PDE8A (phosphodiesterase 8A) - Rat Genome Database

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Gene: PDE8A (phosphodiesterase 8A) Sus scrofa
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Symbol: PDE8A
Name: phosphodiesterase 8A
RGD ID: 13995946
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (inferred); 3',5'-cyclic-GMP phosphodiesterase activity (inferred); 3',5'-cyclic-nucleotide phosphodiesterase activity (inferred); INVOLVED IN negative regulation of cell death (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colon cancer (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,410,779 - 52,556,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,410,766 - 52,558,482 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2757,896,426 - 57,969,573 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
PDE8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,410,779 - 52,556,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,410,766 - 52,558,482 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2757,896,426 - 57,969,573 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1584,980,440 - 85,139,145 (+)EnsemblGRCh38hg38GRCh38
GRCh381584,980,467 - 85,139,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371585,523,698 - 85,682,373 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361583,326,209 - 83,483,377 (+)NCBINCBI36hg18NCBI36
Celera1561,951,944 - 62,111,125 (+)NCBI
Cytogenetic Map15q25.3NCBI
HuRef1561,609,653 - 61,768,261 (+)NCBIHuRef
CHM1_11585,364,949 - 85,523,920 (+)NCBICHM1_1
Pde8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,863,013 - 80,984,283 (+)NCBIGRCm39mm39
GRCm39 Ensembl780,863,344 - 80,984,281 (+)Ensembl
GRCm38781,213,265 - 81,334,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl781,213,596 - 81,334,533 (+)EnsemblGRCm38mm10GRCm38
MGSCv37788,358,690 - 88,478,508 (+)NCBIGRCm37mm9NCBIm37
MGSCv36781,087,251 - 81,208,043 (+)NCBImm8
Celera778,686,223 - 78,738,796 (+)NCBICelera
Cytogenetic Map7D3NCBI
Pde8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21135,166,143 - 135,288,986 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1135,166,237 - 135,288,024 (+)Ensembl
Rnor_6.01143,036,083 - 143,160,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,036,218 - 143,159,433 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,980,312 - 144,102,752 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,415,852 - 137,544,337 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11137,494,257 - 137,622,743 (+)NCBI
Celera1127,217,639 - 127,339,111 (+)NCBICelera
Cytogenetic Map1q31NCBI
Pde8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,063,123 - 14,125,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,063,117 - 14,204,297 (-)NCBIChiLan1.0ChiLan1.0
PDE8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11582,971,764 - 83,127,963 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1582,971,986 - 83,127,957 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01563,649,336 - 63,805,613 (+)NCBIMhudiblu_PPA_v0panPan3
PDE8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1354,278,498 - 54,367,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl354,128,680 - 54,367,400 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha356,852,891 - 57,008,693 (+)NCBI
ROS_Cfam_1.0354,631,013 - 54,787,194 (+)NCBI
UMICH_Zoey_3.1354,151,873 - 54,307,649 (+)NCBI
UNSW_CanFamBas_1.0354,360,516 - 54,516,720 (+)NCBI
UU_Cfam_GSD_1.0354,702,916 - 54,859,444 (+)NCBI
Pde8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640129,171,415 - 129,324,830 (-)NCBI
SpeTri2.0NW_00493648317,009,696 - 17,163,105 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1293,214,183 - 3,367,051 (-)NCBI
ChlSab1.1 Ensembl293,213,165 - 3,367,571 (-)Ensembl
Vero_WHO_p1.0NW_02366605943,694,868 - 43,851,671 (+)NCBI
Pde8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476818,180,066 - 18,352,749 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 1 4 17 2 1 2
Low 2 2 1 2 6 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002027   ⟹   ENSSSCP00000001978
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl752,410,779 - 52,556,884 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000002031   ⟹   ENSSSCP00000001982
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl752,410,779 - 52,556,884 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000002032   ⟹   ENSSSCP00000001983
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl752,410,779 - 52,556,884 (-)Ensembl
RefSeq Acc Id: XM_021098897   ⟹   XP_020954556
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1752,410,766 - 52,556,923 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098898   ⟹   XP_020954557
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1752,410,766 - 52,558,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021098899   ⟹   XP_020954558
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1752,410,766 - 52,557,477 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020954556 (Get FASTA)   NCBI Sequence Viewer  
  XP_020954557 (Get FASTA)   NCBI Sequence Viewer  
  XP_020954558 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020954557   ⟸   XM_021098898
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020954558   ⟸   XM_021098899
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020954556   ⟸   XM_021098897
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000001978   ⟸   ENSSSCT00000002027
RefSeq Acc Id: ENSSSCP00000001983   ⟸   ENSSSCT00000002032
RefSeq Acc Id: ENSSSCP00000001982   ⟸   ENSSSCT00000002031
Protein Domains
PAS   PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001810 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070017737 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001978 UniProtKB/TrEMBL
  ENSSSCP00000001982 UniProtKB/TrEMBL
  ENSSSCP00000001983 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070029330 UniProtKB/TrEMBL
  ENSSSCP00070029342 UniProtKB/TrEMBL
  ENSSSCP00070029348 UniProtKB/TrEMBL
  ENSSSCP00070029357 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002027 UniProtKB/TrEMBL
  ENSSSCT00000002031 UniProtKB/TrEMBL
  ENSSSCT00000002032 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070035120 UniProtKB/TrEMBL
  ENSSSCT00070035132 UniProtKB/TrEMBL
  ENSSSCT00070035139 UniProtKB/TrEMBL
  ENSSSCT00070035148 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
InterPro HD/PDEase_dom UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
  PDEase_PDE8 UniProtKB/TrEMBL
NCBI Gene PDE8A ENTREZGENE
Pfam PAS_9 UniProtKB/TrEMBL
  PDE8 UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PAS UniProtKB/TrEMBL
  PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART HDc UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP SSF55785 UniProtKB/TrEMBL
TIGRFAMs sensory_box UniProtKB/TrEMBL
UniProt A0A4X1UHC5_PIG UniProtKB/TrEMBL
  A0A4X1UL42_PIG UniProtKB/TrEMBL
  A0A4X1UL47_PIG UniProtKB/TrEMBL
  F1RI93_PIG UniProtKB/TrEMBL
  F1RMJ5_PIG UniProtKB/TrEMBL
  F1RMJ6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91263 ENTREZGENE