EVA1A (eva-1 homolog A, regulator of programmed cell death)

Gene: EVA1A (eva-1 homolog A, regulator of programmed cell death) Sus scrofa

Analyze

Symbol:

EVA1A

Name:

eva-1 homolog A, regulator of programmed cell death

RGD ID:

14275231

Description:

ASSOCIATED WITH genetic disease (ortholog); FOUND IN intracellular membrane-bounded organelle (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

protein eva-1 homolog A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	67,680,736 - 67,734,222 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	67,710,915 - 67,730,554 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:17145712

Genomics

Comparative Map Data

EVA1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	67,680,736 - 67,734,222 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	67,710,915 - 67,730,554 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

EVA1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	75,492,318 - 75,569,719 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	75,469,302 - 75,569,722 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	75,719,444 - 75,796,845 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	75,572,952 - 75,650,356 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	75,550,740 - 75,628,141 (-)	NCBI		Celera
Cytogenetic Map	2	p12	NCBI
HuRef	2	75,457,364 - 75,534,681 (-)	NCBI		HuRef
CHM1_1	2	75,648,737 - 75,726,128 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	75,501,601 - 75,579,027 (-)	NCBI		T2T-CHM13v2.0

Eva1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	82,018,058 - 82,070,079 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	82,018,024 - 82,070,080 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	82,041,048 - 82,093,099 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	82,041,043 - 82,093,099 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	81,991,622 - 82,043,093 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	82,007,331 - 82,058,756 (+)	NCBI		MGSCv36	mm8
Celera	6	84,034,678 - 84,086,332 (+)	NCBI		Celera
Cytogenetic Map	6	C3	NCBI
cM Map	6	35.81	NCBI

Eva1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	116,151,595 - 116,200,827 (+)	NCBI		GRCr8
mRatBN7.2	4	114,593,773 - 114,643,011 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	114,593,341 - 114,643,011 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	120,048,186 - 120,097,229 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	115,823,355 - 115,872,408 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	114,443,579 - 114,492,630 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	112,714,023 - 112,823,659 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	112,773,938 - 112,823,659 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	177,461,600 - 177,511,382 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	116,280,880 - 116,330,122 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	103,592,203 - 103,641,231 (+)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

Eva1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	10,340,214 - 10,357,557 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	10,308,586 - 10,358,477 (+)	NCBI	ChiLan1.0	ChiLan1.0

EVA1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	50,736,389 - 50,890,939 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	50,739,143 - 50,893,693 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	75,564,684 - 75,718,677 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	77,068,221 - 77,206,594 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	77,068,221 - 77,136,854 (-)	Ensembl	panpan1.1		panPan2

EVA1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	47,769,808 - 47,818,449 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	47,769,875 - 47,817,560 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	47,413,447 - 47,462,149 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	48,632,667 - 48,681,354 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	48,656,401 - 48,681,262 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	47,648,128 - 47,697,025 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	47,712,232 - 47,760,915 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	48,274,870 - 48,323,553 (+)	NCBI		UU_Cfam_GSD_1.0

Eva1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	9,018,944 - 9,078,741 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936556	1,658,858 - 1,694,822 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936556	1,659,203 - 1,728,245 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EVA1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	31,693,196 - 31,761,317 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	31,732,129 - 31,761,329 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	80,435,308 - 80,503,398 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eva1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	27,798,827 - 27,855,008 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	27,798,705 - 27,854,588 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in EVA1A
465 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium
Low	2		3			20	2	2
Below cutoff	5	4		3	1	3		1	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021087316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK234986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK393156	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK393254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK394343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP326655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01005367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000039996 ⟹ ENSSSCP00000033017

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	67,680,736 - 67,730,528 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000050083 ⟹ ENSSSCP00000051942

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	67,710,947 - 67,734,222 (+)	Ensembl

RefSeq Acc Id:

XM_021087316 ⟹ XP_020942975

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	67,710,915 - 67,730,554 (+)	NCBI

Sequence:

