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Gene: MLLT3 (MLLT3 super elongation complex subunit) Homo sapiens
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Symbol: MLLT3
Name: MLLT3 super elongation complex subunit
Description: Exhibits chromatin binding activity and lysine-acetylated histone binding activity. Involved in negative regulation of canonical Wnt signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; and positive regulation of transcription, DNA-templated. Localizes to the cytosol and transcription elongation factor complex; PARTICIPATES IN RNA polymerase II transcription elongation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AF-9; AF9; ALL1-fused gene from chromosome 9 protein; FLJ2035; MLLT3, super elongation complex subunit; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax (drosophila) homolog) (translocated to, 3); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog) (translocated to, 3); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; translocated to 3; translocated to, 3; YEATS domain-containing protein 3; YEATS3
Orthologs:
Mus musculus (house mouse) : Mllt3 (myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mllt3 (MLLT3, super elongation complex subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mllt3 (MLLT3 super elongation complex subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : MLLT3 (MLLT3 super elongation complex subunit)
Canis lupus familiaris (dog) : MLLT3 (MLLT3 super elongation complex subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mllt3 (MLLT3 super elongation complex subunit)
Sus scrofa (pig) : MLLT3 (MLLT3 super elongation complex subunit)
Chlorocebus sabaeus (green monkey) : MLLT3 (MLLT3 super elongation complex subunit)
Heterocephalus glaber (naked mole-rat) : Mllt3 (MLLT3 super elongation complex subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl920,341,669 - 20,622,518 (-)Ensembl
GRCh38920,341,669 - 20,622,499 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37920,341,663 - 20,622,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36920,334,968 - 20,612,514 (-)NCBINCBI36hg18NCBI36
Build 34920,334,967 - 20,612,450NCBI
Celera920,283,496 - 20,561,027 (-)NCBI
Cytogenetic Map9p21.3NCBI
HuRef920,307,852 - 20,585,160 (-)NCBIHuRef
CHM1_1920,341,444 - 20,622,254 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MLLT3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737507
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.