VSX1 (visual system homeobox 1) - Rat Genome Database

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Gene: VSX1 (visual system homeobox 1) Sus scrofa
Analyze
Symbol: VSX1
Name: visual system homeobox 1
RGD ID: 13878313
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); sequence-specific double-stranded DNA binding (inferred); INVOLVED IN neuron development (inferred); neuron maturation (inferred); regulation of DNA-templated transcription (inferred); ASSOCIATED WITH Auditory Perceptual Disorders (ortholog); corneal dystrophy (ortholog); Craniofacial Abnormalities (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,848,484 - 30,856,213 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,848,497 - 30,856,014 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,997,534 - 35,004,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VSX1Pigcorneal dystrophy  ISOVSX1 (Homo sapiens)9068941associated with Craniofacial Abnormalities more ...RGDPMID:15051220 and REF_RGD_ID:8657029
VSX1Pigcorneal dystrophy  ISOVSX1 (Homo sapiens)9068941KTCN1 more ...RGDPMID:11978762 and REF_RGD_ID:1599773
VSX1PigKeratoconus 1 no_associationISOVSX1 (Homo sapiens)9068941DNA:missense mutations:cds:p.L159M more ...RGDPMID:18216574 and REF_RGD_ID:8657052
VSX1PigKeratoconus 1 no_associationISOVSX1 (Homo sapiens)9068941DNA:missense mutation:cds:p.D144E (human)RGDPMID:17960127 and REF_RGD_ID:8657045
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VSX1PigCraniofacial Anomalies and Anterior Segment Dysgenesis Syndrome  ISOVSX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Craniofacial anomalies and anterior segment dysgenesis syndromeClinVarPMID:15051220 and PMID:25741868
VSX1Piggenetic disease  ISOVSX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
VSX1Pigkeratoconus  ISOVSX1 (Homo sapiens)8554872ClinVar Annotator: match by term: KeratoconusClinVarPMID:23592923 more ...
VSX1PigKeratoconus 1  ISOVSX1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11978762 more ...
VSX1Piglong QT syndrome  ISOVSX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Long QT syndromeClinVarPMID:26132555
VSX1Pigposterior polymorphous corneal dystrophy  ISOVSX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Posterior polymorphous corneal dystrophyClinVarPMID:11978762 more ...
VSX1Pigposterior polymorphous corneal dystrophy 1  ISOVSX1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11978762 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VSX1PigAuditory Perceptual Disorders  ISOVSX1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15051220
VSX1Pigcorneal dystrophy  ISOVSX1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:11978762
VSX1PigCraniofacial Abnormalities  ISOVSX1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15051220
VSX1Pigempty sella syndrome  ISOVSX1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15051220
VSX1PigEye Abnormalities  ISOVSX1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15051220
VSX1Pigretinal disease  ISOVSX1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15051220
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VSX1PigCraniofacial Anomalies and Anterior Segment Dysgenesis Syndrome  ISOVSX1 (Homo sapiens)7240710 OMIM 
VSX1PigKeratoconus 1  ISOVSX1 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VSX1Pigneuron development involved_inIBAMGI:1890816 and PANTHER:PTN008613228150520179 GO_CentralGO_REF:0000033
VSX1Pigneuron development acts_upstream_of_or_withinIEAUniProtKB:Q91V10 and ensembl:ENSMUSP00000039088150520179 EnsemblGO_REF:0000107
VSX1Pigneuron maturation acts_upstream_of_or_withinIEAUniProtKB:Q91V10 and ensembl:ENSMUSP00000039088150520179 EnsemblGO_REF:0000107
VSX1Pigregulation of DNA-templated transcription involved_inIEAInterPro:IPR017970150520179 InterProGO_REF:0000002
VSX1Pigregulation of DNA-templated transcription involved_inIBAPANTHER:PTN001550454 and ZFIN:ZDB-GENE-990415-205150520179 GO_CentralGO_REF:0000033
VSX1Pigregulation of transcription by RNA polymerase II involved_inIEAGO:0000981150520179 GOCGO_REF:0000108
VSX1Pigretinal bipolar neuron differentiation acts_upstream_of_or_withinIEAUniProtKB:Q91V10 and ensembl:ENSMUSP00000039088150520179 EnsemblGO_REF:0000107
VSX1Pigvisual perception acts_upstream_of_or_withinIEAUniProtKB:Q91V10 and ensembl:ENSMUSP00000039088150520179 EnsemblGO_REF:0000107
VSX1Pigvisual perception involved_inIEAUniProtKB-KW:KW-0844150520179 UniProtGO_REF:0000043
1 to 9 of 9 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VSX1Pignucleus located_inIEAUniRule:UR000401037150520179 UniProtGO_REF:0000104
VSX1Pignucleus is_active_inIBAMGI:1890816 and PANTHER:PTN001550454150520179 GO_CentralGO_REF:0000033
VSX1Pignucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
VSX1Pignucleus located_inIEAUniProtKB:Q91V10 and ensembl:ENSMUSP00000039088150520179 EnsemblGO_REF:0000107
VSX1Pignucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
VSX1PigDNA binding enablesIEAUniProtKB-KW:KW-0238 and UniProtKB-KW:KW-0371150520179 UniProtGO_REF:0000043
VSX1PigDNA binding enablesIEAInterPro:IPR001356150520179 InterProGO_REF:0000002
VSX1PigDNA binding enablesIEAUniRule:UR000401037150520179 UniProtGO_REF:0000104
VSX1PigDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAInterPro:IPR017970150520179 InterProGO_REF:0000002
VSX1Pigprotein binding enablesISOUniProtKB:P46379-29068941 PMID:32814053IntActPMID:32814053
VSX1Pigsequence-specific double-stranded DNA binding enablesIEAUniProtKB:Q9NZR4 and ensembl:ENSP00000365899150520179 EnsemblGO_REF:0000107
VSX1Pigtranscription cis-regulatory region binding enablesIBAPANTHER:PTN001550454 and ZFIN:ZDB-GENE-990415-205150520179 GO_CentralGO_REF:0000033

PMID:22301074   PMID:30032202  



VSX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,848,484 - 30,856,213 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,848,497 - 30,856,014 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,997,534 - 35,004,959 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VSX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382025,070,880 - 25,082,141 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2025,070,885 - 25,082,141 (-)EnsemblGRCh38hg38GRCh38
GRCh372025,051,516 - 25,062,777 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362025,004,099 - 25,010,767 (-)NCBINCBI36Build 36hg18NCBI36
Build 342025,007,194 - 25,010,767NCBI
Celera2025,129,909 - 25,136,577 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2025,008,800 - 25,020,295 (-)NCBIHuRef
CHM1_12025,052,457 - 25,063,935 (-)NCBICHM1_1
T2T-CHM13v2.02025,127,147 - 25,146,758 (-)NCBIT2T-CHM13v2.0
Vsx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392150,522,622 - 150,531,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2150,522,622 - 150,531,280 (-)EnsemblGRCm39 Ensembl
GRCm382150,680,702 - 150,689,137 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2150,680,702 - 150,689,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv372150,506,438 - 150,514,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362150,372,143 - 150,380,578 (-)NCBIMGSCv36mm8
Celera2151,915,696 - 151,924,136 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.74NCBI
Vsx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83159,974,693 - 159,982,292 (-)NCBIGRCr8
mRatBN7.23139,514,270 - 139,521,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3139,514,270 - 139,521,869 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3143,410,661 - 143,418,257 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03151,994,390 - 152,001,986 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03149,742,529 - 149,750,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03146,484,235 - 146,494,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3146,484,238 - 146,491,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03152,843,269 - 152,850,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43141,322,816 - 141,330,415 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13141,229,916 - 141,235,812 (-)NCBI
Celera3138,276,455 - 138,284,054 (-)NCBICelera
Cytogenetic Map3q41NCBI
Vsx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,175,452 - 31,180,655 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,174,155 - 31,180,718 (-)NCBIChiLan1.0ChiLan1.0
VSX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22125,940,336 - 25,956,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12025,937,169 - 25,952,911 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02025,011,149 - 25,025,545 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12025,361,211 - 25,372,705 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2025,361,216 - 25,372,705 (-)Ensemblpanpan1.1panPan2
VSX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,268,465 - 1,274,854 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl231,269,139 - 1,274,784 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha231,298,714 - 1,304,409 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,511,603 - 1,517,296 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,511,653 - 1,517,296 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1231,326,829 - 1,332,519 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0231,456,977 - 1,462,672 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0231,440,015 - 1,445,745 (-)NCBIUU_Cfam_GSD_1.0
Vsx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640147,290,512 - 147,297,747 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936620710,671 - 718,595 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936620710,917 - 718,205 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VSX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366762413,463 - 18,381 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vsx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624939375,749 - 381,823 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in VSX1
216 total Variants



