PCSK6 (proprotein convertase subtilisin/kexin type 6) - Rat Genome Database

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Gene: PCSK6 (proprotein convertase subtilisin/kexin type 6) Sus scrofa
Analyze
Symbol: PCSK6
Name: proprotein convertase subtilisin/kexin type 6
RGD ID: 14025967
Description: ENCODES a protein that exhibits endopeptidase activity (inferred); heparin binding (inferred); hydrolase activity (inferred); INVOLVED IN peptide hormone processing (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,508,534 - 145,695,666 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21311,243,196 - 311,347,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK6Pigdeoxynivalenol decreases expressionEXP 6480464deoxynivalenol results in decreased expression of PCSK6 mRNACTDPMID:35307453


Biological Process
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK6Pigdetermination of left/right symmetry acts_upstream_of_or_withinIEAUniProtKB:F6XJP7 and ensembl:ENSMUSP00000053742150520179 EnsemblGO_REF:0000107
PCSK6Pigglycoprotein metabolic process involved_inIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pignerve growth factor production involved_inIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigpeptide hormone processing involved_inIBAMGI:97515 more ...150520179 GO_CentralGO_REF:0000033
PCSK6Pigpeptide hormone processing involved_inIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigpeptide hormone processing  ISOPcsk6 (Rattus norvegicus)9068941 RGDPMID:8070361 and REF_RGD_ID:729476
PCSK6Pigprotein processing acts_upstream_of_or_withinIEAUniProtKB:F6XJP7 and ensembl:ENSMUSP00000053742150520179 EnsemblGO_REF:0000107
PCSK6Pigprotein processing involved_inIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigproteolysis involved_inIEAInterPro:IPR000209 more ...150520179 InterProGO_REF:0000002
PCSK6Pigproteolysis involved_inIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PCSK6Pigsecretion by cell involved_inIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigzygotic determination of anterior/posterior axis, embryo acts_upstream_of_or_withinIEAUniProtKB:F6XJP7 and ensembl:ENSMUSP00000053742150520179 EnsemblGO_REF:0000107
1 to 12 of 12 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK6Pigcell surface is_active_inIBAPANTHER:PTN002872294 and UniProtKB:P29122150520179 GO_CentralGO_REF:0000033
PCSK6Pigcell surface located_inIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigcollagen-containing extracellular matrix is_active_inIBAPANTHER:PTN002872294 and UniProtKB:P29122150520179 GO_CentralGO_REF:0000033
PCSK6Pigcollagen-containing extracellular matrix located_inISOPCSK6 (Homo sapiens)9068941 PMID:12535616BHF-UCLPMID:12535616
PCSK6Pigextracellular space is_active_inIBAPANTHER:PTN002872294 and UniProtKB:P29122150520179 GO_CentralGO_REF:0000033
PCSK6Pigextracellular space located_inIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigmembrane is_active_inIBAFB:FBgn0004509 more ...150520179 GO_CentralGO_REF:0000033

Molecular Function
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PCSK6Pigendopeptidase activity enablesIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigheparin binding enablesIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pighydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
PCSK6Pignerve growth factor binding enablesIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigpeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PCSK6Pigprotein binding enablesISOUniProtKB:Q96D159068941 PMID:16433634UniProtPMID:16433634
PCSK6Pigprotein binding enablesISOUniProtKB:Q8N8Z8 and UniProtKB:Q92824-29068941 PMID:32296183IntActPMID:32296183
PCSK6Pigserine-type endopeptidase activity enablesIBACGD:CAL0000186377 more ...150520179 GO_CentralGO_REF:0000033
PCSK6Pigserine-type endopeptidase activity enablesIEAUniProtKB:P29122 and ensembl:ENSP00000482760150520179 EnsemblGO_REF:0000107
PCSK6Pigserine-type endopeptidase activity enablesIEAUniRule:UR001194527150520179 UniProtGO_REF:0000104
PCSK6Pigserine-type endopeptidase activity enablesIEAInterPro:IPR002884 and InterPro:IPR036852150520179 InterProGO_REF:0000002
PCSK6Pigserine-type peptidase activity enablesIEAUniProtKB-KW:KW-0720150520179 UniProtGO_REF:0000043
PCSK6Pigserine-type peptidase activity enablesIEAInterPro:IPR000209150520179 InterProGO_REF:0000002
1 to 13 of 13 rows

PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  



PCSK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,508,534 - 145,695,666 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21311,243,196 - 311,347,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3815101,303,933 - 101,489,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl15101,289,784 - 101,525,202 (-)EnsemblGRCh38hg38GRCh38
GRCh3715101,844,138 - 102,029,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361599,661,656 - 99,847,710 (-)NCBINCBI36Build 36hg18NCBI36
Celera1578,256,961 - 78,396,788 (-)NCBICelera
Cytogenetic Map15q26.3NCBI
HuRef1577,966,553 - 78,106,326 (-)NCBIHuRef
CHM1_115101,685,119 - 101,871,305 (-)NCBICHM1_1
T2T-CHM13v2.01599,058,998 - 99,244,970 (-)NCBIT2T-CHM13v2.0
Pcsk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39765,511,884 - 65,700,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl765,511,482 - 65,700,134 (+)EnsemblGRCm39 Ensembl
GRCm38765,862,136 - 66,050,386 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl765,861,734 - 66,050,386 (+)EnsemblGRCm38mm10GRCm38
MGSCv37773,007,022 - 73,195,272 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36765,740,684 - 65,929,336 (+)NCBIMGSCv36mm8
Celera763,292,677 - 63,485,752 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.36NCBI
Pcsk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81128,839,742 - 129,038,087 (+)NCBIGRCr8
mRatBN7.21119,428,978 - 119,627,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1119,429,265 - 119,627,596 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1127,422,899 - 127,620,747 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01134,594,338 - 134,792,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,403,150 - 127,601,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01126,749,508 - 126,947,392 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1126,749,508 - 126,947,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01127,884,080 - 128,033,742 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41120,324,843 - 120,476,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11120,403,185 - 120,555,256 (+)NCBI
Celera1111,644,666 - 111,839,248 (+)NCBICelera
Cytogenetic Map1q22NCBI
Pcsk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541628,184,768 - 28,314,759 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541628,184,768 - 28,314,697 (-)NCBIChiLan1.0ChiLan1.0
PCSK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21690,890,545 - 91,092,337 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11594,591,746 - 94,792,956 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01580,029,225 - 80,226,027 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11599,312,512 - 99,456,295 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1599,312,512 - 99,460,444 (-)Ensemblpanpan1.1panPan2
PCSK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1339,582,804 - 39,768,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl339,582,819 - 39,767,929 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha342,273,277 - 42,458,425 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0339,974,680 - 40,160,403 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl339,974,274 - 40,160,332 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1339,508,310 - 39,693,874 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0339,735,714 - 39,930,680 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0339,946,780 - 40,132,048 (+)NCBIUU_Cfam_GSD_1.0
Pcsk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640143,773,158 - 143,960,126 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364832,374,357 - 2,561,384 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364832,374,357 - 2,561,322 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12919,758,198 - 19,949,875 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2919,754,625 - 19,949,382 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605926,590,273 - 26,782,701 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247683,331,207 - 3,516,394 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247683,336,374 - 3,517,697 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in PCSK6
5374 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 5 14 12 23 3 6 1



