Tsacc (TSSK6 activating co-chaperone) - Rat Genome Database

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Gene: Tsacc (TSSK6 activating co-chaperone) Mus musculus
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Symbol: Tsacc
Name: TSSK6 activating co-chaperone
RGD ID: 1331902
MGI Page MGI
Description: Predicted to enable Hsp70 protein binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to act upstream of or within positive regulation of protein kinase activity. Located in cytoplasm. Orthologous to human TSACC (TSSK6 activating cochaperone).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700021C14Rik; MGC130252; SIP; SSTK-interacting protein; TSSK6-activating co-chaperone protein; uncharacterized protein C1orf182 homolog
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,190,059 - 88,204,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,190,064 - 88,204,306 (-)EnsemblGRCm39 Ensembl
GRCm38388,282,752 - 88,296,999 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,282,757 - 88,296,999 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,086,682 - 88,100,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,368,677 - 88,382,870 (-)NCBIMGSCv36mm8
Celera388,322,340 - 88,336,408 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:17967808   PMID:18799693   PMID:20829357   PMID:21873635  


Genomics

Comparative Map Data
Tsacc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,190,059 - 88,204,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,190,064 - 88,204,306 (-)EnsemblGRCm39 Ensembl
GRCm38388,282,752 - 88,296,999 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,282,757 - 88,296,999 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,086,682 - 88,100,760 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,368,677 - 88,382,870 (-)NCBIMGSCv36mm8
Celera388,322,340 - 88,336,408 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.79NCBI
TSACC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,337,314 - 156,346,995 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,337,314 - 156,346,995 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,307,105 - 156,316,786 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,573,727 - 154,583,410 (+)NCBINCBI36Build 36hg18NCBI36
Celera1129,380,041 - 129,389,722 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,667,393 - 127,677,074 (+)NCBIHuRef
CHM1_11157,703,460 - 157,713,141 (+)NCBICHM1_1
T2T-CHM13v2.01155,475,925 - 155,485,606 (+)NCBIT2T-CHM13v2.0
Tsacc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,053,672 - 176,063,412 (-)NCBIGRCr8
mRatBN7.22173,755,841 - 173,765,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,753,786 - 173,765,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,900,493 - 180,910,017 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,922,850 - 178,932,375 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,522,690 - 173,532,236 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,659,103 - 187,668,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,659,106 - 187,668,708 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,062,118 - 207,071,794 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,371,102 - 180,380,656 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,321,214 - 180,330,802 (-)NCBI
Celera2167,701,813 - 167,711,196 (-)NCBICelera
Cytogenetic Map2q34NCBI
TSACC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,499,868 - 93,508,705 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,231,792 - 93,240,630 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,679,671 - 131,709,720 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,509,008 - 135,516,918 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,509,160 - 135,516,912 (+)Ensemblpanpan1.1panPan2
TSACC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,557,977 - 41,566,581 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,538,214 - 41,566,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,046,147 - 41,054,729 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,422,692 - 41,431,296 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1741,204,114 - 41,212,703 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,257,320 - 41,265,905 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,541,399 - 41,549,956 (-)NCBIUU_Cfam_GSD_1.0
Tsacc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,523,970 - 26,530,686 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,559,663 - 5,561,051 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,559,624 - 5,561,051 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSACC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,725,531 - 93,728,761 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,725,672 - 93,735,029 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,427,767 - 102,436,021 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSACC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,509,738 - 7,518,637 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660386,810,117 - 6,819,459 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:319
Count of miRNA genes:181
Interacting mature miRNAs:188
Transcripts:ENSMUST00000010682, ENSMUST00000107556, ENSMUST00000123536
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
10043981Cia5a_mcollagen induced arthritis QTL 5a (mouse)Not determined38717045489140094Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000010682   ⟹   ENSMUSP00000010682
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,190,067 - 88,204,145 (-)Ensembl
GRCm38.p6 Ensembl388,282,760 - 88,296,838 (-)Ensembl
Ensembl Acc Id: ENSMUST00000107556   ⟹   ENSMUSP00000103180
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,190,064 - 88,204,306 (-)Ensembl
GRCm38.p6 Ensembl388,282,757 - 88,296,999 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123536
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl388,202,231 - 88,204,203 (-)Ensembl
GRCm38.p6 Ensembl388,294,924 - 88,296,896 (-)Ensembl
RefSeq Acc Id: NM_001357024   ⟹   NP_001343953
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,190,061 - 88,204,306 (-)NCBI
GRCm38388,282,754 - 88,296,999 (-)NCBI
Sequence:
RefSeq Acc Id: NM_029801   ⟹   NP_084077
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,190,061 - 88,204,145 (-)NCBI
GRCm38388,282,754 - 88,296,838 (-)NCBI
MGSCv37388,086,682 - 88,100,760 (-)RGD
Celera388,322,340 - 88,336,408 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030252882   ⟹   XP_030108742
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,190,059 - 88,204,267 (-)NCBI
GRCm38388,282,752 - 88,296,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030252883   ⟹   XP_030108743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39388,190,059 - 88,202,729 (-)NCBI
GRCm38388,282,752 - 88,295,421 (-)NCBI
Sequence:
RefSeq Acc Id: NP_084077   ⟸   NM_029801
- UniProtKB: Q9DA44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030108742   ⟸   XM_030252882
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030108743   ⟸   XM_030252883
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001343953   ⟸   NM_001357024
- UniProtKB: Q9DA44 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000103180   ⟸   ENSMUST00000107556
Ensembl Acc Id: ENSMUSP00000010682   ⟸   ENSMUST00000010682

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9DA44-F1-model_v2 AlphaFold Q9DA44 1-124 view protein structure

Promoters
RGD ID:6833166
Promoter ID:MM_KWN:34833
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_009836,   NM_029801,   OTTMUST00000052274,   OTTMUST00000052276,   UC008PUL.1,   UC008PUM.1,   UC008PUN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36388,099,871 - 88,101,327 (-)MPROMDB
RGD ID:6881112
Promoter ID:EPDNEW_M4007
Type:initiation region
Name:Tsacc_1
Description:Mus musculus TSSK6 activating co-chaperone , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38388,296,902 - 88,296,962EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924177 AgrOrtholog
Ensembl Genes ENSMUSG00000010538 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000010682 ENTREZGENE
  ENSMUST00000010682.4 UniProtKB/Swiss-Prot
  ENSMUST00000107556 ENTREZGENE
  ENSMUST00000107556.10 UniProtKB/Swiss-Prot
InterPro SSTK-IP UniProtKB/Swiss-Prot
KEGG Report mmu:76927 UniProtKB/Swiss-Prot
MGD MGI:1924177 ENTREZGENE
NCBI Gene 76927 ENTREZGENE
PANTHER PTHR37368 UniProtKB/Swiss-Prot
  TSSK6-ACTIVATING CO-CHAPERONE PROTEIN UniProtKB/Swiss-Prot
Pfam SSTK-IP UniProtKB/Swiss-Prot
PhenoGen Tsacc PhenoGen
UniProt Q9DA44 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-19 Tsacc  TSSK6 activating co-chaperone  1700021C14Rik  RIKEN cDNA 1700021C14 gene  Symbol and/or name change 5135510 APPROVED