PPP1R12A (protein phosphatase 1 regulatory subunit 12A) - Rat Genome Database

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Gene: PPP1R12A (protein phosphatase 1 regulatory subunit 12A) Sus scrofa
Analyze
Symbol: PPP1R12A
Name: protein phosphatase 1 regulatory subunit 12A
RGD ID: 14048072
Description: ENCODES a protein that exhibits phosphoprotein phosphatase activity (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); regulation of establishment of endothelial barrier (ortholog); regulation of nucleocytoplasmic transport (ortholog); ASSOCIATED WITH autosomal dominant centronuclear myopathy (ortholog); congenital structural myopathy (ortholog); genetic disease (ortholog); FOUND IN A band (inferred); actin cytoskeleton (inferred); centrosome (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 130 kDa regulatory subunit of myosin phosphatase; myosin phosphatase, target subunit 1; MYPT1; protein phosphatase 1, regulatory (inhibitor) subunit 12A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5101,490,341 - 101,639,429 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15101,490,282 - 101,639,456 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25106,491,071 - 106,610,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:9918866   PMID:19939965   PMID:20418385   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPP1R12A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5101,490,341 - 101,639,429 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15101,490,282 - 101,639,456 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25106,491,071 - 106,610,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381279,773,563 - 79,935,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1279,773,563 - 79,935,460 (-)EnsemblGRCh38hg38GRCh38
GRCh371280,167,343 - 80,329,240 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361278,692,317 - 78,852,842 (-)NCBINCBI36Build 36hg18NCBI36
Build 341278,670,653 - 78,831,179NCBI
Celera1279,833,868 - 79,995,723 (-)NCBICelera
Cytogenetic Map12q21.2-q21.31NCBI
HuRef1277,223,683 - 77,385,520 (-)NCBIHuRef
CHM1_11280,133,789 - 80,295,575 (-)NCBICHM1_1
T2T-CHM13v2.01279,752,233 - 79,914,115 (-)NCBIT2T-CHM13v2.0
Ppp1r12a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910107,997,913 - 108,115,846 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10107,998,054 - 108,120,336 (+)EnsemblGRCm39 Ensembl
GRCm3810108,162,092 - 108,279,985 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10108,162,193 - 108,284,475 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710107,599,456 - 107,714,631 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610107,566,219 - 107,688,585 (+)NCBIMGSCv36mm8
Celera10110,096,336 - 110,211,438 (+)NCBICelera
Cytogenetic Map10D1NCBI
cM Map1056.33NCBI
Ppp1r12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8745,368,922 - 45,480,158 (+)NCBIGRCr8
mRatBN7.2743,482,808 - 43,593,689 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl743,482,803 - 43,593,425 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx745,390,762 - 45,499,381 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0747,593,881 - 47,702,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0747,371,635 - 47,480,244 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0751,404,971 - 51,515,382 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl751,404,919 - 51,515,373 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0751,417,546 - 51,527,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4746,876,552 - 46,986,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1746,896,822 - 47,006,293 (+)NCBI
Celera740,349,341 - 40,458,007 (+)NCBICelera
Cytogenetic Map7q21NCBI
Ppp1r12a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540518,596,541 - 18,727,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540518,594,191 - 18,727,345 (-)NCBIChiLan1.0ChiLan1.0
PPP1R12A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21087,826,297 - 87,990,301 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11287,822,433 - 87,986,517 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01277,306,155 - 77,459,455 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11280,153,348 - 80,316,131 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1280,155,702 - 80,314,601 (-)Ensemblpanpan1.1panPan2
PPP1R12A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11522,272,291 - 22,413,441 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1522,274,259 - 22,414,359 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1522,698,781 - 22,837,753 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01522,634,434 - 22,773,680 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1522,634,483 - 22,773,936 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11522,210,562 - 22,351,199 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01522,271,520 - 22,410,758 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01522,511,839 - 22,651,103 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r12a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494537,963,878 - 38,100,776 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936698817,943 - 948,368 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936698811,399 - 948,631 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R12A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11175,300,278 - 75,461,498 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1175,319,962 - 75,461,438 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037169,985,567 - 170,152,231 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r12a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475018,363,913 - 18,501,243 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475018,363,618 - 18,498,630 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP1R12A
4783 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000050420   ⟹   ENSSSCP00000055272
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl5101,490,479 - 101,609,196 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000057360   ⟹   ENSSSCP00000047536
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl5101,490,341 - 101,609,705 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000072902   ⟹   ENSSSCP00000066878
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl5101,490,544 - 101,637,345 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000078218   ⟹   ENSSSCP00000068413
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl5101,490,544 - 101,639,429 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000079914   ⟹   ENSSSCP00000059877
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl5101,490,544 - 101,639,442 (+)Ensembl
RefSeq Acc Id: XM_021092811   ⟹   XP_020948470
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.15101,490,282 - 101,639,456 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020948470 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA13969 (Get FASTA)   NCBI Sequence Viewer  
  BAA75064 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000047536.2
  ENSSSCP00000055272.2
  ENSSSCP00000066878.2
  ENSSSCP00000068413
  ENSSSCP00000068413.2
  ENSSSCP00060002979.1
Reference Protein Sequences
RefSeq Acc Id: XP_020948470   ⟸   XM_021092811
- UniProtKB: A0A8D1SYW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000055272   ⟸   ENSSSCT00000050420
RefSeq Acc Id: ENSSSCP00000068413   ⟸   ENSSSCT00000078218
RefSeq Acc Id: ENSSSCP00000059877   ⟸   ENSSSCT00000079914
RefSeq Acc Id: ENSSSCP00000066878   ⟸   ENSSSCT00000072902
RefSeq Acc Id: ENSSSCP00000047536   ⟸   ENSSSCT00000057360
Protein Domains
cGMP-dependent protein kinase interacting


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038973 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00060006470 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000050420.3 UniProtKB/TrEMBL
  ENSSSCT00000057360.3 UniProtKB/TrEMBL
  ENSSSCT00000072902.2 UniProtKB/TrEMBL
  ENSSSCT00000078218 ENTREZGENE
  ENSSSCT00000078218.2 UniProtKB/TrEMBL
  ENSSSCT00060008222.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  6.10.140.390 UniProtKB/TrEMBL
  6.10.250.1820 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  MYPT1/MYPT2/Mbs85 UniProtKB/TrEMBL
  PRKG1_interact UniProtKB/TrEMBL
NCBI Gene PPP1R12A ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12 UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12A UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  PRKG1_interact UniProtKB/TrEMBL
PIRSF PP1_12ABC_vert UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A287ATW2_PIG UniProtKB/TrEMBL
  A0A287BG04_PIG UniProtKB/TrEMBL
  A0A5G2QU87_PIG UniProtKB/TrEMBL
  A0A5G2R8E1_PIG UniProtKB/TrEMBL
  A0A8D1SYW4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91719 ENTREZGENE