Ensembl Acc Id: ENSSSCT00000006361   ⟹   ENSSSCP00000006199
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1145,508,534 - 145,695,666 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000044351   ⟹   ENSSSCP00000041047
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1145,508,534 - 145,695,666 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000082193   ⟹   ENSSSCP00000064395
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1145,508,636 - 145,695,666 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000088878   ⟹   ENSSSCP00000062443
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1145,508,534 - 145,655,304 (+)Ensembl
RefSeq Acc Id: XM_021098934   ⟹   XP_020954593
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098939   ⟹   XP_020954598
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098945   ⟹   XP_020954604
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098951   ⟹   XP_020954610
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020954593   ⟸   XM_021098934
- Peptide Label: isoform X1
- UniProtKB: A0A8D1P3S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954604   ⟸   XM_021098945
- Peptide Label: isoform X3
- UniProtKB: A0A8D1P3K1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954598   ⟸   XM_021098939
- Peptide Label: isoform X2
- UniProtKB: A0A4X1U6K9 (UniProtKB/TrEMBL),   F1RZ92 (UniProtKB/TrEMBL),   A0A8D1P3S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954610   ⟸   XM_021098951
- Peptide Label: isoform X4
- UniProtKB: A0A287AAR7 (UniProtKB/TrEMBL),   A0A4X1U9F2 (UniProtKB/TrEMBL),   A0A8D1P3K1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000062443   ⟸   ENSSSCT00000088878
P/Homo B   PLAC



1 to 40 of 108 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000005785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015049920 UniProtKB/TrEMBL
  ENSSSCG00025001935 UniProtKB/TrEMBL
  ENSSSCG00030022176 UniProtKB/TrEMBL
  ENSSSCG00035078804 UniProtKB/TrEMBL
  ENSSSCG00040042299 UniProtKB/TrEMBL
  ENSSSCG00045007647 UniProtKB/TrEMBL
  ENSSSCG00050076336 UniProtKB/TrEMBL
  ENSSSCG00055026277 UniProtKB/TrEMBL
  ENSSSCG00060042671 UniProtKB/TrEMBL
  ENSSSCG00065016041 UniProtKB/TrEMBL
  ENSSSCG00070014960 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006361 ENTREZGENE
  ENSSSCT00000006361.5 UniProtKB/TrEMBL
  ENSSSCT00000044351 ENTREZGENE
  ENSSSCT00000044351.3 UniProtKB/TrEMBL
  ENSSSCT00000082193.2 UniProtKB/TrEMBL
  ENSSSCT00000088878.2 UniProtKB/TrEMBL
  ENSSSCT00015068918.1 UniProtKB/TrEMBL
  ENSSSCT00015069815.1 UniProtKB/TrEMBL
  ENSSSCT00025002668.1 UniProtKB/TrEMBL
  ENSSSCT00025002691.1 UniProtKB/TrEMBL
  ENSSSCT00025002708.1 UniProtKB/TrEMBL
  ENSSSCT00030030798.1 UniProtKB/TrEMBL
  ENSSSCT00035108132.1 UniProtKB/TrEMBL
  ENSSSCT00035108180.1 UniProtKB/TrEMBL
  ENSSSCT00035108220.1 UniProtKB/TrEMBL
  ENSSSCT00040056643.1 UniProtKB/TrEMBL
  ENSSSCT00040056966.1 UniProtKB/TrEMBL
  ENSSSCT00040057176.1 UniProtKB/TrEMBL
  ENSSSCT00040057377.1 UniProtKB/TrEMBL
  ENSSSCT00045013098.1 UniProtKB/TrEMBL
  ENSSSCT00045013192.1 UniProtKB/TrEMBL
  ENSSSCT00045013297.1 UniProtKB/TrEMBL
  ENSSSCT00050104923.1 UniProtKB/TrEMBL
  ENSSSCT00050104927.1 UniProtKB/TrEMBL
  ENSSSCT00050104935.1 UniProtKB/TrEMBL
  ENSSSCT00055052672.1 UniProtKB/TrEMBL
  ENSSSCT00055052819.1 UniProtKB/TrEMBL
  ENSSSCT00055052934.1 UniProtKB/TrEMBL
1 to 40 of 108 rows