CCL19 (C-C motif chemokine ligand 19)

Gene: CCL19 (C-C motif chemokine ligand 19) Pan paniscus

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Symbol:

CCL19

Name:

C-C motif chemokine ligand 19

RGD ID:

12034718

Description:

ENCODES a protein that exhibits CCR7 chemokine receptor binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cell maturation (ortholog); immunological synapse formation (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); allergic contact dermatitis (ortholog); allergic disease (ortholog); FOUND IN external side of plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-C motif chemokine 19

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	89,912,711 - 89,915,161 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	89,918,652 - 89,921,102 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	34,525,820 - 34,527,628 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	35,334,353 - 35,336,108 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	35,334,353 - 35,336,108 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

allergic contact dermatitis (ISO)

allergic disease (ISO)

anauxetic dysplasia (ISO)

aspergillosis (ISO)

asthma (ISO)

autosomal recessive distal hereditary motor neuronopathy 2 (ISO)

bacterial pneumonia (ISO)

distal arthrogryposis type 1A (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

genetic disease (ISO)

hyperphosphatasia with impaired intellectual development syndrome 2 (ISO)

pneumonia (ISO)

primary ciliary dyskinesia (ISO)

pulmonary fibrosis (ISO)

pulmonary sarcoidosis (ISO)

pulmonary tuberculosis (ISO)

rhinitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

cell maturation (ISO)

cell migration (IEA)

cellular response to virus (IEA)

chemotaxis (IEA)

dendritic cell chemotaxis (IEA)

establishment of T cell polarity (IEA)

immune response (IEA)

immunological synapse formation (ISO)

mature conventional dendritic cell differentiation (ISO)

myeloid dendritic cell chemotaxis (IEA)

negative regulation of dendritic cell apoptotic process (IEA)

positive regulation of canonical NF-kappaB signal transduction (IEA)

positive regulation of cell motility (IEA)

positive regulation of chemotaxis (ISO)

positive regulation of dendritic cell antigen processing and presentation (ISO)

positive regulation of dendritic cell dendrite assembly (ISO)

positive regulation of endocytosis (ISO)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of glycoprotein biosynthetic process (ISO)

positive regulation of interleukin-1 beta production (ISO)

positive regulation of interleukin-12 production (ISO)

positive regulation of JNK cascade (IEA)

positive regulation of neutrophil chemotaxis (IEA)

positive regulation of non-canonical NF-kappaB signal transduction (IEA)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

positive regulation of receptor-mediated endocytosis (ISO)

positive regulation of T cell proliferation (ISO)

positive regulation of T-helper 1 cell differentiation (ISO)

positive regulation of tumor necrosis factor production (ISO)

regulation of cell projection assembly (ISO)

release of sequestered calcium ion into cytosol (IEA)

response to nitric oxide (IEA)

response to prostaglandin E (IEA)

signal transduction (IEA)

T cell costimulation (ISO)

Cellular Component

external side of plasma membrane (ISO)

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

CCR chemokine receptor binding (IEA)

CCR10 chemokine receptor binding (IEA)

CCR7 chemokine receptor binding (ISO)

chemokine activity (IEA)

chemokine receptor binding (IEA)

cytokine activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CCL19
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	89,912,711 - 89,915,161 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	89,918,652 - 89,921,102 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	34,525,820 - 34,527,628 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	35,334,353 - 35,336,108 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	35,334,353 - 35,336,108 (-)	Ensembl	panpan1.1		panPan2

CCL19
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	34,689,570 - 34,691,276 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	34,689,570 - 34,691,276 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	34,689,567 - 34,691,273 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	34,679,567 - 34,681,274 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	34,679,566 - 34,681,274	NCBI
Celera	9	34,621,038 - 34,622,745 (-)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	34,643,820 - 34,645,529 (-)	NCBI		HuRef
CHM1_1	9	34,689,356 - 34,691,063 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	34,708,593 - 34,710,301 (-)	NCBI		T2T-CHM13v2.0

Ccl19
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	42,754,525 - 42,756,558 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	42,754,525 - 42,756,577 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	42,754,525 - 42,756,365 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	42,754,525 - 42,756,577 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	42,768,057 - 42,770,050 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	42,776,285 - 42,778,278 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	4	A5	NCBI
cM Map	4	22.44	NCBI

Ccl19
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	61,759,220 - 61,761,164 (-)	NCBI		GRCr8
mRatBN7.2	5	56,963,364 - 56,965,308 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	56,963,364 - 56,965,308 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	58,937,715 - 58,939,661 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	60,756,547 - 60,758,493 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	60,742,641 - 60,744,587 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	58,181,025 - 58,182,969 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	58,181,026 - 58,183,017 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	62,705,391 - 62,707,335 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	59,221,738 - 59,223,682 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	59,221,917 - 59,223,865 (-)	NCBI
Celera	5	55,555,525 - 55,557,469 (-)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

