MLLT3 (MLLT3 super elongation complex subunit) - Rat Genome Database

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Gene: MLLT3 (MLLT3 super elongation complex subunit) Sus scrofa
Analyze
Symbol: MLLT3
Name: MLLT3 super elongation complex subunit
RGD ID: 13989434
Description: ENCODES a protein that exhibits molecular adaptor activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); gene expression (ortholog); negative regulation of canonical Wnt signaling pathway (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH Diabetic Nephropathies (ortholog); genetic disease (ortholog); FOUND IN cytosol (inferred); intracellular organelle (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); protein AF-9; translocated to, 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1202,318,929 - 202,607,058 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11202,317,458 - 202,604,308 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,899,052 - 226,359,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MLLT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1202,318,929 - 202,607,058 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11202,317,458 - 202,604,308 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,899,052 - 226,359,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MLLT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38920,341,669 - 20,622,499 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl920,341,669 - 20,622,499 (-)EnsemblGRCh38hg38GRCh38
GRCh37920,341,667 - 20,622,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36920,334,968 - 20,612,514 (-)NCBINCBI36Build 36hg18NCBI36
Build 34920,334,967 - 20,612,450NCBI
Celera920,283,496 - 20,561,027 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef920,307,852 - 20,585,160 (-)NCBIHuRef
CHM1_1920,344,745 - 20,622,226 (-)NCBICHM1_1
T2T-CHM13v2.0920,355,454 - 20,636,229 (-)NCBIT2T-CHM13v2.0
Mllt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39487,688,162 - 87,951,652 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl487,688,162 - 87,951,601 (-)EnsemblGRCm39 Ensembl
GRCm38487,769,925 - 88,033,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl487,769,925 - 88,033,364 (-)EnsemblGRCm38mm10GRCm38
MGSCv37487,415,829 - 87,679,311 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36487,243,893 - 87,504,502 (-)NCBIMGSCv36mm8
Celera486,294,560 - 86,557,875 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map441.06NCBI
Mllt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85107,305,008 - 107,561,352 (-)NCBIGRCr8
mRatBN7.25102,259,075 - 102,515,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5102,260,011 - 102,515,361 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5104,613,871 - 104,868,371 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05106,404,352 - 106,658,847 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05106,458,881 - 106,715,826 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05106,103,498 - 106,202,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5106,103,407 - 106,207,126 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05110,089,246 - 110,183,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45107,070,371 - 107,088,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15107,075,575 - 107,093,597 (-)NCBI
Celera5100,747,987 - 100,840,556 (+)NCBICelera
Cytogenetic Map5q32NCBI
Mllt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543422,594,681 - 22,873,826 (-)NCBIChiLan1.0ChiLan1.0
MLLT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211103,938,759 - 104,216,048 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19103,944,705 - 104,222,437 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0920,140,160 - 20,417,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1920,799,010 - 21,073,150 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl920,800,393 - 21,073,046 (-)Ensemblpanpan1.1panPan2
MLLT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11139,923,165 - 40,203,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1139,927,517 - 40,203,281 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1138,587,790 - 38,867,401 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01140,865,722 - 41,146,444 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1140,869,752 - 41,146,462 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11139,557,396 - 39,837,144 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01139,340,486 - 39,620,675 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01139,981,473 - 40,261,006 (-)NCBIUU_Cfam_GSD_1.0
Mllt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947154,371,177 - 154,639,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366522,044,874 - 2,308,832 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366522,040,685 - 2,309,059 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Mllt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473624,298,750 - 24,586,185 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MLLT3
