PDE8A (phosphodiesterase 8A) - Rat Genome Database

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Gene: PDE8A (phosphodiesterase 8A) Sus scrofa
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Symbol: PDE8A
Name: phosphodiesterase 8A
RGD ID: 13995946
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-GMP phosphodiesterase activity (inferred); 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred); INVOLVED IN cAMP catabolic process (inferred); cellular response to epidermal growth factor stimulus (inferred); positive regulation of ERK1 and ERK2 cascade (inferred); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,410,779 - 52,557,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,410,766 - 52,558,482 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2757,896,426 - 57,969,573 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDE8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,410,779 - 52,557,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,410,766 - 52,558,482 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2757,896,426 - 57,969,573 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381584,980,467 - 85,139,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1584,980,440 - 85,139,145 (+)EnsemblGRCh38hg38GRCh38
GRCh371585,523,698 - 85,682,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361583,326,209 - 83,483,377 (+)NCBINCBI36Build 36hg18NCBI36
Celera1561,951,944 - 62,111,125 (+)NCBICelera
Cytogenetic Map15q25.3NCBI
HuRef1561,609,653 - 61,768,261 (+)NCBIHuRef
CHM1_11585,364,949 - 85,523,920 (+)NCBICHM1_1
T2T-CHM13v2.01582,732,711 - 82,891,368 (+)NCBIT2T-CHM13v2.0
Pde8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,863,013 - 80,984,283 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,863,344 - 80,984,281 (+)EnsemblGRCm39 Ensembl
GRCm38781,213,265 - 81,334,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl781,213,596 - 81,334,533 (+)EnsemblGRCm38mm10GRCm38
MGSCv37788,358,690 - 88,478,508 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36781,087,251 - 81,208,043 (+)NCBIMGSCv36mm8
Celera778,686,223 - 78,738,796 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.71NCBI
Pde8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,575,203 - 144,698,216 (+)NCBIGRCr8
mRatBN7.21135,166,143 - 135,288,986 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,166,237 - 135,288,024 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1143,080,882 - 143,202,783 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01150,250,292 - 150,372,196 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,162,918 - 143,285,137 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,036,083 - 143,160,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,036,218 - 143,159,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,980,312 - 144,102,752 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,415,852 - 137,544,337 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,494,257 - 137,622,743 (+)NCBI
Celera1127,217,639 - 127,339,111 (+)NCBICelera
Cytogenetic Map1q31NCBI
Pde8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,063,123 - 14,125,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,063,117 - 14,204,297 (-)NCBIChiLan1.0ChiLan1.0
PDE8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21673,934,543 - 74,094,624 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11578,154,258 - 78,310,579 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01563,649,336 - 63,805,613 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11582,971,764 - 83,127,963 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1582,971,986 - 83,127,957 (+)Ensemblpanpan1.1panPan2
PDE8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1354,278,498 - 54,367,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl354,128,680 - 54,367,400 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha356,852,891 - 57,008,693 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0354,631,013 - 54,787,194 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl354,631,028 - 54,787,190 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1354,151,873 - 54,307,649 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0354,360,516 - 54,516,720 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,702,916 - 54,859,444 (+)NCBIUU_Cfam_GSD_1.0
Pde8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640129,171,415 - 129,324,830 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648317,095,318 - 17,163,114 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648317,009,696 - 17,163,105 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1293,214,183 - 3,367,051 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl293,213,165 - 3,367,571 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605943,694,868 - 43,851,671 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pde8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476818,180,061 - 18,352,830 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476818,180,066 - 18,352,749 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PDE8A