ectoderm
mesenchyme
mesoderm
nervous system
1 1 1 1


RefSeq Transcripts XM_003359919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP565328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSSCT00000025097   ⟹   ENSSSCP00000023121
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1730,848,484 - 30,856,213 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000073186   ⟹   ENSSSCP00000069305
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1730,852,021 - 30,856,213 (-)Ensembl
RefSeq Acc Id: XM_003359919   ⟹   XP_003359967
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11730,848,497 - 30,856,014 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003359967   ⟸   XM_003359919
- UniProtKB: I3LGC8 (UniProtKB/TrEMBL),   A0A4X1V1M7 (UniProtKB/TrEMBL),   A0A8D0N0L3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000023121   ⟸   ENSSSCT00000025097
Ensembl Acc Id: ENSSSCP00000069305   ⟸   ENSSSCT00000073186
CVC   Homeobox



1 to 40 of 55 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000023887 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015022175 UniProtKB/TrEMBL
  ENSSSCG00025055385 UniProtKB/TrEMBL
  ENSSSCG00030046978 UniProtKB/TrEMBL
  ENSSSCG00035048278 UniProtKB/TrEMBL
  ENSSSCG00045019328 UniProtKB/TrEMBL
  ENSSSCG00050025675 UniProtKB/TrEMBL
  ENSSSCG00055014159 UniProtKB/TrEMBL
  ENSSSCG00065043913 UniProtKB/TrEMBL
  ENSSSCG00070021874 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025097 ENTREZGENE
  ENSSSCT00000025097.4 UniProtKB/TrEMBL
  ENSSSCT00000073186.2 UniProtKB/TrEMBL
  ENSSSCT00015029351.1 UniProtKB/TrEMBL
  ENSSSCT00025075800.1 UniProtKB/TrEMBL
  ENSSSCT00030065528.1 UniProtKB/TrEMBL
  ENSSSCT00030065541.1 UniProtKB/TrEMBL
  ENSSSCT00035064311.1 UniProtKB/TrEMBL
  ENSSSCT00035064315.1 UniProtKB/TrEMBL
  ENSSSCT00045032963.1 UniProtKB/TrEMBL
  ENSSSCT00045033053.1 UniProtKB/TrEMBL
  ENSSSCT00050034575.1 UniProtKB/TrEMBL
  ENSSSCT00055027931.1 UniProtKB/TrEMBL
  ENSSSCT00055027965.1 UniProtKB/TrEMBL
  ENSSSCT00065060049.1 UniProtKB/TrEMBL
  ENSSSCT00065060055.1 UniProtKB/TrEMBL
  ENSSSCT00070043466.1 UniProtKB/TrEMBL
  ENSSSCT00070043474.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro CVC UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_domain UniProtKB/TrEMBL
KEGG Report ssc:100620386 UniProtKB/TrEMBL
NCBI Gene VSX1 ENTREZGENE
PANTHER CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG UniProtKB/TrEMBL
  VISUAL SYSTEM HOMEOBOX 1 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PROSITE CVC UniProtKB/TrEMBL
1 to 40 of 55 rows