RGD Reference Report - Expression of macrophage inflammatory protein-3 beta/CCL19 in pulmonary sarcoidosis. - Rat Genome Database

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Expression of macrophage inflammatory protein-3 beta/CCL19 in pulmonary sarcoidosis.

Authors: Gibejova, A  Mrazek, F  Subrtova, D  Sekerova, V  Szotkowska, J  Kolek, V  Du Bois, RM  Petrek, M 
Citation: Gibejova A, etal., Am J Respir Crit Care Med. 2003 Jun 15;167(12):1695-703. Epub 2003 Mar 5.
RGD ID: 5130912
Pubmed: PMID:12626344   (View Abstract at PubMed)
DOI: DOI:10.1164/rccm.200205-487OC   (Journal Full-text)

In this study, messenger RNA (mRNA) expression for novel T lymphocyte chemoattractants, leukotactin-1, macrophage inflammatory protein (MIP)-3 alpha and MIP-3 beta was investigated in bronchoalveolar lavage fluid (BALF) cells from patients with sarcoidosis, a T cell-mediated disease with typical CD4+ lymphocyte alveolitis. Of these three chemokines, only MIP-3 beta mRNA was upregulated in sarcoidosis, and therefore, protein levels of this chemokine, its pharmacologic regulation, and association with disease clinical course were explored. MIP-3 beta protein concentrations were elevated in BALF from sarcoid patients compared with control subjects (p = 0.001) and in patients with chest X-ray stage II chemokine protein levels were increased compared with stage I (p = 0.003). MIP-3 beta protein was associated predominantly with alveolar macrophages and correlated with BALF lymphocytes and T cell subsets. mRNA expression for the MIP-3 beta receptor, CC chemokine receptor 7, was increased in sarcoidosis and correlated with MIP-3 beta protein levels. MIP-3 beta mRNA and protein expression in BALF cells was suppressed by dexamethasone and cyclosporine A in vitro. In conclusion, MIP-3 beta is implicated in T lymphocyte recruitment in sarcoidosis, is associated with disease progression, and is downregulated by drugs used for sarcoidosis treatment. This novel chemokine, therefore, represents a candidate for studies of sarcoidosis pathobiologic mechanisms.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary sarcoidosis  IEP 5130912mRNA and protein:increased expression:lungRGD 
pulmonary sarcoidosis  IEP 5130912mRNA:increased expression:lungRGD 
pulmonary sarcoidosis  ISOCCL19 (Homo sapiens)5130912; 5130912mRNA and protein:increased expression:lungRGD 
pulmonary sarcoidosis  ISOCCR7 (Homo sapiens)5130912; 5130912mRNA:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl19  (C-C motif chemokine ligand 19)
Ccr7  (C-C motif chemokine receptor 7)

Genes (Mus musculus)
Ccl19  (C-C motif chemokine ligand 19)
Ccr7  (C-C motif chemokine receptor 7)

Genes (Homo sapiens)
CCL19  (C-C motif chemokine ligand 19)
CCR7  (C-C motif chemokine receptor 7)


Additional Information