show sequence

AGCATCTCCAGGAGGCCTCCTCTGGATGTCCCATCGAGGCTGCCCTTCTGCTACAACGCGGAAT
TGGTGATCCCCGAGCACGTGGACATGGCTTTGCTCAGCAATATCCTAGCAGCCTATTCCTTTGT
CTCAGAAAATCCCGAGCGAGCAGCTTTGTACTTTGTCTCTGGCGTGTGCATCGGGCTGGTCCTC
ACCCTGGCTGCCTTGGTGATGAGGATCTCTTGCCACACAGACTGCCGGCAGCCTCCCCAGAAGA
AGTTCCTGCAGGACCGAGAAAGCAGCAGCAACAGCAGCGACAGTGAGGATGGCAGCTCGGACGC
CGCCTCCGACATCTCGATCCGGAGACATCGCCGCTTCGAGAGGACTTTGAACAAGAACGTCTTC
ACCTCAGCGGAAGAGCTGGAGCGCGCCCAGAGGCTGGAGGAGCGGGAACGCATCATCAGGGAAA
TTTGGATGAATGGCCAGCCGGAAGTTCCCGGCACCAGAAGCCTGAACCGTTACTACTAGGGGCT
GGGTCAGGACCCCCGCACCGCTGTTAGCCTCCTGGGAGACAAAGGGTCCCCCCAGGGAGGGTGG
CCACAAAAAGCCCAACGCGGTTCTGCTATTGCTAAGGGCCGCAGAGAGGAGCGGGACACCCCCA
TTTTCTAGCCAGAAGGATTGATTTCACCCTTTTAGACTCAATTTATGGAGACGTAGAAAAACCA
AGTTGTTTCATCAACCTTTCCAGGTGCTGAAAACCCGCTCCGCTCCAACACTGTGGATGGAGAT
GCGAGAAATGGAATTGTGGTTTCTCTTGATTTCTGAGGCTCTCGGGCGTTTTTTCAGACTTCAC
TGCGATGTGTTATTTCTTTGCAAAAGGAAACATTATTATAGCCTGAGGGCTAGGAAGAGCAGGG
TTAACCTAACACAGTAAATGCAATGTTCTAGATGACTCCATGCTATGGAGGTGATTTTTGATCC
AGATAGCATGATCCGTGCTTATTATTTAAGGCTGATTTTTAAAAATCTTGTGTTGCAGTGGCAA
CCTCGTCCATTTTAACTGGCACCTCAGGGATTCAAATCCTATTTTTTATTACAGTTCCCACTTC
ACTCATGAAAATGAACATTGTATTATAGGAGATGTGTCAGTGAACTCGGAAAATGGCAATAACC
TCAAAGGATGAAGAGTTTTATTTTAAATATAAAGAACATATTAACATGCACATTCAAAAATGCT
GCACAAGAATAAAAGCTGTGTTCCCCCCCCATTGTTATGACTAGATAATCATGATTTTAAACAT
TTTGTTAAAAAAAATGAATTTGGATTTCTAAGAAAAAAATGGGAATGGGAGGTGAGCAATAAAG
CCCAAATTTTAGATTGGGATAAAAAATAAATATTACCTAAGATCTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_020942975	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000033017
	ENSSSCP00000033017.1
	ENSSSCP00000051942.2
	ENSSSCP00005013986.1
	ENSSSCP00005014003.1
	ENSSSCP00005014022.1
	ENSSSCP00015004309.1
	ENSSSCP00025031955.1
	ENSSSCP00030004381.1
	ENSSSCP00035003917.1
	ENSSSCP00040025493.1
	ENSSSCP00045043013.1
	ENSSSCP00050004226.1
	ENSSSCP00060001621.1

RefSeq Acc Id:	XP_020942975 ⟸ XM_021087316
- UniProtKB:	A0A287B6L2 (UniProtKB/TrEMBL), A0A8D1JUK3 (UniProtKB/TrEMBL)
- Sequence:	show sequence SISRRPPLDVPSRLPFCYNAELVIPEHVDMALLSNILAAYSFVSENPERAALYFVSGVCIGLVL TLAALVMRISCHTDCRQPPQKKFLQDRESSSNSSDSEDGSSDAASDISIRRHRRFERTLNKNVF TSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY hide sequence

RefSeq Acc Id:

ENSSSCP00000051942 ⟸ ENSSSCT00000050083

RefSeq Acc Id:

ENSSSCP00000033017 ⟸ ENSSSCT00000039996

Protein Domains

EVA1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000035958	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00005014925	UniProtKB/TrEMBL
	ENSSSCG00015008325	UniProtKB/TrEMBL
	ENSSSCG00025053935	UniProtKB/TrEMBL
	ENSSSCG00030007610	UniProtKB/TrEMBL
	ENSSSCG00035009190	UniProtKB/TrEMBL
	ENSSSCG00040045036	UniProtKB/TrEMBL
	ENSSSCG00045035681	UniProtKB/TrEMBL
	ENSSSCG00050007215	UniProtKB/TrEMBL
	ENSSSCG00060003922	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000039996	ENTREZGENE
	ENSSSCT00000039996.3	UniProtKB/TrEMBL
	ENSSSCT00000050083.2	UniProtKB/TrEMBL
	ENSSSCT00005023285.1	UniProtKB/TrEMBL
	ENSSSCT00005023307.1	UniProtKB/TrEMBL
	ENSSSCT00005023331.1	UniProtKB/TrEMBL
	ENSSSCT00015010959.1	UniProtKB/TrEMBL
	ENSSSCT00025073867.1	UniProtKB/TrEMBL
	ENSSSCT00030010212.1	UniProtKB/TrEMBL
	ENSSSCT00035011510.1	UniProtKB/TrEMBL
	ENSSSCT00040060701.1	UniProtKB/TrEMBL
	ENSSSCT00045061234.1	UniProtKB/TrEMBL
	ENSSSCT00050009844.1	UniProtKB/TrEMBL
	ENSSSCT00060004862.1	UniProtKB/TrEMBL
InterPro	EVA1_dom	UniProtKB/TrEMBL
NCBI Gene	EVA1A	ENTREZGENE
PANTHER	PROTEIN EVA-1 HOMOLOG A	UniProtKB/TrEMBL
	PROTEIN EVA-1 HOMOLOG B-RELATED	UniProtKB/TrEMBL
Pfam	FAM176	UniProtKB/TrEMBL
UniProt	A0A287B6L2	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1W726_PIG	UniProtKB/TrEMBL
	A0A8D1JUK3	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A0A286ZN58	UniProtKB/TrEMBL
VGNC ID	VGNC:97988	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar