HCG22 (HLA complex group 22 (non-protein coding))

Advanced Search (OLGA)

Gene: HCG22 (HLA complex group 22 (non-protein coding)) Homo sapiens

Analyze

No known orthologs.

Symbol:

HCG22

Name:

HLA complex group 22 (non-protein coding)

RGD ID:

1353415

HGNC Page

HGNC:27780

Description:

Predicted to be located in extracellular region.

Type:

ncrna (Ensembl: lncRNA)

RefSeq Status:

VALIDATED

Previously known as:

FLJ37114; HLA complex group 22; HLA complex group 22 (gene/pseudogene); panbronchiolitis related mucin-like 2; panbronchiolitis-related mucin-like protein 2; PBMUCL2

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,053,449 - 31,059,849 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,053,311 - 31,065,229 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,021,226 - 31,027,626 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	31,129,963 - 31,135,632 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	31,129,962 - 31,135,632	NCBI
Celera	6	32,622,207 - 32,627,873 (+)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	30,824,382 - 30,830,823 (+)	NCBI		HuRef
CHM1_1	6	31,023,370 - 31,029,801 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	30,921,184 - 30,927,585 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

megacolon (IAGP)

proteasome-associated autoinflammatory syndrome 1 (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

benzo[a]pyrene (EXP)

hydralazine (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

extracellular region (IEA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Megacolon (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:14702039	PMID:19851445	PMID:20981447	PMID:21051598	PMID:21738480	PMID:22493691	PMID:23001997	PMID:23263863	PMID:25429064	PMID:25813999	PMID:28005267	PMID:31236983
PMID:33649984	PMID:34859625	PMID:38497386

Genomics

Variants

Variants in HCG22
5 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3	copy number gain	See cases [RCV000143497]	Chr6:156974..46789291 [GRCh38] Chr6:156974..46757028 [GRCh37] Chr6:101974..46864987 [NCBI36] Chr6:6p25.3-12.3	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3	copy number gain	See cases [RCV000512067]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)	copy number gain	See cases [RCV000510595]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3	copy number gain	not provided [RCV000745403]	Chr6:108666..170980171 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3	copy number gain	not provided [RCV000745400]	Chr6:60107..171054786 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3	copy number gain	not provided [RCV000745404]	Chr6:165632..170919470 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3	copy number gain	not provided [RCV000745592]	Chr6:28130359..32108367 [GRCh37] Chr6:6p22.1-21.32	uncertain significance
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367)	copy number gain	not provided [RCV000767714]	Chr6:29455465..81447367 [GRCh37] Chr6:6p22.1-q14.1	pathogenic
NC_000006.11:g.(?_30695893)_(31937492_?)dup	duplication	not provided [RCV003107453]	Chr6:30695893..31937492 [GRCh37] Chr6:6p21.33	uncertain significance
NC_000006.11:g.28005012_31683185del	deletion	Megacolon [RCV001290055]	Chr6:28005012..31683185 [GRCh37] Chr6:6p22.1-21.33	likely pathogenic
NC_000006.11:g.(?_30695893)_(36953949_?)dup	duplication	Proteasome-associated autoinflammatory syndrome 1 [RCV003113679]	Chr6:30695893..36953949 [GRCh37] Chr6:6p21.33-21.2	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	882
Count of miRNA genes:	490
Interacting mature miRNAs:	523
Transcripts:	ENST00000426185, ENST00000562344, ENST00000565192, ENST00000566475, ENST00000570223
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
407128388	GWAS777364_H	BMI-adjusted waist-hip ratio QTL GWAS777364 (human)		5e-12	BMI-adjusted waist-hip ratio		6	31055051	31055052	Human
407211717	GWAS860693_H	age at diagnosis, hyperlipidemia QTL GWAS860693 (human)		3e-08	age at diagnosis, hyperlipidemia		6	31059559	31059560	Human
407190022	GWAS838998_H	blood protein measurement QTL GWAS838998 (human)		3e-32	blood protein measurement	blood protein measurement (CMO:0000028)	6	31057019	31057020	Human
1298458	BW9_H	Body weight QTL 9 (human)	2.7	0.0002	Body fat amount		6	6911960	32911960	Human
407155337	GWAS804313_H	lactobacillus phage virus seropositivity QTL GWAS804313 (human)		4e-13	lactobacillus phage virus seropositivity		6	31059559	31059560	Human
407153941	GWAS802917_H	staphylococcus seropositivity QTL GWAS802917 (human)		9e-22	staphylococcus seropositivity		6	31059559	31059560	Human
1358854	MULTSCL4_H	Multiple sclerosis susceptibility QTL 4 (human)			Multiple sclerosis susceptibility		6	6911960	32911960	Human
407095440	GWAS744416_H	type 2 diabetes mellitus QTL GWAS744416 (human)		1e-17	type 2 diabetes mellitus		6	31058459	31058460	Human
407158993	GWAS807969_H	clostridiales seropositivity QTL GWAS807969 (human)		2e-14	clostridiales seropositivity		6	31059559	31059560	Human
407134301	GWAS783277_H	severe acute respiratory syndrome, COVID-19 QTL GWAS783277 (human)		1e-10	severe acute respiratory syndrome, COVID-19		6	31058657	31058658	Human
407259036	GWAS908012_H	sarcoidosis QTL GWAS908012 (human)		0.000001	sarcoidosis		6	31054381	31054382	Human
407154456	GWAS803432_H	lactobacillus phage virus seropositivity QTL GWAS803432 (human)		9e-21	lactobacillus phage virus seropositivity		6	31059559	31059560	Human
1358857	MULTSCL19_H	Multiple sclerosis susceptibility QTL 19 (human)			Multiple sclerosis susceptibility		6	19584311	45584311	Human
1643399	BMD5_H	Bone mineral density QTL 5 (human)	2.32	0.0005	Bone mineral density		6	6911960	32911960	Human
407135972	GWAS784948_H	BMI-adjusted hip circumference QTL GWAS784948 (human)		3e-08	BMI-adjusted hip circumference	hip circumference (CMO:0000014)	6	31055051	31055052	Human
1358839	MULTSCL5_H	Multiple sclerosis susceptibility QTL 5 (human)			Multiple sclerosis susceptibility		6	19584311	45584311	Human
407064102	GWAS713078_H	Inguinal hernia QTL GWAS713078 (human)		2e-08	Inguinal hernia		6	31057019	31057020	Human
1643377	BW325_H	Body weight QTL 325 (human)	2.32	0.0005	Body fat amount		6	6911960	32911960	Human
1643569	GLUCO21_H	Glucose level QTL 21 (human)		0.021	Glucose level	non-insulin-dependent	6	6911960	32911960	Human
407076203	GWAS725179_H	BMI-adjusted waist-hip ratio QTL GWAS725179 (human)		3e-11	BMI-adjusted waist-hip ratio		6	31055051	31055052	Human
407212013	GWAS860989_H	essential hypertension, age at diagnosis QTL GWAS860989 (human)		4e-08	essential hypertension, age at diagnosis		6	31059559	31059560	Human
407221871	GWAS870847_H	BMI-adjusted hip circumference QTL GWAS870847 (human)		2e-10	BMI-adjusted hip circumference	hip circumference (CMO:0000014)	6	31054381	31054382	Human
407207535	GWAS856511_H	protein measurement QTL GWAS856511 (human)		3e-08	protein measurement		6	31059792	31059793	Human
1298431	RA11_H	Rheumatoid arthritis QTL 11 (human)		0.0000024	Joint/bone inflammation	rheumatoid arthritis	6	19911883	40191709	Human
407189431	GWAS838407_H	blood protein measurement QTL GWAS838407 (human)		4e-29	blood protein measurement	blood protein measurement (CMO:0000028)	6	31057019	31057020	Human
406932275	GWAS581251_H	disease QTL GWAS581251 (human)		5e-09	disease		6	31059559	31059560	Human
407012858	GWAS661834_H	HIV-1 infection QTL GWAS661834 (human)		1e-08	HIV-1 infection		6	31057031	31057032	Human
407161018	GWAS809994_H	response to thioamide, Drug-induced agranulocytosis QTL GWAS809994 (human)		6e-19	response to thioamide, Drug-induced agranulocytosis		6	31056824	31056825	Human

