ARHGEF4 (Rho guanine nucleotide exchange factor 4) - Rat Genome Database

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Gene: ARHGEF4 (Rho guanine nucleotide exchange factor 4) Sus scrofa
Analyze
Symbol: ARHGEF4
Name: Rho guanine nucleotide exchange factor 4
RGD ID: 14080089
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN filopodium assembly (ortholog); lamellipodium assembly (ortholog); ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1557,115,853 - 57,374,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11557,260,772 - 57,378,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074  


Genomics

Comparative Map Data
ARHGEF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1557,115,853 - 57,374,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11557,260,772 - 57,378,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARHGEF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382130,836,914 - 131,047,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2130,836,914 - 131,047,263 (+)EnsemblGRCh38hg38GRCh38
GRCh372131,594,487 - 131,804,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,390,694 - 131,521,306 (+)NCBINCBI36Build 36hg18NCBI36
Build 342131,507,955 - 131,638,568NCBI
Celera2124,772,847 - 124,903,056 (-)NCBICelera
Cytogenetic Map2q21.1NCBI
HuRef2123,744,169 - 123,803,670 (+)NCBIHuRef
CHM1_12131,678,231 - 131,808,841 (+)NCBICHM1_1
T2T-CHM13v2.02131,271,158 - 131,481,546 (+)NCBIT2T-CHM13v2.0
Arhgef4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,717,263 - 34,851,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,717,269 - 34,852,390 (+)EnsemblGRCm39 Ensembl
GRCm38134,677,949 - 34,812,754 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,678,188 - 34,813,309 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl134,801,794 - 34,801,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,858,567 - 34,869,599 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,746,268 - 34,757,300 (+)NCBIMGSCv36mm8
Celera134,571,295 - 34,582,266 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map113.34NCBI
Arhgef4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,357,716 - 44,500,959 (+)NCBIGRCr8
mRatBN7.2936,861,800 - 37,005,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,861,835 - 37,005,075 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0941,160,562 - 41,305,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,295,909 - 41,302,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,829,962 - 40,973,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,395,974 - 33,539,597 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera934,646,792 - 34,790,632 (+)NCBICelera
Cytogenetic Map9q21NCBI
Arhgef4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955459321,683 - 534,108 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21344,598,671 - 44,805,585 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B44,613,644 - 44,820,559 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B29,583,389 - 29,716,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B131,669,743 - 131,800,705 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B131,594,345 - 131,800,705 (+)Ensemblpanpan1.1panPan2
ARHGEF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11920,618,860 - 20,734,458 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1920,618,492 - 20,734,162 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1920,893,924 - 20,980,407 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01921,971,698 - 22,058,440 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1921,940,870 - 22,058,440 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11920,582,693 - 20,698,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01920,842,403 - 20,959,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01921,914,410 - 22,001,460 (+)NCBIUU_Cfam_GSD_1.0
Arhgef4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303100,150,254 - 100,308,313 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493646941,352,361 - 41,467,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037568,740 - 772,089 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473214,885,119 - 15,110,134 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGEF4
2008 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 3 23 3 2 5 13 11 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000040686   ⟹   ENSSSCP00000055644
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1557,115,854 - 57,374,604 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000047509   ⟹   ENSSSCP00000056702
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1557,115,854 - 57,374,604 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000077960   ⟹   ENSSSCP00000059863
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1557,294,258 - 57,372,409 (+)Ensembl
RefSeq Acc Id: XM_021075744   ⟹   XP_020931403
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11557,294,258 - 57,378,634 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075745   ⟹   XP_020931404
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11557,273,088 - 57,378,634 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075746   ⟹   XP_020931405
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11557,260,772 - 57,378,634 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075747   ⟹   XP_020931406
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11557,291,629 - 57,378,634 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021075748   ⟹   XP_020931407
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11557,360,442 - 57,378,634 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020931405   ⟸   XM_021075746
- Peptide Label: isoform X3
- UniProtKB: A0A8D1QPE7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931404   ⟸   XM_021075745
- Peptide Label: isoform X2
- UniProtKB: A0A8D1QPE7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931406   ⟸   XM_021075747
- Peptide Label: isoform X4
- UniProtKB: A0A8D0ZJ36 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931403   ⟸   XM_021075744
- Peptide Label: isoform X1
- UniProtKB: A0A8D1U3K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020931407   ⟸   XM_021075748
- Peptide Label: isoform X5
- UniProtKB: A0A8D0ZFG7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000055644   ⟸   ENSSSCT00000040686
Ensembl Acc Id: ENSSSCP00000059863   ⟸   ENSSSCT00000077960
Ensembl Acc Id: ENSSSCP00000056702   ⟸   ENSSSCT00000047509
Protein Domains
DH   PH   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035828 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025069363 UniProtKB/TrEMBL
  ENSSSCG00030071165 UniProtKB/TrEMBL
  ENSSSCG00035032706 UniProtKB/TrEMBL
  ENSSSCG00040018188 UniProtKB/TrEMBL
  ENSSSCG00045011591 UniProtKB/TrEMBL
  ENSSSCG00055015336 UniProtKB/TrEMBL
  ENSSSCG00065024052 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040686 ENTREZGENE
  ENSSSCT00000040686.3 UniProtKB/TrEMBL
  ENSSSCT00000047509.3 UniProtKB/TrEMBL
  ENSSSCT00025096018.1 UniProtKB/TrEMBL
  ENSSSCT00030099672.1 UniProtKB/TrEMBL
  ENSSSCT00035043342.1 UniProtKB/TrEMBL
  ENSSSCT00035043348.1 UniProtKB/TrEMBL
  ENSSSCT00040024665.1 UniProtKB/TrEMBL
  ENSSSCT00045019823.1 UniProtKB/TrEMBL
  ENSSSCT00055030405.1 UniProtKB/TrEMBL
  ENSSSCT00055030622.1 UniProtKB/TrEMBL
  ENSSSCT00065032043.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
NCBI Gene ARHGEF4 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 4 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A287BGI4_PIG UniProtKB/TrEMBL
  A0A287BJB8_PIG UniProtKB/TrEMBL
  A0A8D0ZFG7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ZJ36 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QPE7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1U3K9 ENTREZGENE, UniProtKB/TrEMBL