Zbtb6 (zinc finger and BTB domain containing 6) - Rat Genome Database

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Gene: Zbtb6 (zinc finger and BTB domain containing 6) Mus musculus
Analyze
Symbol: Zbtb6
Name: zinc finger and BTB domain containing 6
RGD ID: 1550368
MGI Page MGI
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in mitochondrion. Predicted to be active in nucleoplasm. Is expressed in several structures, including bladder; intestine smooth muscle circular layer; nervous system; and retina. Orthologous to human ZBTB6 (zinc finger and BTB domain containing 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A830092L04Rik; MGC41441; Zfp48; Zfp482; ZID; zinc finger and BTB domain-containing protein 6; zinc finger protein 482
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39237,315,512 - 37,320,931 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl237,315,512 - 37,333,183 (-)EnsemblGRCm39 Ensembl
GRCm38237,425,500 - 37,430,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl237,425,500 - 37,443,171 (-)EnsemblGRCm38mm10GRCm38
MGSCv37237,281,020 - 37,286,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36237,248,854 - 37,252,872 (-)NCBIMGSCv36mm8
Celera237,109,509 - 37,114,928 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (ISO)
nucleoplasm  (IBA,ISO)
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12477932   PMID:12904583   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16919269  
PMID:18287559   PMID:18799693   PMID:20059953   PMID:21267068   PMID:21873635   PMID:22988430   PMID:26930384   PMID:32325033   PMID:34351428  


Genomics

Comparative Map Data
Zbtb6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39237,315,512 - 37,320,931 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl237,315,512 - 37,333,183 (-)EnsemblGRCm39 Ensembl
GRCm38237,425,500 - 37,430,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl237,425,500 - 37,443,171 (-)EnsemblGRCm38mm10GRCm38
MGSCv37237,281,020 - 37,286,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36237,248,854 - 37,252,872 (-)NCBIMGSCv36mm8
Celera237,109,509 - 37,114,928 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
ZBTB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,908,056 - 122,913,323 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,908,056 - 122,913,323 (-)EnsemblGRCh38hg38GRCh38
GRCh379125,670,335 - 125,675,602 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,710,150 - 124,715,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 349122,749,888 - 122,755,163NCBI
Celera996,318,642 - 96,323,916 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef995,285,160 - 95,290,432 (-)NCBIHuRef
CHM1_19125,818,992 - 125,824,264 (-)NCBICHM1_1
T2T-CHM13v2.09135,105,281 - 135,110,546 (-)NCBIT2T-CHM13v2.0
Zbtb6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8341,600,488 - 41,603,902 (-)NCBIGRCr8
mRatBN7.2321,189,160 - 21,207,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl321,187,483 - 21,207,849 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx324,659,008 - 24,662,493 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0333,243,971 - 33,247,457 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,054,780 - 31,058,196 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0321,679,181 - 21,697,532 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl321,680,727 - 21,684,132 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0326,918,356 - 26,936,619 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4317,187,505 - 17,190,919 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1317,084,933 - 17,087,572 (-)NCBI
Celera319,626,273 - 19,629,687 (-)NCBICelera
Cytogenetic Map3q11NCBI
Zbtb6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554195,031,584 - 5,052,526 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554195,031,584 - 5,052,538 (+)NCBIChiLan1.0ChiLan1.0
ZBTB6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,436,305 - 16,443,294 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1916,440,305 - 16,445,864 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0994,034,161 - 94,056,677 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19122,367,795 - 122,373,101 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9122,370,535 - 122,371,809 (-)Ensemblpanpan1.1panPan2
ZBTB6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1959,860,525 - 59,880,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl959,870,841 - 59,879,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha959,055,671 - 59,075,474 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0960,779,855 - 60,799,629 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl960,790,139 - 60,799,168 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1959,538,628 - 59,558,419 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0959,853,634 - 59,873,426 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0959,946,382 - 59,966,175 (+)NCBIUU_Cfam_GSD_1.0
Zbtb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947191,626,057 - 191,645,780 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648711,394,589 - 11,401,398 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZBTB6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1263,823,857 - 263,846,856 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11263,823,854 - 263,846,908 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21297,291,514 - 297,311,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZBTB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11215,203,582 - 15,226,507 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1215,222,963 - 15,224,237 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666079841,103 - 847,051 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zbtb6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476012,013,920 - 12,024,143 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476012,018,209 - 12,021,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zbtb6
198 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2059
Count of miRNA genes:542
Interacting mature miRNAs:714
Transcripts:ENSMUST00000053098, ENSMUST00000112932
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2767911541679261Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2823629642236396Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2830805142308240Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2938444643384575Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2938444643384575Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21421456748214713Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
12792980Fbmd1_mfemoral bone mineral density 1, females only (mouse)22503449245034492Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23120303544508204Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
13464253Ifvrq1_minfluenza virus resistance QTL 1 (mouse)23303449252034492Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse

Markers in Region
BE099743  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38237,432,249 - 37,432,396UniSTSGRCm38
MGSCv37237,287,769 - 37,287,916UniSTSGRCm37
Celera237,116,257 - 37,116,404UniSTS
Cytogenetic Map2BUniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000053098   ⟹   ENSMUSP00000056100
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl237,315,512 - 37,320,931 (-)Ensembl
GRCm38.p6 Ensembl237,425,500 - 37,430,919 (-)Ensembl
RefSeq Acc Id: ENSMUST00000112932   ⟹   ENSMUSP00000108554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl237,315,515 - 37,333,183 (-)Ensembl
GRCm38.p6 Ensembl237,425,503 - 37,443,171 (-)Ensembl
RefSeq Acc Id: NM_146253   ⟹   NP_666365
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39237,315,512 - 37,320,931 (-)NCBI
GRCm38237,425,500 - 37,430,919 (-)ENTREZGENE
MGSCv37237,281,020 - 37,286,439 (-)RGD
Celera237,109,509 - 37,114,928 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_666365 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH32933 (Get FASTA)   NCBI Sequence Viewer  
  BAC31788 (Get FASTA)   NCBI Sequence Viewer  
  BAC34426 (Get FASTA)   NCBI Sequence Viewer  
  EDL08708 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000056100
  ENSMUSP00000056100.6
  ENSMUSP00000108554.2
GenBank Protein Q8K088 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_666365   ⟸   NM_146253
- UniProtKB: A2AWA4 (UniProtKB/Swiss-Prot),   Q8BLM4 (UniProtKB/Swiss-Prot),   Q8K088 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000056100   ⟸   ENSMUST00000053098
RefSeq Acc Id: ENSMUSP00000108554   ⟸   ENSMUST00000112932
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K088-F1-model_v2 AlphaFold Q8K088 1-423 view protein structure

Promoters
RGD ID:6833098
Promoter ID:MM_KWN:28982
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:UC008JMS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36237,286,276 - 37,287,342 (-)MPROMDB
RGD ID:6877178
Promoter ID:EPDNEW_M2040
Type:initiation region
Name:Zbtb6_1
Description:Mus musculus zinc finger and BTB domain containing 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38237,430,881 - 37,430,941EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442998 AgrOrtholog
Ensembl Genes ENSMUSG00000066798 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000068945
Ensembl Transcript ENSMUST00000053098 ENTREZGENE
  ENSMUST00000053098.6 UniProtKB/Swiss-Prot
  ENSMUST00000112932.2 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:241322 UniProtKB/Swiss-Prot
MGD MGI:2442998 ENTREZGENE
NCBI Gene 241322 ENTREZGENE
PANTHER AGAP004733-PA UniProtKB/Swiss-Prot
  ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 22 UniProtKB/Swiss-Prot
Pfam BTB UniProtKB/Swiss-Prot
  zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Zbtb6 PhenoGen
PROSITE BTB UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART BTB UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot
UniProt A2AWA4 ENTREZGENE
  Q8BLM4 ENTREZGENE
  Q8K088 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2AWA4 UniProtKB/Swiss-Prot
  Q8BLM4 UniProtKB/Swiss-Prot