ARHGEF4 (Rho guanine nucleotide exchange factor 4) - Rat Genome Database

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Gene: ARHGEF4 (Rho guanine nucleotide exchange factor 4) Canis lupus familiaris
Analyze
Symbol: ARHGEF4
Name: Rho guanine nucleotide exchange factor 4
RGD ID: 12414939
Description: ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN filopodium assembly (ortholog); lamellipodium assembly (ortholog); ASSOCIATED WITH schizophrenia (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11920,618,860 - 20,734,458 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1920,618,492 - 20,734,162 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1920,893,924 - 20,980,407 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01921,971,698 - 22,058,440 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1921,940,870 - 22,058,440 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11920,582,693 - 20,698,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01920,842,403 - 20,959,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01921,914,410 - 22,001,460 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ARHGEF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11920,618,860 - 20,734,458 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1920,618,492 - 20,734,162 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1920,893,924 - 20,980,407 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01921,971,698 - 22,058,440 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1921,940,870 - 22,058,440 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11920,582,693 - 20,698,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01920,842,403 - 20,959,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01921,914,410 - 22,001,460 (+)NCBIUU_Cfam_GSD_1.0
ARHGEF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382130,836,914 - 131,047,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2130,836,914 - 131,047,263 (+)EnsemblGRCh38hg38GRCh38
GRCh372131,594,487 - 131,804,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,390,694 - 131,521,306 (+)NCBINCBI36Build 36hg18NCBI36
Build 342131,507,955 - 131,638,568NCBI
Celera2124,772,847 - 124,903,056 (-)NCBICelera
Cytogenetic Map2q21.1NCBI
HuRef2123,744,169 - 123,803,670 (+)NCBIHuRef
CHM1_12131,678,231 - 131,808,841 (+)NCBICHM1_1
T2T-CHM13v2.02131,271,158 - 131,481,546 (+)NCBIT2T-CHM13v2.0
Arhgef4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,717,263 - 34,851,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,717,269 - 34,852,390 (+)EnsemblGRCm39 Ensembl
GRCm38134,677,949 - 34,812,754 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,678,188 - 34,813,309 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl134,801,794 - 34,801,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,858,567 - 34,869,599 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,746,268 - 34,757,300 (+)NCBIMGSCv36mm8
Celera134,571,295 - 34,582,266 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map113.34NCBI
Arhgef4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,357,716 - 44,500,959 (+)NCBIGRCr8
mRatBN7.2936,861,800 - 37,005,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,861,835 - 37,005,075 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0941,160,562 - 41,305,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,295,909 - 41,302,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,829,962 - 40,973,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,395,974 - 33,539,597 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera934,646,792 - 34,790,632 (+)NCBICelera
Cytogenetic Map9q21NCBI
Arhgef4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955459321,683 - 534,108 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21344,598,671 - 44,805,585 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B44,613,644 - 44,820,559 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B29,583,389 - 29,716,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B131,669,743 - 131,800,705 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B131,594,345 - 131,800,705 (+)Ensemblpanpan1.1panPan2
Arhgef4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303100,150,254 - 100,308,313 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493646941,352,361 - 41,467,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1557,115,853 - 57,374,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11557,260,772 - 57,378,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARHGEF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037568,740 - 772,089 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473214,885,119 - 15,110,134 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARHGEF4
1294 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_038425901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038454825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_540976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000006766   ⟹   ENSCAFP00000006261
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1920,618,492 - 20,734,162 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032553   ⟹   ENSCAFP00845025458
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1921,940,870 - 22,058,440 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032649   ⟹   ENSCAFP00845025535
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1921,940,870 - 22,058,440 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845032753   ⟹   ENSCAFP00845025627
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1921,971,087 - 22,058,440 (+)Ensembl