Markers in Region

D6S2693

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,023,014 - 31,023,173	UniSTS	GRCh37
Build 36	6	31,130,993 - 31,131,152	RGD	NCBI36
Celera	6	32,623,237 - 32,623,396	RGD
Cytogenetic Map	6	p21.33	UniSTS
HuRef	6	30,826,169 - 30,826,328	UniSTS

D6S2694

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,020,572 - 31,020,881	UniSTS	GRCh37
GRCh37	6	31,020,566 - 31,020,823	UniSTS	GRCh37
Build 36	6	31,128,545 - 31,128,802	RGD	NCBI36
Celera	6	32,620,792 - 32,621,046	RGD
Celera	6	32,620,798 - 32,621,104	UniSTS
HuRef	6	30,823,729 - 30,824,036	UniSTS
HuRef	6	30,823,723 - 30,823,978	UniSTS

C2_4_5

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,022,709 - 31,023,144	UniSTS	GRCh37
Build 36	6	31,130,688 - 31,131,123	RGD	NCBI36
Celera	6	32,622,932 - 32,623,367	RGD
Cytogenetic Map	6	p21.33	UniSTS
HuRef	6	30,825,864 - 30,826,299	UniSTS

D6S2942

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,020,545 - 31,020,850	UniSTS	GRCh37
Build 36	6	31,128,524 - 31,128,829	RGD	NCBI36
Celera	6	32,620,771 - 32,621,073	RGD
HuRef	6	30,823,702 - 30,824,005	UniSTS

D6S2941

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,023,018 - 31,023,186	UniSTS	GRCh37
Build 36	6	31,130,997 - 31,131,165	RGD	NCBI36
Celera	6	32,623,241 - 32,623,409	RGD
HuRef	6	30,826,173 - 30,826,341	UniSTS

D6S2694

Human Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	6	p21.33	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
1179	1962	2418	1939	4384	1218	1729	319	1503	161	1961	5505	5499	24	3537	607	1259	1348	169	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NR_003948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_145427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB560771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB600644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK094433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL663093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL669830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL805909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX247900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX927139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR753812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR759772	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR759964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT009481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GQ472773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KC312698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000426185

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,159 - 31,059,894 (+)	Ensembl

Ensembl Acc Id:

ENST00000562344

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,446 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000565192

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,450 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000566475

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,147 - 31,060,810 (+)	Ensembl

Ensembl Acc Id:

ENST00000570223

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,202 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000615046

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,072 - 31,059,876 (+)	Ensembl

Ensembl Acc Id:

ENST00000646461

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,330 - 31,059,876 (+)	Ensembl

Ensembl Acc Id:

ENST00000805383

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,176 - 31,065,229 (+)	Ensembl

Ensembl Acc Id:

ENST00000805384

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,371 - 31,064,192 (+)	Ensembl

Ensembl Acc Id:

ENST00000805385

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,449 - 31,064,190 (+)	Ensembl

Ensembl Acc Id:

ENST00000805386

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,449 - 31,064,190 (+)	Ensembl

Ensembl Acc Id:

ENST00000805387

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,449 - 31,064,190 (+)	Ensembl

Ensembl Acc Id:

ENST00000805388

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,202 - 31,064,190 (+)	Ensembl

Ensembl Acc Id:

ENST00000805389

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,207 - 31,064,190 (+)	Ensembl

Ensembl Acc Id:

ENST00000805390

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,237 - 31,064,190 (+)	Ensembl

Ensembl Acc Id:

ENST00000805391

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,237 - 31,064,190 (+)	Ensembl

Ensembl Acc Id:

ENST00000805392

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,239 - 31,064,187 (+)	Ensembl

Ensembl Acc Id:

ENST00000805393

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,311 - 31,060,812 (+)	Ensembl

Ensembl Acc Id:

ENST00000805394

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,100 - 31,060,812 (+)	Ensembl

Ensembl Acc Id:

ENST00000805395

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,202 - 31,060,810 (+)	Ensembl

Ensembl Acc Id:

ENST00000805396

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,371 - 31,059,849 (+)	Ensembl

Ensembl Acc Id:

ENST00000805397

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,445 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000805398