4416 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 3 1 2 10 1
Low 8 3 4 13 2 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005694   ⟹   ENSSSCP00000005553
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1202,319,445 - 202,604,273 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050425   ⟹   ENSSSCP00000059604
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1202,317,453 - 202,607,061 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000063612   ⟹   ENSSSCP00000038822
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1202,318,929 - 202,607,058 (+)Ensembl
RefSeq Acc Id: XM_003121886   ⟹   XP_003121934
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11202,318,851 - 202,604,308 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013993520   ⟹   XP_013848974
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11202,319,360 - 202,604,308 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013993522   ⟹   XP_013848976
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11202,317,458 - 202,604,308 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013848976   ⟸   XM_013993522
- Peptide Label: isoform X1
- UniProtKB: A0A4X1WD13 (UniProtKB/TrEMBL),   A0A8D0J400 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003121934   ⟸   XM_003121886
- Peptide Label: isoform X2
- UniProtKB: A0A287A4E4 (UniProtKB/TrEMBL),   A0A4X1WD08 (UniProtKB/TrEMBL),   A0A8D0J400 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848974   ⟸   XM_013993520
- Peptide Label: isoform X3
- UniProtKB: A0A4X1W628 (UniProtKB/TrEMBL),   F1SNG3 (UniProtKB/TrEMBL),   A0A8D0J400 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000005553   ⟸   ENSSSCT00000005694
RefSeq Acc Id: ENSSSCP00000059604   ⟸   ENSSSCT00000050425
RefSeq Acc Id: ENSSSCP00000038822   ⟸   ENSSSCT00000063612
Protein Domains
AF-9 ANC1 homology


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005166 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005020449 UniProtKB/TrEMBL
  ENSSSCG00015005525 UniProtKB/TrEMBL
  ENSSSCG00025061168 UniProtKB/TrEMBL
  ENSSSCG00030055974 UniProtKB/TrEMBL
  ENSSSCG00035000188 UniProtKB/TrEMBL
  ENSSSCG00040073244 UniProtKB/TrEMBL
  ENSSSCG00045012630 UniProtKB/TrEMBL
  ENSSSCG00050041312 UniProtKB/TrEMBL
  ENSSSCG00055019103 UniProtKB/TrEMBL
  ENSSSCG00060028402 UniProtKB/TrEMBL
  ENSSSCG00065019474 UniProtKB/TrEMBL
  ENSSSCG00070030248 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005694 ENTREZGENE
  ENSSSCT00000005694.5 UniProtKB/TrEMBL
  ENSSSCT00000063612 ENTREZGENE
  ENSSSCT00000063612.3 UniProtKB/TrEMBL
  ENSSSCT00005032799.1 UniProtKB/TrEMBL
  ENSSSCT00015007364.1 UniProtKB/TrEMBL
  ENSSSCT00015007373.1 UniProtKB/TrEMBL
  ENSSSCT00015007381.1 UniProtKB/TrEMBL
  ENSSSCT00025083750.1 UniProtKB/TrEMBL
  ENSSSCT00025083978.1 UniProtKB/TrEMBL
  ENSSSCT00025084060.1 UniProtKB/TrEMBL
  ENSSSCT00030078011.1 UniProtKB/TrEMBL
  ENSSSCT00030078047.1 UniProtKB/TrEMBL
  ENSSSCT00030078069.1 UniProtKB/TrEMBL
  ENSSSCT00035000198.1 UniProtKB/TrEMBL
  ENSSSCT00035000201.1 UniProtKB/TrEMBL
  ENSSSCT00040101002.1 UniProtKB/TrEMBL
  ENSSSCT00040101040.1 UniProtKB/TrEMBL
  ENSSSCT00040101063.1 UniProtKB/TrEMBL
  ENSSSCT00045021481.1 UniProtKB/TrEMBL
  ENSSSCT00045021501.1 UniProtKB/TrEMBL
  ENSSSCT00045021518.1 UniProtKB/TrEMBL
  ENSSSCT00050056009.1 UniProtKB/TrEMBL
  ENSSSCT00050056011.1 UniProtKB/TrEMBL
  ENSSSCT00050056015.1 UniProtKB/TrEMBL
  ENSSSCT00055037416.1 UniProtKB/TrEMBL
  ENSSSCT00055037537.1 UniProtKB/TrEMBL
  ENSSSCT00055037603.1 UniProtKB/TrEMBL
  ENSSSCT00060038411.1 UniProtKB/TrEMBL
  ENSSSCT00060038418.1 UniProtKB/TrEMBL
  ENSSSCT00060038424.1 UniProtKB/TrEMBL
  ENSSSCT00065025928.1 UniProtKB/TrEMBL
  ENSSSCT00065025932.1 UniProtKB/TrEMBL
  ENSSSCT00065025945.1 UniProtKB/TrEMBL
  ENSSSCT00065025952.1 UniProtKB/TrEMBL
  ENSSSCT00070060867.1 UniProtKB/TrEMBL
  ENSSSCT00070060869.1 UniProtKB/TrEMBL
  ENSSSCT00070060870.1 UniProtKB/TrEMBL
  ENSSSCT00070060872.1 UniProtKB/TrEMBL
  ENSSSCT00070060875.1 UniProtKB/TrEMBL
  ENSSSCT00070060877.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.290 UniProtKB/TrEMBL
  2.60.40.1970 UniProtKB/TrEMBL
InterPro AF-9_AHD UniProtKB/TrEMBL
  YEAST_sf UniProtKB/TrEMBL
  YEATS UniProtKB/TrEMBL
KEGG Report ssc:100524063 UniProtKB/TrEMBL
NCBI Gene MLLT3 ENTREZGENE
PANTHER AHD DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PROTEIN AF-9 UniProtKB/TrEMBL
Pfam AHD UniProtKB/TrEMBL
  YEATS UniProtKB/TrEMBL
PROSITE YEATS UniProtKB/TrEMBL
UniProt A0A287A4E4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W628 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WBL4_PIG UniProtKB/TrEMBL
  A0A4X1WD08 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WD13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0J400 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0T011_PIG UniProtKB/TrEMBL
  A0A8D1XT78_PIG UniProtKB/TrEMBL
  A0A8D1XW07_PIG UniProtKB/TrEMBL
  F1SNG3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:90256 ENTREZGENE