KCTD21 (potassium channel tetramerization domain containing 21) - Rat Genome Database

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Gene: KCTD21 (potassium channel tetramerization domain containing 21) Sus scrofa
Analyze
Symbol: KCTD21
Name: potassium channel tetramerization domain containing 21
RGD ID: 14149665
Description: ENCODES a protein that exhibits cullin family protein binding (inferred); histone deacetylase binding (inferred); identical protein binding (inferred); INVOLVED IN monoatomic ion transmembrane transport (inferred); negative regulation of smoothened signaling pathway (inferred); protein homooligomerization (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BTB/POZ domain-containing protein KCTD21; potassium channel tetramerisation domain containing 21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl912,570,408 - 12,585,862 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1912,570,117 - 12,585,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2913,798,095 - 13,799,623 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCTD21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl912,570,408 - 12,585,862 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1912,570,117 - 12,585,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2913,798,095 - 13,799,623 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCTD21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381178,171,249 - 78,188,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1178,171,249 - 78,188,626 (-)EnsemblGRCh38hg38GRCh38
GRCh371177,882,295 - 77,899,672 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,559,943 - 77,577,312 (-)NCBINCBI36Build 36hg18NCBI36
Celera1175,190,768 - 75,208,148 (-)NCBICelera
Cytogenetic Map11q14.1NCBI
HuRef1174,180,069 - 74,197,611 (-)NCBIHuRef
CHM1_11177,765,461 - 77,782,827 (-)NCBICHM1_1
T2T-CHM13v2.01178,104,491 - 78,121,889 (-)NCBIT2T-CHM13v2.0
Kctd21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39796,981,524 - 96,999,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl796,981,534 - 96,999,420 (+)EnsemblGRCm39 Ensembl
GRCm38797,332,308 - 97,350,216 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,332,327 - 97,350,213 (+)EnsemblGRCm38mm10GRCm38
MGSCv377104,480,833 - 104,498,726 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36797,207,519 - 97,225,401 (+)NCBIMGSCv36mm8
Celera797,654,615 - 97,657,537 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.47NCBI
Kctd21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,061,318 - 161,081,002 (+)NCBIGRCr8
mRatBN7.21151,650,074 - 151,669,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,650,104 - 151,667,645 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1159,653,063 - 159,653,943 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,833,231 - 166,834,111 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01159,706,746 - 159,707,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,307,746 - 162,325,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,320,730 - 162,325,013 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,514,299 - 168,531,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41154,587,686 - 154,588,566 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1149,763,966 - 149,764,846 (+)NCBICelera
Cytogenetic Map1q32NCBI
Kctd21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541413,782,671 - 13,798,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541413,779,193 - 13,798,349 (+)NCBIChiLan1.0ChiLan1.0
KCTD21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2979,104,377 - 79,122,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,148,273 - 80,165,953 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01173,231,381 - 73,248,796 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,853,124 - 76,870,500 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,855,648 - 76,856,430 (-)Ensemblpanpan1.1panPan2
KCTD21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12120,660,758 - 20,676,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2120,673,802 - 20,674,584 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2120,555,582 - 20,571,695 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02120,864,227 - 20,880,320 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2120,863,444 - 20,880,297 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12120,640,139 - 20,656,208 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02120,855,847 - 20,871,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02120,779,997 - 20,796,076 (+)NCBIUU_Cfam_GSD_1.0
Kctd21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494765,130,456 - 65,150,584 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364986,732,228 - 6,733,010 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364986,730,073 - 6,750,115 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,378,210 - 69,394,743 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl169,380,769 - 69,381,551 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604356,350,912 - 56,367,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kctd21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248631,173,113 - 1,181,503 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248631,173,113 - 1,192,382 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCTD21
