CCL19 (C-C motif chemokine ligand 19) - Rat Genome Database

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Gene: CCL19 (C-C motif chemokine ligand 19) Sus scrofa
Analyze
Symbol: CCL19
Name: C-C motif chemokine ligand 19
RGD ID: 14046333
Description: ENCODES a protein that exhibits CCR7 chemokine receptor binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cell maturation (ortholog); immunological synapse formation (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); allergic contact dermatitis (ortholog); allergic disease (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C motif chemokine 19; CCL19 chemokine
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,110,065 - 32,112,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,110,366 - 32,112,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,250,009 - 36,252,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell chemotaxis  (IEA)
cell maturation  (ISO)
cell migration  (IEA)
cellular response to virus  (IEA)
chemotaxis  (IEA)
dendritic cell chemotaxis  (IEA)
establishment of T cell polarity  (IEA)
immune response  (IEA)
immunological synapse formation  (ISO)
inflammatory response  (IEA)
mature conventional dendritic cell differentiation  (ISO)
myeloid dendritic cell chemotaxis  (IEA)
negative regulation of dendritic cell apoptotic process  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell motility  (IEA)
positive regulation of chemotaxis  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of dendritic cell dendrite assembly  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of JNK cascade  (IEA)
positive regulation of JUN kinase activity  (ISO)
positive regulation of neutrophil chemotaxis  (IEA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of protein kinase activity  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 1 cell differentiation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of cell projection assembly  (ISO)
release of sequestered calcium ion into cytosol  (IEA)
response to nitric oxide  (IEA)
response to prostaglandin E  (IEA)
signal transduction  (IEA)
T cell costimulation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15242943   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCL19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,110,065 - 32,112,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,110,366 - 32,112,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,250,009 - 36,252,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,689,570 - 34,691,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,689,570 - 34,691,276 (-)EnsemblGRCh38hg38GRCh38
GRCh37934,689,567 - 34,691,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,679,567 - 34,681,274 (-)NCBINCBI36Build 36hg18NCBI36
Build 34934,679,566 - 34,681,274NCBI
Celera934,621,038 - 34,622,745 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,643,820 - 34,645,529 (-)NCBIHuRef
CHM1_1934,689,356 - 34,691,063 (-)NCBICHM1_1
T2T-CHM13v2.0934,708,593 - 34,710,301 (-)NCBIT2T-CHM13v2.0
Ccl19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39442,754,525 - 42,756,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl442,754,525 - 42,756,577 (-)EnsemblGRCm39 Ensembl
GRCm38442,754,525 - 42,756,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl442,754,525 - 42,756,577 (-)EnsemblGRCm38mm10GRCm38
MGSCv37442,768,057 - 42,770,050 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36442,776,285 - 42,778,278 (-)NCBIMGSCv36mm8
Cytogenetic Map4A5NCBI
cM Map422.44NCBI
Ccl19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,759,220 - 61,761,164 (-)NCBIGRCr8
mRatBN7.2556,963,364 - 56,965,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,963,364 - 56,965,308 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx558,937,715 - 58,939,661 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,756,547 - 60,758,493 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,742,641 - 60,744,587 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,181,025 - 58,182,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,181,026 - 58,183,017 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,705,391 - 62,707,335 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,221,738 - 59,223,682 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,221,917 - 59,223,865 (-)NCBI
Celera555,555,525 - 55,557,469 (-)NCBICelera
Cytogenetic Map5q22NCBI
Ccl19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,444,316 - 1,446,490 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,444,598 - 1,446,488 (+)NCBIChiLan1.0ChiLan1.0
CCL19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,912,711 - 89,915,161 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,918,652 - 89,921,102 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,525,820 - 34,527,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,334,353 - 35,336,108 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,334,353 - 35,336,108 (-)Ensemblpanpan1.1panPan2
CCL19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,357,706 - 51,359,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,340,530 - 51,359,365 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1149,985,833 - 49,987,334 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01152,298,251 - 52,299,753 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,281,068 - 52,299,911 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,960,957 - 50,962,456 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,829,100 - 50,830,599 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,593,870 - 51,595,370 (-)NCBIUU_Cfam_GSD_1.0
Ccl19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,217,691 - 166,219,774 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,765,267 - 2,767,385 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,765,271 - 2,767,259 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11245,928,212 - 45,930,897 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,929,071 - 45,930,904 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603843,045,463 - 43,047,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473639,088,921 - 39,090,394 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473639,088,741 - 39,090,745 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCL19
46 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 22 3 1 5 14 12 22 3 6 2

Sequence


Ensembl Acc Id: ENSSSCT00000012003   ⟹   ENSSSCP00000011695
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1032,110,065 - 32,112,734 (+)Ensembl
RefSeq Acc Id: NM_001170516   ⟹   NP_001163987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11032,110,366 - 32,112,529 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001163987 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ84093 (Get FASTA)   NCBI Sequence Viewer  
  CAP45767 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000011695
  ENSSSCP00000011695.2
  ENSSSCP00005046255.1
  ENSSSCP00015008235.1
  ENSSSCP00045003140.1
  ENSSSCP00065042085.1
RefSeq Acc Id: NP_001163987   ⟸   NM_001170516
- Peptide Label: precursor
- UniProtKB: D0Z5W4 (UniProtKB/TrEMBL),   A0A8D1GKZ3 (UniProtKB/TrEMBL),   A0A8D0MVS1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000011695   ⟸   ENSSSCT00000012003
Protein Domains
Chemokine interleukin-8-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010966 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005045608 UniProtKB/TrEMBL
  ENSSSCG00015015783 UniProtKB/TrEMBL
  ENSSSCG00045002999 UniProtKB/TrEMBL
  ENSSSCG00065070058 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012003 ENTREZGENE
  ENSSSCT00000012003.6 UniProtKB/TrEMBL
  ENSSSCT00005073743.1 UniProtKB/TrEMBL
  ENSSSCT00015020942.1 UniProtKB/TrEMBL
  ENSSSCT00045004806.1 UniProtKB/TrEMBL
  ENSSSCT00065096182.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/TrEMBL
  Chemokine_CC_DCCL UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report ssc:494464 UniProtKB/TrEMBL
NCBI Gene CCL19 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 19 UniProtKB/TrEMBL
  PTHR12015 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PRINTS INTERLEUKIN8 UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CC UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniProt A0A4X1UQX9_PIG UniProtKB/TrEMBL
  A0A8D0MVS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1GKZ3 ENTREZGENE, UniProtKB/TrEMBL
  D0Z5W4 ENTREZGENE, UniProtKB/TrEMBL
  Q6EKW5_PIG UniProtKB/TrEMBL
UniProt Secondary F1S3U4 UniProtKB/TrEMBL
VGNC ID VGNC:95483 ENTREZGENE