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,449 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000805399

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,449 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000805400

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,448 - 31,059,849 (+)	Ensembl

Ensembl Acc Id:

ENST00000805401

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,451 - 31,059,849 (+)	Ensembl

Ensembl Acc Id:

ENST00000805402

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,202 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000805403

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,202 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000805404

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,202 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000805405

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,235 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000805406

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,054,241 - 31,059,890 (+)	Ensembl

Ensembl Acc Id:

ENST00000805407

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,053,465 - 31,054,990 (+)	Ensembl

RefSeq Acc Id:

NR_003948

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,053,449 - 31,059,849 (+)	NCBI
GRCh37	6	31,021,227 - 31,027,667 (+)	NCBI
Build 36	6	31,129,963 - 31,135,632 (+)	NCBI Archive
Celera	6	32,622,207 - 32,627,873 (+)	RGD
HuRef	6	30,824,382 - 30,830,823 (+)	NCBI
CHM1_1	6	31,023,370 - 31,029,801 (+)	NCBI
T2T-CHM13v2.0	6	30,921,184 - 30,927,585 (+)	NCBI

Sequence:

show sequence

CTCATTTTCTCTTGCCGCCACTGTGTAAGAAGTGCCTTTTGTCTCCCTCCGTGATTCTGAGGCC
TCCCCAGCCATGTGGAACTCCTCTTCTGCCCTGCCCGGCCACTCCTTTGAGTGACAGGGGGTAA
TTGAGAAGCTGCTCCTCCCTCCAGGAAGGAAGACCCGGAGCTCTGGCTTCCCTCGGCAAAGCAC
ATATAAACCCACAGCCACTGCGGGTGGAAGGAGAAGGGCAGGGTGGAAAAAGTTTGAGAGAAGG
AGGGAGGAAAAGGTGTCCTGGCTAGCACCATGTGGATTCTCTTGAGATGAGAAGAAAATGCCCC
GCTACGTCCCCCTTCTGCTGCTCCTGCTTCTCCTGAGGTGTTCAGAACGGGGTGGAGGAGTTAA
TTTTGGTGAGAAGGATGCAAAAGTCCCCGGGACCTGGAGAGATGGAGTCAGGGTCCCTGGAGAA
GGAGCCTCTTGGGACTCAGACAGGGCCAGTCCCGAGCGAAGGTACGGAATAGATGGAGCACCTG
GCCAGCTGTCTCATTTTAAATCATATACCAAGCATGACCTGAGTGTAATCTCTAACATGAATCA
CAGCTTCTGCCTCATTGGTTTGCCAGAACCGCAGGCACAAATGGATGAGAGGAGACACCTATGA
ACATGGAGCCAGAATACCCCAATTGCTGAAACACCAGTTCAGAGAGGAGTGAGCTTGAGAAAGA
GTCAGGTTTAGTGTCCCACGGAAAGAGACCAGACCTGGAAAAGACAGAGTCAAAGCTGGGTGAG
CAGGCCTTCGAAGGGCGTGGCTCAGCAAAGATAATCCATATTGTAGTGCAAGAGGATTCTTGTG
GAATATGTTTTACCAGAATTAAACCAAAAATGCCAAATGATCCCTAACTGGAATAAATCTCACC
ACATTACCTGGGGAGAGGTGTCATTTGGATGTGAGGATAGTTATGAAAATACTGAGCAGAGCAG
ATGAGGATAGGCCATCAACAATTCACATTAAATGAGATTACTTTTTAGTAGGACTAAGCCAAAG
CATTTCCACTAAGCACCCAGAGACCAGCCCTAAAGACTCAAGAATAAGAGAAAATGATGTAACT
GCAGATGGAAGGACCACTGAGGACCACATCACTGCAGACCCAGGGACCACCGAGGACTCTGTCA
CTGCAGACCCAGGGACCACTGAGGACAATGTGACTGTGGACCCAGGGACCACCGAGGGCTCTGT
CACTGCAGACCCAGCGACCACCAAGGACTATGTGTCTGCAGACCCAGGGACCACCAAGGATTCT
GTCACTGCAGACCCAGGGACCACTCACTGAGAACTTTGTCACTGCAGACCCAGGGACCACCAAG
GACTCCATCACTGCAGACCCAAGGACCACAGAGGACTCCGTCACTGCAGACCCAGGGACCACCA
AACACTCCATCACTGTAGACCCAGGGACCACTGAGGACTCTGTCACTGCAGACCCAGGGACCAC
CAAACACTCCATCACTGCAGACCCAGGGACCACCGAGGACTCCGTCACTGCAGACCCAGGGACC
ACAGAAGATGAAACCACTAAACATGGTGACACTCACCTTCTGTGAACTACTTCAGTCACAGCAG
TGAAACCCACCAGGCTCCTGACACCCATGGGAATTATCCTCATATCCCTGGCTGCAACCACAGT
CACTGTTGTGCTCTTTGTTGGATTGGGCTTCATTGTGAAAGAGTGTTTCCTGCCTCCATTAAAT
CCATCCACCAGGGTTATTTATCATCCCCATGTCATGGACTACAGTACACCATAAAGAGGACCCC
AGCAGTGACTACAGTTGGTTCTAGAAAAAGGAGACCCCTCATCCGCCTCTGCAAGACTATACAG
CATGATGTGTATCCTCAGGCCTCCACTCCTCCGCCCTAGTCTGGAGCCCTGGGACCACCACATG
AGGAAGGCAGCTGGCCCCTGGAATAAGCATGTGGAGGACACTCAGAAGGATGCCCATCTGCTCT
GAGTGTCTCCTAATTCTGCCTGACCTTGGTTACTTCCTCTGGACAATCGCCTTTACCTATCTAC
CAGGTTTTGAGGAATTACACACAGCTCAGGTATAAGAGATATTCGGTAAGTCTGATCAAATCAA
TAAAGCAAATTTTATCTGTTTTTGTCTGGGA

