PCSK6 (proprotein convertase subtilisin/kexin type 6) - Rat Genome Database

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Gene: PCSK6 (proprotein convertase subtilisin/kexin type 6) Sus scrofa
Analyze
Symbol: PCSK6
Name: proprotein convertase subtilisin/kexin type 6
RGD ID: 14025967
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); INVOLVED IN determination of left/right symmetry (ortholog); peptide hormone processing (ortholog); protein processing (ortholog); FOUND IN cell surface (ortholog); collagen-containing extracellular matrix (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,508,636 - 145,697,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21311,243,196 - 311,347,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
PCSK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,508,636 - 145,697,009 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21311,243,196 - 311,347,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl15101,289,784 - 101,525,202 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl15101,297,142 - 101,525,202 (-)EnsemblGRCh38hg38GRCh38
GRCh3815101,303,933 - 101,489,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3715101,844,138 - 102,029,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361599,661,656 - 99,847,710 (-)NCBINCBI36hg18NCBI36
Celera1578,256,961 - 78,396,788 (-)NCBI
Cytogenetic Map15q26.3NCBI
HuRef1577,966,553 - 78,106,326 (-)NCBIHuRef
CHM1_115101,685,119 - 101,871,305 (-)NCBICHM1_1
Pcsk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39765,511,884 - 65,700,134 (+)NCBIGRCm39mm39
GRCm39 Ensembl765,511,482 - 65,700,134 (+)Ensembl
GRCm38765,862,136 - 66,050,386 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl765,861,734 - 66,050,386 (+)EnsemblGRCm38mm10GRCm38
MGSCv37773,007,022 - 73,195,272 (+)NCBIGRCm37mm9NCBIm37
MGSCv36765,740,684 - 65,929,336 (+)NCBImm8
Celera763,292,677 - 63,485,752 (+)NCBICelera
Cytogenetic Map7CNCBI
cM Map735.36NCBI
Pcsk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21119,428,978 - 119,627,626 (+)NCBI
Rnor_6.0 Ensembl1126,749,508 - 126,947,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01126,749,508 - 126,947,392 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01127,884,080 - 128,033,742 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41120,324,843 - 120,476,913 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11120,403,185 - 120,555,256 (+)NCBI
Celera1111,644,666 - 111,839,248 (+)NCBICelera
Cytogenetic Map1q22NCBI
Pcsk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541628,184,768 - 28,314,759 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541628,184,768 - 28,314,697 (-)NCBIChiLan1.0ChiLan1.0
PCSK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11599,312,512 - 99,456,295 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1599,312,512 - 99,460,444 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01580,029,225 - 80,226,027 (-)NCBIMhudiblu_PPA_v0panPan3
PCSK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1339,582,804 - 39,768,838 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl339,582,819 - 39,767,929 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha342,273,277 - 42,458,425 (+)NCBI
ROS_Cfam_1.0339,974,680 - 40,160,403 (+)NCBI
UMICH_Zoey_3.1339,508,310 - 39,693,874 (+)NCBI
UNSW_CanFamBas_1.0339,735,714 - 39,930,680 (+)NCBI
UU_Cfam_GSD_1.0339,946,780 - 40,132,048 (+)NCBI
Pcsk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640143,773,158 - 143,960,126 (-)NCBI
SpeTri2.0NW_0049364832,374,357 - 2,561,322 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12919,758,198 - 19,949,875 (-)NCBI
ChlSab1.1 Ensembl2919,754,625 - 19,949,382 (-)Ensembl
Pcsk6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247683,336,374 - 3,517,697 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 2 12 1
Low 9 2 3 5 2 11 2 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000006361   ⟹   ENSSSCP00000006199
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1145,508,636 - 145,697,004 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000044351   ⟹   ENSSSCP00000041047
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1145,508,636 - 145,697,009 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082193   ⟹   ENSSSCP00000064395
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1145,508,636 - 145,697,004 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000088878   ⟹   ENSSSCP00000062443
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1145,508,636 - 145,655,304 (+)Ensembl
RefSeq Acc Id: XM_021098934   ⟹   XP_020954593
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098939   ⟹   XP_020954598
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098945   ⟹   XP_020954604
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098951   ⟹   XP_020954610
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11145,508,658 - 145,697,017 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020954593 (Get FASTA)   NCBI Sequence Viewer  
  XP_020954598 (Get FASTA)   NCBI Sequence Viewer  
  XP_020954604 (Get FASTA)   NCBI Sequence Viewer  
  XP_020954610 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020954593   ⟸   XM_021098934
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020954604   ⟸   XM_021098945
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020954598   ⟸   XM_021098939
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020954610   ⟸   XM_021098951
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000062443   ⟸   ENSSSCT00000088878
RefSeq Acc Id: ENSSSCP00000041047   ⟸   ENSSSCT00000044351
RefSeq Acc Id: ENSSSCP00000006199   ⟸   ENSSSCT00000006361
RefSeq Acc Id: ENSSSCP00000064395   ⟸   ENSSSCT00000082193
Protein Domains
P/Homo B   PLAC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005785 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070014960 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000006199 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000041047 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000062443 UniProtKB/TrEMBL
  ENSSSCP00000064395 UniProtKB/TrEMBL
  ENSSSCP00070024499 UniProtKB/TrEMBL
  ENSSSCP00070024510 UniProtKB/TrEMBL
  ENSSSCP00070024527 UniProtKB/TrEMBL
  ENSSSCP00070024539 UniProtKB/TrEMBL
  ENSSSCP00070024554 UniProtKB/TrEMBL
  ENSSSCP00070024569 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006361 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000044351 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000082193 UniProtKB/TrEMBL
  ENSSSCT00000088878 UniProtKB/TrEMBL
  ENSSSCT00070029398 UniProtKB/TrEMBL
  ENSSSCT00070029409 UniProtKB/TrEMBL
  ENSSSCT00070029428 UniProtKB/TrEMBL
  ENSSSCT00070029442 UniProtKB/TrEMBL
  ENSSSCT00070029460 UniProtKB/TrEMBL
  ENSSSCT00070029478 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.260 UniProtKB/TrEMBL
  3.30.70.850 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kexin/furin UniProtKB/TrEMBL
  P_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/TrEMBL
NCBI Gene PCSK6 ENTREZGENE
Pfam GF_recep_IV UniProtKB/TrEMBL
  P_proprotein UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  SM00261 UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/TrEMBL
  SSF52743 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A287AAR7_PIG UniProtKB/TrEMBL
  A0A4X1U4E9_PIG UniProtKB/TrEMBL
  A0A4X1U4G6_PIG UniProtKB/TrEMBL
  A0A4X1U6K9_PIG UniProtKB/TrEMBL
  A0A4X1U8S3_PIG UniProtKB/TrEMBL
  A0A4X1U9B0_PIG UniProtKB/TrEMBL
  A0A4X1U9F2_PIG UniProtKB/TrEMBL
  A0A5G2QE53_PIG UniProtKB/TrEMBL
  A0A5G2QQQ5_PIG UniProtKB/TrEMBL
  F1RZ92_PIG UniProtKB/TrEMBL
VGNC ID VGNC:103148 ENTREZGENE