UniProtKB/Swiss-Prot),   Q3U0C1 (UniProtKB/Swiss-Prot),   Q69ZD0 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PB60-F1-model_v2 AlphaFold Q6PB60 1-539 view protein structure

Promoters
RGD ID:6845532
Promoter ID:MM_KWN:61932
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Brain,   ES_Cell,   Kidney,   MEF_B4,   Spleen
Transcripts:NM_001098222,   NM_198161,   OTTMUST00000045135
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X132,419,966 - 132,420,597 (+)MPROMDB
RGD ID:6845529
Promoter ID:MM_KWN:61933
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000113141
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X132,423,896 - 132,424,447 (+)MPROMDB
RGD ID:13681400
Promoter ID:EPDNEW_M24849
Type:single initiation site
Name:Bhlhb9_2
Description:Mus musculus basic helix-loop-helix domain containing, classB9 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24850  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X135,866,685 - 135,866,745EPDNEW
RGD ID:13681402
Promoter ID:EPDNEW_M24850
Type:initiation region
Name:Bhlhb9_1
Description:Mus musculus basic helix-loop-helix domain containing, classB9 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24849  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X135,885,927 - 135,885,987EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917487 AgrOrtholog
Ensembl Genes ENSMUSG00000055275
  ENSMUSG00000072964 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000068755 ENTREZGENE
  ENSMUST00000068755.14 UniProtKB/Swiss-Prot
  ENSMUST00000148374.8 UniProtKB/TrEMBL
  ENSMUST00000180025 ENTREZGENE
  ENSMUST00000180025.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-rpt_dom UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  BHLHb9/GASP-1/GASP-2 UniProtKB/Swiss-Prot
KEGG Report mmu:70237 UniProtKB/Swiss-Prot
MGD MGI:1917487 ENTREZGENE
NCBI Gene 70237 ENTREZGENE
PANTHER PROTEIN BHLHB9 UniProtKB/Swiss-Prot
  PTHR46414 UniProtKB/Swiss-Prot
Pfam Arm_2 UniProtKB/Swiss-Prot
PhenoGen Bhlhb9 PhenoGen
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt A2AGB8_MOUSE UniProtKB/TrEMBL
  BHLH9_MOUSE UniProtKB/Swiss-Prot
  Q3U0C1 ENTREZGENE
  Q69ZD0 ENTREZGENE
  Q6PB60 ENTREZGENE
UniProt Secondary Q3U0C1 UniProtKB/Swiss-Prot
  Q69ZD0 UniProtKB/Swiss-Prot