RefSeq Acc Id: XM_038425901   ⟹   XP_038281829
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01921,971,698 - 22,058,440 (+)NCBI
RefSeq Acc Id: XM_038425902   ⟹   XP_038281830
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01922,030,794 - 22,058,440 (+)NCBI
RefSeq Acc Id: XM_038425903   ⟹   XP_038281831
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01922,044,185 - 22,058,440 (+)NCBI
RefSeq Acc Id: XM_038425904   ⟹   XP_038281832
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01922,044,185 - 22,058,440 (+)NCBI
RefSeq Acc Id: XM_038425905   ⟹   XP_038281833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01922,045,545 - 22,058,440 (+)NCBI
RefSeq Acc Id: XM_038454821   ⟹   XP_038310749
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1920,893,924 - 20,980,407 (+)NCBI
RefSeq Acc Id: XM_038454822   ⟹   XP_038310750
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1920,953,011 - 20,980,407 (+)NCBI
RefSeq Acc Id: XM_038454823   ⟹   XP_038310751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1920,966,399 - 20,980,407 (+)NCBI
RefSeq Acc Id: XM_038454824   ⟹   XP_038310752
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1920,966,399 - 20,980,407 (+)NCBI
RefSeq Acc Id: XM_038454825   ⟹   XP_038310753
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1920,967,759 - 20,980,407 (+)NCBI
RefSeq Acc Id: XM_038502117   ⟹   XP_038358045
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11920,582,693 - 20,698,963 (+)NCBI
RefSeq Acc Id: XM_038564797   ⟹   XP_038420725
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01921,914,410 - 22,001,460 (+)NCBI
RefSeq Acc Id: XM_038564798   ⟹   XP_038420726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01921,973,493 - 22,001,460 (+)NCBI
RefSeq Acc Id: XM_038564799   ⟹   XP_038420727
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01921,986,920 - 22,001,460 (+)NCBI
RefSeq Acc Id: XM_038564800   ⟹   XP_038420728
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01921,986,920 - 22,001,460 (+)NCBI
RefSeq Acc Id: XM_038564801   ⟹   XP_038420729
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01921,988,280 - 22,001,460 (+)NCBI
RefSeq Acc Id: XM_038629360   ⟹   XP_038485288
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01920,842,403 - 20,959,173 (+)NCBI
Ensembl Acc Id: ENSCAFP00000006261   ⟸   ENSCAFT00000006766
RefSeq Acc Id: XP_038358045   ⟸   XM_038502117
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038485288   ⟸   XM_038629360
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038281829   ⟸   XM_038425901
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MT51 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038281830   ⟸   XM_038425902
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038281831   ⟸   XM_038425903
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JT00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038281832   ⟸   XM_038425904
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JT00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038281833   ⟸   XM_038425905
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JT00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310749   ⟸   XM_038454821
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MT51 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310750   ⟸   XM_038454822
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038310751   ⟸   XM_038454823
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JT00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310752   ⟸   XM_038454824
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JT00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038310753   ⟸   XM_038454825
- Peptide Label: isoform X3
- UniProtKB: A0A8C0JT00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420725   ⟸   XM_038564797
- Peptide Label: isoform X1
- UniProtKB: A0A8C0T0B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420726   ⟸   XM_038564798
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038420727   ⟸   XM_038564799
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038420728   ⟸   XM_038564800
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038420729   ⟸   XM_038564801
- Peptide Label: isoform X3
Ensembl Acc Id: ENSCAFP00845025535   ⟸   ENSCAFT00845032649
Ensembl Acc Id: ENSCAFP00845025458   ⟸   ENSCAFT00845032553
Ensembl Acc Id: ENSCAFP00845025627   ⟸   ENSCAFT00845032753
Protein Domains
DH   PH   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004213 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010054 UniProtKB/TrEMBL
  ENSCAFG00040017089 UniProtKB/TrEMBL
  ENSCAFG00845018410 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006766.5 UniProtKB/TrEMBL
  ENSCAFT00000055766.3 UniProtKB/TrEMBL
  ENSCAFT00000106605.1 UniProtKB/TrEMBL
  ENSCAFT00030018837.1 UniProtKB/TrEMBL
  ENSCAFT00040031768.1 UniProtKB/TrEMBL
  ENSCAFT00845032553.1 UniProtKB/TrEMBL
  ENSCAFT00845032649.1 UniProtKB/TrEMBL
  ENSCAFT00845032753 ENTREZGENE
  ENSCAFT00845032753.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
NCBI Gene ARHGEF4 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 4 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A8C0JT00 ENTREZGENE
  A0A8C0MT51 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T0B8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P0A8_CANLF UniProtKB/TrEMBL
  A0A8I3P0S4_CANLF UniProtKB/TrEMBL
  A0A8I3PDM8_CANLF UniProtKB/TrEMBL
  A0A8P0NWP1_CANLF UniProtKB/TrEMBL
  A0A8P0S9Y1_CANLF UniProtKB/TrEMBL
  A0A8P0TNU1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54802 ENTREZGENE