TTN (titin) - Rat Genome Database

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Gene: TTN (titin) Sus scrofa
Analyze
Symbol: TTN
Name: titin
RGD ID: 14272498
Description: ENCODES a protein that exhibits actin filament binding (ortholog); actinin binding (ortholog); ankyrin binding (ortholog); INVOLVED IN adult heart development (ortholog); cardiac muscle cell development (ortholog); cardiac muscle contraction (ortholog); ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); arrhythmogenic right ventricular dysplasia 9 (ortholog); FOUND IN A band (ortholog); condensed nuclear chromosome (ortholog); I band (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: connectin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11584,226,953 - 84,501,320 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21593,758,133 - 93,780,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
atrial fibrillation  (ISO)
autosomal recessive centronuclear myopathy  (ISO)
autosomal recessive limb-girdle muscular dystrophy  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2J  (ISO)
Brugada syndrome  (ISO)
cardiac amyloidosis  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
centronuclear myopathy  (ISO)
cerebral palsy  (ISO)
clubfoot  (ISO)
congenital muscular dystrophy  (ISO)
congenital myopathy  (ISO)
congenital myopathy 1B  (ISO)
congenital myopathy 5  (ISO)
congenital structural myopathy  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Diastolic Dysfunction  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1G  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
distal myopathy  (ISO)
Dwarfism  (ISO)
dystonia 16  (ISO)
Failure to Thrive  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
Gaucher's disease  (ISO)
Gaucher's disease type I  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 2  (ISO)
hypertrophic cardiomyopathy 9  (ISO)
inclusion body myositis  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
Left Ventricular Noncompaction 2  (ISO)
leukocyte adhesion deficiency 1  (ISO)
limb-girdle muscular dystrophy  (ISO)
long QT syndrome  (ISO)
long QT syndrome 1  (ISO)
mitral valve prolapse  (ISO)
Muscle Hypotonia  (ISO)
Muscle Weakness  (ISO)
muscular disease  (ISO)
muscular dystrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myofibrillar myopathy 1  (ISO)
myofibrillar myopathy 9  (ISO)
myopathy  (ISO)
neuromuscular disease  (ISO)
orofacial cleft 1  (ISO)
restrictive cardiomyopathy  (ISO)
Romano-Ward Syndrome  (ISO)
Sudden Cardiac Death  (ISO)
sudden infant death syndrome  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Supraventricular Tachycardia  (ISO)
Syncope  (ISO)
systolic heart failure  (ISO)
third-degree atrioventricular block  (ISO)
tibial muscular dystrophy  (ISO)
transthyretin amyloidosis  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 6  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:12785098   PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
TTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11584,226,953 - 84,501,320 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21593,758,133 - 93,780,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382178,525,989 - 178,807,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2178,525,989 - 178,830,802 (-)EnsemblGRCh38hg38GRCh38
GRCh372179,390,716 - 179,672,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362179,098,962 - 179,380,395 (-)NCBINCBI36Build 36hg18NCBI36
Celera2172,993,600 - 173,266,525 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2171,261,156 - 171,540,118 (-)NCBIHuRef
CHM1_12179,396,760 - 179,678,208 (-)NCBICHM1_1
T2T-CHM13v2.02179,008,783 - 179,290,485 (-)NCBIT2T-CHM13v2.0
Ttn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39276,534,324 - 76,812,901 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl276,534,324 - 76,812,891 (-)EnsemblGRCm39 Ensembl
GRCm38276,703,980 - 76,982,557 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl276,703,980 - 76,982,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv37276,542,041 - 76,820,604 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36276,504,823 - 76,783,386 (-)NCBIMGSCv36mm8
Celera278,365,659 - 78,644,178 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map245.13NCBI
Ttn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8382,059,648 - 82,332,130 (-)NCBIGRCr8
mRatBN7.2361,652,432 - 61,924,912 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl361,652,439 - 61,924,741 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0363,565,160 - 63,837,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0370,138,896 - 70,408,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4359,404,023 - 59,665,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1359,490,644 - 59,514,338 (-)NCBI
Celera361,137,881 - 61,409,292 (-)NCBICelera
Cytogenetic Map3q24NCBI
Ttn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540318,057,344 - 18,328,389 (+)NCBIChiLan1.0ChiLan1.0
TTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21381,172,170 - 81,452,915 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B81,187,144 - 81,467,889 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B65,783,512 - 66,064,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B183,487,352 - 183,767,268 (-)NCBIpanpan1.1PanPan1.1panPan2
TTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13622,146,870 - 22,417,858 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3622,147,824 - 22,417,826 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3622,165,230 - 22,439,415 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03622,290,643 - 22,564,715 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3622,291,570 - 22,564,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13622,399,838 - 22,673,559 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03622,362,753 - 22,636,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03622,479,043 - 22,752,940 (-)NCBIUU_Cfam_GSD_1.0
Ttn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303139,179,523 - 139,445,548 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365097,733,426 - 7,999,503 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11064,074,994 - 64,379,055 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1064,076,021 - 64,347,205 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040135,225,819 - 135,499,926 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624844484,593 - 760,155 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TTN
3593 total Variants

Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021075901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH009121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK390619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK396667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU550661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01104111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U82223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_021075901   ⟹   XP_020931560
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11584,226,953 - 84,501,320 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020931560 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD00528 (Get FASTA)   NCBI Sequence Viewer  
  AAF30404 (Get FASTA)   NCBI Sequence Viewer  
  AAF30405 (Get FASTA)   NCBI Sequence Viewer  
  BAA12876 (Get FASTA)   NCBI Sequence Viewer  
  BAA12877 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_020931560   ⟸   XM_021075901
- UniProtKB: A0A480SN35 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Fibronectin type-III   Ig-like   Protein kinase


Additional Information

Database Acc Id Source(s)
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Cell_Adh-Cytoskel_Orgn UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MyBP-C_THB UniProtKB/TrEMBL
  PPAK_motif UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
NCBI Gene TTN ENTREZGENE
PANTHER CONTACTIN 5 UniProtKB/TrEMBL
  MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 UniProtKB/TrEMBL
  PTHR14340:SF24 UniProtKB/TrEMBL
  WRAPPER_REGA-1_KLINGON HOMOLOG UniProtKB/TrEMBL
Pfam fn3; 132 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  PPAK UniProtKB/TrEMBL
  THB UniProtKB/TrEMBL
PRINTS FNTYPEIII UniProtKB/TrEMBL
PROSITE FN3; 132 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART FN3; 132 UniProtKB/TrEMBL
  IGc2; 120 UniProtKB/TrEMBL
  IGv UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP Fibronectin type III UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A480SN35 ENTREZGENE, UniProtKB/TrEMBL
  Q9N250_PIG UniProtKB/TrEMBL
  Q9N251_PIG UniProtKB/TrEMBL