CCL19 (C-C motif chemokine ligand 19) - Rat Genome Database

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Gene: CCL19 (C-C motif chemokine ligand 19) Sus scrofa
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Symbol: CCL19
Name: C-C motif chemokine ligand 19
RGD ID: 14046333
Description: ENCODES a protein that exhibits CCR7 chemokine receptor binding (ortholog); chemokine receptor binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cell maturation (ortholog); dendritic cell chemotaxis (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); allergic disease (ortholog); amyotrophic lateral sclerosis type 14 (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-C motif chemokine 19; CCL19 chemokine
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,110,064 - 32,112,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,110,366 - 32,112,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,250,009 - 36,252,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell maturation  (ISO)
cellular response to interferon-gamma  (IBA)
cellular response to interleukin-1  (IBA)
cellular response to tumor necrosis factor  (IBA)
cellular response to virus  (IEA)
chemokine-mediated signaling pathway  (IBA)
dendritic cell chemotaxis  (ISO)
establishment of T cell polarity  (IEA)
G protein-coupled receptor signaling pathway  (IBA)
immunological synapse formation  (ISO)
inflammatory response  (IBA)
killing of cells of other organism  (ISO)
lymphocyte chemotaxis  (IBA)
mature conventional dendritic cell differentiation  (ISO)
monocyte chemotaxis  (IBA)
myeloid dendritic cell chemotaxis  (IEA)
negative regulation of dendritic cell apoptotic process  (IEA)
neutrophil chemotaxis  (IBA)
positive regulation of cell motility  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of dendritic cell dendrite assembly  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of GTPase activity  (IBA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of JNK cascade  (IEA)
positive regulation of JUN kinase activity  (ISO)
positive regulation of neutrophil chemotaxis  (IEA)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of phosphatidylinositol 3-kinase activity  (IEA)
positive regulation of protein kinase activity  (IEA)
positive regulation of protein kinase B signaling  (IEA)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 1 cell differentiation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
regulation of cell projection assembly  (ISO)
release of sequestered calcium ion into cytosol  (IEA)
response to nitric oxide  (IEA)
response to prostaglandin E  (IEA)
T cell costimulation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15242943   PMID:17145712  


Genomics

Comparative Map Data
CCL19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,110,064 - 32,112,739 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,110,366 - 32,112,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,250,009 - 36,252,173 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl934,689,570 - 34,691,276 (-)EnsemblGRCh38hg38GRCh38
GRCh38934,689,570 - 34,691,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37934,689,567 - 34,691,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,679,567 - 34,681,274 (-)NCBINCBI36hg18NCBI36
Build 34934,679,566 - 34,681,274NCBI
Celera934,621,038 - 34,622,745 (-)NCBI
Cytogenetic Map9p13.3NCBI
HuRef934,643,820 - 34,645,529 (-)NCBIHuRef
CHM1_1934,689,356 - 34,691,063 (-)NCBICHM1_1
Ccl19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39442,754,525 - 42,756,365 (-)NCBIGRCm39mm39
GRCm39 Ensembl442,754,525 - 42,756,577 (-)Ensembl
GRCm38442,754,525 - 42,756,365 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl442,754,525 - 42,756,577 (-)EnsemblGRCm38mm10GRCm38
MGSCv37442,768,057 - 42,770,050 (-)NCBIGRCm37mm9NCBIm37
MGSCv36442,776,285 - 42,778,278 (-)NCBImm8
Cytogenetic Map4A5NCBI
Ccl19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2556,963,364 - 56,965,308 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl556,963,364 - 56,965,308 (-)Ensembl
Rnor_6.0558,181,025 - 58,182,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,181,026 - 58,183,017 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,705,391 - 62,707,335 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,221,738 - 59,223,682 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1559,221,917 - 59,223,865 (-)NCBI
Celera555,555,525 - 55,557,469 (-)NCBICelera
Cytogenetic Map5q22NCBI
Ccl19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,444,316 - 1,446,490 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,444,598 - 1,446,488 (+)NCBIChiLan1.0ChiLan1.0
CCL19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1935,334,353 - 35,336,108 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,334,353 - 35,336,108 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0934,525,820 - 34,527,628 (-)NCBIMhudiblu_PPA_v0panPan3
CCL19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,357,706 - 51,359,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,340,530 - 51,359,365 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1149,985,833 - 49,987,334 (-)NCBI
ROS_Cfam_1.01152,298,251 - 52,299,753 (-)NCBI
UMICH_Zoey_3.11150,960,957 - 50,962,456 (-)NCBI
UNSW_CanFamBas_1.01150,829,100 - 50,830,599 (-)NCBI
UU_Cfam_GSD_1.01151,593,870 - 51,595,370 (-)NCBI
Ccl19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,217,691 - 166,219,774 (-)NCBI
SpeTri2.0NW_0049365242,765,271 - 2,767,259 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11245,928,212 - 45,930,897 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,929,071 - 45,930,904 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603843,045,463 - 43,047,648 (+)NCBIVero_WHO_p1.0
Ccl19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473639,088,741 - 39,090,745 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 2 1
Low 2 2 3 2 21 2 1 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000012003   ⟹   ENSSSCP00000011695
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1032,110,064 - 32,112,739 (+)Ensembl
RefSeq Acc Id: NM_001170516   ⟹   NP_001163987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11032,110,366 - 32,112,529 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001163987 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ84093 (Get FASTA)   NCBI Sequence Viewer  
  CAP45767 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001163987   ⟸   NM_001170516
- Peptide Label: precursor
- UniProtKB: D0Z5W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000011695   ⟸   ENSSSCT00000012003
Protein Domains
SCY


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010966 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011695 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000012003 ENTREZGENE, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/TrEMBL
  Chemokine_CC_DCCL UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report ssc:494464 UniProtKB/TrEMBL
NCBI Gene CCL19 ENTREZGENE
PANTHER PTHR12015 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CC UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniProt D0Z5W4 ENTREZGENE, UniProtKB/TrEMBL
  F1S3U4_PIG UniProtKB/TrEMBL
  Q6EKW5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:95483 ENTREZGENE