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Gene: ARHGEF4 (Rho guanine nucleotide exchange factor 4) Homo sapiens
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Symbol: ARHGEF4
Name: Rho guanine nucleotide exchange factor 4
Description: Exhibits Rac guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Involved in filopodium assembly and lamellipodium assembly. Predicted to localize to cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APC-stimulated guanine nucleotide exchange factor; APC-stimulated guanine nucleotide exchange factor 1; ASEF; ASEF1; GEF4; Rho guanine nucleotide exchange factor (GEF) 4; SMIM39; STM6
Orthologs:
Mus musculus (house mouse) : Arhgef4 (Rho guanine nucleotide exchange factor (GEF) 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arhgef4 (Rho guanine nucleotide exchange factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arhgef4 (Rho guanine nucleotide exchange factor 4)
Canis lupus familiaris (dog) : ARHGEF4 (Rho guanine nucleotide exchange factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arhgef4 (Rho guanine nucleotide exchange factor 4)
Sus scrofa (pig) : ARHGEF4 (Rho guanine nucleotide exchange factor 4)
Chlorocebus sabaeus (African green monkey) : ARHGEF4 (Rho guanine nucleotide exchange factor 4)
Heterocephalus glaber (naked mole-rat) : Arhgef4 (Rho guanine nucleotide exchange factor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2130,836,916 - 131,047,263 (+)EnsemblGRCh38hg38GRCh38
GRCh382130,836,914 - 131,051,514 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372131,594,489 - 131,804,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,390,694 - 131,521,306 (+)NCBINCBI36hg18NCBI36
Build 342131,507,955 - 131,638,568NCBI
Celera2124,772,847 - 124,903,056 (-)NCBI
Cytogenetic Map2q21.1NCBI
HuRef2123,744,169 - 123,803,670 (+)NCBIHuRef
CHM1_12131,678,231 - 131,808,841 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ARHGEF4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312054
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.