658 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system respiratory system
High
Medium
Low 2 19 2
Below cutoff 9 3 1 3 1 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000056545   ⟹   ENSSSCP00000049070
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl912,570,655 - 12,585,391 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000056629   ⟹   ENSSSCP00000041176
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl912,570,408 - 12,585,862 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000076424   ⟹   ENSSSCP00000073893
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl912,570,655 - 12,585,710 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090822   ⟹   ENSSSCP00000065482
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl912,571,997 - 12,581,655 (-)Ensembl
RefSeq Acc Id: XM_021062565   ⟹   XP_020918224
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1912,570,117 - 12,585,857 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021062566   ⟹   XP_020918225
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1912,570,117 - 12,585,734 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020918224   ⟸   XM_021062565
- UniProtKB: A0A287AY49 (UniProtKB/TrEMBL),   A0A4X1SKE1 (UniProtKB/TrEMBL),   M3VK38 (UniProtKB/TrEMBL),   A0A8D0PWB6 (UniProtKB/TrEMBL),   A0A8D1CIH1 (UniProtKB/TrEMBL),   A0A8D1NGD4 (UniProtKB/TrEMBL),   A0A8D1R8J9 (UniProtKB/TrEMBL),   A0A8D0TAV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918225   ⟸   XM_021062566
- UniProtKB: A0A287AY49 (UniProtKB/TrEMBL),   A0A4X1SKE1 (UniProtKB/TrEMBL),   M3VK38 (UniProtKB/TrEMBL),   A0A8D0PWB6 (UniProtKB/TrEMBL),   A0A8D1CIH1 (UniProtKB/TrEMBL),   A0A8D1NGD4 (UniProtKB/TrEMBL),   A0A8D1R8J9 (UniProtKB/TrEMBL),   A0A8D0TAV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000065482   ⟸   ENSSSCT00000090822
RefSeq Acc Id: ENSSSCP00000073893   ⟸   ENSSSCT00000076424
RefSeq Acc Id: ENSSSCP00000049070   ⟸   ENSSSCT00000056545
RefSeq Acc Id: ENSSSCP00000041176   ⟸   ENSSSCT00000056629
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033506 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005031677 UniProtKB/TrEMBL
  ENSSSCG00015071986 UniProtKB/TrEMBL
  ENSSSCG00025072631 UniProtKB/TrEMBL
  ENSSSCG00030072808 UniProtKB/TrEMBL
  ENSSSCG00035021866 UniProtKB/TrEMBL
  ENSSSCG00035043246 UniProtKB/TrEMBL
  ENSSSCG00040012417 UniProtKB/TrEMBL
  ENSSSCG00045026571 UniProtKB/TrEMBL
  ENSSSCG00050062262 UniProtKB/TrEMBL
  ENSSSCG00055019123 UniProtKB/TrEMBL
  ENSSSCG00060065203 UniProtKB/TrEMBL
  ENSSSCG00065059832 UniProtKB/TrEMBL
  ENSSSCG00070001876 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000056545 ENTREZGENE
  ENSSSCT00000056545.3 UniProtKB/TrEMBL
  ENSSSCT00000056629 ENTREZGENE
  ENSSSCT00000056629.3 UniProtKB/TrEMBL
  ENSSSCT00005050537.1 UniProtKB/TrEMBL
  ENSSSCT00005050561.1 UniProtKB/TrEMBL
  ENSSSCT00005050566.1 UniProtKB/TrEMBL
  ENSSSCT00015096585.1 UniProtKB/TrEMBL
  ENSSSCT00015096660.1 UniProtKB/TrEMBL
  ENSSSCT00015096737.1 UniProtKB/TrEMBL
  ENSSSCT00015096826.1 UniProtKB/TrEMBL
  ENSSSCT00025099867.1 UniProtKB/TrEMBL
  ENSSSCT00025099895.1 UniProtKB/TrEMBL
  ENSSSCT00025099921.1 UniProtKB/TrEMBL
  ENSSSCT00025099958.1 UniProtKB/TrEMBL
  ENSSSCT00030101947.1 UniProtKB/TrEMBL
  ENSSSCT00030101958.1 UniProtKB/TrEMBL
  ENSSSCT00030101968.1 UniProtKB/TrEMBL
  ENSSSCT00030101977.1 UniProtKB/TrEMBL
  ENSSSCT00035028517.1 UniProtKB/TrEMBL
  ENSSSCT00035057451.1 UniProtKB/TrEMBL
  ENSSSCT00035057455.1 UniProtKB/TrEMBL
  ENSSSCT00035057459.1 UniProtKB/TrEMBL
  ENSSSCT00035057462.1 UniProtKB/TrEMBL
  ENSSSCT00040016373.1 UniProtKB/TrEMBL
  ENSSSCT00040016393.1 UniProtKB/TrEMBL
  ENSSSCT00040016412.1 UniProtKB/TrEMBL
  ENSSSCT00040016425.1 UniProtKB/TrEMBL
  ENSSSCT00045045207.1 UniProtKB/TrEMBL
  ENSSSCT00045045242.1 UniProtKB/TrEMBL
  ENSSSCT00045045270.1 UniProtKB/TrEMBL
  ENSSSCT00045045296.1 UniProtKB/TrEMBL
  ENSSSCT00050084815.1 UniProtKB/TrEMBL
  ENSSSCT00050084816.1 UniProtKB/TrEMBL
  ENSSSCT00050084819.1 UniProtKB/TrEMBL
  ENSSSCT00050084820.1 UniProtKB/TrEMBL
  ENSSSCT00055037414.1 UniProtKB/TrEMBL
  ENSSSCT00055037450.1 UniProtKB/TrEMBL
  ENSSSCT00055037487.1 UniProtKB/TrEMBL
  ENSSSCT00055037518.1 UniProtKB/TrEMBL
  ENSSSCT00060088984.1 UniProtKB/TrEMBL
  ENSSSCT00060088998.1 UniProtKB/TrEMBL
  ENSSSCT00060089005.1 UniProtKB/TrEMBL
  ENSSSCT00060089010.1 UniProtKB/TrEMBL
  ENSSSCT00065081948.1 UniProtKB/TrEMBL
  ENSSSCT00065081952.1 UniProtKB/TrEMBL
  ENSSSCT00065081959.1 UniProtKB/TrEMBL
  ENSSSCT00065081961.1 UniProtKB/TrEMBL
  ENSSSCT00070003495.1 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  KCTD11/21_C UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
NCBI Gene KCTD21 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD21 UniProtKB/TrEMBL
  POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
  KCTD11_21_C UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
UniProt A0A287AY49 ENTREZGENE
  A0A4X1SKE1 ENTREZGENE
  A0A8D0PWB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0TAV9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CIH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1NGD4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R8J9 ENTREZGENE, UniProtKB/TrEMBL
  M3VK38 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287AY49 UniProtKB/TrEMBL
  A0A4X1SKE1 UniProtKB/TrEMBL
VGNC ID VGNC:89400 ENTREZGENE