KCTD21 (potassium channel tetramerization domain containing 21) - Rat Genome Database

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Gene: KCTD21 (potassium channel tetramerization domain containing 21) Pan paniscus
Analyze
Symbol: KCTD21
Name: potassium channel tetramerization domain containing 21
RGD ID: 11669483
Description: ENCODES a protein that exhibits cullin family protein binding (inferred); histone deacetylase binding (inferred); identical protein binding (inferred); INVOLVED IN negative regulation of smoothened signaling pathway (inferred); protein homooligomerization (inferred); protein ubiquitination (inferred); ASSOCIATED WITH genetic disease (ortholog); intellectual disability (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: BTB/POZ domain-containing protein KCTD21; potassium channel tetramerisation domain containing 21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2979,104,377 - 79,122,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,148,273 - 80,165,953 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01173,231,381 - 73,248,796 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,853,124 - 76,870,500 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,855,648 - 76,856,430 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCTD21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2979,104,377 - 79,122,103 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,148,273 - 80,165,953 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01173,231,381 - 73,248,796 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,853,124 - 76,870,500 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,855,648 - 76,856,430 (-)Ensemblpanpan1.1panPan2
KCTD21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381178,171,249 - 78,188,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1178,171,249 - 78,188,626 (-)EnsemblGRCh38hg38GRCh38
GRCh371177,882,295 - 77,899,672 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,559,943 - 77,577,312 (-)NCBINCBI36Build 36hg18NCBI36
Celera1175,190,768 - 75,208,148 (-)NCBICelera
Cytogenetic Map11q14.1NCBI
HuRef1174,180,069 - 74,197,611 (-)NCBIHuRef
CHM1_11177,765,461 - 77,782,827 (-)NCBICHM1_1
T2T-CHM13v2.01178,104,491 - 78,121,889 (-)NCBIT2T-CHM13v2.0
Kctd21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39796,981,524 - 96,999,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl796,981,534 - 96,999,420 (+)EnsemblGRCm39 Ensembl
GRCm38797,332,308 - 97,350,216 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,332,327 - 97,350,213 (+)EnsemblGRCm38mm10GRCm38
MGSCv377104,480,833 - 104,498,726 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36797,207,519 - 97,225,401 (+)NCBIMGSCv36mm8
Celera797,654,615 - 97,657,537 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.47NCBI
Kctd21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,061,318 - 161,081,002 (+)NCBIGRCr8
mRatBN7.21151,650,074 - 151,669,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,650,104 - 151,667,645 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1159,653,063 - 159,653,943 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,833,231 - 166,834,111 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01159,706,746 - 159,707,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,307,746 - 162,325,284 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,320,730 - 162,325,013 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,514,299 - 168,531,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41154,587,686 - 154,588,566 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1149,763,966 - 149,764,846 (+)NCBICelera
Cytogenetic Map1q32NCBI
Kctd21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541413,782,671 - 13,798,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541413,779,193 - 13,798,349 (+)NCBIChiLan1.0ChiLan1.0
KCTD21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12120,660,758 - 20,676,870 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2120,673,802 - 20,674,584 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2120,555,582 - 20,571,695 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02120,864,227 - 20,880,320 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2120,863,444 - 20,880,297 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12120,640,139 - 20,656,208 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02120,855,847 - 20,871,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02120,779,997 - 20,796,076 (+)NCBIUU_Cfam_GSD_1.0
Kctd21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494765,130,456 - 65,150,584 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364986,732,228 - 6,733,010 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364986,730,073 - 6,750,115 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl912,570,408 - 12,585,862 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1912,570,117 - 12,585,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2913,798,095 - 13,799,623 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCTD21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,378,210 - 69,394,743 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl169,380,769 - 69,381,551 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604356,350,912 - 56,367,880 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kctd21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248631,173,113 - 1,181,503 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248631,173,113 - 1,192,382 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000000611   ⟹   ENSPPAP00000000147
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1176,855,648 - 76,856,430 (-)Ensembl
RefSeq Acc Id: XM_003805160   ⟹   XP_003805208
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2979,104,377 - 79,122,103 (-)NCBI
NHGRI_mPanPan11180,148,273 - 80,165,953 (-)NCBI
Mhudiblu_PPA_v01173,231,381 - 73,248,796 (-)NCBI
PanPan1.11176,853,124 - 76,870,500 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008968278   ⟹   XP_008966526
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2979,104,377 - 79,121,676 (-)NCBI
NHGRI_mPanPan11180,148,279 - 80,165,570 (-)NCBI
Mhudiblu_PPA_v01173,231,911 - 73,248,670 (-)NCBI
PanPan1.11176,853,124 - 76,870,436 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034933446   ⟹   XP_034789337
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2979,104,377 - 79,121,785 (-)NCBI
NHGRI_mPanPan11180,148,279 - 80,165,668 (-)NCBI
Mhudiblu_PPA_v01173,231,911 - 73,248,763 (-)NCBI
RefSeq Acc Id: XM_055094729   ⟹   XP_054950704
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2979,104,377 - 79,121,753 (-)NCBI
NHGRI_mPanPan11180,148,279 - 80,165,647 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003805208 (Get FASTA)   NCBI Sequence Viewer  
  XP_008966526 (Get FASTA)   NCBI Sequence Viewer  
  XP_034789337 (Get FASTA)   NCBI Sequence Viewer  
  XP_054950704 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000000147.1
Reference Protein Sequences
RefSeq Acc Id: XP_003805208   ⟸   XM_003805160
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008966526   ⟸   XM_008968278
- Peptide Label: isoform X2
- UniProtKB: A0A2R8Z5X6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034789337   ⟸   XM_034933446
- Peptide Label: isoform X2
- UniProtKB: A0A2R8Z5X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000000147   ⟸   ENSPPAT00000000611
RefSeq Acc Id: XP_054950704   ⟸   XM_055094729
- Peptide Label: isoform X2
- UniProtKB: A0A2R8Z5X6 (UniProtKB/TrEMBL)
Protein Domains
BTB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000000521 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000000611.1 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  KCTD11/21_C UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
KEGG Report pps:100976702 UniProtKB/TrEMBL
NCBI Gene KCTD21 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD21 UniProtKB/TrEMBL
  POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
  KCTD11_21_C UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
UniProt A0A2R8Z5X6 ENTREZGENE, UniProtKB/TrEMBL