hide sequence

RefSeq Acc Id:

NR_145427

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,053,449 - 31,059,849 (+)	NCBI
T2T-CHM13v2.0	6	30,921,184 - 30,927,585 (+)	NCBI

Sequence:

show sequence

CTCATTTTCTCTTGCCGCCACTGTGTAAGAAGTGCCTTTTGTCTCCCTCCGTGATTCTGAGGCC
TCCCCAGCCATGTGGAACTCCTCTTCTGCCCTGCCCGGCCACTCCTTTGAGTGACAGGGGGTAA
TTGAGAAGCTGCTCCTCCCTCCAGGAAGGAAGACCCGGAGCTCTGGCTTCCCTCGGCAAAGCAC
ATATAAACCCACAGCCACTGCGGGTGGAAGGAGAAGGGCAGGGTGGAAAAAGTTTGAGAGAAGG
AGGGAGGAAAAGGTGTCCTGGCTAGCACCATGTGGATTCTCTTGAGATGAGAAGAAAATGCCCC
GCTACGTCCCCCTTCTGCTGCTCCTGCTTCTCCTGAGGTGTTCAGAACGGGGTGGAGGAGTTAA
TTTTGGTGAGAAGGATGCAAAAGTCCCCGGGACCTGGAGAGATGGAGTCAGGGTCCCTGGAGAA
GGAGCCTCTTGGGACTCAGACAGGGCCAGTCCCGAGCGAAGGTACGGAATAGTAGGACTAAGCC
AAAGCATTTCCACTAAGCACCCAGAGACCAGCCCTAAAGACTCAAGAATAAGAGAAAATGATGT
AACTGCAGATGGAAGGACCACTGAGGACCACATCACTGCAGACCCAGGGACCACCGAGGACTCT
GTCACTGCAGACCCAGGGACCACTGAGGACAATGTGACTGTGGACCCAGGGACCACCGAGGGCT
CTGTCACTGCAGACCCAGCGACCACCAAGGACTATGTGTCTGCAGACCCAGGGACCACCAAGGA
TTCTGTCACTGCAGACCCAGGGACCACTCACTGAGAACTTTGTCACTGCAGACCCAGGGACCAC
CAAGGACTCCATCACTGCAGACCCAAGGACCACAGAGGACTCCGTCACTGCAGACCCAGGGACC
ACCAAACACTCCATCACTGTAGACCCAGGGACCACTGAGGACTCTGTCACTGCAGACCCAGGGA
CCACCAAACACTCCATCACTGCAGACCCAGGGACCACCGAGGACTCCGTCACTGCAGACCCAGG
GACCACAGAAGATGAAACCACTAAACATGGTGACACTCACCTTCTGTGAACTACTTCAGTCACA
GCAGTGAAACCCACCAGGCTCCTGACACCCATGGGAATTATCCTCATATCCCTGGCTGCAACCA
CAGTCACTGTTGTGCTCTTTGTTGGATTGGGCTTCATTGTGAAAGAGTGTTTCCTGCCTCCATT
AAATCCATCCACCAGGGTTATTTATCATCCCCATGTCATGGACTACAGTACACCATAAAGAGGA
CCCCAGCAGTGACTACAGTTGGTTCTAGAAAAAGGAGACCCCTCATCCGCCTCTGCAAGACTAT
ACAGCATGATGTGTATCCTCAGGCCTCCACTCCTCCGCCCTAGTCTGGAGCCCTGGGACCACCA
CATGAGGAAGGCAGCTGGCCCCTGGAATAAGCATGTGGAGGACACTCAGAAGGATGCCCATCTG
CTCTGAGTGTCTCCTAATTCTGCCTGACCTTGGTTACTTCCTCTGGACAATCGCCTTTACCTAT
CTACCAGGTTTTGAGGAATTACACACAGCTCAGGTATAAGAGATATTCGGTAAGTCTGATCAAA
TCAATAAAGCAAATTTTATCTGTTTTTGTCTGGGA

hide sequence

Protein Sequences


GenBank Protein	BAJ24155	(Get FASTA)	NCBI Sequence Viewer
	BAJ33503	(Get FASTA)	NCBI Sequence Viewer
	E2RYF7	(Get FASTA)	NCBI Sequence Viewer

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E2RYF7-F1-model_v2	AlphaFold	E2RYF7	1-251	view protein structure

Promoters

RGD ID:

6804290

Promoter ID:

HG_KWN:52886

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Lymphoblastoid

Transcripts:

OTTHUMT00000076351

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	6	31,129,104 - 31,129,604 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:27780	AgrOrtholog
COSMIC	HCG22	COSMIC
Ensembl Genes	ENSG00000228789	Ensembl, ENTREZGENE
Ensembl Transcript	ENST00000426185	ENTREZGENE
	ENST00000565192	ENTREZGENE
GTEx	ENSG00000228789	GTEx
HGNC ID	HGNC:27780	ENTREZGENE
Human Proteome Map	HCG22	Human Proteome Map
InterPro	EZH_Inhibitor	UniProtKB/Swiss-Prot
NCBI Gene	285834	ENTREZGENE
OMIM	613918	OMIM
PANTHER	PROTEIN PBMUCL2	UniProtKB/Swiss-Prot
	UNCHARACTERIZED	UniProtKB/Swiss-Prot
PharmGKB	PA134876212	PharmGKB
RNAcentral	URS00026A223E	RNACentral
	URS00026A27B5	RNACentral
UniProt	E2RYF7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-01-29	HCG22	HLA complex group 22 (non-protein coding)	HCG22	HLA complex group 22 (gene/pseudogene)	Symbol and/or name change	19259463	PROVISIONAL
2020-11-09	HCG22	HLA complex group 22 (gene/pseudogene)	HCG22	HLA complex group 22	Symbol and/or name change	19259463	PROVISIONAL
2020-05-11	HCG22	HLA complex group 22	HCG22	HLA complex group 22 (gene/pseudogene)	Symbol and/or name change	19259463	PROVISIONAL
2017-08-22	HCG22	HLA complex group 22 (gene/pseudogene)		HLA complex group 22	Symbol and/or name change	5135510	APPROVED
2013-12-24	HCG22	HLA complex group 22		HLA complex group 22 (non-protein coding)	Symbol and/or name change	5135510	APPROVED
2011-09-13	HCG22	HLA complex group 22 (non-protein coding)	HCG22	HLA complex group 22	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Human Phenotype Annotations - ClinVar

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Imported Disease Annotations - ClinVar

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