3127 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000002027   ⟹   ENSSSCP00000001978
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl752,410,779 - 52,556,789 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000002031   ⟹   ENSSSCP00000001982
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl752,410,779 - 52,556,789 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000002032   ⟹   ENSSSCP00000001983
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl752,410,779 - 52,557,645 (-)Ensembl
RefSeq Acc Id: XM_021098897   ⟹   XP_020954556
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1752,410,766 - 52,556,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098898   ⟹   XP_020954557
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1752,410,766 - 52,558,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098899   ⟹   XP_020954558
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1752,410,766 - 52,557,477 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020954557   ⟸   XM_021098898
- Peptide Label: isoform X2
- UniProtKB: A0A4X1UL42 (UniProtKB/TrEMBL),   A0A8D0Q9J4 (UniProtKB/TrEMBL),   A0A8D0T2P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954558   ⟸   XM_021098899
- Peptide Label: isoform X2
- UniProtKB: A0A4X1UL42 (UniProtKB/TrEMBL),   A0A8D0Q9J4 (UniProtKB/TrEMBL),   A0A8D0T2P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954556   ⟸   XM_021098897
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UL47 (UniProtKB/TrEMBL),   A0A480KMJ1 (UniProtKB/TrEMBL),   A0A8D0T250 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000001978   ⟸   ENSSSCT00000002027
Ensembl Acc Id: ENSSSCP00000001983   ⟸   ENSSSCT00000002032
Ensembl Acc Id: ENSSSCP00000001982   ⟸   ENSSSCT00000002031
Protein Domains
PAS   PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001810 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005015561 UniProtKB/TrEMBL
  ENSSSCG00015078936 UniProtKB/TrEMBL
  ENSSSCG00025066866 UniProtKB/TrEMBL
  ENSSSCG00030065867 UniProtKB/TrEMBL
  ENSSSCG00035055617 UniProtKB/TrEMBL
  ENSSSCG00040002560 UniProtKB/TrEMBL
  ENSSSCG00045003894 UniProtKB/TrEMBL
  ENSSSCG00055017505 UniProtKB/TrEMBL
  ENSSSCG00060042192 UniProtKB/TrEMBL
  ENSSSCG00065077145 UniProtKB/TrEMBL
  ENSSSCG00070017737 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002027 ENTREZGENE
  ENSSSCT00000002027.5 UniProtKB/TrEMBL
  ENSSSCT00000002031.5 UniProtKB/TrEMBL
  ENSSSCT00000002032 ENTREZGENE
  ENSSSCT00000002032.5 UniProtKB/TrEMBL
  ENSSSCT00005024295.1 UniProtKB/TrEMBL
  ENSSSCT00005024403.1 UniProtKB/TrEMBL
  ENSSSCT00005024432.1 UniProtKB/TrEMBL
  ENSSSCT00005024508.1 UniProtKB/TrEMBL
  ENSSSCT00005024678.1 UniProtKB/TrEMBL
  ENSSSCT00015107403.1 UniProtKB/TrEMBL
  ENSSSCT00015107540.1 UniProtKB/TrEMBL
  ENSSSCT00015107570.1 UniProtKB/TrEMBL
  ENSSSCT00025092115.1 UniProtKB/TrEMBL
  ENSSSCT00025092362.1 UniProtKB/TrEMBL
  ENSSSCT00025092646.1 UniProtKB/TrEMBL
  ENSSSCT00030092468.1 UniProtKB/TrEMBL
  ENSSSCT00035074265.1 UniProtKB/TrEMBL
  ENSSSCT00035074275.1 UniProtKB/TrEMBL
  ENSSSCT00035074291.1 UniProtKB/TrEMBL
  ENSSSCT00040003282.1 UniProtKB/TrEMBL
  ENSSSCT00045006477.1 UniProtKB/TrEMBL
  ENSSSCT00055034982.1 UniProtKB/TrEMBL
  ENSSSCT00055035144.1 UniProtKB/TrEMBL
  ENSSSCT00055035323.1 UniProtKB/TrEMBL
  ENSSSCT00060057209.1 UniProtKB/TrEMBL
  ENSSSCT00065106774.1 UniProtKB/TrEMBL
  ENSSSCT00070035120.1 UniProtKB/TrEMBL
  ENSSSCT00070035132.1 UniProtKB/TrEMBL
  ENSSSCT00070035139.1 UniProtKB/TrEMBL
  ENSSSCT00070035148.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
  PDEase_PDE8 UniProtKB/TrEMBL
NCBI Gene PDE8A ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE PHOSPHODIESTERASE UniProtKB/TrEMBL
  HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A UniProtKB/TrEMBL
Pfam PAS_9 UniProtKB/TrEMBL
  PDE8 UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PAS UniProtKB/TrEMBL
  PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP HD-domain/PDEase-like UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A480KMJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UHC5_PIG UniProtKB/TrEMBL
  A0A4X1UL42 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UL47 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0IIL8_PIG UniProtKB/TrEMBL
  A0A8D0IS68_PIG UniProtKB/TrEMBL
  A0A8D0LJH7_PIG UniProtKB/TrEMBL
  A0A8D0Q9J4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0T250 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0T2P5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0UE39_PIG UniProtKB/TrEMBL
  A0A8D0UEK6_PIG UniProtKB/TrEMBL
  A0A8D1A823_PIG UniProtKB/TrEMBL
  F1RI93_PIG UniProtKB/TrEMBL
  F1RMJ5_PIG UniProtKB/TrEMBL
  F1RMJ6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91263 ENTREZGENE