GWAS860989_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS860989_H (essential hypertension, age at diagnosis QTL GWAS860989 (human)) Homo sapiens

Symbol: GWAS860989_H
Name: essential hypertension, age at diagnosis QTL GWAS860989 (human)
RGD ID: 407212013
Trait: essential hypertension, age at diagnosis
LOD Score: Not Available
P Value: 4.0E-8
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38631,059,559 - 31,059,560RGD_MAPPER_PIPELINEGRCh38
GRCh37631,027,336 - 31,027,337RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model



Experimental Factor Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
GWAS860989_HHumanage at diagnosis  IAGPrs2517521405850206 GWAS_CATALOGPMID:32589924
GWAS860989_HHumanessential hypertension  IAGPrs2517521405850206 GWAS_CATALOGPMID:32589924
References

References - curated
# Reference Title Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1353415HCG22HLA complex group 22 (non-protein coding)63105344931059849Human

Position Markers

Peak: (rs2517521)
Human AssemblyChrPosition (strand)Source
GRCh38631,059,559 - 31,059,560RGD_MAPPER_PIPELINE


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407211717GWAS860693_Hage at diagnosis, hyperlipidemia QTL GWAS860693 (human)3e-08age at diagnosis, hyperlipidemia63105955931059560Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
1643377BW325_HBody weight QTL 325 (human)2.320.0005Body fat amount6691196032911960Human
1643569GLUCO21_HGlucose level QTL 21 (human)0.021Glucose levelnon-insulin-dependent6691196032911960Human
407212013GWAS860989_Hessential hypertension, age at diagnosis QTL GWAS860989 (human)4e-08essential hypertension, age at diagnosis63105955931059560Human
1298458BW9_HBody weight QTL 9 (human)2.70.0002Body fat amount6691196032911960Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
407155337GWAS804313_Hlactobacillus phage virus seropositivity QTL GWAS804313 (human)4e-13lactobacillus phage virus seropositivity63105955931059560Human
407153941GWAS802917_Hstaphylococcus seropositivity QTL GWAS802917 (human)9e-22staphylococcus seropositivity63105955931059560Human
1358854MULTSCL4_HMultiple sclerosis susceptibility QTL 4 (human)Multiple sclerosis susceptibility6691196032911960Human
406932275GWAS581251_Hdisease QTL GWAS581251 (human)5e-09disease63105955931059560Human
407158993GWAS807969_Hclostridiales seropositivity QTL GWAS807969 (human)2e-14clostridiales seropositivity63105955931059560Human
407154456GWAS803432_Hlactobacillus phage virus seropositivity QTL GWAS803432 (human)9e-21lactobacillus phage virus seropositivity63105955931059560Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human
1643399BMD5_HBone mineral density QTL 5 (human)2.320.0005Bone mineral density6691196032911960Human


Additional Information

GWAS QTLs Related by Peak Marker
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL GWAS Catalog Study Disease Trait Study Size Risk Allele Risk Allele Frequency P Value P Value MLOG Peak Marker Reported Odds Ratio or Beta-coefficient Ontology Accession PubMed
GWAS581251_H GCST90267290 Number of non-cancer illnesses (standard GWA) 283,743 European ancestry individuals A NR 5E-9 8.302 rs2517521 0.041206 disease (EFO:0000408)
 PMID:37106081
GWAS802917_H GCST90295573 Seropositivity for staphylococcus aureus subsp. aureus MRSA252 peptide (agilent_84757) 1,745 individuals ? NR 9E-22 21.046 rs2517521 9.585 staphylococcus seropositivity (EFO:0803650)
 PMID:37164013
GWAS803432_H GCST90294657 Seropositivity for lactobacillus phage LFEINF peptide (twist_88894) 1,745 individuals ? NR 9E-21 20.046 rs2517521 9.348 lactobacillus phage virus seropositivity (EFO:0803663)
 PMID:37164013
GWAS804313_H GCST90294658 Seropositivity for lactobacillus phage LFEINF peptide (twist_64023) 1,745 individuals ? NR 4E-13 12.398 rs2517521 7.269 lactobacillus phage virus seropositivity (EFO:0803663)
 PMID:37164013
GWAS807969_H GCST90293580 Seropositivity for clostridiales peptide (agilent_68956) 1,745 individuals ? NR 2E-14 13.699 rs2517521 7.68 clostridiales seropositivity (EFO:0803616)
 PMID:37164013
GWAS860693_H GCST010772 Hyperlipidemia (time to event) 35,623 British ancestry cases, 247,248 British ancestry controls ? NR 3E-8 7.523 rs2517521 N/A age at diagnosis (EFO:0004918)
 PMID:32589924
GWAS860989_H GCST010774 Essential hypertension (time to event) 76,566 British ancestry cases, 206,305 British ancestry controls ? NR 4E-8 7.398 rs2517521 N/A age at diagnosis (EFO:0004918)
 PMID:32589924
Database Acc Id Source(s)
GWAS Catalog GCST010774 GWAS Catalog

RGD Curation Notes
Note Type Note Reference