Ccl19
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	1,444,316 - 1,446,490 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	1,444,598 - 1,446,488 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCL19
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	51,357,706 - 51,359,207 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	51,340,530 - 51,359,365 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	49,985,833 - 49,987,334 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	52,298,251 - 52,299,753 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	52,281,068 - 52,299,911 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	50,960,957 - 50,962,456 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	50,829,100 - 50,830,599 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	51,593,870 - 51,595,370 (-)	NCBI		UU_Cfam_GSD_1.0

Ccl19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	166,217,691 - 166,219,774 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	2,765,267 - 2,767,385 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	2,765,271 - 2,767,259 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCL19
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	32,110,065 - 32,112,734 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	32,110,366 - 32,112,529 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	36,250,009 - 36,252,173 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCL19
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	45,928,212 - 45,930,897 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	45,929,071 - 45,930,904 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	43,045,463 - 43,047,648 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ccl19
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	39,088,921 - 39,090,394 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624736	39,088,741 - 39,090,745 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003829813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000042851 ⟹ ENSPPAP00000020066

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	35,334,353 - 35,336,108 (-)	Ensembl

RefSeq Acc Id:

XM_003829813 ⟹ XP_003829861

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	11	89,912,711 - 89,915,161 (+)	NCBI
NHGRI_mPanPan1	9	89,918,652 - 89,921,102 (+)	NCBI
Mhudiblu_PPA_v0	9	34,525,820 - 34,527,628 (-)	NCBI
PanPan1.1	9	35,334,353 - 35,336,108 (-)	NCBI

Sequence:

show sequence

AGAAAGTGAAGCTCTGGCCATAAATAAGAGTCAGCTGCAGGGCTCACATTCCCAGCCTCACATC
ACTCACACCTTGCATTTCACCCCTGCATCCCAGTCGCCCTGCAGCCTCACACAGATCCTGCACA
CACCCAGACAGCTGGCGCTCACACATTCACCGTTGGCCTGCCTCTGTTCACCCTCCATGGCCCT
GCTACTGGCCCTCAGCCTGCTGGTTCTCTGGACTTCCCCAGCCCCAACTCTGAGTGGCACCAAT
GATGCTGAAGACTGCTGCCTGTCTGTGACCCAGAAACCCATCCCGGGGTACATCGTGAGGAACT
TCCACTACCTTCTCATCAAGGATGGCTGCAGGGTGCCTGCTGTAGTGTTCACCACACTAAGGGG
CCGCCAGCTCTGTGCACCCCCAGACCAGCCCTGGGTAGAACGCATCATCCAGAGACTGCAGAGG
ACCTCAGCCAAGATGAAGCGCCGCAGCAATTAACCTATGACCATGCAGAGGGAGCCCGGAGTCC
AAGTGAAGCATTGTGAATTATTACCTAACCTGGGGAACCGAGGACCAGAAGGAAGGACCAGGCT
TCCAGCTCCTCTGCACCAGACCTGACCAGCCAGGACAGGGCCTGGGGTGTGTGTGAGTGTGAGT
GTGATCGAGAGGGTGAGTGTGGTCAGAGTAAAGCTGCTCCACCCCCAGATTGCAATGCTACCAA
TAAAGCCACCTGGTGTTTACAACTAATTGATCACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003829861	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000020066
	ENSPPAP00000020066.1

RefSeq Acc Id:	XP_003829861 ⟸ XM_003829813
- UniProtKB:	A0A2R9ARU8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALLLALSLLVLWTSPAPTLSGTNDAEDCCLSVTQKPIPGYIVRNFHYLLIKDGCRVPAVVFTT LRGRQLCAPPDQPWVERIIQRLQRTSAKMKRRSN hide sequence

RefSeq Acc Id:

ENSPPAP00000020066 ⟸ ENSPPAT00000042851

Protein Domains

Chemokine interleukin-8-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000033242	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000042851.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.40	UniProtKB/TrEMBL
InterPro	Chemokine_b/g/d	UniProtKB/TrEMBL
	Chemokine_CC_CS	UniProtKB/TrEMBL
	Chemokine_CC_DCCL	UniProtKB/TrEMBL
	Chemokine_IL8-like_dom	UniProtKB/TrEMBL
	Interleukin_8-like_sf	UniProtKB/TrEMBL
KEGG Report	pps:100978242	UniProtKB/TrEMBL
NCBI Gene	CCL19	ENTREZGENE
PANTHER	C-C MOTIF CHEMOKINE 19	UniProtKB/TrEMBL
	PTHR12015	UniProtKB/TrEMBL
Pfam	IL8	UniProtKB/TrEMBL
PROSITE	SMALL_CYTOKINES_CC	UniProtKB/TrEMBL
SMART	SCY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54117	UniProtKB/TrEMBL
UniProt	A0A2R9ARU8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD